Cited by 221Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAntioxidant Activity and Oxidative Stress

Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects

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Wojsiat, Joanna, Zoltowska, Katarzyna Marta, Laskowska-Kaszub, Katarzyna, Wojda, Urszula·2018·Oxidative Medicine and Cellular Longevity

Abstract

Alzheimer’s disease (AD) is the most common cause of dementia and a great socioeconomic burden in the aging society. Compelling evidence demonstrates that molecular change characteristics for AD, such as oxidative stress and amyloid β (Aβ) oligomerization, precede by decades the onset of clinical dementia and that the disease represents a biological and clinical continuum of stages, from asymptomatic to severely impaired. Nevertheless, the sequence of the early molecular alterations and the interplay between them are incompletely understood. This review presents current knowledge about the oxidative stress‐induced impairments and compromised oxidative stress defense mechanisms in AD brain and the cross‐talk between various pathophysiological insults, with the focus on excessive reactive oxygen species (ROS) generation and Aβ overproduction at the early stages of the disease. Prospects for AD therapies targeting oxidant/antioxidant imbalance are being discussed, as well as for the development of novel oxidative stress‐related, blood‐based biomarkers for early, noninvasive AD diagnostics.

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Authors
Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U.
Affiliations
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
Corresponding author
Wojda, Urszula
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2018-01
Volume
2018
Issue
1
Pages
6435861-6435861
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2788808587
Cited by
221
References
218
Citations by year
2026: 16 · 2025: 8 · 2024: 18 · 2023: 22 · 2022: 27 · 2021: 45 · 2020: 50 · 2019: 27 · 2018: 8
FWCI
4.28
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
European Regional Development Fund
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
Alzheimer's disease, oxidative stress, oxidant-antioxidant imbalance, reactive oxygen species, amyloid-beta oligomerization, early Alzheimer's disease, blood-based biomarkers, non-invasive diagnosis, therapeutic target
MeSH terms
Alzheimer Disease, Antioxidants, Humans, Biomarkers, Oxidants

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