Short‐Term Effects of Gastric Bypass Surgery on Circulating Ghrelin Levels
Open accessAbstract
Objective: To prospectively evaluate the short‐term effects of Roux‐en‐Y gastric bypass (RYGBP) on ghrelin secretion and its relevance on food intake and body weight changes. Research Methods and Procedures: Ghrelin response to a standardized test meal was evaluated in eight obese patients (BMI, 43.5 to 59.1 kg/m 2) before and 6 weeks after RYGBP. Ghrelin response was compared with that of an age‐matched group of six normal weight individuals (BMI, 19.6 to 24.9 kg/m 2). Results: Fasting serum ghrelin levels were lower in obese subjects compared with controls (p < 0.05). Meal ingestion significantly suppressed ghrelin concentration in controls (p < 0.05) and obese subjects (p < 0.05), albeit to a lesser degree in the latter group (p < 0.05). Despite a 10.3 ± 1.5% weight loss, fasting serum ghrelin levels were paradoxically further decreased in obese subjects 6 weeks after RYGBP (p < 0.05). Moreover, at this time‐point, food intake did not elicit a significant ghrelin suppression. The changes in ghrelin secretion after RYGBP correlated with changes in insulin sensitivity (p < 0.05) and caloric intake (p < 0.05). Discussion: This study showed that the adaptive response of ghrelin to body weight loss was already impaired 6 weeks after RYGBP. Our study provides circumstantial evidence for the potential role of ghrelin in the negative energy balance in RYGBP‐operated patients.
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The relative decrease in fasting ghrelin after RYGB is mostly a result of altered anatomy.
“In contrast, the relative decrease in fasting ghrelin after RYGB occurs as early as 2–6 weeks post-surgery as also reported by Morinigo et al (25) suggesting that the decrease in ghrelin is mostly a result of altered anatomy (26).”
From Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass (2009) · cites this paper as [25]
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- Authors
- Morínigo, R., Casamitjana, R., Moizé, V., Lacy, A. M., Delgado, S., Gomis, R., & Vidal, J.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Venue
- Obesity Research
- Publisher
- Wiley
- Published
- 2004-07
- Volume
- 12
- Issue
- 7
- Pages
- 1108-1116
- ISSN
- 1071-7323 (ISSN-L)
- 1550-8528
- OpenAlex
- W1983815567
- Cited by
- 108
- References
- 46
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 7 · 2013: 5 · 2012: 10
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- Roux-en-Y gastric bypass, ghrelin, bariatric surgery, obesity, dietary intake, weight loss, insulin sensitivity, energy intake, energy balance
- MeSH terms
- Adult, Energy Intake, Eating, Energy Metabolism, Fasting, Female, Food, Humans, Insulin, Male, Middle Aged, Obesity, Time Factors, Gastric Bypass, Weight Loss, Body Mass Index, Peptide Hormones, Ghrelin
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