Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD) are recognized as the universal neurodegenerative diseases, with the involvement of misfolded proteins pathology, leading to oxidative stress, glial cells activation, neuroinflammation, mitochondrial dysfunction, and cellular apoptosis. Several discoveries indicate that accumulation of pathogenic proteins, i.e. amyloid β (Aβ), the microtubule-binding protein tau, and α-synuclein, are parallel with oxidative stress, neuroinflammation, and mitochondrial dysfunction. Whether the causative factors are misfolded proteins or these pathophysiological changes, leading to neurodegeneration still remain ambiguous. Importantly, directing pharmacological researches towards the prevention of AD and PD seem a promising approach to detect these complicating mechanisms, and provide new insight into therapy for AD and PD patients. Mangiferin (MGF, 2-C-β-D-glucopyranosyl-1, 3, 6, 7-tetrahydroxyxanthone), well-known as a natural product, is detached from multiple plants, including Mangifera indica L. With the structure of C-glycosyl and phenolic moiety, MGF possesses multipotent properties starting from anti-oxidant effects, to the alleviation of mitochondrial dysfunction, neuroinflammation, and cellular apoptosis. In particular, MGF can cross the blood-brain barrier to exert neuronal protection. Different researches implicate that MGF is able to protect the central nervous system from oxidative stress, mitochondrial dysfunction, neuroinflam…
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MGF exerts protective effects across a broad spectrum of pathological conditions, including inflammatory, neurodegenerative, ocular, renal, cardiovascular, dermatological and infectious diseases.
“In addition to its well-characterized roles in diabetes and cancer, MGF exerts protective effects across a broad spectrum of pathological conditions. These include inflammatory, neurodegenerative, ocular, renal, cardiovascular, dermatological and infectious diseases (7,36,106,115-118).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [115]
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Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works
Self-citation
- Authors
- Feng, S.-T., Wang, Z.-Z., Yuan, Y.-H., Sun, H.-M., Chen, N.-H., & Zhang, Y.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing University of Chinese Medicine (CN)
- Corresponding author
- Zhang, Yi
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 146
- Pages
- 104336
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2954306404
- Cited by
- 96
- References
- 19
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 14 · 2023: 16 · 2022: 7 · 2021: 19 · 2020: 9 · 2019: 4
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Specialized Research Fund for the Doctoral Program of Higher Education of China
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- mangiferin, Alzheimer's disease, Parkinson's disease, neurodegeneration, neuroprotection, oxidative stress, neuroinflammation, mitochondrial dysfunction, apoptosis, amyloid-beta, tau protein, alpha-synuclein, blood-brain barrier, cognitive impairment, mango, natural products
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Biological Products, Humans, Parkinson Disease, Oxidative Stress, Xanthones
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