Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation

Qinghaosu (Artemisinin): an Antimalarial Drug from China

Klayman, D. L. (1985) · Science · doi:10.1126/science.3887571 · Cited by 2,186 · see citing works

Plant terpenoid synthases: Molecular biology and phylogenetic analysis

Bohlmann, J., Meyer-Gauen, G., & Croteau, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4126 · Cited by 1,122 · see citing works

Biochemistry and Molecular Biology of the Isoprenoid Biosynthetic Pathway in Plants

Chappell, J. (1995) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.pp.46.060195.002513 · Cited by 527 · see citing works

Enzymic formation of sesquiterpenes

Cane, D. E. (1990) · Chemical Reviews · doi:10.1021/cr00105a002 · Cited by 469 · see citing works

Induction of Sesquiterpene Cyclase and Suppression of Squalene Synthetase Activities in Plant Cell Cultures Treated with Fungal Elicitor

Vögeli, U., & Chappell, J. (1988) · PLANT PHYSIOLOGY · doi:10.1104/pp.88.4.1291 · Cited by 213 · see citing works

Gene Transfer to Plants

Potrykus, I., & SPANGENBERG, G. C. (1995) · Springer eBooks · doi:10.1007/978-3-642-79247-2 · Cited by 154 · see citing works

Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L.

Woerdenbag, H. J., Lüers, J. F. J., van Uden, W., Pras, N., Malingré, T. M., & Alfermann, A. W. (1993) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/bf00029850 · Cited by 120 · see citing works

Artemisinin production by transformed roots of Artemisia annua

Weathers, P. J., Cheetham, R. D., Follansbee, E., & Teoh, K. H. (1994) · Biotechnology Letters · doi:10.1007/bf00149632 · Cited by 117 · see citing works

Spektrometrische Hochdruck-Flüssigkeits-Chromatographische (HPLC) Untersuchungen zur Analytik von Qinghaosu

Zhao, S.-S., & Zeng, M.-Y. (1985) · Planta Medica · doi:10.1055/s-2007-969466 · Cited by 97 · see citing works

Cloning and analysis of a cDNA encoding farnesyl diphosphate synthase from Artemisia annua

Matsushita, Y., Kang, W., & Charlwood, B. V. (1996) · Gene · doi:10.1016/0378-1119(96)00054-6 · Cited by 95 · see citing works

State of the art of the production of the antimalarial compound artemisinin in plants

Geldre, E. V., Vergauwe, A., & den Eeckhout, E. V. (1997) · Plant Molecular Biology · doi:10.1023/a:1005716600612 · Cited by 84 · see citing works

Cloning of an Arabidopsis thaliana cDNA coding for farnesyl diphosphate synthase by functional complementation in yeast

Delourme, D., Lacroute, F., & Karst, F. (1994) · Plant Molecular Biology · doi:10.1007/bf00019499 · Cited by 83 · see citing works

Artemisinin production by Artemisia annua L.-transformed organ cultures

Paniego, N. B., & Giulietti, A. M. (1996) · Enzyme and Microbial Technology · doi:10.1016/0141-0229(95)00216-2 · Cited by 75 · see citing works

Agrobacterium tumefaciens-mediated transformation of Artemisia annua L. and regeneration of transgenic plants

Vergauwe, A., Cammaert, R., Vandenberghe, D., Genetello, C., Inzé, D., Montagu, M. V., & den Eeckhout, E. V. (1996) · Plant Cell Reports · doi:10.1007/bf00231590 · Cited by 72 · see citing works

Establishment of Normal and Transformed Root Cultures ofArtemisia annua L. for Artemisinin Production

Jazir, M., Shimomura, K., Yoshimatsu, K., Fauconnier, M., Marlier, M., & Homès, J. (1995) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)81866-3 · Cited by 71 · see citing works

Effect of Sterol Inhibitors on the Incorporation of¹⁴<i>C</i>-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System from<i>Artemisia annua</i>Tissue Cultures and Plants

Kudakasseril, G., Lam, L., & Staba, E. (1987) · Planta Medica · doi:10.1055/s-2006-962706 · Cited by 70 · see citing works

ChemInform Abstract: Enzymatic Formation of Sesquiterpenes

Cane, D. E. (1991) · ChemInform · doi:10.1002/chin.199108386 · Cited by 49 · see citing works

Regulation of a Sesquiterpene Cyclase in Cellulase-Treated Tobacco Cell Suspension Cultures

Vögeli, U., & Chappell, J. (1990) · PLANT PHYSIOLOGY · doi:10.1104/pp.94.4.1860 · Cited by 45 · see citing works

Hairy root culture of Artemisia annua L. by Ri plasmid transformation and biosynthesis of artemisinin.

Cai, G., Li, G., Ye, H., & Li, G. (1995) · PubMed · Cited by 40 · see citing works

A cDNA Encoding Farnesyl Pyrophosphate Synthase in White Lupin

Attucci, S., Aitken, S.-M., Ibrahim, R. K., & Gulick, P. J. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.2.835 · Cited by 34 · see citing works

In VitroAmoebicidal Testing of Natural Products; Part 2. Alkaloids Related to Emetine

Keene, A. T., Phillipson, J. D., Warhurst, D. C., Koch, M. C., & Seguin, E. (1987) · Planta Medica · doi:10.1055/s-2006-962672 · Cited by 33 · see citing works

Induction of Hairy Root from Artemisia annua with Agrobacterium rhizogenes and Its Culture in Vitro

Qin, M., Guo-zhen, L., Yue, Y., Ye, H., & Li, G. (1994) · Journal of Integrative Plant Biology · Cited by 31 · see citing works

Ultrastructural changes of parenchyma cells in detached garlic scape during storage

Wang, Y., Chenghou, L., & Shi-jie, Y. (1994) · Europe PMC (PubMed Central) · Cited by 13 · see citing works

Culture of transgenic Artemisia annua hairy root with cotton cadinene synthase gene

Chen, D., Meng, Y., Ye, H., Li, G., & Chen, X. (1998) · Europe PMC (PubMed Central) · Cited by 9 · see citing works

Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology

Canter, P. H., Thomas, H., & Ernst, E. K. (2005) · Trends in biotechnology · doi:10.1016/j.tibtech.2005.02.002 · Cited by 550 · see citing works

Volatile science? Metabolic engineering of terpenoids in plants

Aharoni, A., Jongsma, M. A., & Bouwmeester, H. J. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.10.005 · Cited by 428 · see citing works

Engineering secondary metabolite production in plants

Verpoorte, R., & Memelink, J. (2002) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(02)00308-7 · Cited by 377 · see citing works

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works

Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis

Ma, D., Pu, G., Lei, C., Ma, L., Wang, H., Guo, Y., Chen, J., Du, Z., Wang, H., Li, G., et al. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp149 · Cited by 333 · see citing works

Enhanced Levels of the Aroma and Flavor Compound S-Linalool by Metabolic Engineering of the Terpenoid Pathway in Tomato Fruits

Lewinsohn, E. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.127.3.1256 · Cited by 322 · see citing works

Attracting friends to feast on foes: engineering terpene emission to make crop plants more attractive to herbivore enemies

Degenhardt, J., Gershenzon, J., Baldwin, I. T., & Keßler, A. (2003) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(03)00025-9 · Cited by 284 · see citing works

Artemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced Production

Abdin, M. Z., Israr, M., Rehman, R. U., & Jain, S. K. (2003) · Planta Medica · doi:10.1055/s-2003-38871 · Cited by 252 · see citing works

Metabolic engineering of plant monoterpenes, sesquiterpenes and diterpenes—current status and future opportunities

Lange, B. M., & Ahkami, A. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12022 · Cited by 206 · see citing works

Development of transgenic <i>Artemisia annua</i> (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti‐malarial drug, by hairpin‐RNA‐mediated gene silencing

Zhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., Sun, X., & Tang, K. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20080068 · Cited by 206 · see citing works

Engineering secondary metabolite production in hairy roots

Chandra, S., & Chandra, R. (2011) · Phytochemistry Reviews · doi:10.1007/s11101-011-9210-8 · Cited by 202 · see citing works

Metabolic Engineering of Terpenoid Biosynthesis in Plants

Aharoni, A., Jongsma, M. A., Kim, T.-Y., Ri, M.-B., Giri, A. P., Verstappen, F. W. A., Schwab, W. G., & Bouwmeester, H. J. (2006) · Phytochemistry Reviews · doi:10.1007/s11101-005-3747-3 · Cited by 191 · see citing works

In vivo transformations of dihydroartemisinic acid in Artemisia annua plants

Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183 · see citing works

Development and application of medicinal plant tissue cultures for production of drugs and herbal medicinals in China

Zhou, L., & Wu, J. (2006) · Natural Product Reports · doi:10.1039/b610767b · Cited by 176 · see citing works

Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

Liu, C., Zhao, Y., & Wang, Y. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0452-0 · Cited by 158 · see citing works

Enhanced production of asiaticoside from hairy root cultures of Centella asiatica (L.) Urban elicited by methyl jasmonate

Kim, O.-T., Bang, K.-H., Shin, Y.-S., Lee, M. J., Jung, S., Hyun, D.-Y., Kim, Y., Seong, N.-S., Cha, S.-W., & Hwang, B. (2007) · Plant Cell Reports · doi:10.1007/s00299-007-0400-1 · Cited by 147 · see citing works

Isoprenoid biosynthesis in Artemisia annua: cloning and heterologous expression of a germacrene A synthase from a glandular trichome cDNA library

Bertea, C. M., Voster, A., Verstappen, F. W. A., Maffei, M., Beekwilder, J., & Bouwmeester, H. J. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.02.026 · Cited by 134 · see citing works

A Review of Biotechnological Artemisinin Production in Plants

Ikram, N. K. K., & Simonsen, H. T. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01966 · Cited by 130 · see citing works

Current progress in the study on biosynthesis and regulation of ganoderic acids

Shi, L., Ren, A., Mu, D., & Zhao, M. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2871-1 · Cited by 130 · see citing works

Diversity, regulation, and genetic manipulation of plant mono- and sesquiterpenoid biosynthesis

Yu, F., & Utsumi, R. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0066-7 · Cited by 129 · see citing works

The genetic manipulation of medicinal and aromatic plants

Gómez‐Galera, S., Pelacho, A. M., Gené, A., Capell, T., & Christou, P. (2007) · Plant Cell Reports · doi:10.1007/s00299-007-0384-x · Cited by 127 · see citing works

Changing trends in biotechnology of secondary metabolism in medicinal and aromatic plants

Gandhi, S. G., Mahajan, V., & Bedi, Y. S. (2014) · Planta · doi:10.1007/s00425-014-2232-x · Cited by 124 · see citing works

Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway

Jing, F., Zhang, L., Li, M., Tang, Y., Wang, Y., Wang, Y., Wang, Q., Pan, Q., Wang, G., & Tang, K. (2009) · Biologia · doi:10.2478/s11756-009-0040-8 · Cited by 123 · see citing works

Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase

Kim, O.-T., Kim, S. H., Ohyama, K., Muranaka, T., Choi, Y. E., Lee, H.-Y., Kim, M. Y., & Hwang, B. (2010) · Plant Cell Reports · doi:10.1007/s00299-010-0831-y · Cited by 121 · see citing works

UV-B and UV-C pre-treatments induce physiological changes and artemisinin biosynthesis in Artemisia annua L. – An antimalarial plant

Rai, R., Meena, R. P., Smita, S. S., Shukla, A., Kumar, S., & Rai, S. P. (2011) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2011.09.004 · Cited by 116 · see citing works

Methyl Jasmonate-Elicited Transcriptional Responses and Pentacyclic Triterpene Biosynthesis in Sweet Basil

Misra, R. C., Maiti, P., Chanotiya, C. S., Shanker, K., & Ghosh, S. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.232884 · Cited by 116 · see citing works

Effects of Overexpression of the Endogenous Farnesyl Diphosphate Synthase on the Artemisinin Content in <i>Artemisia annua</i> L.

Han, J., Liu, B., Ye, H., Wang, H., Li, Z., & Li, G. (2006) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2006.00208.x · Cited by 115 · see citing works

Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence‐like response and reduced cytokinin levels

Masferrer, A., Arró, M., Manzano, D., Schaller, H., Fernàndez‐Busquets, X., Moncaleán, P., Fernández, B., Cunillera, N., Boronat, A., & Ferrer, A. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01273.x · Cited by 112 · see citing works

Effects of ipt gene expression on the physiological and chemical characteristics of Artemisia annua L.

Geng, S., Ma, M., Ye, H., Liu, B., Li, G., & Chong, K. (2001) · Plant Science · doi:10.1016/s0168-9452(00)00453-2 · Cited by 110 · see citing works

Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants

Han, J., Wang, H., Lundgren, A., & Brodelius, P. E. (2014) · Phytochemistry · doi:10.1016/j.phytochem.2014.02.011 · Cited by 110 · see citing works

Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content

Alam, P., & Abdin, M. Z. (2011) · Plant Cell Reports · doi:10.1007/s00299-011-1099-6 · Cited by 108 · see citing works

Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L.

Banyai, W., Kirdmanee, C., Mii, M., & Supaibulwatana, K. (2010) · Plant Cell, Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-010-9775-8 · Cited by 105 · see citing works

A novel homodimeric geranyl diphosphate synthase from the orchid Phalaenopsis bellina lacking a DD( X ) 2–4 D motif

Hsiao, Y., Jeng, M., Tsai, W., Chuang, Y., Li, C., Wu, T., Kuoh, C., Chen, W., & Chen, H. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03547.x · Cited by 105 · see citing works

Transgenic approach to increase artemisinin content in Artemisia annua L.

Tang, K., Shen, Q., Yan, T., & Fu, X. (2014) · Plant Cell Reports · doi:10.1007/s00299-014-1566-y · Cited by 96 · see citing works

In vivo transformations of artemisinic acid in Artemisia annua plants

Brown, G. D., & Sy, L.-K. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.06.062 · Cited by 100 · see citing works

Artemisinin: the biosynthetic pathway and its regulation in Artemisia annua, a terpenoid-rich species

Weathers, P. J., Elkholy, S., & Wobbe, K. K. (2006) · In Vitro Cellular &amp; Developmental Biology - Plant · doi:10.1079/ivp2006782 · Cited by 97 · see citing works

Short term UV-B radiation-mediated transcriptional responses and altered secondary metabolism of in vitro propagated plantlets of Artemisia annua L.

Pandey, N., & Rai, S. P. (2013) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-013-0413-0 · Cited by 87 · see citing works

Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua

Arsenault, P. R., Vail, D. R., Wobbe, K. K., Erickson, K., & Weathers, P. J. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.162552 · Cited by 85 · see citing works

Enhancement of artemisinin content by constitutive expression of the HMG-CoA reductase gene in high-yielding strain of Artemisia annua L.

Nafis, T., Akmal, M., Ram, M., Alam, P., Ahlawat, S., Mohd, A., & Abdin, M. Z. (2011) · Plant Biotechnology Reports · doi:10.1007/s11816-010-0156-x · Cited by 83 · see citing works

Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.

Liu, B., Wang, H., Du, Z., Li, G., & Ye, H. (2010) · Plant Cell Reports · doi:10.1007/s00299-010-0967-9 · Cited by 82 · see citing works

Scale‐up of Artemisia annua L. hairy root cultures produces complex patterns of terpenoid gene expression

Souret, F. F., Kim, Y., Wyslouzil, B. E., Wobbe, K. K., & Weathers, P. J. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10711 · Cited by 81 · see citing works

The production of artemisinin precursors in tobacco

Zhang, Y., Nowak, G., Reed, D. W., & Covello, P. S. (2010) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2010.00556.x · Cited by 81 · see citing works

Enhancement of artemisinin content in tetraploidArtemisia annuaplants by modulating the expression of genes in artemisinin biosynthetic pathway

Lin, X., Zhou, Y., Zhang, J., Lu, X., Zhang, F., Shen, Q., Wu, S., Chen, Y., Wang, T., & Tang, K. (2011) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.13 · Cited by 80 · see citing works

Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches

Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works

Expression profiling of the triterpene saponin biosynthesis genes FPS, SS, SE, and DS in the medicinal plant Panax notoginseng

Niu, Y., Luo, H., Sun, C., Yang, T., Dong, L., Huang, L., & Chen, S. (2013) · Gene · doi:10.1016/j.gene.2013.09.045 · Cited by 76 · see citing works

Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography–electrospray quadrupole time-of-flight tandem mass spectrometry

Nieuwerburgh, F. V., Casteele, S. V., Maes, L., Goossens, A., Inzé, D., Bocxlaer, J. V., & Deforce, D. L. D. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.03.121 · Cited by 73 · see citing works

Medicinal plant biotechnology

Arora, R. (2010) · CABI eBooks · doi:10.1079/9781845936785.0000 · Cited by 73 · see citing works

High efficiency of genetic transformation and regeneration of Artemisia annua L. via Agrobacterium tumefaciens-mediated procedure

Han, J., Wang, H., Ye, H., Liu, Y., Li, Z., Zhang, Y., Zhang, Y., Fang, Y., & Li, G. (2004) · Plant Science · doi:10.1016/j.plantsci.2004.07.020 · Cited by 67 · see citing works

Expression of β‐glucosidase increases trichome density and artemisinin content in transgenic <i>Artemisia annua</i> plants

Singh, N. D., Kumar, S., & Daniell, H. (2016) · Plant Biotechnology Journal · doi:10.1111/pbi.12476 · Cited by 67 · see citing works

Recent advances in medicinal plant biotechnology

Khan, M. Y., Aliabbas, S., Kumar, V., & Rajkumar, S. (2009) · Indian Journal of Biotechnology · Cited by 67 · see citing works

Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

Nguyen, K. T., Arsenault, P. R., & Weathers, P. J. (2011) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-011-9343-x · Cited by 66 · see citing works

From Plant to Yeast—Advances in Biosynthesis of Artemisinin

Zhao, L., Zhu, Y., Jia, H., Han, Y., Zheng, X., Wang, M., & Feng, W. (2022) · Molecules · doi:10.3390/molecules27206888 · Cited by 64 · see citing works

Advances in the Plant Isoprenoid Biosynthesis Pathway and Its Metabolic Engineering

Liu, Y., Wang, H., Ye, H., & Li, G. (2005) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2005.00111.x · Cited by 60 · see citing works

Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites

Muangphrom, P., Seki, H., Fukushima, E. O., & Muranaka, T. (2016) · Journal of Natural Medicines · doi:10.1007/s11418-016-1008-y · Cited by 59 · see citing works

Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production

Pulice, G., Pelaz, S., & Matías-Hernández, L. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00329 · Cited by 53 · see citing works

Molecular characterization of ginseng farnesyl diphosphate synthase gene and its up-regulation by methyl jasmonate

Kim, O. T., Bang, K.-H., Jung, S. J., Kim, Y. C., Hyun, D. Y., Kim, S. H., & W., S. (2010) · Biologia Plantarum · doi:10.1007/s10535-010-0007-1 · Cited by 58 · see citing works

Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts

Muntendam, R., Melillo, E., Rydén, A., & Kayser, O. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2150-1 · Cited by 56 · see citing works

Effect of Sugars on Artemisinin Production in Artemisia annua L.: Transcription and Metabolite Measurements

Arsenault, P. R., Vail, D. R., Wobbe, K. K., & Weathers, P. J. (2010) · Molecules · doi:10.3390/molecules15042302 · Cited by 54 · see citing works

Increased Accumulation of Artemisinin and Anthocyanins in Artemisia annua Expressing the Arabidopsis Blue Light Receptor CRY1

Hong, G., Hu, W., Li, J., Chen, X., & Wang, L.-J. (2009) · Plant Molecular Biology Reporter · doi:10.1007/s11105-008-0088-6 · Cited by 55 · see citing works

Biotechnological Approaches for Production of Artemisinin, an Anti-Malarial Drug from Artemisia annua L.

Al-Khayri, J. M., Sudheer, W. N., Lakshmaiah, V. V., Mukherjee, E., Nizam, A., Thiruvengadam, M., Nagella, P., Alessa, F. M., Al-Mssallem, M. Q., Adel Abdel-Sabour, R. E. Z. K., et al. (2022) · Molecules · doi:10.3390/molecules27093040 · Cited by 54 · see citing works

Ganoderma lucidum: A potential pleiotropic approach of ganoderic acids in health reinforcement and factors influencing their production

Ahmad, M. F., Wahab, S., Ahmad, F. A., Ashraf, S. A., Abullais, S. S., & Saad, H. H. (2022) · Fungal Biology Reviews · doi:10.1016/j.fbr.2021.12.003 · Cited by 52 · see citing works

Effect of salicylic acid and yeast extract on the accumulation of jasmonic acid and sesquiterpenoids in Panax ginseng adventitious roots

Rahimi, S., Devi, B. S. R., Khorolragchaa, A., Kim, Y. J., Kim, J. H., Jung, S.-K., & Yang, D. (2014) · Russian Journal of Plant Physiology · doi:10.1134/s1021443714060156 · Cited by 51 · see citing works

Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production

Pandey, N., & Rai, S. P. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0805-6 · Cited by 48 · see citing works

Enhanced artemisinin yield by expression of rol genes in Artemisia annua.

Dilshad, E., Cusido, R. M., Palazon, J., Estrada, K. R., Bonfill, M., & Mirza, B. (2015) · Malaria Journal · doi:10.1186/s12936-015-0951-5 · Cited by 47 · see citing works

Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth

Saxena, B., Subramani, M., Malhotra, K., Bhavesh, N. S., Potlakayala, S. D., & Kumar, S. B. (2014) · Journal of Biosciences · doi:10.1007/s12038-013-9402-z · Cited by 46 · see citing works

Salicylic acid restrains arsenic induced oxidative burst in two varieties of Artemisia annua L. by modulating antioxidant defence system and artemisinin production

Naeem, M., Sadiq, Y., Jahan, A., Nabi, A., Aftab, T., & Khan, M. M. A. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110851 · Cited by 46 · see citing works

Genetic Manipulation of Secondary Metabolites Producers

Rastegari, A. A., Yadav, A. N., & Yadav, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-63504-4.00002-5 · Cited by 45 · see citing works

Medicinal Plant Biotechnology

Latha, D. J. N. L., Mishra, D. K. K., Rajput, D. D. S., & Arul, D. V. (2006) · Wiley eBooks · doi:10.1002/9783527619771 · Cited by 46 · see citing works

Molecular approaches for improvement of medicinal and aromatic plants

Kumar, J., & Gupta, P. K. (2008) · Plant Biotechnology Reports · doi:10.1007/s11816-008-0059-2 · Cited by 43 · see citing works

Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L.

Li, Y., Yang, Y., Li, L., Tang, K., Hao, X., & Kai, G. (2024) · Horticulture Research · doi:10.1093/hr/uhad292 · Cited by 42 · see citing works

Overexpression of an Isoprenyl Diphosphate Synthase in Spruce Leads to Unexpected Terpene Diversion Products That Function in Plant Defense

Nagel, R., Berasategui, A., Paetz, C., Gershenzon, J., & Schmidt, A. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.228940 · Cited by 42 · see citing works

Quantitative Transcript Profiling Reveals Down-Regulation of A Sterol Pathway Relevant Gene and Overexpression of Artemisinin Biogenetic Genes in Transgenic<i>Artemisia annua</i>Plants

Yang, R.-Y., Feng, L.-L., Yang, X.-Q., Yin, L.-L., Xu, X.-L., & Zeng, Q.-P. (2008) · Planta Medica · doi:10.1055/s-2008-1081333 · Cited by 41 · see citing works

Genetic Transformation System for Woody Plant Tripterygium wilfordii and Its Application to Product Natural Celastrol

Zhao, Y., Zhang, Y., Su, P., Yang, J. T., Huang, L., & Gao, W. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2017.02221 · Cited by 41 · see citing works

Molecular Cloning and Characterisation of Farnesyl Pyrophosphate Synthase from Tripterygium wilfordii

Zhao, Y., Chen, X., Zhang, M., Su, P., Liu, Y., Tong, Y., Wang, X., Huang, L., & Gao, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125415 · Cited by 40 · see citing works

Oligomers of carrageenan regulate functional activities and artemisinin production in Artemisia annua L. exposed to arsenic stress

Naeem, M., Nabi, A., Aftab, T., & Khan, M. M. A. (2019) · PROTOPLASMA · doi:10.1007/s00709-019-01475-y · Cited by 40 · see citing works

Synergistic re-channeling of mevalonate pathway for enhanced artemisinin production in transgenic Artemisia annua

Feng, L.-L., Yang, R.-Y., Yang, X.-Q., Zeng, X.-M., Lu, W.-J., & Zeng, Q.-P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.03.014 · Cited by 39 · see citing works

Expression of artemisinin biosynthesis genes in eight Artemisia species at three developmental stages

Ranjbar, M., Naghavi, M. R., Alizadeh, H., & Soltanloo, H. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.07.077 · Cited by 40 · see citing works

Agrobacterium tumefaciens mediated genetic transformation of Ocimum gratissimum: A medicinally important crop

Khan, S. H., Fahim, N., Singh, P., & Rahman, L. U. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.03.080 · Cited by 39 · see citing works

Engineering storage capacity for volatile sesquiterpenes in Nicotiana benthamiana leaves

Delatte, T., Scaiola, G., Molenaar, J., Farias, K. D. S., Albertti, L. A. G., Busscher, J., Verstappen, F. W. A., Carollo, C. A., Bouwmeester, H. J., & Beekwilder, J. (2018) · Plant Biotechnology Journal · doi:10.1111/pbi.12933 · Cited by 39 · see citing works

Important Secondary Metabolites and Essential Oils of Species Within the Anthemideae (Asteraceae)

da Silva, J. A. T., Yonekura, L., Kaganda, J., Mookdasanit, J., Nhựt, D. T., & Afach, G. (2005) · Journal of Herbs Spices & Medicinal Plants · doi:10.1300/j044v11n01_01 · Cited by 39 · see citing works

Mapping the potential distribution of high artemisinin-yielding Artemisia annua L. (Qinghao) in China with a geographic information system

Huang, L., Xie, C., Duan, B., & Chen, S. (2010) · Chinese Medicine · doi:10.1186/1749-8546-5-18 · Cited by 38 · see citing works

Biotechnological approaches for artemisinin production in Artemisia

Kayani, W. K., Kiani, B. H., Dilshad, E., & Mirza, B. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2432-9 · Cited by 37 · see citing works

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

Kalalagh, K. F., Kashkooli, A. B., Babaei, A., Rezaei, A., & van der Krol, A. R. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.780257 · Cited by 39 · see citing works

Metabolic Engineering with Plants for a Sustainable Biobased Economy

Yoon, J. M., Zhao, L., & Shanks, J. V. (2013) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061312-103320 · Cited by 34 · see citing works

Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family

Aminfar, Z., Rabiei, B., Tohidfar, M., & Mirjalili, M. H. (2019) · Scientific Reports · doi:10.1038/s41598-019-52090-z · Cited by 35 · see citing works

Overexpression of a type‐I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase

Ma, D., Li, G., Alejos-González, F., Zhu, Y., Xue, Z. H., Wang, A., Zhang, H., Li, X., Ye, H., Wang, H., et al. (2017) · The Plant Journal · doi:10.1111/tpj.13583 · Cited by 32 · see citing works

Molecular characterization of two isoforms of a farnesyl pyrophosphate synthase gene in wheat and their roles in sesquiterpene synthesis and inducible defence against aphid infestation

Zhang, Y., Li, Z., Yu, X., Fan, J., Pickett, J. A., Jones, H. D., Zhou, J., Birkett, M. A., Caulfield, J. C., Napier, J. A., et al. (2015) · New Phytologist · doi:10.1111/nph.13302 · Cited by 32 · see citing works

Genetic Engineering of BVOC Emissions from Trees

Rosenkranz, M., & Schnitzler, J. (2013) · Tree physiology/Tree physiology (Dordrecht) · doi:10.1007/978-94-007-6606-8_4 · Cited by 31 · see citing works

Cloning and expression of a farnesyl diphosphate synthase in Centella asiatica (L.) Urban

Kim, O. T., Ahn, J. C., Hwang, S. J., & Hwang, B. (2005) · Molecules and Cells · doi:10.1016/s1016-8478(23)13171-2 · Cited by 29 · see citing works

In vitro regeneration and transient expression of recombinant sesquiterpene cyclase (SQC) in Artemisia annua L.

Mirzaee, H., Sharafi, A., & Sohi, H. H. (2016) · South African Journal of Botany · doi:10.1016/j.sajb.2015.10.005 · Cited by 30 · see citing works

Three-step pathway engineering results in more incidence rate and higher emission of nerolidol and improved attraction of Diadegma semiclausum

Houshyani, B., Assareh, M., Busquets, A., Ferrer, A., Bouwmeester, H. J., & Kappers, I. F. (2012) · Metabolic Engineering · doi:10.1016/j.ymben.2012.10.002 · Cited by 29 · see citing works

Elevation of artemisinin content by co-transformation of artemisinin biosynthetic pathway genes and trichome-specific transcription factors in Artemisia annua

Hassani, D., Taheri, A., Fu, X., Qin, W. D., Liu, H., Ma, Y., & Tang, K. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1118082 · Cited by 29 · see citing works

Metabolic engineering is key to a sustainable chemical industry

Murphy, A. C. (2011) · Natural Product Reports · doi:10.1039/c1np00029b · Cited by 29 · see citing works

Validation and application of reference genes for quantitative gene expression analyses in various tissues of Bupleurum chinense

Dong, L., Sui, C., Liu, Y., Yang, Y., Wei, J., & Yang, Y. (2010) · Molecular Biology Reports · doi:10.1007/s11033-010-0648-3 · Cited by 27 · see citing works

Cellular engineering of Artemisia annua and Artemisia dubia with the rol ABC genes for enhanced production of potent anti-malarial drug artemisinin

Kiani, B. H., Suberu, J., & Mirza, B. (2016) · Malaria Journal · doi:10.1186/s12936-016-1312-8 · Cited by 27 · see citing works

Secondary Metabolic Profiling and Artemisinin Biosynthesis of Two Genotypes ofArtemisia annua

Wang, H., Ma, C., Ma, L., Du, Z., Wang, H., Ye, H., Li, G., Liu, B., & Xu, G. (2009) · Planta Medica · doi:10.1055/s-0029-1185814 · Cited by 26 · see citing works

REVIEW PAPER Artemisia species in vitro cultures for production of biologically active secondary metabolites

Grech‐Baran, M., & Pietrosiuk, A. (2014) · Biotechnologia · doi:10.5114/bta.2012.46591 · Cited by 26 · see citing works

Genetic engineering of artemisinin biosynthesis: prospects to improve its production

Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25 · see citing works

High-Temperature Stress and Metabolism of Secondary Metabolites in Plants

Bhattacharya, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817562-0.00005-7 · Cited by 26 · see citing works

Effect of Development Stage on the Artemisinin Content and the Sequence Characterized Amplified Region (SCAR) Marker of High‐Artemisinin Yielding Strains of Artemisia annua L.

Zhang, L., Ye, H., & Li, G. (2006) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2006.00288.x · Cited by 25 · see citing works

Ri-mediated transformation of Artemisia annua with a recombinant farnesyl diphosphate synthase gene for artemisinin production

Chen, D.-H., Liu, C.-J., Ye, H.-C., Li, G.-F., Liu, B.-Y., Meng, Y.-L., & Chen, X.-Y. (1999) · Plant Cell, Tissue and Organ Culture · doi:10.1023/a:1006326818509 · Cited by 65 · see citing works

Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L.

Banyai, W., Kirdmanee, C., Mii, M., & Supaibulwatana, K. (2010) · Plant Cell, Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-010-9775-8 · Cited by 105 · see citing works

Agrobacterium tumefaciens-mediated transformation of Artemisia annua L. and regeneration of transgenic plants

Vergauwe, A., Cammaert, R., Vandenberghe, D., Genetello, C., Inzé, D., Montagu, M. V., & den Eeckhout, E. V. (1996) · Plant Cell Reports · doi:10.1007/bf00231590 · Cited by 72 · see citing works

An improved Agrobacterium tumefaciens mediated transformation of Artemisia annua L. by using stem internodes as explants

Tian, N., Liu, S., Ting, H., Huang, J., van der Krol, A. R., Bouwmeester, H. J., & Liu, Z. (2013) · Czech Journal of Genetics and Plant Breeding · doi:10.17221/105/2012-cjgpb · Cited by 5 · see citing works

Agrobacterium tumefaciens?mediated transformation of Artemisia annua L. and regenration of transgenic plants

Vergauwe, A., Cammaert, R., Vanderberghe, D., Genetello, C., Inzé, D., Montagu, M. V., & den Eeckhout, E. V. (1996) · Plant Cell Reports · doi:10.1007/s002990050151 · Cited by 1 · see citing works