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The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea
Abstract
Obstructive sleep apnea (OSA) is independently associated with glucose intolerance and insulin resistance, and recent studies have shown that continuous positive airway pressure (CPAP) improves insulin sensitivity. The objective of this study was to describe the change in glycosylated hemoglobin (HbA1c) after treatment with CPAP in patients with type 2 diabetes mellitus and OSA. To test this hypothesis, we performed a retrospective analysis of 38 patients seen in the sleep clinic of an urban public teaching hospital. All patients had OSA and type 2 diabetes mellitus, and their diabetic medication regimen had remained unchanged during the period of CPAP therapy. Sixty-one percent were men, body mass index was 42+/-9.5 kg/m(2), and the Apnea-Hypopnea Index was 53+/-36 per hour. HbA1c before therapy with CPAP was 7.8+/-1.4% and decreased to 7.3+/-1.3% after 134+/-119 days of therapy (p<0.001). Treatment with CPAP leads to a clinically significant drop in HbA1c in patients with type 2 diabetes mellitus and severe OSA.
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“Improvement in glycemic control has been demonstrated after 3 months of CPAP use, with improvement related to number of hours of nightly CPAP use(107, 108).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [107]
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Metadata
- Authors
- Hassaballa, H. A., Tulaimat, A., Herdegen, J. J., & Mokhlesi, B.
- Affiliations
- Rush University Medical Center (US)
- John H. Stroger, Jr. Hospital of Cook County (US)
- Corresponding author
- Tulaimat, Aiman
- Venue
- Sleep And Breathing
- Published
- 2005-11-08
- Volume
- 9
- Issue
- 4
- Pages
- 176-180
- ISSN
- 1520-9512 (ISSN-L)
- 1522-1709
- OpenAlex
- W2091933728
- Cited by
- 142
- References
- 26
- Citations by year
- 2026: 3 · 2025: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 11 · 2015: 17 · 2014: 10 · 2013: 8 · 2012: 14
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Sleep And Breathing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- continuous positive airway pressure, obstructive sleep apnea, type 2 diabetes, glycemic control, HbA1c, insulin resistance, impaired glucose tolerance, CPAP therapy
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Retrospective Studies, Severity of Illness Index, Body Mass Index, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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