The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro
Abstract
This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO(4), sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Combination of the phenolic acids inhibited AChE and BChE activities antagonistically. Furthermore, pro-oxidants such as, FeSO(4), sodium nitroprusside and quinolinic acid caused increase in the malondialdehyde (MDA) contents of the brain which was significantly decreased dose-dependently by the phenolic acids. Inhibition of AChE and BChE activities slows down acetylcholine and butyrylcholine breakdown in the brain. Therefore, one possible mechanism through which the phenolic acids exert their neuroprotective properties is by inhibiting AChE and BChE activities as well as preventing oxidative stress-induced neurodegeneration. However, esterification of caffeic acid with quinic acid producing chlorogenic acid affects these neuroprotective properties.
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In the citing paper
“It is suggested that the fraction of phenolic compounds, consisting mainly of caffeic acid (CA), quinic acid (QA), and the chlorogenic acids family, are the main compounds responsible for these properties [145,146,147,148,149,150,151].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [150]
In the citing paper
“Results showed that QA had greater inhibition potential than CQA, concluding that these bioactive molecules can exert neuroprotective properties through the inhibition of AchE and BuChe, suggesting a possible mechanism that slows the ACh and butyrylcholine hydrolysis in the brain [150].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [150]
In the citing paper
“Results showed that QA had greater inhibition potential than CQA, concluding that these bioactive molecules can exert neuroprotective properties through the inhibition of AchE and BuChe, suggesting a possible mechanism that slows the ACh and butyrylcholine hydrolysis in the brain [150].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [150]
Citations
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Sorted by citations
Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions
Liang, N., & Kitts, D. D. (2015) · Nutrients · doi:10.3390/nu8010016 · Cited by 838
“The scopolamine-induced amnesic mouse, an animal model to study Alzheimer’s disease, has produced data to show that 5-CQA decreased the MDA level in both the frontal cortex and the hippocampus of scopolamine-induced anemia in mice [71].”
BackgroundResultInfluentialLu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12620 · Cited by 476
Nguyen, V., Taine, E. G., Meng, D., Cui, T., & Tan, W. (2024) · Nutrients · doi:10.3390/nu16070924 · Cited by 445
“CGA inhibits acetylcholinesterase (AChE) activity in rat brains, suggesting its bene fi cial e ff ect against cognitive impairment [218,219].”
BackgroundInfluentialHo, L., Ono, K., Tsuji, M., Mazzola, P., Singh, R., & Pasinetti, G. M. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1400909 · Cited by 376
Agunloye, O. M., Oboh, G., Ademiluyi, A. O., Ademosun, A. O., Akindahunsi, A. A., Oyagbemi, A. A., Omóbòwálé, T. O., Ajibade, T. O., & Adedapo, A. A. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.044 · Cited by 286
Metadata
- Authors
- Oboh, G., Agunloye, O. M., Akinyemi, A. J., Ademiluyi, A. O., & Adefegha, S. A.
- Affiliations
- Federal University of Technology (NG)
- Corresponding author
- Oboh, Ganiyu
- Akinyemi, Ayodele J.
- Venue
- Neurochemical Research
- Published
- 2012-11-27
- Volume
- 38
- Issue
- 2
- Pages
- 413-419
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W1973733191
- Cited by
- 333
- References
- 42
- Citations by year
- 2026: 12 · 2025: 19 · 2024: 38 · 2023: 39 · 2022: 43 · 2021: 32 · 2020: 37 · 2019: 19 · 2018: 20 · 2017: 25 · 2016: 21 · 2015: 17 · 2014: 7 · 2013: 4
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- caffeic acid, chlorogenic acid, phenolic acids, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, Alzheimer's disease, oxidative stress, pro-oxidants, malondialdehyde, neuroprotection, quinolinic acid, sodium nitroprusside, iron sulfate, brain
- MeSH terms
- Acetylcholinesterase, Alzheimer Disease, Animals, Brain, Butyrylcholinesterase, Caffeic Acids, Chlorogenic Acid, Cholinesterase Inhibitors, Male, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Rats
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