Mangiferin Antagonizes Rotenone: Induced Apoptosis Through Attenuating Mitochondrial Dysfunction and Oxidative Stress in SK-N-SH Neuroblastoma Cells

Kavitha, Mani; Manivasagam, Thamilarasan; Essa, Musthafa Mohamed; Tamilselvam, Kuppusamy; Selvakumar, Govindasamy Pushpavathy; Karthikeyan, Subran; Thenmozhi, Justin Arokiasamy; Subash, Selvaraju

doi:10.1007/s11064-014-1249-7

Mangiferin Antagonizes Rotenone: Induced Apoptosis Through Attenuating Mitochondrial Dysfunction and Oxidative Stress in SK-N-SH Neuroblastoma Cells

In the present study, using a human neuroblastoma SK-N-SH cells, we explored antioxidant, mitochondrial protective and antiapoptotic properties of mangiferin against rotenone-mediated cytotoxicity. SK-N-SH cells are divided into four experimental groups based on 3-(4,5-dimethyl2-yl)-2,5-diphenylt…