Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications

Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease

Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802 · see citing works

Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366 · see citing works

The Diagnosis of Stupor and Coma.

Plum, F., & Posner, J. B. (1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-66-1-244 · Cited by 1,156 · see citing works

Simplified Statistics for Small Numbers of Observations

Dean, R. B., & Dixon, W. J. (1951) · Analytical Chemistry · doi:10.1021/ac60052a025 · Cited by 949 · see citing works

Molecular pathways to neurodegeneration

Bossy-Wetzel, E., Schwarzenbacher, R., & Lipton, S. A. (2004) · Nature Medicine · doi:10.1038/nm1067 · Cited by 740 · see citing works

Apolipoprotein E Type 4 Allele and Cerebral Glucose Metabolism in Relatives at Risk for Familial Alzheimer Disease

Small, G. W. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03520360056039 · Cited by 604 · see citing works

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

Mutisya, E. M., Bowling, A. C., & Beal, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062179.x · Cited by 531 · see citing works

Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease

Davis, K. L. (1999) · JAMA · doi:10.1001/jama.281.15.1401 · Cited by 492 · see citing works

β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities

Casley, C. S., Canevari, L., Land, J. M., Clark, J. B., & Sharpe, M. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00681.x · Cited by 485 · see citing works

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

Maurer, I. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00112-3 · Cited by 475 · see citing works

Alzheimer's disease: the two-hit hypothesis.

Zhu, X.-W., Raina, A., Perry, G., & Smith, M. A. (2004) · Lancet Neurology · doi:10.1016/s1474-4422(04)00707-0 · Cited by 449 · see citing works

[2] Citrate synthase from rat liver

Shepherd, D., & Garland, P. B. (1969) · Methods in Enzymology · doi:10.1016/0076-6879(69)13006-2 · Cited by 434 · see citing works

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

Bergeron, M., Gidday, J. M., Yu, A. Y., Semenza, G. L., Ferriero, D. M., & Sharp, F. R. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200009)48:3 · Cited by 427 · see citing works

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

Gibson, G. E., Sheu, K. ‐. R., Blass, J. P., Baker, A., Carlson, K., Harding, B. N., & Perrino, P. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520320022009 · Cited by 425 · see citing works

Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain

Sorbi, S., Bird, E. D., & Blass, J. P. (1983) · Annals of Neurology · doi:10.1002/ana.410130116 · Cited by 395 · see citing works

The diagnosis of stupor and coma

Tucker, J. S. (1981) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(81)90070-5 · Cited by 380 · see citing works

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., & Yankner, B. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36875-8 · Cited by 373 · see citing works

Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates

Weinberg, J. M., Venkatachalam, M. A., Roeser, N. F., & Nissim, I. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2826 · Cited by 317 · see citing works

IMPAIRED SYNTHESIS OF ACETYLCHOLINE IN BRAIN ACCOMPANYING MILD HYPOXIA AND HYPOGLYCEMIA

Gibson, G. E., & Blass, J. P. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb01540.x · Cited by 315 · see citing works

Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease

Haroutunian, V. (1998) · Archives of Neurology · doi:10.1001/archneur.55.9.1185 · Cited by 289 · see citing works

Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease

Planel, E., Miyasaka, T., Launey, T., Chui, D.-H., Tanemura, K., Sato, S., Murayama, O., Ishiguro, K., Tatebayashi, Y., & Takashima, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5561-03.2004 · Cited by 261 · see citing works

Energy Hypometabolism in Posterior Cingulate Cortex of Alzheimer's Patients: Superficial Laminar Cytochrome Oxidase Associated with Disease Duration

Valla, J. E., Berndt, J. D., & Gonzalez-Lima, F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04923.2001 · Cited by 237 · see citing works

Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase

Perry, E. K., Perry, R. H., Tomlinson, B. E., Blessed, G., & Gibson, P. H. (1980) · Neuroscience Letters · doi:10.1016/0304-3940(80)90220-7 · Cited by 236 · see citing works

Insulin Effects on Glucose Metabolism, Memory, and Plasma Amyloid Precursor Protein in Alzheimer's Disease Differ According to Apolipoprotein‐E Genotype

Craft, S., Asthana, S., Schellenberg, G. D., Baker, L. D., Cherrier, M. M., Boyt, A., Martins, R. N., Raskind, M. A., Peskind, E. R., & Plymate, S. R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06371.x · Cited by 191 · see citing works

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

Sheu, K. R., Kim, Y., Blass, J. P., & Weksler, M. E. (1985) · Annals of Neurology · doi:10.1002/ana.410170505 · Cited by 180 · see citing works

The α-Ketoglutarate–Dehydrogenase Complex: A Mediator Between Mitochondria and Oxidative Stress in Neurodegeneration

Gibson, G. E., Blass, J. P., Beal, M. F., & Bunik, V. I. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:043 · Cited by 180 · see citing works

Causes and Consequences of Disturbances of Cerebral Glucose Metabolism in Sporadic Alzheimer Disease: Therapeutic Implications

Hoyer, S. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8969-7_8 · Cited by 173 · see citing works

[16] Succinate dehydrogenase

Veeger, C., Dervartanian, D. V., & Zeylemaker, W. P. (1969) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(69)13020-7 · Cited by 172 · see citing works

[17] Fumarase

Hill, R. L., & Bradshaw, R. A. (1969) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(69)13021-9 · Cited by 171 · see citing works

Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

Butterworth, R. F., & Besnard, A.-M. (1990) · Metabolic Brain Disease · doi:10.1007/bf00997071 · Cited by 164 · see citing works

Model of a Quinary Structure between Krebs TCA Cycle Enzymes: A Model for the Metabolon

Vélot, C., Mixon, M. B., Teige, M., & Srere, P. A. (1997) · Biochemistry · doi:10.1021/bi972011j · Cited by 163 · see citing works

[19] Intra- and extramitochondrial malate dehydrogenases from chicken and tuna heart

Kitto, G. B. (1969) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(69)13023-2 · Cited by 156 · see citing works

Metal and Inflammatory Targets for Alzheimers Disease

Rogers, J. T., & Lahiri, D. K. (2004) · Current Drug Targets · doi:10.2174/1389450043345272 · Cited by 149 · see citing works

Brain protein and α‐ketoglutarate dehydrogenase complex activity in alzheimer‐s disease

Mastrogiacomo, F., LINDSAY, J. G., Bettendorff, L., Rice, J., & Kish, S. J. (1996) · Annals of Neurology · doi:10.1002/ana.410390508 · Cited by 132 · see citing works

Clinical Deterioration in Probable Alzheimer's Disease Correlates with Progressive Metabolic Impairment of Association Areas

Mielke, R., Herholz, K., Grond, M., Kessler, J., & Heiß, W.-D. (1994) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106692 · Cited by 121 · see citing works

Global Transcription Analysis of Krebs Tricarboxylic Acid Cycle Mutants Reveals an Alternating Pattern of Gene Expression and Effects on Hypoxic and Oxidative Genes

McCammon, M. T., Epstein, C. B., Przybyla‐Zawislak, B., McAlister-Henn, L., & Butow, R. A. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-07-0422 · Cited by 121 · see citing works

Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3‐nitropropionic acid neurotoxicity

Klivènyi, P., Starkov, A. A., Calingasan, N. Y., Gardian, G., Browne, S. E., Yang, L., Bubber, P., Gibson, G. E., Patel, M. S., & Beal, M. F. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02263.x · Cited by 108 · see citing works

Ischemia and the aging brain — studies on glucose and energy-metabolism in rat cerebral-cortex

Hoyer, S., & Krier, C. (1986) · Neurobiology of Aging · doi:10.1016/0197-4580(86)90022-9 · Cited by 98 · see citing works

Cell Degeneration Induced by Amyloid-β Peptides: Implications for Alzheimer's Disease

Pereira, C., Ferreiro, E. B., Cardoso, S. M., & Oliveira, C. R. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:1-2:097 · Cited by 88 · see citing works

Decreased Brain Protein Levels of Cytochrome Oxidase Subunits in Alzheimer's Disease and in Hereditary Spinocerebella Ataxia Disorders

Kish, S. J., Mastrogiacomo, F., Guttman, M., Furukawa, Y., Taanman, J., Dozic, S., Pandolfo, M., Lamarche, J. B., DiStefano, L. M., & Chang, L. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720700.x · Cited by 85 · see citing works

INHIBITION OF ACETYLCHOLINE SYNTHESIS AND OF CARBOHYDRATE UTILIZATION BY MAPLE‐SYRUP‐URINE DISEASE METABOLITES

Gibson, G. E., & Blass, J. P. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb06988.x · Cited by 77 · see citing works

Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease

Héroux, M., Rao, V. L. R., Lavoie, J., et al. (1996) · Metabolic Brain Disease · doi:10.1007/bf02080933 · Cited by 68 · see citing works

Cerebrometabolic Aspects of Delirium in Relationship to Dementia

Blass, J. P., & Gibson, G. E. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017165 · Cited by 68 · see citing works

Some Cerebral Proteins and Enzyme Systems in Alzheimer's Presenile and Senile Dementia

den Velde, W. O., & STAM, F. C. (1976) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1976.tb03247.x · Cited by 64 · see citing works

Inhibition of α‐ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase‐3 activation, and necrotic cell death

Huang, H.-M., Ou, H., Xu, H., Chen, H.-L., Fowler, C., & Gibson, G. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10756 · Cited by 61 · see citing works

Studies on the Pyruvate Dehydrogenase Complex in Brain with the Arylamine Acetyltransferase‐Coupled Assay

Ksiȩżak-Reding, H., Blass, J. P., & Gibson, G. E. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb06643.x · Cited by 58 · see citing works

[13] Succinate thiokinase from pig heart

Cha, S. (1969) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(69)13017-7 · Cited by 53 · see citing works

Impairment of brain mitochondrial function by hydrogen peroxide

Sims, N. R., Anderson, M. F., Hobbs, L. M., Kong, J. Y., Phillips, S., Powell, J. A., & Zaidan, E. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00049-8 · Cited by 48 · see citing works

[10] Influence of calcium ions on mammalian intramitochondrial dehydrogenases

McCormack, J. G., & Denton, R. M. (1989) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(89)74013-1 · Cited by 47 · see citing works

Chronic Hypoxia in Development Selectively Alters the Activities of Key Enzymes of Glucose Oxidative Metabolism in Brain Regions

Lai, J. C. K., White, B. K., Buerstatte, C. R., Haddad, G. G., Novotny, E. J., & Behar, K. L. (2003) · Neurochemical Research · doi:10.1023/a:1023235712524 · Cited by 45 · see citing works

Reduction in the E2k Subunit of the α-Ketoglutarate Dehydrogenase Complex Has Effects Independent of Complex Activity

Shi, Q., Chen, H., Xu, H., & Gibson, G. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409064200 · Cited by 38 · see citing works

Loss of lung mitochondrial aconitase activity due to hyperoxia in bronchopulmonary dysplasia in primates

MORTON, R. L., Iklé, D. N., & White, C. W. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.1.l127 · Cited by 38 · see citing works

Deafferentation of the septo‐hippocampal pathway in rats as a model of the metabolic events in Alzheimer's disease

Krügel, U., Bigl, V., Eschrich, K., & Bigl, M. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(01)00010-7 · Cited by 36 · see citing works

Energetic metabolism in mouse cerebral cortex during chronic hypoxia

Cáceda, R., Gamboa, J. L., Boero, J., Monge-C, C., & Arregui, A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01630-5 · Cited by 34 · see citing works

(r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia

Fr�lich, L., G�tz, M. E., Weinm�ller, M., Youdim, M. B. H., Barth, N., Dirr, A., Gsell, W., Jellinger, K. A., Beckmann, H., & Riederer, P. F. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0043-5 · Cited by 26 · see citing works

Purification and Stabilization of a Monomeric Isocitrate Dehydrogenase fromCorynebacterium glutamicum

Bai, C., Fernandez, E., Yang, H., et al. (1999) · Protein Expression and Purification · doi:10.1006/prep.1999.1034 · Cited by 22 · see citing works

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Tönnies, E., & Trushina, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161088 · Cited by 1,750 · see citing works

The role of oxidative stress in neurodegenerative diseases

Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355 · see citing works

Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease

Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357 · see citing works

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224 · see citing works

Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14103 · Cited by 943 · see citing works

Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives

Hajam, Y. A., Rani, R., Ganie, S. Y., Sheikh, T. A., Javaid, D., Qadri, S. S., Pramodh, S., Alsulimani, A., Alkhanani, M. F., Harakeh, S., et al. (2022) · Cells · doi:10.3390/cells11030552 · Cited by 915 · see citing works

Mitochondrial Dysfunction in Neurodegenerative Diseases

Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806 · see citing works

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723 · see citing works

The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Hansson Petersen, C. A., Alikhani, N., Behbahani, H., Wiehager, B., Pavlov, P. F., Alafuzoff, I., Leinonen, V., Ito, A., Winblad, B., Glaser, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806192105 · Cited by 693 · see citing works

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer’s disease

Risner, M. E., Saunders, A. M., Altman, J. F. B., Ormandy, G. C., Craft, S., Foley, I. M., Zvartau-Hind, M. E., Hosford, D. A., Roses, A. D., & for the Rosiglitazone in Alzheimer's Disease Study Group (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500369 · Cited by 686 · see citing works

Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease

Area‐Gomez, E., del Carmen Lara Castillo, M., Tambini, M. D., Guardia‐Laguarta, C., de Groof, A. J. C., Madra, M., Ikenouchi, J., Umeda, M., Bird, T. D., Sturley, S. L., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.202 · Cited by 638 · see citing works

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

Kapogiannis, D., & Mattson, M. P. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70277-5 · Cited by 594 · see citing works

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

Wang, M., Roussos, P., McKenzie, A., Zhou, X., Kajiwara, Y., Brennand, K. J., De Luca, G. C., Crary, J. F., Casaccia, P., Buxbaum, J. D., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0355-3 · Cited by 314 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works

4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies

Perluigi, M., Coccia, R., & Butterfield, D. A. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4406 · Cited by 229 · see citing works

Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

Correia, S. C., Santos, R. X., Perry, G., Zhu, X., Moreira, P. I., & Smith, M. A. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.01.001 · Cited by 212 · see citing works

Vitamin B1 (thiamine) and dementia

Gibson, G. E., Hirsch, J. A., Fonzetti, P., Jordan, B. D., Cirio, R. T., & Elder, J. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13031 · Cited by 214 · see citing works

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

Guo, L., Tian, J., & Du, H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160702 · Cited by 211 · see citing works

Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

Reed, T. T., Pierce, W. M., Markesbery, W. R., & Butterfield, D. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.009 · Cited by 190 · see citing works

The role of mitochondria in inherited neurodegenerative diseases

Kwong, J. Q., Beal, M. F., & Manfredi, G. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03990.x · Cited by 180 · see citing works

Alzheimer’s Disease: Exploring the Landscape of Cognitive Decline

Tenchov, R., Sasso, J. M., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00339 · Cited by 170 · see citing works

Alpha‐ketoglutarate dehydrogenase complex‐dependent succinylation of proteins in neurons and neuronal cell lines

Gibson, G. E., Xu, H., Chen, H., Chen, W., Denton, T. T., & Zhang, S. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13096 · Cited by 137 · see citing works

A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments

Gibson, G. E., & Shi, Q. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100336 · Cited by 124 · see citing works

Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis–mass spectrometry

González‐Domínguez, R., García, A., García‐Barrera, T., Barbas, C., & Gómez‐Ariza, J. L. (2014) · ELECTROPHORESIS · doi:10.1002/elps.201400196 · Cited by 119 · see citing works

The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics

Di Domenico, F., Barone, E., Perluigi, M., & Butterfield, D. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6759 · Cited by 114 · see citing works

Increased Protein and Lipid Oxidative Damage in Mitochondria Isolated from Lymphocytes from Patients with Alzheimer's Disease: Insights into the Role of Oxidative Stress in Alzheimer's Disease and Initial Investigations into a Potential Biomarker for this Dementing Disorder

Sultana, R., Mecocci, P., Mangialasche, F., Cecchetti, R., Baglioni, M., & Butterfield, D. A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-101425 · Cited by 111 · see citing works

Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease

Andersen, J. V., Skotte, N. H., Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, E. W., Diaz-delCastillo, M., Sun, R. C., et al. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04237-y · Cited by 104 · see citing works

Vascular and metabolic dysfunction in Alzheimer’s disease: a review

Murray, I. V. J., Proza, J. F., Sohrabji, F., & Lawler, J. M. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.010355 · Cited by 104 · see citing works

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

Pritchard, S. M., Dolan, P. J., Vitkus, A., & Johnson, G. V. W. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01273.x · Cited by 89 · see citing works

Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease

McDaid, J., Mustaly-Kalimi, S., & Stutzmann, G. E. (2020) · Cells · doi:10.3390/cells9122655 · Cited by 73 · see citing works

Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones

(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.02.010 · Cited by 58 · see citing works

Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer’s disease and mild cognitive impairment

Mangialasche, F., Baglioni, M., Cecchetti, R., Kivipelto, M., Ruggiero, C., Piobbico, D., Kussmaul, L., Monastero, R., Brancorsini, S., & Mecocci, P. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142052 · Cited by 53 · see citing works

Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches

González-Domínguez, R., García-Barrera, T., Vitorica, J., & Gómez-Ariza, J. L. (2015) · Biochimie · doi:10.1016/j.biochi.2015.01.005 · Cited by 49 · see citing works

Nilotinib Improves Bioenergetic Profiling in Brain Astroglia in the 3xTg Mouse Model of Alzheimer’s Disease

Adlimoghaddam, A., Odero, G. G., Glazner, G., Turner, R. S., & Albensi, B. C. (2021) · Aging and disease · doi:10.14336/ad.2020.0910 · Cited by 38 · see citing works

Quantitative proteomics of synaptosome <i>S</i>‐nitrosylation in Alzheimer’s disease

Wijasa, T. S., Sylvester, M., Brocke‐Ahmadinejad, N., Schwartz, S., Santarelli, F., Gieselmann, V., Klockgether, T., Brosseron, F., & Heneka, M. T. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14870 · Cited by 41 · see citing works

Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease

Feldhaus, P., Fraga, D. B., Ghedim, F. V., De Luca, R. D., Bruna, T. D., Heluany, M., Matos, M. P., Ferreira, G. K., Jeremias, I. C., Heluany, C., et al. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9253-y · Cited by 27 · see citing works

Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations

Sun, D., Wei, Y., Zheng, H.-X., Jin, L., & Wang, J. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00128 · Cited by 21 · see citing works

Genetics of human-mouse somatic cell hybrids: Linkage of human genes for isocitrate dehydrogenase and malate dehydrogenase

Shows, T. B. (1972) · Biochemical Genetics · doi:10.1007/bf00484817 · Cited by 38 · see citing works

Development of pyrurate dehydrogenase complex

Qi-huan, W. (2004) · Journal of Baotou University of Iron and Steel Technology · Cited by 1 · see citing works

Effect of the carbon source and cyclic AMP on isocitrate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase in Klebsiella pneumoniae C3

Juárez, A., Parés, R., & Vives-Rego, J. (1982) · Canadian Journal of Microbiology · doi:10.1139/m82-164 · Cited by 5 · see citing works

[Variations of various enzymatic activities of the Krebs cycle (malate dehydrogenase, isocitrate dehydrogenase, succinate dehydrogenase) during experimental ischemic shock in the rat. Influence of adenosine 5' triphosphoric acid].

Jonadet, M., Jp, T., Villié, F., et al. (1976) · PubMed

The α-ketoacid dehydrogenase complexes. Sequence similarity of rat pyruvate dehydrogenase with Escherichia coli and Azotobacter vinelandii α-ketoglutarate dehydrogenase

Matuda, S., Nakano, K., Ohta, S., Saheki, T., Kawanishi, Y., & Miyata, T. (1991) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(91)90076-x · Cited by 31 · see citing works