Measuring quality of life in women with endometriosis: tests of data quality, score reliability, response rate and scaling assumptions of the Endometriosis Health Profile Questionnaire
Open accessAbstract
BACKGROUND: To test the data quality, scaling assumptions and scoring algorithms underlying the Endometriosis Health Profile-30 (EHP-30) questionnaire: a questionnaire developed to measure the health-related quality of life (HRQoL) of women with endometriosis. METHODS: A cross-sectional postal survey to 727 women with surgically confirmed endometriosis recruited from an existing genetic linkage study (OXEGENE), The National Endometriosis Society (NES), UK and the outpatient gynaecology clinics of the Women's Centre, John Radcliffe Hospital, Oxford. Tests of data quality included secondary factor analysis, internal reliability consistency, descriptive statistics of the data, missing data levels, floor and ceiling effects and corrected item to total correlation scores. RESULTS: Six hundred and ten women (83.9%) returned the questionnaire. Secondary factor analysis verified the domain structure of the EHP-30. All 11 dimensions were internally reliable with Cronbach's alpha scores ranging from 0.80 to 0.96. Missing response rates ranged from 0.2 to 1.3%, and all items were found to be most highly correlated with their own (corrected) scale. CONCLUSIONS: Results confirmed the factor structure, scoring and scaling assumptions of the questionnaire. The high rate of data completeness indicated that the EHP-30 was acceptable and understandable to the respondents, thereby verifying its suitability for measuring the HRQoL of women with endometriosis.
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Prior patient-reported outcome studies concluded that endometriosis impairs health-related quality of life, particularly physical, psychological, and social function.
“These studies concluded that endometriosis impairs health related quality of life (HRQoL), specifically in areas related to physical, psychological, and social function.”
From Patients’ report on how endometriosis affects health, work, and daily life (2010) · cites this paper as [23]
Only a few patient-reported outcome studies have quantified the impact of endometriosis.
“Despite the fact that endometriosis is a common gynecologic disorder that poses a significant economic impact to health care systems around the world, only a few Patient-Reported Outcome (PRO) studies have been conducted to quantify its impact (21-24).”
From Patients’ report on how endometriosis affects health, work, and daily life (2010) · cites this paper as [23]
Pain and control and powerlessness items do not appear to reflect the same underlying construct.
“In a similar vein, ‘pain’ and ‘control and powerlessness’ items do not appear to reflect the same underlying construct as suggested by Jones et al. (2006).”
From Health-related quality of life in women with endometriosis: psychometric validation of the Endometriosis Health Profile 30 questionnaire using confirmatory factor analysis (2022) · cites this paper as Jones et al., 2006
To date, four studies have supported the original five-factor structure of the EHP-30, one study found a four-factor structure, one obtained mixed results and suggested four to five factors, and two recent studies suggested a three-factor structure.
“To date, four studies have supported the original five-factor structure of the EHP-30 (Jenkinson et al., 2008 (American); Jia et al., 2013 (Chinese); Nojomi et al., 2011 (Persian); van de Burgt et al., 2011 (Dutch)), one study found a four-factor structure (Jones et al., 2006 (English)), and one obtained mixed results and suggested four to five factors (Chauvet et al., 2017 (French)). Two recent”
From Health-related quality of life in women with endometriosis: psychometric validation of the Endometriosis Health Profile 30 questionnaire using confirmatory factor analysis (2022) · cites this paper as Jones et al., 2006
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- Authors
- Jones, G., Jenkinson, C., Taylor, N., Mills, A., & Kennedy, S.
- Affiliations
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Central Queensland University (AU)
- University of Sheffield (GB)
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07-04
- Volume
- 21
- Issue
- 10
- Pages
- 2686-2693
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2115109894
- Cited by
- 138
- References
- 31
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 6 · 2021: 12 · 2020: 11 · 2019: 4 · 2018: 10 · 2017: 12 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Acquire (CQUniversity) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Pfizer
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Keywords
- endometriosis, health-related quality of life, Endometriosis Health Profile-30, questionnaire validation, factor structure, internal consistency, missing data, floor and ceiling effects, scaling assumptions, women's health
- MeSH terms
- Adolescent, Adult, Cross-Sectional Studies, Endometriosis, Female, Health Status, Humans, Middle Aged, Quality of Life, Surveys and Questionnaires, Reproducibility of Results
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