Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
Open accessAbstract
Alzheimer’s disease (AD) is the most common cause of dementia and a great socioeconomic burden in the aging society. Compelling evidence demonstrates that molecular change characteristics for AD, such as oxidative stress and amyloid β (Aβ) oligomerization, precede by decades the onset of clinical dementia and that the disease represents a biological and clinical continuum of stages, from asymptomatic to severely impaired. Nevertheless, the sequence of the early molecular alterations and the interplay between them are incompletely understood. This review presents current knowledge about the oxidative stress‐induced impairments and compromised oxidative stress defense mechanisms in AD brain and the cross‐talk between various pathophysiological insults, with the focus on excessive reactive oxygen species (ROS) generation and Aβ overproduction at the early stages of the disease. Prospects for AD therapies targeting oxidant/antioxidant imbalance are being discussed, as well as for the development of novel oxidative stress‐related, blood‐based biomarkers for early, noninvasive AD diagnostics.
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ARE activation occurs in Alzheimer's patients.
“which is consistent with ARE activation in Alzheimer’s patients [101]”
From Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice (2019) · cites this paper as [101]
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The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging
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- Authors
- Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U.
- Affiliations
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Corresponding author
- Wojda, Urszula
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2018-01
- Volume
- 2018
- Issue
- 1
- Pages
- 6435861-6435861
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5831771
- OpenAlex
- W2788808587
- Cited by
- 221
- References
- 218
- Citations by year
- 2026: 16 · 2025: 8 · 2024: 18 · 2023: 22 · 2022: 27 · 2021: 45 · 2020: 50 · 2019: 27 · 2018: 8
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- Alzheimer's disease, oxidative stress, oxidant-antioxidant imbalance, reactive oxygen species, amyloid-beta oligomerization, early Alzheimer's disease, blood-based biomarkers, non-invasive diagnosis, therapeutic target
- MeSH terms
- Alzheimer Disease, Antioxidants, Humans, Biomarkers, Oxidants
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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