A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea
Open accessAbstract
The effects of treatment of obstructive sleep apnoea (OSA) on glucose metabolism have been investigated previously with conflicting results. This study evaluated the impact of nasal continuous positive airway pressure (nCPAP) treatment of OSA on insulin sensitivity. Males with moderate/severe OSA and no significant comorbidity were randomised to a therapeutic or sham nCPAP treatment group for 1 week and then reassessed. Those who received therapeutic nCPAP were further evaluated at 12 weeks. Insulin sensitivity (K itt) was estimated by the short insulin tolerance test. Other evaluations included blood pressure, metabolic profile, urinary catecholamines and intra-abdominal fat. In total, 61 Chinese subjects were randomised. 31 subjects receiving therapeutic nCPAP showed an increase in K itt(6.6±2.9 to 7.6±3.2 %·min−1; p = 0.017), while the 30 patients on sham CPAP had no significant change, and the changes in K itt were different between the two groups (p = 0.022). At 12 weeks, improvement in K itt was seen in 20 subjects with BMI ≥25 kg·m−2(median (interquartile range) 28.3 (26.6–31.5); p = 0.044), but not in the nine subjects with BMI<25 kg·m−2, or the entire group. The findings indicate that therapeutic nCPAP treatment of OSA for 1 week improved insulin sensitivity in nondiabetic males, and the improvement appeared to be maintained after 12 weeks of treatment in those with moderate obesity.
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Several trials in those without diabetes suggest that CPAP therapy for comorbid OSA may reduce insulin resistance.
“Despite the lack of improvement in fasting glucose levels, there have been several trials in those without diabetes suggesting CPAP therapy for comorbid OSA may reduce insulin resistance.[170][171][172]”
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- Authors
- Lam, J. C. M., Lam, B., Yao, T. J., Lai, A. Y. K., Ooi, C. G., Tam, S., Lam, K. S. L., & Ip, M. S. M.
- Affiliations
- Queen Mary Hospital (CN)
- University of Hong Kong (HK)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2009-07-16
- Volume
- 35
- Issue
- 1
- Pages
- 138-145
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2113279632
- Cited by
- 170
- References
- 40
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 11 · 2018: 17 · 2017: 6 · 2016: 7 · 2015: 19 · 2014: 16 · 2013: 14 · 2012: 16
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Queen Mary University of London
- University of Hong Kong
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obstructive sleep apnea, nasal continuous positive airway pressure, insulin sensitivity, glucose metabolism, insulin tolerance test, obesity, body mass index, sham CPAP, urinary catecholamines, intra-abdominal fat, blood pressure
- MeSH terms
- Adult, Aged, Double-Blind Method, Humans, Insulin, Male, Middle Aged, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Young Adult
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