Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease
Abstract
Alzheimer disease (AD) is a progressive neurodegenerative disease associated with cognitive impairment in multiple domains, such as memory and executive functions. Studies reveal damage in the electron transport chain of patients with AD, suggesting that this mitochondrial dysfunction plays an important role in the pathophysiology of the disease. Blood samples were taken from patients with AD (n = 20) and older subjects without dementia (n = 40) to evaluate the activity of complexes I, II, II-III, and IV of the mitochondrial respiratory chain in isolated lymphocytes. Results from the patient and control groups were compared. The activity of complexes II and IV was increased among patients compared to the control group. No significant difference was observed between controls who were not using psychotropic medication and patients. Our findings point out a mechanism of cellular compensation in which the mitochondrial respiratory chain requires an increase in electron transport to supply the energy needed for cellular functioning. Additional studies are needed to better clarify the mechanisms involved in the mitochondrial dynamics of AD.
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A significant increase in the activity of electron transport chain complexes II and IV is reported in mitochondria isolated from AD lymphocytes.
“Consistent with a possible compensatory mechanism in the progression of the disease is a significant increase in the activity of electron transport chain complexes II and IV reported in mitochondria isolated from AD lymphocytes [108]”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [108]
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“Consistent with a possible compensatory mechanism in the progression of the disease is a significant increase in the activity of electron transport chain complexes II and IV reported in mitochondria isolated from AD lymphocytes [108]; however, in mitochondria isolated from AD platelets, the activity of complex IV, or…”
Background
- Authors
- Feldhaus, P., Fraga, D. B., Ghedim, F. V., De Luca, R. D., Bruna, T. D., Heluany, M., Matos, M. P., Ferreira, G. K., Jeremias, I. C., Heluany, C., Streck, E. L., & Zugno, A. I.
- Affiliations
- Universidade do Extremo Sul Catarinense (BR)
- Corresponding author
- Zugno, Alexandra I.
- ORCID
- Venue
- Metabolic Brain Disease
- Published
- 2011-07-26
- Volume
- 26
- Issue
- 3
- Pages
- 229-236
- ISSN
- 0885-7490 (ISSN-L)
- 1573-7365
- OpenAlex
- W2062188401
- Cited by
- 27
- References
- 68
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Metabolic Brain Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, mitochondrial dysfunction, electron transport chain, lymphocytes, complex II, cytochrome c oxidase, psychotropic drugs, mitochondrial dynamics
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Electron Transport Complex IV, Electron Transport, Female, Humans, Lymphocytes, Male, Middle Aged, Mitochondria, Electron Transport Complex III, Case-Control Studies, Electron Transport Complex II, Electron Transport Complex I
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