Obstructive Sleep Apnea and Metabolic Syndrome: Alterations in Glucose Metabolism and Inflammation
Abstract
Metabolic syndrome (MS), the commonly used term for the clustering of obesity, insulin resistance, hypertension, and dyslipidemia, affects millions of people worldwide, and is associated with an increased risk of cardiovascular disease and type 2 diabetes. Recently, it has been suggested that obstructive sleep apnea (OSA), an increasingly prevalent condition, may contribute to the development of MS and diabetes. Despite substantial evidence from both clinical and population studies to suggest an independent link between OSA and metabolic abnormalities, the issue still remains controversial. Obesity, particularly visceral obesity, is an important factor in the assessment of adverse metabolic outcome in OSA. Further prospective and interventional studies, with adequate sample sizes and longer follow-up, rigorous control for adiposity, and, ideally, randomization and control for any therapeutic intervention, are clearly needed to address the direction of causality. There are multiple mechanistic pathways involved in the interaction between OSA, obesity, and metabolic derangements. Chronic intermittent hypoxia and sleep fragmentation with sleep loss in OSA are likely key triggers that initiate or contribute to the sustenance of inflammation as a prominent phenomenon, but their complex interplay remains to be elucidated. In summary, OSA may represent a novel risk factor for MS and diabetes, and thus clinicians should be encouraged to systematically evaluate the presence of metabolic abnormalities in OSA and vice versa.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Obstructive sleep apnea is independently associated with glucose intolerance, insulin resistance, and diabetes, after accounting for age, sex, BMI, and other confounders.
“It is now well-documented that OSA, independently of age, sex, BMI, and other confounders, is associated with glucose intolerance, insulin resistance, and diabetes (for review, see [175, 177]).”
From Sleep and metabolic function (2012) · cites this paper as [175]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
The metabolic syndrome—a new worldwide definition
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works
Impact of sleep debt on metabolic and endocrine function
Spiegel, K., Leproult, R., & Van Cauter, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01376-8 · Cited by 3,668 · see citing works
Sympathetic neural mechanisms in obstructive sleep apnea.
Somers, V. K., Dyken, M. E., Clary, M. P., & Abboud, F. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118235 · Cited by 2,527 · see citing works
Spiegel, K., Tasali, E., Penev, P., & Cauter, E. V. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00008 · Cited by 2,459 · see citing works
Self-citationThe metabolic consequences of sleep deprivation
Knutson, K. L., Spiegel, K., Penev, P., & Van Cauter, E. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.01.002 · Cited by 1,365 · see citing works
Young, T. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.8.893 · Cited by 1,304 · see citing works
Obstructive Sleep Apnea Is Independently Associated with Insulin Resistance
Ip, M. S. M., Lam, B., Ng, M. M. T., Lam, W. K., Tsang, K. W. T., & Lam, K. S. L. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.5.2103001 · Cited by 1,300 · see citing works
Self-citationGangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2006) · Hypertension · doi:10.1161/01.hyp.0000217362.34748.e0 · Cited by 1,284 · see citing works
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Hopper, K. D., Lotsikas, A. J., LIN, H., Kales, A., & Chrousos, G. P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6484 · Cited by 1,196 · see citing works
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195 · see citing works
Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes
Spiegel, K., Knutson, K., Leproult, R., Tasali, E., & Cauter, E. V. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2005 · Cited by 1,175 · see citing works
Self-citationPunjabi, N. M. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh261 · Cited by 1,107 · see citing works
Obstructive sleep apnoea syndrome – an oxidative stress disorder
Lavie, L. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0261 · Cited by 993 · see citing works
Elevated C-Reactive Protein in Patients With Obstructive Sleep Apnea
Shamsuzzaman, A. S. M., Winnicki, M., Lanfranchi, P., Wolk, R., Kara, T., Accurso, V., & Somers, V. K. (2002) · Circulation · doi:10.1161/01.cir.0000018948.95175.03 · Cited by 974 · see citing works
Ryan, S., Taylor, C. T., & McNicholas, W. T. (2005) · Circulation · doi:10.1161/circulationaha.105.556746 · Cited by 970 · see citing works
Yokoe, T., Minoguchi, K., Matsuo, H., Oda, N., Minoguchi, H., Yoshino, G., Hirano, T., & Adachi, M. (2003) · Circulation · doi:10.1161/01.cir.0000052627.99976.18 · Cited by 961 · see citing works
Sleep-disordered Breathing and Insulin Resistance in Middle-aged and Overweight Men
Punjabi, N. M., Sorkin, J. D., Katzel, L. I., Goldberg, A. P., Schwartz, A. R., & SMITH, P. L. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.5.2104087 · Cited by 955 · see citing works
McNicholas, W. T., Bonsignore, M. R., & the Management Committee of EU COST ACTION B26 (2007) · European Respiratory Journal · doi:10.1183/09031936.00027406 · Cited by 911 · see citing works
A prospective study of self-reported sleep duration and incident diabetes in women
Ayas, N. T., White, D. P., Al-Delaimy, W. K., Manson, J. E., Stampfer, M. J., Speizer, F. E., Patel, S., & Hu, F. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.380 · Cited by 883 · see citing works
Coughlin, S. R. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.02.021 · Cited by 840 · see citing works
Sleep duration as a risk factor for the development of type 2 diabetes
Yaggi, H. K., Araujo, A. B., & McKinlay, J. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-0879 · Cited by 790 · see citing works
Association of Sleep Apnea and Type II Diabetes
Reichmuth, K. J., Austin, D., Skatrud, J. B., & Young, T. B. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-637oc · Cited by 770 · see citing works
Dyugovskaya, L., Lavie, P., & Lavie, L. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.7.2104126 · Cited by 742 · see citing works
Fröhlich, M., Imhof, A., Berg‐Beckhoff, G., Hutchinson, W. L., Pepys, M. B., Boeing, H., Muche, R., Brenner, H., & Köenig, W. (2000) · Diabetes Care · doi:10.2337/diacare.23.12.1835 · Cited by 683 · see citing works
Role of Sleep Duration and Quality in the Risk and Severity of Type 2 Diabetes Mellitus
Knutson, K. L. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1768 · Cited by 641 · see citing works
Enhanced Release of Superoxide from Polymorphonuclear Neutrophils in Obstructive Sleep Apnea
Schulz, R., MAHMOUDI, S., Hattar, K., Sibelius, U., Olschewski, H., Mayer, K., Seeger, W., & Grimminger, F. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9908091 · Cited by 639 · see citing works
Newman, A. B. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.1.50 · Cited by 603 · see citing works
Harsch, I. A., Schahin, S. P., Radespiel-Tröger, M., Weintz, O., Jahreiß, H., Fuchs, F. S., Wiest, G. H., Hahn, E. G., Lohmann, T., Konturek, P. C., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200302-206oc · Cited by 583 · see citing works
Sleep apnea is a manifestation of the metabolic syndrome
Vgontzas, A. N., Bixler, E. O., & Chrousos, G. P. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.006 · Cited by 556 · see citing works
The metabolic syndrome and adipocytokines
Matsuzawa, Y. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.04.028 · Cited by 541 · see citing works
Ridker, P. M., & Cook, N. R. (2004) · Circulation · doi:10.1161/01.cir.0000125690.80303.a8 · Cited by 511 · see citing works
Reaven, G. M. (2002) · Circulation · doi:10.1161/01.cir.0000019884.36724.d9 · Cited by 494 · see citing works
Ip, M., LAM, B. K., Chan, L., Zheng, L., TSANG, K. W. T., Fung, P. C. W., & Lam, W. K. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.2002126 · Cited by 479 · see citing works
Self-citationBabu, A. R., Herdegen, J., Fogelfeld, L., Shott, S., & Mazzone, T. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.4.447 · Cited by 453 · see citing works
Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea
Phillips, B. G., Kato, M., Narkiewicz, K., Choe, I., & Somers, V. K. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.1.h234 · Cited by 430 · see citing works
Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea
Minoguchi, K., Yokoe, T., 田崎, 俊., Minoguchi, H., Tanaka, A., Oda, N., Okada, S., Ohta, S., Naito, H., & Adachi, M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200412-1652oc · Cited by 421 · see citing works
Serum Leptin and Vascular Risk Factors in Obstructive Sleep Apnea
Ip, M., Lam, K. S. L., Ho, C., Tsang, K. W. T., & Lam, W.-K. (2000) · CHEST Journal · doi:10.1378/chest.118.3.580 · Cited by 417 · see citing works
Self-citationWest, S. D., Nicoll, D. J., Wallace, T. M., Matthews, D. R., & Stradling, J. R. (2007) · Thorax · doi:10.1136/thx.2006.074351 · Cited by 408 · see citing works
Vorona, R. D., Winn, M. P., Babineau, T. W., Eng, B. P., Feldman, H. R., & Ware, J. C. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.1.25 · Cited by 405 · see citing works
High Incidence of Diabetes in Men With Sleep Complaints or Short Sleep Duration
Mallon, L., Broman, J.-E., & Hetta, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.11.2762 · Cited by 391 · see citing works
Oxidative Stress in Obstructive Sleep Apnea
Yamauchi, M., Nakano, H., Maekawa, J., Okamoto, Y., Ohnishi, Y., Suzuki, T., & Kimura, H. (2005) · CHEST Journal · doi:10.1378/chest.127.5.1674 · Cited by 388 · see citing works
Intermittent Hypoxia Increases Insulin Resistance in Genetically Obese Mice
Polotsky, V. Y., Li, J., Punjabi, N. M., Rubin, A. E., Smith, P. L., Schwartz, A. R., & O'Donnell, C. P. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.048173 · Cited by 375 · see citing works
Intermittent Hypoxia Causes Insulin Resistance in Lean Mice Independent of Autonomic Activity
Iiyori, N., Alonso, L. C., Li, J., Sanders, M. H., Garcia-Ocana, A., O'Doherty, R. M., Polotsky, V. Y., & O'Donnell, C. P. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200610-1527oc · Cited by 373 · see citing works
Prevalence of obstructive sleep apnoea in men with type 2 diabetes
West, S. D., Nicoll, D., & Stradling, J. R. (2006) · Thorax · doi:10.1136/thx.2005.057745 · Cited by 372 · see citing works
fer, H. S. A., Pauleit, D. O., Sudhop, T., Gouni‐Berthold, I., Ewig, S., & Berthold, H. K. (2002) · CHEST Journal · doi:10.1378/chest.122.3.829 · Cited by 357 · see citing works
Predictors of Elevated Nuclear Factor-κB–dependent Genes in Obstructive Sleep Apnea Syndrome
Ryan, S., Taylor, C. T., & McNicholas, W. T. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200601-066oc · Cited by 354 · see citing works
Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
van Cauter, E., Holmbäck, U., Knutson, K., Leproult, R., Miller, A., Nedeltcheva, A., Pannain, S., Penev, P., Tasali, E., & Spiegel, K. (2007) · Hormone Research in Paediatrics · doi:10.1159/000097543 · Cited by 353 · see citing works
Self-citationIncidence of Diabetes in Middle-Aged Men Is Related to Sleep Disturbances
Nilsson, P. M., Rööst, M., Engström, G., Hedblad, B., & Berglund, G. (2004) · Diabetes Care · doi:10.2337/diacare.27.10.2464 · Cited by 322 · see citing works
Ford, E. S. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00134-5 · Cited by 315 · see citing works
Cardiovascular and metabolic effects of CPAP in obese males with OSA
Coughlin, S. R., Mawdsley, L., Mugarza, J. A., Wilding, J. P. H., & Calverley, P. M. (2007) · European Respiratory Journal · doi:10.1183/09031936.00043306 · Cited by 313 · see citing works
Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome
Meslier, N., Gagnadoux, F., Giraud, P., Person, C., Ouksel, H., Urban, T., & Racineux, J.-L. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00089902 · Cited by 301 · see citing works
Schulz, R. (2000) · Thorax · doi:10.1136/thorax.55.12.1046 · Cited by 297 · see citing works
Brooks, B. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.79.6.1681 · Cited by 295 · see citing works
Sleep‐disordered breathing and glucose metabolism in hypertensive men: a population‐based study
Elmasry, A., Lindberg, E., Berne, C., Janson, C., Gíslason, Þ., Tageldin, M. A., & Boman, G. (2001) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2001.00787.x · Cited by 286 · see citing works
The relationship between serum cytokine levels with obesity and obstructive sleep apnea syndrome
Çiftçi, T. U., Köktürk, O., Bukan, N. C., & Bi̇lgi̇han, A. (2004) · Cytokine · doi:10.1016/j.cyto.2004.07.003 · Cited by 280 · see citing works
Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome
Ohga, E., Nagase, T., Tomita, T., Teramoto, S., Matsuse, T., Katayama, H., & Ouchi, Y. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.10 · Cited by 265 · see citing works
Snoring as a risk factor for disease: an epidemiological survey.
Norton, P. G., & Dunn, E. C. (1985) · BMJ · doi:10.1136/bmj.291.6496.630 · Cited by 257 · see citing works
Prevalence and Correlates of Snoring and Observed Apneas in 5,201 Older Adults
Enright, P., Newman, A. B., Wahl, P. W., Manolio, T. A., Haponik, F. E., & Boyle, P. J. R. (1996) · SLEEP · doi:10.1093/sleep/19.7.531 · Cited by 257 · see citing works
Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia
Li, J., Savransky, V., Nanayakkara, A., Smith, P. L., O'Donnell, C. P., & Polotsky, V. Y. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01081.2006 · Cited by 248 · see citing works
Sleep Disturbance and Onset of Type 2 Diabetes
Kawakami, N., Takatsuka, N., & Shimizu, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.282 · Cited by 247 · see citing works
Obstructive Sleep Apnea Syndrome Is Associated With Some Components of Metabolic Syndrome
Kono, M., Tatsumi, K., Saibara, T., Nakamura, A., Tanabe, N., Takiguchi, Y., & Kuriyama, T. (2007) · CHEST Journal · doi:10.1378/chest.06-1807 · Cited by 246 · see citing works
Metabolic Risk Factors for Vascular Disease in Obstructive Sleep Apnea
McArdle, N., Hillman, D. R., Beilin, L. J., & Watts, G. F. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200602-270oc · Cited by 242 · see citing works
Suzuki, Y., Jain, V., Park, A.-M., & Day, R. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.008 · Cited by 239 · see citing works
Fibrinogen Levels and Obstructive Sleep Apnea in Ischemic Stroke
Wessendorf, T., Thilmann, A. F., WANG, Y.-M., SCHREIBER, A., Konietzko, N., & Teschler, H. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.2001048 · Cited by 238 · see citing works
Study, T. M. A. C., Meisinger, C., Heier, M., & Loewel, H. (2005) · Diabetologia · doi:10.1007/s00125-004-1634-x · Cited by 234 · see citing works
Leptin, obesity, and respiratory function
O'Donnell, C. P., Tankersley, C. G., Polotsky, V. P., Schwartz, A. R., & Smith, P. L. (2000) · Respiration Physiology · doi:10.1016/s0034-5687(99)00111-5 · Cited by 233 · see citing works
Prevalence of Sleep Apnea in a Population of Adults with Type 2 Diabetes Mellitus
Einhorn, D., Stewart, D. A., Erman, M. K., Gordon, N., Philis-Tsimikas, A., & Casal, E. (2007) · Endocrine Practice · doi:10.4158/ep.13.4.355 · Cited by 232 · see citing works
C-Reactive Protein and Sleep-Disordered Breathing
Guilleminault, C., Kirisoglu, C., & Ohayon, M. M. (2004) · SLEEP · doi:10.1093/sleep/27.8.1507 · Cited by 231 · see citing works
Chin, K., Nakamura, T., Shimizu, K., Mishima, M., Nakamura, T., Miyasaka, M., & Ohi, M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00580-5 · Cited by 229 · see citing works
C-reactive Protein is Associated With Sleep Disordered Breathing Independent of Adiposity
Punjabi, N. M., & Beamer, B. A. (2007) · SLEEP · doi:10.1093/sleep/30.1.29 · Cited by 227 · see citing works
Silent Brain Infarction and Platelet Activation in Obstructive Sleep Apnea
Minoguchi, K., Yokoe, T., 田崎, 俊., Minoguchi, H., Oda, N., Tanaka, A., Yamamoto, M., Ohta, S., O'Donnell, C. P., & Adachi, M. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200608-1141oc · Cited by 227 · see citing works
Minimal Model: Perspective from 2005
Bergman, R. (2006) · Hormone Research in Paediatrics · doi:10.1159/000089312 · Cited by 226 · see citing works
Chronic intermittent hypoxia activates nuclear factor-κB in cardiovascular tissues in vivo
Greenberg, H. E., Ye, X., Wilson, D., Htoo, A. K., Hendersen, T., & Liu, S. F. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.015 · Cited by 225 · see citing works
Harsch, I. A., Schahin, S. P., Brückner, K., Radespiel-Tröger, M., Fuchs, F. S., Hahn, E. G., Konturek, P. C., Lohmann, T., & Ficker, J. H. (2004) · Respiration · doi:10.1159/000077423 · Cited by 219 · see citing works
Greniér, P., & Beigelman‐Aubry, C. (1998) · Thorax · doi:10.1136/thx.53.2008.s25 · Cited by 212 · see citing works
Htoo, A. K., Greenberg, H. E., Tongia, S., Chen, G., Henderson, T., Wilson, D., & Liu, S. F. (2006) · Sleep And Breathing · doi:10.1007/s11325-005-0046-6 · Cited by 200 · see citing works
Elmasry, A., Janson, C., Lindberg, E., Gíslason, Þ., Tageldin, M. A., & Boman, G. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00683.x · Cited by 196 · see citing works
Antioxidant defense responses to sleep loss and sleep recovery
Everson, C. A., Laatsch, C. D., & Hogg, N. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00565.2004 · Cited by 192 · see citing works
Gruber, A., Horwood, F., Sithole, J., Ali, N. D. A., & IDRIS, I. R. (2006) · Cardiovascular Diabetology · doi:10.1186/1475-2840-5-22 · Cited by 190 · see citing works
Insulin Levels, Blood Pressure and Sleep Apnea
Strohl, K. P., Novak, R. D., Singer, W., Cahan, C., Boehm, K. D., Denko, C. W., & Hoffstein, V. (1994) · SLEEP · doi:10.1093/sleep/17.7.614 · Cited by 189 · see citing works
Relationship of Metabolic Syndrome and Obstructive Sleep Apnea
Parish, J. M., Adam, T. J., & Facchiano, L. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26910 · Cited by 188 · see citing works
Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea
Foster, G. E., Poulin, M. J., & Hanly, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.035204 · Cited by 178 · see citing works
Sharma, S. K., Kumpawat, S., Goel, A., Banga, A., Ramakrishnan, L., & Chaturvedi, P. K. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2006.06.014 · Cited by 174 · see citing works
Insulin Resistance and Sleep-Disordered Breathing in Healthy Humans
Stoohs, R. A., Facchini, F., & Guilleminault, C. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.1.8680675 · Cited by 174 · see citing works
Grunstein, R. R., Stenlöf, K., Hedner, J. A., & Sjöström, L. (1995) · PubMed · Cited by 170 · see citing works
Effect of episodic hypoxia on sympathetic activity and blood pressure
Fletcher, E. C. (2000) · Respiration Physiology · doi:10.1016/s0034-5687(99)00114-0 · Cited by 164 · see citing works
Phenotypic and Functional Characterization of Blood γδ T Cells in Sleep Apnea
Dyugovskaya, L., Lavie, P., & Lavie, L. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200210-1226oc · Cited by 160 · see citing works
Sleep Disturbances in Midlife Unrelated to 32-Year Diabetes Incidence
Björkelund, C., Bondyr-Carlsson, D., Lapidus, L., Lissner, L., Månsson, J., Skoog, I., & Bengtsson, C. (2005) · Diabetes Care · doi:10.2337/diacare.28.11.2739 · Cited by 158 · see citing works
Hui, D. S. C., Ko, F. W. S., Fok, J. P. C., Chan, M. C. W., Li, T. S., Tomlinson, B., & Cheng, G. Y.-M. (2004) · CHEST Journal · doi:10.1378/chest.125.5.1768 · Cited by 153 · see citing works
Cooper, B. G., White, J., Ashworth, L., Alberti, K. G. M. M., & Gibson, G. J. (1995) · SLEEP · doi:10.1093/sleep/18.3.172 · Cited by 152 · see citing works
CPAP treatment of a population-based sample—what are the benefits and the treatment compliance?
Lindberg, E., Berne, C., Elmasry, A., Hedner, J. A., & Janson, C. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2005.12.010 · Cited by 150 · see citing works
Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity
Ryan, S., Nolan, G. M., Hannigan, E., Cunningham, S., Taylor, C. T., & McNicholas, W. T. (2007) · Thorax · doi:10.1136/thx.2006.066720 · Cited by 146 · see citing works
Obstructive Sleep Apnea, Cardiovascular Disease, and Pulmonary Hypertension
Golbin, J. M., Somers, V. K., & Caples, S. M. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-143mg · Cited by 145 · see citing works
Hassaballa, H. A., Tulaimat, A., Herdegen, J. J., & Mokhlesi, B. (2005) · Sleep And Breathing · doi:10.1007/s11325-005-0033-y · Cited by 142 · see citing works
Serum Cardiovascular Risk Factors in Obstructive Sleep Apnea
Can, M., Açıkgöz, Ş., Mungan, G., Bayraktaroğlu, T., Koçak, E., Güven, B., & Demırtaş, S. (2006) · CHEST Journal · doi:10.1378/chest.129.2.233 · Cited by 136 · see citing works
Neuropeptide Y and Leptin in Patients with Obstructive Sleep Apnea Syndrome
Barceló, A., Barbé, F., Llompart, E., de la Peña, M., Durán‐Cantolla, J., Ladaria, A., Bosch, M., Guerra, L., & Agustí, A. G. N. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200405-579oc · Cited by 136 · see citing works
Barceló, A., Barbé, F., Llompart, E., Mayoralas, L. R., Ladaria, A., Bosch, M., & Agustí, A. G. N. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.01.025 · Cited by 130 · see citing works
Metabolic Syndrome in Japanese Patients with Obstructive Sleep Apnea Syndrome
Sasanabe, R., Banno, K., Otake, K., Hasegawa, R., Kengo, U. S. U. I., Morita, M., & Shiomi, T. (2006) · Hypertension Research · doi:10.1291/hypres.29.315 · Cited by 128 · see citing works
The association of OSA with insulin resistance, inflammation and metabolic syndrome
Peled, N., Kassirer, M., Shitrit, D., Kogan, Y., Shlomi, D., Berliner, A. S., & Kramer, M. R. (2007) · Respiratory Medicine · doi:10.1016/j.rmed.2007.02.025 · Cited by 128 · see citing works
Influence of treatment on leptin levels in patients with obstructive sleep apnoea
Sanner, B. M., Kollhosser, P., Buechner, N., Zidek, W., & Tepel, M. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00067804 · Cited by 117 · see citing works
Tumour necrosis factor-α (−308) gene polymorphism in obstructive sleep apnoea–hypopnoea syndrome
Riha, R. L., Brander, P. E., Vennelle, M., McArdle, N., Kerr, S. M., Anderson, N. H., & Douglas, N. J. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00130804 · Cited by 116 · see citing works
Differences in Polysomnography Predictors for Hypertension and Impaired Glucose Tolerance
Sulit, L., Storfer‐Isser, A., Kirchner, H. L., & Redline, S. S. (2006) · SLEEP · doi:10.1093/sleep/29.6.777 · Cited by 116 · see citing works
CPAP treatment does not affect glucose–insulin metabolism in sleep apneic patients
Smurra, M. V., Philip, P., Taillard, J., Guilleminault, C., Bioulac, B. H., & Gin, H. (2001) · Sleep Medicine · doi:10.1016/s1389-9457(00)00079-4 · Cited by 114 · see citing works
The severity of obstructive sleep apnoea is associated with insulin resistance
Tiihonen, M., Partinen, M., & Närvänen, S. (1993) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1993.tb00062.x · Cited by 114 · see citing works
Lindberg, E., Berne, C., Franklin, K. A., Svensson, M., & Janson, C. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.10.015 · Cited by 114 · see citing works
Tassone, F., Lanfranco, F., Gianotti, L., Pivetti, S., Navone, F., Rossetto, R., Grottoli, S., Gai, V., Ghigo, E., & Maccario, M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01859.x · Cited by 102 · see citing works
Obstructive sleep apnea, cardiovascular disease, and inflammation—is NF-κB the key?
Williams, A. L., & Scharf, S. M. (2007) · Sleep And Breathing · doi:10.1007/s11325-007-0106-1 · Cited by 101 · see citing works
Continuous Positive Airway Pressure Treatment
Saini, J., Krieger, J., BRANDENBERGER, G., Wittersheim, G., Simon, C., & FOLLENIUS, M. (1993) · Hormone and Metabolic Research · doi:10.1055/s-2007-1002123 · Cited by 98 · see citing works
Davies, R. J., TURNER, R., Crosby, J., & Stradling, J. R. (1994) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1994.tb00126.x · Cited by 97 · see citing works
Galletti, F., Barbato, A., Versiero, M., Iacone, R., Russo, O., Barba, G., Siani, A., Cappuccio, F. P., Farinaro, E., Valle, E. D., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281afa09e · Cited by 95 · see citing works
Association of Habitual Snoring with Glucose and Insulin Metabolism in Nonobese Korean Adult Men
Shin, C., Kim, J., Kim, J. H., Lee, S. Y., Shim, J.-J., In, K.-H., Kang, K.-H., Yoo, S., Cho, N.-H., Kimm, K., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-906oc · Cited by 92 · see citing works
Structural and serum surrogate markers of cerebrovascular disease in obstructive sleep apnea (OSA)
Saletu, M., Nosiska, D., Kapfhammer, G., Lalouschek, W., Saletu, B., Benesch, T., & Zeitlhofer, J. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0110-6 · Cited by 91 · see citing works
Effect of nasal CPAP treatment on insulin sensitivity and plasma leptin
Saarelainen, S., Lahtela, J. T., & Kallonen, E. (1997) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1997.00034.x · Cited by 82 · see citing works
Relationship between Obstructive Sleep Apnea and Diurnal Leptin Rhythms
Patel, S. R., Palmer, L. J., Larkin, E. K., Jenny, N. S., White, D. P., & Redline, S. S. (2004) · SLEEP · doi:10.1093/sleep/27.2.235 · Cited by 80 · see citing works
Reduced levels of adiponectin in sleep apnea syndrome
Masserini, B., Morpurgo, P. S., Donadio, F., Baldessari, C., Bossi, R., Beck‐Peccoz, P., & Orsi, E. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03344179 · Cited by 67 · see citing works
Sleep and Glucose Intolerance/Diabetes Mellitus
Ip, M., & Mokhlesi, B. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2006.12.002 · Cited by 67 · see citing works
Self-citationLeptin receptor and functional effects of leptin in human endothelial progenitor cells
Wolk, R. A., Deb, A., Caplice, N. M., & SOMERS, V. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.048 · Cited by 66 · see citing works
Autonomic dysfunction in obstructive sleep apnea is associated with impaired glucose regulation
Peltier, A., Consens, F. B., Sheikh, K., Wang, L., Song, Y., & Russell, J. W. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.06.010 · Cited by 57 · see citing works
The relationship of glucose tolerance to sleep disorders and daytime sleepiness
Renko, A.-K., Hiltunen, L. A., Laakso, M., Rajala, U., & Keinanen-Kiukaanniemi, S. M. (2004) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.06.003 · Cited by 56 · see citing works
Habitual snoring is associated with elevated hemoglobin A1c levels in non‐obese middle‐aged adults
Joo, S.-J., Lee, S., Choi, H. A., Kim, J., Kim, E., Kimm, K., Kim, J. H., & Shin, C. (2006) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2006.00556.x · Cited by 48 · see citing works
Czupryniak, L., Loba, J. M., Pawlowski, M., Nowak, D., & Białasiewicz, P. (2005) · SLEEP · doi:10.1093/sleep/28.5.601 · Cited by 47 · see citing works
Thomas, G. N., Jiang, C., Lao, X. Q., McGhee, S. M., Zhang, W. S., Schooling, C. M., Adab, P., Lam, T. H., & Cheng, K. K. (2006) · SLEEP · doi:10.1093/sleep/29.7.896 · Cited by 46 · see citing works
Onat, A., Hergenç, G., Uyarel, H., Yazıcı, M., Tuncer, M., Doğan, Y., Can, G., & Rasche, K. (2006) · Sleep And Breathing · doi:10.1007/s11325-006-0077-7 · Cited by 45 · see citing works
Snoring, sympathetic activity and cardiovascular risk factors in a 70 year old population
Jennum, P., Schultz‐Larsen, K., & Christensen, N. J. (1993) · European Journal of Epidemiology · doi:10.1007/bf00209524 · Cited by 43 · see citing works
Metabolic syndrome in obstructive sleep apnea and related cardiovascular risk
Ambrosetti, M., Lucioni, A. M., Conti, S., Pedretti, R. F. E., & Neri, M. (2006) · Journal of Cardiovascular Medicine · doi:10.2459/01.jcm.0000250873.01649.41 · Cited by 40 · see citing works
Relation of habitual snoring with components of metabolic syndrome in Korean adults
Cho, N., Joo, S., Kim, J., Abbott, R. D., Kim, J., Kimm, K., & Shin, C. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.06.011 · Cited by 38 · see citing works
Tuomilehto, H., Peltonen, M., Partinen, M., Seppä, J., Saaristo, T., Korpi-Hyövälti, E., Oksa, H. H., Saltevo, J. T., Puolijoki, H., Vanhala, M. J., et al. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00729.x · Cited by 37 · see citing works
von Känel, R., Loredo, J. S., Ancoli‐Israel, S., Mills, P. J., & Dimsdale, J. E. (2007) · Metabolism · doi:10.1016/j.metabol.2007.02.010 · Cited by 34 · see citing works
Okada, M., Takamizawa, A., Tsushima, K., Urushihata, K., Fujimoto, K., & Kubo, K. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1592 · Cited by 28 · see citing works
Obesity and respiratory function
Chiovato, L. (2016) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2006.566 · Cited by 13 · see citing works
Pallayová, M., Donič, V., Doničová, V., & Tomori, Z. (2006) · Sleep Medicine · doi:10.1016/j.sleep.2006.07.129 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Olsen, M., Angell, S., Asma, S., Boutouyrie, P., Burger, D., Chirinos, J., Damasceno, A. A., Delles, C., Gimenez-Roqueplo, A., Hering, D., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31134-5 · Cited by 825 · see citing works
Effects of poor and short sleep on glucose metabolism and obesity risk
Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857 · see citing works
Self-citationObstructive Sleep Apnea in Adults
Veasey, S. C., & Rosen, I. M. (2019) · New England Journal of Medicine · doi:10.1056/nejmcp1816152 · Cited by 615 · see citing works
Role of sleep timing in caloric intake and BMI
Baron, K. G., Reid, K. J., Kern, A. S., & Zee, P. C. (2011) · Obesity · doi:10.1038/oby.2011.100 · Cited by 549 · see citing works
CPAP, Weight Loss, or Both for Obstructive Sleep Apnea
Chirinos, J. A., Gurubhagavatula, I., Teff, K., Rader, D. J., Wadden, T. A., Townsend, R., Foster, G. D., Maislin, G., Saif, H., Broderick, P., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1306187 · Cited by 523 · see citing works
Epidemiology of obstructive sleep apnea: a population-based perspective
Lee, W. J., Nagubadi, S., Kryger, M. H., & Mokhlesi, B. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.3.349 · Cited by 517 · see citing works
Obstructive sleep apnea and type 2 diabetes
Rasche, K., Keller, T., Tautz, B., Hader, C., Hergenç, G., Antosiewicz, J., Giulio, C. D., & Pokorski, M. (2010) · European journal of medical research · doi:10.1186/2047-783x-15-s2-152 · Cited by 366 · see citing works
Peri‐operative management of the obese surgical patient 2015
Party:, M. O. T. W., Nightingale, C. E., Margarson, M., Shearer, E., Redman, J., Lucas, D. N., Cousins, J., Fox, W. T. A., Kennedy, N. J., Venn, P. J. H., et al. (2015) · Anaesthesia · doi:10.1111/anae.13101 · Cited by 349 · see citing works
Sleep, sleep-disordered breathing and metabolic consequences
Levy, P. A., Bonsignore, M. R., & Eckel, J. (2009) · European Respiratory Journal · doi:10.1183/09031936.00166808 · Cited by 339 · see citing works
Alterations in Glucose Disposal in Sleep-disordered Breathing
Punjabi, N. M., & Beamer, B. A. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200809-1392oc · Cited by 304 · see citing works
Obstructive Sleep Apnea and Incident Diabetes. A Historical Cohort Study
Kendzerska, T., Gershon, A. S., Hawker, G., Tomlinson, G., & Leung, R. S. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201312-2209oc · Cited by 280 · see citing works
Kendzerska, T., Mollayeva, T., Gershon, A. S., Leung, R. S. T., HAWKER, G. A., & TOMLINSON, G. A. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.01.003 · Cited by 265 · see citing works
Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease
Mesarwi, O. A., Loomba, R. S., & Malhotra, A. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1109tr · Cited by 265 · see citing works
Hypoxia and Inflammation: Insights From High-Altitude Physiology
Pham, K., Parikh, K. D., & Heinrich, E. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.676782 · Cited by 250 · see citing works
Sleep-Related Problems in Common Medical Conditions
Parish, J. M. (2009) · CHEST Journal · doi:10.1378/chest.08-0934 · Cited by 240 · see citing works
Metabolic Syndrome and the Lung
Baffi, C. W., Wood, L. G., Winnica, D., Strollo, P. J., Gladwin, M. T., Que, L. G., & Holguín, F. (2016) · CHEST Journal · doi:10.1016/j.chest.2015.12.034 · Cited by 236 · see citing works
Pépin, J.-L., Tamisier, R., Barone-Rochette, G., Launois, S. H., Lévy, P., & Baguet, J.-P. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1803oc · Cited by 232 · see citing works
Obstructive Sleep Apnea and Type 2 Diabetes: Is There a Link?
Pamidi, S., & Tasali, E. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00126 · Cited by 231 · see citing works
Self-citationNonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management
Marjot, T., Moolla, A., Cobbold, J. F., Hodson, L., & Tomlinson, J. W. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz009 · Cited by 228 · see citing works
Obstructive Sleep Apnea and Cardiovascular Disease
Pack, A. I., & Gislason, T. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.01.002 · Cited by 228 · see citing works
Araghi, M. H., Chen, Y.-F., Jagielski, A., Choudhury, S., Banerjee, D., Hussain, S., Thomas, G. N., & Taheri, S. (2013) · Sleep · doi:10.5665/sleep.3056 · Cited by 214 · see citing works
Autonomic imbalance: prophet of doom or scope for hope?
Vinik, A. I., Maser, R. E., & Ziegler, D. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03184.x · Cited by 205 · see citing works
Marshall, N. S., WONG, K. K. H., Phillips, C. L., Liu, P. Y., Knuiman, M. W., & Grunstein, R. R. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27387 · Cited by 198 · see citing works
Morselli, L. L., Guyon, A., & Spiegel, K. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1053-z · Cited by 199 · see citing works
“It is now well-documented that OSA, independently of age, sex, BMI, and other confounders, is associated with glucose intolerance, insulin resistance, and diabetes (for review, see [175, 177]).”
Lam, J. C. M., Lam, B., Yao, T. J., Lai, A. Y. K., Ooi, C. G., Tam, S., Lam, K. S. L., & Ip, M. S. M. (2010) · European Respiratory Journal · doi:10.1183/09031936.00047709 · Cited by 170 · see citing works
Self-citationInsulin resistance and daytime sleepiness in patients with sleep apnoea
Barceló, A., Barbé, F., de la Peña, M., Martinez, P., Soriano, J. B., Piérola, J., & Agustí, A. G. N. (2008) · Thorax · doi:10.1136/thx.2007.093740 · Cited by 167 · see citing works
Winslow, D. H., Bowden, C. H., DiDonato, K. P., & McCullough, P. A. (2012) · Sleep · doi:10.5665/sleep.2204 · Cited by 163 · see citing works
Unexpected Benefits of Intermittent Hypoxia: Enhanced Respiratory and Nonrespiratory Motor Function
Dale, E. A., Mabrouk, F. B., & Mitchell, G. S. (2014) · Physiology · doi:10.1152/physiol.00012.2013 · Cited by 160 · see citing works
Obstructive sleep apnoea: definitions, epidemiology & natural history.
Lam, J., Sharma, S. K., & LAM, B. K. (2010) · PubMed · Cited by 153 · see citing works
Comorbidities Associated with Obstructive Sleep Apnea: a Retrospective Study
Pinto, J., Cavallini, A., Duarte, C., Freitas, G., & Ribeiro, D. K. (2016) · International Archives of Otorhinolaryngology · doi:10.1055/s-0036-1579546 · Cited by 142 · see citing works
Adipose tissue in obesity and obstructive sleep apnoea
Bonsignore, M. R., McNicholas, W. T., Montserrat, J. M., & Eckel, J. (2011) · European Respiratory Journal · doi:10.1183/09031936.00047010 · Cited by 138 · see citing works
β-cell death and proliferation after intermittent hypoxia: Role of oxidative stress
Xu, J., Long, Y., Gozal, D., & Epstein, P. N. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.026 · Cited by 132 · see citing works
Reduced Sleep Duration or Quality: Relationships With Insulin Resistance and Type 2 Diabetes
Tasali, E., Leproult, R., & Spiegel, K. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.10.002 · Cited by 129 · see citing works
Self-citationMalnutrition in Bariatric Surgery Candidates: Multiple Micronutrient Deficiencies Prior to Surgery
Frame, L. A., Cheskin, L. J., Furtado, M. M., Papas, K. A., Schweitzer, M., Magnuson, T. H., & Steele, K. E. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1844-y · Cited by 129 · see citing works
Tasali, E., Chapotot, F., Leproult, R., Whitmore, H. R., & Ehrmann, D. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1187 · Cited by 126 · see citing works
Self-citationNonalcoholic fatty liver disease and obstructive sleep apnea
Aron‐Wisnewsky, J., Clément, K., & Pépin, J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.05.004 · Cited by 124 · see citing works
Obstructive sleep apnea: role in the risk and severity of diabetes
Pamidi, S., Aronsohn, R. S., & Tasali, E. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.08.009 · Cited by 121 · see citing works
Self-citationObstructive sleep apnea as a risk factor for type 2 diabetes mellitus
Greenberg, H. E., & Rajan, P. (2015) · Nature and Science of Sleep · doi:10.2147/nss.s90835 · Cited by 119 · see citing works
Kawaguchi, Y., Fukumoto, S., Inaba, M., Koyama, H., Shoji, T., Shoji, S., & Nishizawà, Y. (2010) · Obesity · doi:10.1038/oby.2010.170 · Cited by 112 · see citing works
Tasali, E., Van Cauter, E., Hoffman, L., & Ehrmann, D. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0925 · Cited by 111 · see citing works
Self-citationFarlane, S. I. M. (2018) · Sleep Medicine and Disorders International Journal · doi:10.15406/smdij.2018.02.00045 · Cited by 112 · see citing works
Eastwood, P. R., MALHOTRA, A., Palmer, L. J., Kezirian, E. J., Horner, R. L., IP, M. S. M., Thurnheer, R., Antic, N. A., & Hillman, D. R. (2010) · Respirology · doi:10.1111/j.1440-1843.2009.01699.x · Cited by 105 · see citing works
Self-citationBasoglu, Ö. K., Saraç, F., Sarac, S., Uluer, H., & Yılmaz, C. (2011) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.82440 · Cited by 103 · see citing works
Morbidities associated with obstructive sleep apnea
Vijayan, V. K. (2012) · Expert Review of Respiratory Medicine · doi:10.1586/ers.12.44 · Cited by 101 · see citing works
Spinal plasticity following intermittent hypoxia: implications for spinal injury
Dale, E. A., Hoffman, M. S., MacFarlane, P. M., Satriotomo, I., Lovett-Barr, M. R., Vinit, S., & Mitchell, G. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05499.x · Cited by 99 · see citing works
Lam, D. C.-L., Lui, M. M., Lam, J., Ong, L. H. Y., Lam, K. S. L., & Ip, M. (2010) · CHEST Journal · doi:10.1378/chest.10-0596 · Cited by 98 · see citing works
Self-citationGarbarino, S., Scoditti, E., Lanteri, P., Conte, L., Magnavita, N., & Toraldo, D. M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00505 · Cited by 92 · see citing works
Bozkurt, N. C., Çakal, E., Şahi̇n, M., Ozkaya, E. C., Fırat, H., & Delibaşı, T. (2012) · Endocrine · doi:10.1007/s12020-012-9595-1 · Cited by 92 · see citing works
Poor Sleep and Obesity: Concurrent Epidemics in Adolescent Youth
Gohil, A., & Hannon, T. S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00364 · Cited by 96 · see citing works
Han, T. S., & Lean, M. E. J. (2014) · Medicine · doi:10.1016/j.mpmed.2014.11.006 · Cited by 87 · see citing works
Sustained sleep fragmentation affects brain temperature, food intake and glucose tolerance in mice
Baud, M. O., Magistretti, P. J., & PETIT, J. (2012) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2012.01029.x · Cited by 81 · see citing works
Clinical and Societal Consequences of Obstructive Sleep Apnea and Excessive Daytime Sleepiness
Rakel, R. E. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.01.1957 · Cited by 83 · see citing works
Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms
Mesarwi, O. A., Sharma, E. V., Jun, J. C., & Polotsky, V. Y. (2014) · Sleep and Biological Rhythms · doi:10.1111/sbr.12078 · Cited by 81 · see citing works
Mechanisms of intermittent hypoxia induced hypertension
Bosc, L. V. G., Resta, T. C., Walker, B. R., & Kanagy, N. L. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00929.x · Cited by 79 · see citing works
Ohkuma, T., Fujii, H., Iwase, M., Kaizu, S., Ide, H., Kikuchi, Y., Idewaki, Y., Jodai, T., Hirakawa, Y., Nakamura, U., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.12.001 · Cited by 81 · see citing works
Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN
Piguet, A., Stroka, D., Zimmermann, A., & Dufour, J. (2009) · Clinical Science · doi:10.1042/cs20090313 · Cited by 79 · see citing works
Morgenstern, M., Wang, J., Beatty, N., Batemarco, T., Sica, A. L., & Greenberg, H. (2014) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.002 · Cited by 76 · see citing works
Nock, N. L., Li, L., Larkin, E. K., Patel, S. R., & Redline, S. S. (2009) · SLEEP · doi:10.1093/sleep/32.5.615 · Cited by 76 · see citing works
Neural Control of the Upper Airway: Respiratory and State‐Dependent Mechanisms
Kubin, L. K. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160002 · Cited by 89 · see citing works
Hypoadiponectinemia is Related to Sympathetic Activation and Severity of Obstructive Sleep Apnea
Lam, J., Xu, A., Tam, S., Khong, P.-I., Yao, T., Lam, D. C.-L., Lai, A. Y. K., LAM, B. K., Lam, K. S. L., & Ip, M. (2008) · SLEEP · doi:10.1093/sleep/31.12.1721 · Cited by 74 · see citing works
Self-citationTelomere shortening in sleep apnea syndrome
Barceló, A., Piérola, J., López‐Escribano, H., de la Peña, M., Soriano, J. B., Alonso‐Fernández, A., Ladaria, A., & Agustí, A. G. N. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.03.025 · Cited by 74 · see citing works
Metabolomics Profiling for Obstructive Sleep Apnea and Simple Snorers
Xu, H., Zheng, X., Qian, Y., Guan, J., Yi, H., Zou, J., Wang, Y., Meng, L., Zhao, A., Yin, S., et al. (2016) · Scientific Reports · doi:10.1038/srep30958 · Cited by 73 · see citing works
Expenditure on Health Care in Obese Women with and without Sleep Apnea
Banno, K., Ramsey, C. D., Walld, R., & Kryger, M. H. (2009) · SLEEP · doi:10.1093/sleep/32.2.247 · Cited by 71 · see citing works
Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38
Ota, H., Tamaki, S., Itaya‐Hironaka, A., Yamauchi, A., Sakuramoto‐Tsuchida, S., Morioka, T., Takasawa, S., & Kimura, H. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.11.011 · Cited by 68 · see citing works
Sleep deprivation, sleep apnea and cardiovascular diseases
Levy, P. A. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/521 · Cited by 70 · see citing works
Association between obesity and sleep disorders in postmenopausal women
Naufel, M. F., Frange, C., Andersen, M. L., Girão, M. J. B. C., Tufik, S., Ribeiro, E. B., & Hachul, H. (2017) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000962 · Cited by 69 · see citing works
Recognition and Diagnosis of Obstructive Sleep Apnea in Older Americans
Braley, T. J., Dunietz, G. L., Chervin, R. D., Lisabeth, L. D., Skolarus, L. E., & Burke, J. F. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15372 · Cited by 67 · see citing works
Obstructive sleep apnea syndrome and fatty liver: Association or causal link?
Ahmed, M. H. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i34.4243 · Cited by 67 · see citing works
Sleep apnoea syndrome in 2011: current concepts and future directions
Levy, P. A., Tamisier, R., Minville, C., Launois, S. H., & Pépin, J. (2011) · European Respiratory Review · doi:10.1183/09059180.00003111 · Cited by 66 · see citing works
Benzodiazepines Associated With Acute Respiratory Failure in Patients With Obstructive Sleep Apnea
Wang, S., Chen, W.-S., Tang, S.-E., Lin, H., Peng, C., Chu, H., & Kao, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01513 · Cited by 66 · see citing works
Farrell, P. C., & Richards, G. N. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1211-y · Cited by 64 · see citing works
Obstructive sleep apnoea and metabolic impairment in severe obesity
Gasa, M., Salord, N., Fortuna, A. M., Mayos, M., Vilarrasa, N., Dorca, J., Montserrat, J. M., Bonsignore, M. R., & Monasterio, C. (2011) · European Respiratory Journal · doi:10.1183/09031936.00198810 · Cited by 62 · see citing works
Remmers, J. E. (1984) · American Review of Respiratory Disease · doi:10.1164/arrd.1984.130.2.153 · Cited by 75 · see citing works
Spinal metaplasticity in respiratory motor control
Fields, D. P., & Mitchell, G. S. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00002 · Cited by 62 · see citing works
The Use of Sub-Mental Ultrasonography for Identifying Patients with Severe Obstructive Sleep Apnea
Shu, C., Lee, P., Lin, J., Huang, C., Chang, Y., Yu, C., & Wang, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062848 · Cited by 60 · see citing works
Sleep disturbances in HIV infection and their biological basis
O'Brien, K. E., Riddell, N. E., Gómez-Olivé, F. X., Rae, D. E., Scheuermaier, K. D., & von Schantz, M. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101571 · Cited by 58 · see citing works
Lesser, D. J., Bhatia, R., Tran, W. H., Oliveira, F. M. G. S. A., Ortega, R., Keens, T. G., Mittelman, S. D., Khoo, M. C. K., & Ward, S. L. D. (2012) · Pediatric Research · doi:10.1038/pr.2012.73 · Cited by 57 · see citing works
Sleep-disordered breathing, type 2 diabetes and the metabolic syndrome
Seetho, I. W., & Wilding, J. P. (2014) · Chronic Respiratory Disease · doi:10.1177/1479972314552806 · Cited by 57 · see citing works
Obstructive sleep apnoea and diabetes
Tahrani, A. A., Ali, A., & Stevens, M. J. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e3283659da5 · Cited by 56 · see citing works
Božić, J., Borovac, J. A., Galić, T., Kurir, T. T., Šupe‐Domić, D., & Đogaš, Z. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7204 · Cited by 56 · see citing works
Waist circumference and postmenopause stages as the main associated factors for sleep apnea in women
Polesel, D. N., Hirotsu, C., Nozoe, K. T., Boin, A. C., Bittencourt, L., Tufik, S. B., Andersen, M. L., & Hachul, H. (2015) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000406 · Cited by 55 · see citing works
Joyeux‐Faure, M., Baguet, J.-P., Barone‐Rochette, G., Faure, P., Sosner, P., Mounier‐Véhier, C., Levy, P. A., Tamisier, R., & Pépin, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00318 · Cited by 54 · see citing works
Ota, H., Itaya‐Hironaka, A., Yamauchi, A., Sakuramoto‐Tsuchida, S., Miyaoka, T., Fujimura, T., Tsujinaka, H., Yoshimoto, K., Nakagawara, K.-I., Tamaki, S., et al. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.09.001 · Cited by 54 · see citing works
Kim, K. S., Kwak, J. W., Lim, S. J., Park, Y. K., Yang, H. S., & Kim, H. J. (2016) · Aging and Disease · doi:10.14336/ad.2016.0215 · Cited by 53 · see citing works
OSAS‐Related Inflammatory Mechanisms of Liver Injury in Nonalcoholic Fatty Liver Disease
Paschetta, E., Belci, P., Alisi, A., Liccardo, D., Cutrera, R., Musso, G., & Nobili, V. (2015) · Mediators of Inflammation · doi:10.1155/2015/815721 · Cited by 52 · see citing works
Sleep & the metabolic syndrome.
Lam, J., & Ip, M. (2010) · PubMed · Cited by 52 · see citing works
Self-citationThe Association between Obstructive Sleep Apnea and Metabolic Markers and Lipid Profiles
Wu, W., Tsai, S.-S., Shih, T., Lin, M., Chou, T., Ting, H., Wu, T.-N., & Liou, S.-H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130279 · Cited by 51 · see citing works
Uchiyama, T., Itaya‐Hironaka, A., Yamauchi, A., Makino, M., Sakuramoto‐Tsuchida, S., Shobatake, R., Ota, H., Takeda, M., Ohbayashi, C., & Takasawa, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081960 · Cited by 50 · see citing works
The sleep apnea cardiovascular endpoints (SAVE) trial: Rationale and start-up phase.
McEvoy, R. D., Anderson, C. S., Antic, N. A., Chen, B.-Y., He, Q.-Y., Heeley, E. L., Huang, S., Huang, Y., Wang, J., & Zhong, N. (2010) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2072-1439.2010.02.03.5 · Cited by 49 · see citing works
Olonode, E. T., Aderibigbe, A. O., Adeoluwa, O. A., Eduviere, A. T., & Ben‐Azu, B. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.024 · Cited by 49 · see citing works
Liu, R., Zee, P. C., Chervin, R. D., Arguelles, L. M., Birne, J., Zhang, S., Christoffel, K. K., Brickman, W. J., Zimmerman, D., Wang, B., et al. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2011.04.006 · Cited by 48 · see citing works
Lui, M. M., & Sau-Man, M. (2012) · PubMed Central · doi:10.3978/j.issn.2072-1439.2012.01.06 · Cited by 47 · see citing works
The Sleep Apnea cardioVascular Endpoints (SAVE) Trial: Rationale, Ethics, Design, and Progress
Antic, N. A., Heeley, E. L., Anderson, C. S., Luo, Y., Wang, J., Neal, B. C., Grunstein, R. R., Barbé, F., Lorenzi‐Filho, G., Huang, S., et al. (2015) · SLEEP · doi:10.5665/sleep.4902 · Cited by 47 · see citing works
Qian, X., Yin, T., Li, T., Kang, C., Guo, R., Sun, B., & Liu, C. (2012) · Inflammation · doi:10.1007/s10753-012-9464-3 · Cited by 44 · see citing works
Cardiovascular and metabolic comorbidities in patients with obstructive sleep apnoea syndrome.
Fusetti, M., Fioretti, A. B., Valenti, M., Masedu, F., Lauriello, M., & Pagliarella, M. (2012) · Europe PMC (PubMed Central) · Cited by 43 · see citing works
Mild Maternal Obstructive Sleep Apnea in Non-obese Pregnant Women and Accelerated Fetal Growth
Telerant, A., Dunietz, G. L., Many, A., & Tauman, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-29052-y · Cited by 45 · see citing works
Morning headache in habitual snorers: Frequency, characteristics, predictors and impacts
Chen, P.-K., Fuh, J., Lane, H., Chiu, P., Tien, H.-C., & Wang, S. (2011) · Cephalalgia · doi:10.1177/0333102411403635 · Cited by 44 · see citing works
Gharib, S. A., Khalyfa, A., Abdelkarim, A., Bhushan, B., & Gozal, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037669 · Cited by 43 · see citing works
Estimating sleep from multisensory armband measurements: validity and reliability in teens
Roane, B. M., Reen, E. V., Hart, C. N., Wing, R. R., & Carskadon, M. A. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12317 · Cited by 43 · see citing works
Cardiovascular disease risk reduction with sleep apnea treatment
Jean‐Louis, G., Brown, C. D., Zizi, F., Ogedegbe, G. G., Boutin‐Foster, C., Gorga, J. A., & McFarlane, S. I. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.55 · Cited by 42 · see citing works
- Authors
- Tasali, E., & Ip, M. S. M.
- Affiliations
- University of Chicago (US)
- Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People's Republic of China
- ORCID
- Tasali, Esra
- Venue
- Proceedings of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-02
- Volume
- 5
- Issue
- 2
- Pages
- 207-217
- ISSN
- 1546-3222 (ISSN-L)
- 1943-5665
- OpenAlex
- W1972056446
- Cited by
- 365
- References
- 136
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 8 · 2023: 15 · 2022: 11 · 2021: 18 · 2020: 16 · 2019: 14 · 2018: 21 · 2017: 13 · 2016: 20 · 2015: 24 · 2014: 22 · 2013: 31 · 2012: 26
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Proceedings of the American Thoracic Society (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- National Center for Research Resources (P41RR013642)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obstructive sleep apnea, metabolic syndrome, glucose metabolism, insulin resistance, inflammation, intermittent hypoxia, sleep fragmentation, obesity, visceral obesity, type 2 diabetes, cardiovascular risk
- MeSH terms
- Adult, Blood Glucose, Humans, Inflammation, Risk Factors, Sleep Apnea, Obstructive, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
