Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L.

Molecular Cloning: A Laboratory Manual

Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589

Molecular cloning: A laboratory manual

Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684

A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue Cultures

Murashige, T., & Skoog, F. K. (1962) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1962.tb08052.x · Cited by 67,420

Floral dip: a simplified method for Agrobacterium ‐mediated transformation of Arabidopsis thaliana

Clough, S. J., & Bent, A. F. (1998) · The Plant Journal · doi:10.1046/j.1365-313x.1998.00343.x · Cited by 22,014

Rapid isolation of high molecular weight plant DNA

Murray, M. G., & Thompson, W. F. (1980) · Nucleic Acids Research · doi:10.1093/nar/8.19.4321 · Cited by 12,156

Isolation of plant DNA from fresh tissue

Doyle, J. J. (1990) · Focus eBooks · Cited by 10,802

GUS fusions: beta‐glucuronidase as a sensitive and versatile gene fusion marker in higher plants.

Jefferson, R., Kavanagh, T. A., & Bevan, M. W. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02730.x · Cited by 9,854

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

Napoli, C. A., Lemieux, C., & Jorgensen, R. A. (1990) · The Plant Cell · doi:10.1105/tpc.2.4.279 · Cited by 2,892

In planta Agrobacterium mediated gene transfer by infiltration of adult Arabidopsis thaliana plants

Bechtold, N., Baquero, M., Bonhomme, S., Ferault, M., Horlow, C., Laroche, L., Migdal, M., Mollier, P., Montoro, P., Roux, D., et al. (1993) · HAL · Cited by 1,774

NewAgrobacterium helper plasmids for gene transfer to plants

Hood, E. E., Gelvin, S. B., Melchers, L. S., & Hoekema, A. (1993) · Transgenic Research · doi:10.1007/bf01977351 · Cited by 1,404

Production of Plant Secondary Metabolites: Examples, Tips and Suggestions for Biotechnologists

Guerriero, G., Berni, R., Muñoz-Sánchez, J. A., Apone, F., Abdel-Salam, E. M., Qahtan, A. A., Alatar, A. A., Cantini, C., Cai, G., Hausman, J.-F., et al. (2018) · Genes · doi:10.3390/genes9060309 · Cited by 406

The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis

Shen, Q., Zhang, L., Liao, Z., Wang, S., Yan, T., Shi, P., Liu, M., Fu, X., Pan, Q., Wang, Y., et al. (2018) · Molecular Plant · doi:10.1016/j.molp.2018.03.015 · Cited by 315

Glandular trichomes: what comes after expressed sequence tags?

Tissier, A. F. (2012) · The Plant Journal · doi:10.1111/j.1365-313x.2012.04913.x · Cited by 267

A Basic Leucine Zipper Transcription Factor, AabZIP1, Connects Abscisic Acid Signaling with Artemisinin Biosynthesis in Artemisia annua

Zhang, F., Fu, X., Lv, Z., Lu, X., Shen, Q., Zhang, L., Zhu, M., Wang, G., Sun, X., Liao, Z., et al. (2015) · Molecular Plant · doi:10.1016/j.molp.2014.12.004 · Cited by 248

Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes—current status and future opportunities

Lange, B. M., & Ahkami, A. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12022 · Cited by 206

Effect of prolonged water stress on specialized secondary metabolites, peltate glandular trichomes, and pathway gene expression in Artemisia annua L.

Yadav, R. K., Sangwan, R. S., Sabir, F., Srivastava, A. K., & Sangwan, N. S. (2013) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2013.10.023 · Cited by 170

Relative expression of genes of terpene metabolism in different tissues of Artemisia annuaL

Olofsson, L., Engström, A., Lundgren, A., & Brodelius, P. E. (2011) · BMC Plant Biology · doi:10.1186/1471-2229-11-45 · Cited by 144

A Review of Biotechnological Artemisinin Production in Plants

Ikram, N. K. K., & Simonsen, H. T. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01966 · Cited by 131

Transgenic approach to increase artemisinin content in Artemisia annua L.

Tang, K., Shen, Q., Yan, T., & Fu, X. (2014) · Plant Cell Reports · doi:10.1007/s00299-014-1566-y · Cited by 96

Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment

Banyai, W., Mii, M., & Supaibulwatana, K. (2010) · Plant Growth Regulation · doi:10.1007/s10725-010-9510-9 · Cited by 89

Enhanced Triterpene Accumulation in Panax ginseng Hairy Roots Overexpressing Mevalonate-5-pyrophosphate Decarboxylase and Farnesyl Pyrophosphate Synthase

Kim, Y. K., Kim, Y. B., Uddin, M. R., Lee, S., Kim, S.-U., & Park, S. U. (2014) · ACS Synthetic Biology · doi:10.1021/sb400194g · Cited by 81

Enhancement of artemisinin content in tetraploidArtemisia annuaplants by modulating the expression of genes in artemisinin biosynthetic pathway

Lin, X., Zhou, Y., Zhang, J., Lu, X., Zhang, F., Shen, Q., Wu, S., Chen, Y., Wang, T., & Tang, K. (2011) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.13 · Cited by 80

Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches

Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74

Overexpression of the cytochrome P450 monooxygenase (cyp71av1) and cytochrome P450 reductase (cpr) genes increased artemisinin content in Artemisia annua (Asteraceae)

Shen, Q., Chen, Y. F., Wang, T., Wu, S. Y., Lu, X., Zhang, L., Zhang, F. Y., Jiang, W., & Tang, K. (2012) · Genetics and Molecular Research · doi:10.4238/2012.september.12.13 · Cited by 73

Red and Blue Light Promote the Accumulation of Artemisinin in Artemisia annua L.

Zhang, D., Sun, W., Shi, Y., Wu, L., Zhang, T., & Li, X. (2018) · Molecules · doi:10.3390/molecules23061329 · Cited by 72

Overexpression ofAaWRKY1Leads to an Enhanced Content of Artemisinin inArtemisia annua

Jiang, W., Fu, X., Pan, Q., Tang, Y., Shen, Q., Lv, Z., Yan, T., Shi, P., Li, L., Zhang, L., et al. (2016) · BioMed Research International · doi:10.1155/2016/7314971 · Cited by 70

Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

Nguyen, K. T., Arsenault, P. R., & Weathers, P. J. (2011) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-011-9343-x · Cited by 66

The Integration of Metabolomics and Next-Generation Sequencing Data to Elucidate the Pathways of Natural Product Metabolism in Medicinal Plants

Scossa, F., Benina, M., Alseekh, S., Zhang, Y., & Fernie, A. R. (2018) · Planta Medica · doi:10.1055/a-0630-1899 · Cited by 69

From Plant to Yeast—Advances in Biosynthesis of Artemisinin

Zhao, L., Zhu, Y., Jia, H., Han, Y., Zheng, X., Wang, M., & Feng, W. (2022) · Molecules · doi:10.3390/molecules27206888 · Cited by 64

Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites

Muangphrom, P., Seki, H., Fukushima, E. O., & Muranaka, T. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-1008-y · Cited by 63

Metabolic engineering of Bacillus subtilis for terpenoid production

Guan, Z., Xue, D., Abdallah, I. I., Dijkshoorn, L., Setroikromo, R., Lv, G., & Quax, W. J. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6950-1 · Cited by 55

Promotion of artemisinin biosynthesis in transgenic Artemisia annua by overexpressing ADS, CYP71AV1 and CPR genes

Lu, X., Shen, Q., Zhang, L., Zhang, F., Jiang, W., Lv, Z., Yan, T., Fu, X., Wang, G., & Tang, K. (2013) · Industrial Crops and Products · doi:10.1016/j.indcrop.2013.04.045 · Cited by 53

The molecular basis of glandular trichome development and secondary metabolism in plants

Tian, N., Liu, F., Wang, P., Zhang, X., Li, X., & Wu, G. (2017) · Plant Gene · doi:10.1016/j.plgene.2017.05.010 · Cited by 51

Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in Artemisia annua by exogenous MeJA treatment

Xiang, L., Zhu, S., Zhao, T., Zhang, M., Liu, W., Chen, M., Lan, X., & Liao, Z. (2015) · Plant Growth Regulation · doi:10.1007/s10725-014-0004-z · Cited by 52

Overproduction of artemisinin in tetraploid Artemisia annua L.

Banyai, W., Sangthong, R., Karaket, N., Inthima, P., Mii, M., & Supaibulwatana, K. (2010) · Plant Biotechnology · doi:10.5511/plantbiotechnology.10.0726a · Cited by 52

Isoprenyl diphosphate synthases: the chain length determining step in terpene biosynthesis

Nagel, R., Schmidt, A., & Peters, R. J. (2018) · Planta · doi:10.1007/s00425-018-3052-1 · Cited by 52

Promotion of artemisinin content in Artemisia annua by overexpression of multiple artemisinin biosynthetic pathway genes

Shi, P., Fu, X., Liu, M., Shen, Q., Jiang, W., Li, L., Sun, X., & Tang, K. (2017) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1173-z · Cited by 50

Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production

Pandey, N., & Rai, S. P. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0805-6 · Cited by 48

Computational Identification of Sweet Wormwood (Artemisia Annua) microRNA and Their mRNA Targets

Pani, A., Mahapatra, R. K., Behera, N., & Naik, P. K. (2011) · Genomics Proteomics & Bioinformatics · doi:10.1016/s1672-0229(11)60023-5 · Cited by 46

Present status of Catharanthus roseus monoterpenoid indole alkaloids engineering in homo- and hetero-logous systems

Sharma, A., Amin, D., Sankaranarayanan, A., Arora, R., & Mathur, A. K. (2019) · Biotechnology Letters · doi:10.1007/s10529-019-02757-4 · Cited by 43

Overexpression of an Isoprenyl Diphosphate Synthase in Spruce Leads to Unexpected Terpene Diversion Products That Function in Plant Defense

Nagel, R., Berasategui, A., Paetz, C., Gershenzon, J., & Schmidt, A. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.228940 · Cited by 42

Regulation of sesquiterpenoid metabolism in recombinant and elicited Valeriana officinalis hairy roots

Ricigliano, V. A., Kumar, S., Kinison, S., Brooks, C., Nybo, S. E., Chappell, J., & Howarth, D. G. (2016) · Phytochemistry · doi:10.1016/j.phytochem.2016.02.011 · Cited by 43

Strategies to enhance biologically active-secondary metabolites in cell cultures ofArtemisia– current trends

Ali, M., Abbasi, B. H., Ahmad, N., Khan, H., & Ali, G. S. (2017) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2016.1261082 · Cited by 43

Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii

Zhao, Y., Chen, X., Zhang, M., Su, P., Liu, Y., Tong, Y., Wang, X., Huang, L., & Gao, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125415 · Cited by 40

The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L.

Chen, Y., Shen, Q., Wang, Y., Wang, T., Wu, S., Zhang, L., Lu, X., Zhang, F., Jiang, W., Qiu, B., et al. (2013) · Plant Biotechnology Reports · doi:10.1007/s11816-012-0262-z · Cited by 38

Overexpression of a 10-deacetylbaccatin III-10 β-O-acetyltransferase gene leads to increased taxol yield in cells of Taxus chinensis

Zhang, P., Li, S.-T., Liu, T., Fu, C., Zhou, P., Zhao, C., & Yu, L. (2010) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-010-9894-2 · Cited by 39

A basic helix loop helix transcription factor, AaMYC2-Like positively regulates artemisinin biosynthesis in Artemisia annua L.

Hurrah, I. M., Kumar, A., & Abbas, N. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.10.083 · Cited by 36

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

Kalalagh, K. F., Kashkooli, A. B., Babaei, A., Rezaei, A., & van der Krol, A. R. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.780257 · Cited by 40

Molecular Cloning and Characterization of a Trichome-Specific Promoter of Artemisinic Aldehyde Δ11(13) Reductase (DBR2) in Artemisia annua

Jiang, W., Lu, X., Qiu, B., Zhang, F., Shen, Q., Lv, Z., Fu, X., Yan, T., Gao, E., Zhu, M., et al. (2013) · Plant Molecular Biology Reporter · doi:10.1007/s11105-013-0603-2 · Cited by 34

High-quality reference genes for quantifying the transcriptional responses of Oryza sativa L. (ssp. indica and japonica) to abiotic stress conditions

Maksup, S., Supaibulwatana, K., & Selvaraj, G. (2013) · Chinese Science Bulletin · doi:10.1007/s11434-013-5726-1 · Cited by 33

Variation in terpenoids in leaves of Artemisia annua grown under different LED spectra resulting in diverse antimalarial activities against Plasmodium falciparum

Sankhuan, D., Niramolyanun, G., Kangwanrangsan, N., Nakano, M., & Supaibulwatana, K. (2022) · BMC Plant Biology · doi:10.1186/s12870-022-03528-6 · Cited by 34

Molecular regulation of santalol biosynthesis in Santalum album L.

Rani, A., Ravikumar, P., Reddy, M. D., & Kush, A. K. (2013) · Gene · doi:10.1016/j.gene.2013.06.080 · Cited by 33

High level production of amorphadiene using Bacillus subtilis as an optimized terpenoid cell factory

Pramastya, H., Xue, D., Abdallah, I. I., Setroikromo, R., & Quax, W. J. (2020) · New Biotechnology · doi:10.1016/j.nbt.2020.10.007 · Cited by 32

In vitro regeneration and transient expression of recombinant sesquiterpene cyclase (SQC) in Artemisia annua L.

Mirzaee, H., Sharafi, A., & Sohi, H. H. (2016) · South African Journal of Botany · doi:10.1016/j.sajb.2015.10.005 · Cited by 30

Elevation of artemisinin content by co-transformation of artemisinin biosynthetic pathway genes and trichome-specific transcription factors in Artemisia annua

Hassani, D., Taheri, A., Fu, X., Qin, W. D., Liu, H., Ma, Y., & Tang, K. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1118082 · Cited by 29

De novo assembly and comparative transcriptome analysis: novel insights into terpenoid biosynthesis in Chamaemelum nobile L.

Liu, X., Wang, X., Chen, Z., Ye, J., Liao, Y., Zhang, W., Chang, J., & Xu, F. (2018) · Plant Cell Reports · doi:10.1007/s00299-018-2352-z · Cited by 28

Overexpression of the gibberellin 20-oxidase gene from Torenia fournieri resulted in modified trichome formation and terpenoid metabolities of Artemisia annua L.

Inthima, P., Nakano, M., Otani, M., Niki, T., Nishijima, T., Koshioka, M., & Supaibulwatana, K. (2017) · Plant Cell, Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1171-1 · Cited by 26

Genetic engineering of artemisinin biosynthesis: prospects to improve its production

Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25

RNAi suppression and overexpression studies of hydroxyphenylpyruvate reductase (HPPR) and rosmarinic acid synthase (RAS) genes related to rosmarinic acid biosynthesis in hairy root cultures of Coleus blumei

Hücherig, S., & Petersen, M. (2012) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-012-0277-8 · Cited by 25

Dihydroartemisinic acid dehydrogenase-mediated alternative route for artemisinin biosynthesis

Guo, Z., Zhou, Y., Li, J., Liu, D., Huang, Y., Zhang, Y., Yu, R., & Zhu, J. (2025) · Nature Communications · doi:10.1038/s41467-025-59312-1 · Cited by 23

In vitro regeneration and Agrobacterium mediated genetic transformation of Artemisia aucheri Boiss

Sharafi, A., Sohi, H. H., Mirzaee, H., & Azadi, P. (2014) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-014-0248-0 · Cited by 24

An updated review on distribution, biosynthesis and pharmacological effects of artemisinin: A wonder drug

Nabi, N., Singh, S. K., & Saffeullah, P. (2023) · Phytochemistry · doi:10.1016/j.phytochem.2023.113798 · Cited by 25

Artemisinin production strategies for industrial scale: Current progress and future directions

Qamar, F., Ashrafi, K., Singh, A., Dash, P. K., & Abdin, M. Z. (2024) · Industrial Crops and Products · doi:10.1016/j.indcrop.2024.118937 · Cited by 24

Genetic mapping of EST-derived simple sequence repeats (EST-SSRs) to identify QTL for leaf morphological characters in a Quercus robur full-sib family

Gailing, O., Bodénès, C., Finkeldey, R., Kremer, A., & Plomion, C. (2013) · Tree Genetics & Genomes · doi:10.1007/s11295-013-0633-9 · Cited by 23

Characterization of a trichome-specific promoter of the aldehyde dehydrogenase 1 (ALDH1) gene in Artemisia annua

Liu, M., Shi, P., Fu, X., Brodelius, P. E., Shen, Q., Jiang, W., He, Q., & Tang, K. (2016) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-016-1015-4 · Cited by 22

Glandular trichome-specific expression of alcohol dehydrogenase 1 (ADH1) using a promoter-GUS fusion in Artemisia annua L.

He, Q., Fu, X., Shi, P., Liu, M., Shen, Q., & Tang, K. (2017) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1204-9 · Cited by 21

Production of monoterpenoids and aroma compounds from cell suspension cultures of Camellia sinensis

Grover, A., Yadav, J. S., Biswas, R., Pavan, C. S. S., Mishra, P., Bisaria, V. S., & Sundar, D. (2011) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-011-0046-0 · Cited by 21

Increased artemisinin production in Artemisia annua L. by co-overexpression of six key biosynthetic enzymes

Qamar, F., Mishra, A., Ashrafi, K., Saifi, M., Dash, P. K., Kumar, S. B., & Abdin, M. Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136291 · Cited by 19

An Intronless β-amyrin Synthase Gene is More Efficient in Oleanolic Acid Accumulation than its Paralog in Gentiana straminea

Liu, Y., Zhao, Z., Xue, Z., Wang, L., Cai, Y., Wang, P., Wei, T., Gong, J., Liu, Z., Li, J., et al. (2016) · Scientific Reports · doi:10.1038/srep33364 · Cited by 18

Functional characterization and transcriptional activity analysis of Dryopteris fragrans farnesyl diphosphate synthase genes

Zhang, D., Tang, X., Chen, L., Qiu, X., Song, C., Wang, H., & Chang, Y. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1105240 · Cited by 18

Biological Activities of Artemisinins Beyond Anti-Malarial: a Review

Saeed-ur-Rahman, Khalid, M., Kayani, S., Jan, F., Ullah, A., & Tang, K. (2019) · Tropical Plant Biology · doi:10.1007/s12042-019-09228-0 · Cited by 17

Overexpression of GPS and FPS from Chrysanthemum indicum var. aromaticum resulted in modified trichome formation and terpenoid biosynthesis in tobacco

Gao, W., Meng, Q., Wang, X., Chen, F., He, M., & Zhou, Y. (2022) · Plant Growth Regulation · doi:10.1007/s10725-022-00927-5 · Cited by 15

Selection of transgenic Petunia plants using the green fluorescent protein (GFP)

Mußmann, V., Serek, M., & Winkelmann, T. (2011) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-011-9998-3 · Cited by 14

Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) under stressed environments

Tripathi, A., Pandey, P., Tripathi, S. N., & Kalra, A. (2025) · Plant Stress · doi:10.1016/j.stress.2025.100757 · Cited by 14

Molecular cloning, characterization, and promoter analysis of the isochorismate synthase (AaICS1) gene from Artemisia annua

Wang, L., Zhang, Y., Fu, X., Zhang, T., Ma, J., Zhang, L., Qian, H., Tang, K., Li, S., & Zhao, J. (2017) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1600223 · Cited by 13

Biosynthesis of Sesquiterpene Lactones in Plants and Metabolic Engineering for Their Biotechnological Production

Perassolo, M., Cardillo, A. B., Busto, V. D., Giulietti, A. M., & Talou, J. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-78274-4_4 · Cited by 13

Tissue culture and regeneration of an antimalarial plant, Artemisia sieberi Besser

Sharafi, A., Sohi, H. H., Sharafi, A., Azadi, P., & Mousavi, A. (2014) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 12

Enhanced Production of β-Caryophyllene by Farnesyl Diphosphate Precursor-Treated Callus and Hairy Root Cultures of Artemisia vulgaris L.

Balasubramani, S., Kumari, B. D. R., Moola, A. K., Sathish, D., Kumar, G. P., Srimurali, S., & Rajendran, R. B. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.634178 · Cited by 12

Molecular cloning and characterization of the trichome specific chrysanthemyl diphosphate/chrysanthemol synthase promoter from Tanacetum cinerariifolium

Sultana, S., Hu, H., Gao, L., Mao, J., Luo, J., Jongsma, M. A., & Wang, C. (2015) · Scientia Horticulturae · doi:10.1016/j.scienta.2015.01.032 · Cited by 12

The truncated AaActin1 promoter is a candidate tool for metabolic engineering of artemisinin biosynthesis in Artemisia annua L.

Li, Y., Chen, T., Liu, H., Qin, W. D., Yan, X., Wu-Zhang, K., Peng, B., Zhang, Y., Yao, X., Fu, X., et al. (2022) · Journal of Plant Physiology · doi:10.1016/j.jplph.2022.153712 · Cited by 11

Efficient protocol for mass micropropagation of Artemisia annua L.

Zayova, E. G., Nedev, T., Petrova, D. H., Zhiponova, M., & Chaneva, G. (2018) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2018.5.2.0119 · Cited by 10

A bicistronic transgene system for genetic modification of Parthenium argentatum

Ponciano, G., Dong, N., Chen, G., & McMahan, C. M. (2018) · Plant Biotechnology Reports · doi:10.1007/s11816-018-0478-7 · Cited by 9

Efficient Agrobacterium-mediated transformation of Artemisia annua L. using young inflorescence

Wang, J., Nie, J., Pattanaik, S., & Yuan, L. (2016) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-015-9744-3 · Cited by 8

Unlocking the potential of Artemisia annua for artemisinin production: current insights and emerging strategies

Vashisth, D., & Mishra, S. (2025) · 3 Biotech · doi:10.1007/s13205-025-04332-3 · Cited by 8

Metabolic regulation and engineering of artemisinin biosynthesis in A. annua

Tang, Y., Xiang, L., Zhang, F., Tang, K., & Liao, Z. (2023) · Medicinal Plant Biology · doi:10.48130/mpb-2023-0004 · Cited by 7

Yeast Synthetic Biology for Production of Artemisinin as an Antimalarial Drug

Kashkooli, A. B., Kalalagh, K. F., & Babaei, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-89680-5_6 · Cited by 7

Plant growth regulator studies and emerging biotechnological approaches in Artemisia annua L.: A comprehensive overview

Mosoh, D. A. (2025) · South African Journal of Botany · doi:10.1016/j.sajb.2025.04.016 · Cited by 6

Metabolic regulation of the artemisinin biosynthetic pathway in Artemisia annua L.

Zeng, L. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr11.1461 · Cited by 6

Bioactive Plant Isoprenoids

Galata, M., & Mahmoud, S. S. (2012) · Studies in natural products chemistry · doi:10.1016/b978-0-444-59514-0.00005-5 · Cited by 6

Current state, strategies, and perspectives in enhancing artemisinin production

Zakariya, A. M., Saiman, M. Z., Simonsen, H. T., & Ikram, N. K. K. (2023) · Phytochemistry Reviews · doi:10.1007/s11101-023-09897-6 · Cited by 5

RNA sequencing in Artemisia annua L explored the genetic and metabolic responses to hardly soluble aluminum phosphate treatment

Wan, L., Huang, Q., Ji, X., Song, L., Zhang, Z., Pan, L., Fu, J., Elbaiomy, R. G., Eldomiaty, A. S., Rather, S. A., et al. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01067-3 · Cited by 3

Removing limitations surrounding terpenoid biosynthesis by biotechnological techniques in Ferula sp.: A review

Aghaali, Z., Yang, J., Naghavi, M. R., & Zargar, M. (2025) · Current Plant Biology · doi:10.1016/j.cpb.2025.100455 · Cited by 3

Transgenic Medicinal Plants for Improved Plant Metabolites Production

Balasubramani, S., Chen, Q., Zhou, Z., Moola, A. K., Duraisamy, S. M., Prakash, P., Gayathiri, E., Satish, L., & Swamy, M. K. (2022) · Springer eBooks · doi:10.1007/978-981-19-5779-6_16 · Cited by 3

Transfer Of Rol Genes And Evaluation Of Artemisinin Synthesis In Transgenic Artemisia Annua L. And Artemisia Dubia Wall

Kiani, B. H. (2012) · HEC National Digital Library · Cited by 3

T-DNA Insertion Alters the Terpenoid Content Composition and Bioactivity of Transgenic Artemisia annua

Karaket, N., Wiyakrutta, S., Lacaille‐Dubois, M., & Supaibulwatana, K. (2014) · Natural Product Communications · doi:10.1177/1934578x1400900320 · Cited by 2

An ecological implication of glandular trichome-sequestered artemisinin: as a sink of biotic/abiotic stress-triggered singlet oxygenPreprint

He, J., Gao, Q., Liao, T., & Zeng, Q.-P. (2015) · doi:10.7287/peerj.preprints.827v1 · Cited by 2

Yield and artemisinin content of six polyploid accessions of Artemisia annua grown at medium altitude in Indonesia

Siswanto, U., Subositi, D., Isnawati, A., & Widiyastuti, Y. (2025) · International Journal of Agricultural Technology · doi:10.63369/ijat.2025.21.2.673-684 · Cited by 1

Cellular Engineering for Enhanced Production of Potent Antimalarial Drug: Artemisinin

Ram, M., Niranjan, R., & Jain, D. C. (2013) · Cited by 1

Agrobacterial Transformation of Tobacco with a Genetic Module of the Biosynthesis of the Antimalarial Agent Artemisinin

Firsov, A. P., Mitiushkina, T. Y., Pushin, A. S., Tzareva, A. K., Vainstein, A., & Dolgov, S. V. (2021) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683821070024 · Cited by 1

Metabolic engineering of microbial and plant chasses to optimize artemisinin production

Behera, J. R., Ekwudo, M. N., Nohoesu, O. R., & Kilaru, A. (2023) · CABI Reviews · doi:10.1079/cabireviews.2023.0044 · Cited by 1

Biosynthesis and Production of Artemisinin: A Novel Class of Molecule

Ali, A., Khan, M. A., & Zainul, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_133 · Cited by 1

An ecological implication of glandular trichome-sequestered artemisinin: as a sink of biotic/abiotic stress-triggered singlet oxygenPreprint

He, J., Gao, Q., Liao, T., & Zeng, Q.-P. (2015) · doi:10.7287/peerj.preprints.827 · Cited by 1

Antimalarial Compound Synthesis from Transgenic Cultures

Kundu, S., Mukherjee, S., & Ghosh, B. (2017) · Reference series in phytochemistry · doi:10.1007/978-3-319-28669-3_22

Roots and hormones: synergistic control of artemisinin production in Artemisia annua L. shoots

Nguyen, K. V. (2011) · Digital WPI

Advances in Molecular Regulation of Artemisinin Biosynthesis

王, 路. (2016) · Botanical Research · doi:10.12677/br.2016.53016

Agrobacteium Transformation of Tobacco with a Genetic Module of Antimalarial Agent Artemisinin Biosynthesis

Mitiuchkina, T. Y., Pushin, A. S., Tzareva, A. K., Vainstein, A., & Dolgov, S. V. (2020) · Biotekhnologiya · doi:10.21519/0234-2758-2020-36-3-34-45

Advances in Molecular Regulation of Artemisinin Biosynthesis

Wang, L., Zhang, Y., Tang, K., Li, S., Zhao, J., & Guangdong, G. (2016)

Overexpression of geranyl diphosphate synthase and farnesyl diphosphate synthase gene from Chrysanthemum indicum var. aromaticum resulted in modified trichome formation and terpenoid biosynthesis in transgenic tobaccoPreprint

Gao, W., Meng, Q., Wang, X., Chen, F., He, M., & Zhou, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1365857/v1

Antimalarial Compound Synthesis from Transgenic Cultures

Kundu, S., Mukherjee, S., & Ghosh, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-27490-4_22-1

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Hallajian, M. T., Mohammadi, S. T., Ebrahimi, M. A., Naghavi, M. R., & Kordrostami, M. (2025) · Research Square · doi:10.21203/rs.3.rs-7265007/v1

Effects of Overexpression of the Endogenous Farnesyl Diphosphate Synthase on the Artemisinin Content in Artemisia annua L.

Han, J., Liu, B., Ye, H., Wang, H., Li, Z., & Li, G. (2006) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2006.00208.x · Cited by 115

Co-overexpression of the HMGR and FPS genes enhances artemisinin content in Artemisia annua L.

Wang, Y., Jing, F., Yu, S., Chen, Y., Wang, T., Pin, L., Wang, G., Sun, X., & Tang, K. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000369 · Cited by 26

The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L.

Chen, Y., Shen, Q., Wang, Y., Wang, T., Wu, S., Zhang, L., Lu, X., Zhang, F., Jiang, W., Qiu, B., et al. (2013) · Plant Biotechnology Reports · doi:10.1007/s11816-012-0262-z · Cited by 38

Ri-mediated transformation of Artemisia annua with a recombinant farnesyl diphosphate synthase gene for artemisinin production

Chen, D.-H., Liu, C.-J., Ye, H.-C., Li, G.-F., Liu, B.-Y., Meng, Y.-L., & Chen, X.-Y. (1999) · Plant Cell, Tissue and Organ Culture · doi:10.1023/a:1006326818509 · Cited by 65

Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation

Chen, D.-H., Ye, H.-C., & Li, G.-F. (2000) · Plant Science · doi:10.1016/s0168-9452(00)00217-x · Cited by 225