Ri-mediated transformation of Artemisia annua with a recombinant farnesyl diphosphate synthase gene for artemisinin production
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Investigators have concentrated on expressing enzymes from phases 1 and 2 of the artemisinin biosynthetic route in transgenic organisms, including HMGR, FPPS, ADS, and CYP71AV1.
“To date, investigators have concentrated on expressing the enzymes from phases 1 and 2 of the biosynthetic route to artemisinin in transgenic organisms (see Scheme 9 in Section 3). These have included: HMG-CoA reductase (HMGR) [370]; farnesyl diphosphate synthase (FPPS) [371, 372,373,374]; amorpha-4,11-diene synthase (ADS) [375,376,377]; and the P450 enzyme which oxidises amorpha-4,11-diene to art”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [371]
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
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- Authors
- Chen, D.-H., Liu, C.-J., Ye, H.-C., Li, G.-F., Liu, B.-Y., Meng, Y.-L., & Chen, X.-Y.
- Affiliations
- Chinese Academy of Sciences (CN)
- ORCID
- Chen, Xiao-Ya
- Venue
- Plant Cell, Tissue and Organ Culture
- Published
- 1999-06
- Volume
- 57
- Issue
- 3
- Pages
- 157-162
- ISSN
- 0167-6857 (ISSN-L)
- 1573-5044
- OpenAlex
- W226556942
- Cited by
- 65
- References
- 25
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 0.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Plant Cell Tissue and Organ Culture (PCTOC) (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
- Keywords
- Artemisia annua, artemisinin production, farnesyl diphosphate synthase, Agrobacterium rhizogenes-mediated transformation, hairy roots, transgenic plants, recombinant gene expression, kanamycin resistance, callus formation, secondary metabolite biosynthesis
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