Cited by 333Cholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionPhytochemicals and Antioxidant Activities

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Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro

Oboh, Ganiyu, Agunloye, Odunayo M., Akinyemi, Ayodele J., Ademiluyi, Adedayo O., Adefegha, Stephen A.·2013·Neurochemical Research

DOI 10.1007/s11064-012-0935-6

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Abstract

This study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and some pro-oxidants (FeSO(4), sodium nitroprusside and quinolinic acid) induced oxidative stress in rat brain in vitro. The result revealed that caffeic acid and chlorogenic acid inhibited AChE and BChE activities in dose-dependent manner; however, caffeic acid had a higher inhibitory effect on AChE and BChE activities than chlorogenic acid. Combination of the phenolic acids inhibited AChE and BChE activities antagonistically. Furthermore, pro-oxidants such as, FeSO(4), sodium nitroprusside and quinolinic acid caused increase in the malondialdehyde (MDA) contents of the brain which was significantly decreased dose-dependently by the phenolic acids. Inhibition of AChE and BChE activities slows down acetylcholine and butyrylcholine breakdown in the brain. Therefore, one possible mechanism through which the phenolic acids exert their neuroprotective properties is by inhibiting AChE and BChE activities as well as preventing oxidative stress-induced neurodegeneration. However, esterification of caffeic acid with quinic acid producing chlorogenic acid affects these neuroprotective properties.

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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,746
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,986
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress
Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 1,013
Chlorogenic Acid and Caffeic Acid Are Absorbed in Humans
Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975
Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS
Stone, T. W., & Perkins, M. N. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90587-2 · Cited by 751
The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal
Ferreira, A., Proença, C., Serralheiro, M. L. M., & Araújo, M. E. M. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.04.010 · Cited by 480
Alzheimer’s disease pathogenesis and therapeutic interventions
Parihar, M. S., & Hemnani, T. (2004) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2003.12.007 · Cited by 441
Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
Kwon, S.-H., Lee, H.-K., Kim, J.-A., Hong, S.-I., Kim, H.-C., Jo, T.-H., Park, Y.-I., Lee, C.-K., Kim, Y.-B., Lee, S.-Y., et al. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.001 · Cited by 437

Show all 42 references

Research works printed but not linked: 1

Arnold SE, Kumar A (1993) Reversible dementias. Med Clin North Am 77(215):230

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Background
In vitro neuroprotective properties of some commonly consumed green leafy vegetables in Southern Nigeria
Nwanna, E. E., Oyeleye, S. I., Ogunsuyi, O. B., Oboh, G., Boligon, A. A., & Athayde, M. L. (2015) · NFS Journal · doi:10.1016/j.nfs.2015.12.002 · Cited by 53
Caffeic acid and chlorogenic acid: Evaluation of antioxidant effect and inhibition of key enzymes linked with hypertension
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An outlook on the role of decaffeinated coffee in neurodegenerative diseases
Colombo, R., & Papetti, A. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1550384 · Cited by 54
5-Caffeoylquinic Acid Ameliorates Cognitive Decline and Reduces Aβ Deposition by Modulating Aβ Clearance Pathways in APP/PS2 Transgenic Mice
Ishida, K., Misawa, K., Nishimura, H., Hirata, T., Yamamoto, M., & Ota, N. (2020) · Nutrients · doi:10.3390/nu12020494 · Cited by 53
An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera
Azlan, U. K., Annuar, N. A. K., Mediani, A., Aizat, W. M., Damanhuri, H. A., Tong, X., Yanagisawa, D., Tooyama, I., Ngah, W. Z. W., Jantan, I., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1035220 · Cited by 70
Microalgae as a Potential Functional Ingredient: Evaluation of the Phytochemical Profile, Antioxidant Activity and In-Vitro Enzymatic Inhibitory Effect of Different Species
Vieira, M. V., Turkiewicz, I. P., Tkacz, K., Fuentes-Grünewald, C., Pastrana, L. M., Fuciños, P., Wojdyło, A., & Nowicka, P. (2021) · Molecules · doi:10.3390/molecules26247593 · Cited by 51
Chemical, Biological, and Pharmacological Prospects of Caffeic Acid
(2022) · Biointerface Research in Applied Chemistry · doi:10.33263/briac134.324 · Cited by 55
Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer’s Disease: A Review
Xu, H., Zhou, Q., Liu, B., Cheng, K., Chen, F., & Wang, M. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c04049 · Cited by 50
Blanching alters the phenolic constituents and in vitro antioxidant and anticholinesterases properties of fireweed (Crassocephalum crepidioides)
Adedayo, B. C., Oboh, G., Oyeleye, S. I., Ejakpovi, I. I., Boligon, A. A., & Athayde, M. L. (2015) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2015.09.003 · Cited by 47
Tanacetum vulgare L. (Tansy) as an effective bioresource with promising pharmacological effects from natural arsenal
Ak, G., Gevrenova, R., Sinan, K. I., Zengin, G., Zheleva‐Dimitrova, D., Mahomoodally, M. F., Şenkardeş, İ., Brunetti, L., Leone, S., Simone, S. C. D., et al. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112268 · Cited by 50
Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer's disease.
Siddique, Y., Rahul, Ara, G., Afzal, M., Varshney, H., Gaur, K., Subhan, I., Mantasha, I., & Shahid, M. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110120 · Cited by 37
Phenolic Composition and Evaluation of Methanol and Aqueous Extracts of Bitter Gourd ( Momordica charantia L) Leaves on Angiotensin-I-Converting Enzyme and Some Pro-oxidant-Induced Lipid Peroxidation In Vitro
Shodehinde, S. A., Adefegha, S. A., Oboh, G., Oyeleye, S. I., Olasehinde, T. A., Nwanna, E. E., Adedayo, B. C., & Boligon, A. A. (2016) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587216636505 · Cited by 47
Polyphenols and inhibitory effects of crude and purified extracts from tomato varieties on the formation of advanced glycation end products and the activity of angiotensin-converting and acetylcholinesterase enzymes
Błaszczak, W., Jeż, M., & Szwengiel, A. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126181 · Cited by 46
Caffeic Acid Protects against Iron-Induced Cardiotoxicity by Suppressing Angiotensin-Converting Enzyme Activity and Modulating Lipid Spectrum, Gluconeogenesis and Nucleotide Hydrolyzing Enzyme Activities
Salau, V. F., Erukainure, O. L., & Islam, M. S. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02227-3 · Cited by 44
Cognitive Enhancing and Antioxidative Potentials of Velvet Beans (Mucuna pruriens) and Horseradish (Moringa oleifera) Seeds Extracts: A Comparative Study
Adefegha, S. A., Oboh, G., Oyeleye, S. I., Dada, F. A., Ejakpovi, I. I., & Boligon, A. A. (2016) · Journal of Food Biochemistry · doi:10.1111/jfbc.12292 · Cited by 44
Nardostachys jatamansi Ethanol Extract Ameliorates Aβ42 Cytotoxicity
Liu, Q. F., Jeon, Y., Sung, Y.-W., Lee, J. H., Jeong, H., Kim, Y., Yun, H. S., Chin, Y., Jeon, S., Cho, K. S., et al. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00750 · Cited by 43
HPLC-DAD fingerprinting analysis, antioxidant activities of Tithonia diversifolia (Hemsl.) A. Gray leaves and its inhibition of key enzymes linked to Alzheimer’s disease
Ojo, O. A., Ojo, A. B., Ajiboye, B. O., Olaiya, O. E., Okesola, M. A., Boligon, A. A., de Campos, M. M. A., Oyinloye, B. E., & Kappo, A. P. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2018.05.003 · Cited by 43
Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer’s disease model mice (APP/PS1) via the SIRT1/ /PGC-1α/PPARγ signaling pathway
Shi, D., Hao, Z., Qi, W., Jiang, F., Liu, K., & Shi, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1269952 · Cited by 45
Phenolic Extracts fromClerodendrum volubileLeaves Inhibit Cholinergic and Monoaminergic Enzymes Relevant to the Management of Some Neurodegenerative Diseases
Oboh, G., Ogunruku, O. O., Oyeleye, S. I., Olasehinde, T. A., Ademosun, A. O., & Boligon, A. A. (2016) · Journal of Dietary Supplements · doi:10.1080/19390211.2016.1237401 · Cited by 42
Biologically active compounds from two members of the Asteraceae family:Tragopogon dubiusScop. andTussilago farfaraL.
Uysal, Ş., Şenkardeş, İ., Mollica, A., Zengin, G., Bulut, G., Doğan, A., Glamočlija, J., Sokóvić, M., Lobine, D., & Mahomoodally, M. F. (2018) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2018.1506361 · Cited by 46
The impact of some phenolic compounds on serum acetylcholinesterase: kinetic analysis of an enzyme/inhibitor interaction and molecular docking study
Işık, M., & Beydemir, Ş. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1801509 · Cited by 42
The impact of high-pressure processing on the polyphenol profile and anti-glycaemic, anti-hypertensive and anti-cholinergic activities of extracts obtained from kiwiberry (Actinidia arguta) fruits
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Chemical Profiling, Antioxidant, Anticholinesterase, and Antiprotozoal Potentials of Artemisia copa Phil. (Asteraceae)
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Post-stroke cognitive impairment and synaptic plasticity: A review about the mechanisms and Chinese herbal drugs strategies
Chi, X., Wang, L., Liu, H., Zhang, Y., & Shen, W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1123817 · Cited by 43
Exploring the multifaceted potential of chlorogenic acid: Journey from nutraceutical to nanomedicine
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Transcriptional regulation of chlorogenic acid biosynthesis in carrot root slices exposed to UV-B light
Bartley, G. E., Avena‐Bustillos, R. J., Du, W., Hidalgo, M. B., Cain, B., & Breksa, A. P. (2016) · Plant Gene · doi:10.1016/j.plgene.2016.07.001 · Cited by 41
Biophenols pharmacology against the amyloidogenic activity in Alzheimer’s disease
Omar, S. H. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.051 · Cited by 42
Cabbage and cucumber extracts exhibited anticholinesterase, antimonoamine oxidase and antioxidant properties
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Main Bioactive Components and Their Biological Activities from Natural and Processed Rhizomes of Polygonum sibiricum
Chen, S., Yang, C.-S., & Chen, J. (2022) · Antioxidants · doi:10.3390/antiox11071383 · Cited by 40
Optimization of accelerated solvent extraction of bioactive compounds from Eucalyptus intertexta using response surface methodology and evaluation of its phenolic composition and biological activities
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Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol
Gül, Z., Demircan, C., Bağdaş, D., & Buyukuysal, R. L. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1919-8 · Cited by 40
Antioxidant properties of eugenol, butylated hydroxylanisole, and butylated hydroxyl toluene with key biomolecules relevant to Alzheimer’s diseases—In vitro
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Tomato plant leaves: From by-products to the management of enzymes in chronic diseases
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The fruit of Crataegus pinnatifida ameliorates memory deficits in β-amyloid protein-induced Alzheimer's disease mouse model
Lee, J., Cho, E., Kwon, H., Jeon, J., Jung, C. J., Moon, M., Jun, M., Lee, Y. C., Kim, D. H., & Jung, J. W. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112107 · Cited by 37
Impact of Tea Processing on Tryptophan, Melatonin, Phenolic and Flavonoid Contents in Mulberry (Morus alba L.) Leaves: Quantitative Analysis by LC-MS/MS
Panyatip, P., Padumanonda, T., Yongram, C., Kasikorn, T., Sungthong, B., & Puthongking, P. (2022) · Molecules · doi:10.3390/molecules27154979 · Cited by 37
Protective role ofSpondias mombinleaf andCola acuminataseed extracts against scopolamine-induced cognitive dysfunction
Ishola, I. O., Ikuomola, B. O., & Adeyemi, O. O. (2017) · Alexandria Journal of Medicine · doi:10.1016/j.ajme.2016.08.001 · Cited by 36
Phenolic profile and Enzyme Inhibitory activities of Almond (Terminalia catappa) leaf and Stem bark
Oyeleye, S. I., Adebayo, A. A., Ogunsuyi, O. B., Dada, F. A., & Oboh, G. (2017) · International Journal of Food Properties · doi:10.1080/10942912.2017.1375945 · Cited by 36
Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats
Bağdaş, D., Etöz, B. Ç., İnan, S., Çinkılıç, N., Özyiğit, M. Ö., Gül, Z., Işbil-Büyükcoşkun, N., Özlük, K., & Gurun, M. S. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00635 · Cited by 36

Authors: Oboh, G., Agunloye, O. M., Akinyemi, A. J., Ademiluyi, A. O., & Adefegha, S. A.
Affiliations: Federal University of Technology (NG)
Corresponding author: Oboh, Ganiyu
Akinyemi, Ayodele J.
ORCID: Oboh, Ganiyu
Agunloye, Odunayo M.
Akinyemi, Ayodele J.
Ademiluyi, Adedayo O.
Adefegha, Stephen A.
Venue: Neurochemical Research
Publisher: Springer Science and Business Media LLC
Published: 2012-11-27
Volume: 38
Issue: 2
Pages: 413-419
ISSN: 0364-3190 (ISSN-L)
1573-6903
DOI: 10.1007/s11064-012-0935-6
OpenAlex: W1973733191
Cited by: 333
References: 42
Citations by year: 2026: 12 · 2025: 19 · 2024: 38 · 2023: 39 · 2022: 43 · 2021: 32 · 2020: 37 · 2019: 19 · 2018: 20 · 2017: 25 · 2016: 21 · 2015: 17 · 2014: 7 · 2013: 4
FWCI: 6.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neurochemical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: caffeic acid, chlorogenic acid, phenolic acids, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, Alzheimer's disease, oxidative stress, pro-oxidants, malondialdehyde, neuroprotection, quinolinic acid, sodium nitroprusside, iron sulfate, brain
MeSH terms: Acetylcholinesterase, Alzheimer Disease, Animals, Brain, Butyrylcholinesterase, Caffeic Acids, Chlorogenic Acid, Cholinesterase Inhibitors, Male, Rats, Wistar, Reactive Oxygen Species, Oxidative Stress, Rats

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Comparative Study on the Inhibitory Effect of Caffeic and Chlorogenic Acids on Key Enzymes Linked to Alzheimer’s Disease and Some Pro-oxidant Induced Oxidative Stress in Rats’ Brain-In Vitro

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