Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency
Open accessAbstract
In the present review we discuss the potential use of two long-lived mice of the genus Peromyscus--the white-footed mouse (P. leucopus) and the deer mouse (P. maniculatus) maximum lifespan potential approximately 8 years for both--to test predictions of theories about aging from the oxidative stress theory, mitochondrial theory and inflammatory theory. Previous studies have shown that P. leucopus cells exhibit superior antioxidant defense mechanisms and lower cellular production of reactive oxygen species (ROS) than do cells of the house mouse, Mus musculus (maximum lifespan approximately 3.5 years). We present new data showing that mitochondria in P. leucopus cells produce substantially less ROS than mitochondria in M. musculus cells, and that P. leucopus mitochondria exhibit superior stress resistance to those of M. musculus. We also provide evidence that components of the DNA repair system (e.g., pathways involved in repair of DNA damage induced by gamma-irradiation) are likely to be more efficient in P. leucopus than in M. musculus. We propose that mitochondrial stress resistance, ROS detoxification pathways and more efficient DNA repair contribute to the previously documented resistance of P. leucopus cells toward oxidative stress-induced apoptosis. The link between these three pathways and species longevity is discussed.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DNA repair pathways have been implicated previously in longevity.
“which have been implicated previously in longevity”
From Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program (2019) · cites this paper as Ungvari et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390 · see citing works
Self-citationInstability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works
Nowak, R. (2018) · doi:10.1353/book.59141 · Cited by 4,102 · see citing works
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133 · see citing works
The Biologic Clock: The Mitochondria?
Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 1,991 · see citing works
Extension of murine life span by overexpression of catalase targeted to mitochondria
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724 · see citing works
Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
Ischiropoulos, H., & Beckman, J. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317638 · Cited by 748 · see citing works
Hart, R. W., & Setlow, R. B. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.6.2169 · Cited by 739 · see citing works
Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734 · see citing works
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works
Self-citationDirect Evidence of Endothelial Oxidative Stress With Aging in Humans
Donato, A. J., Eskurza, I., Silver, A., Levy, A., Pierce, G. L., Gates, P. E., & Seals, D. R. (2007) · Circulation Research · doi:10.1161/01.res.0000269183.13937.e8 · Cited by 558 · see citing works
Steppan, S. J., Adkins, R. M., & Anderson, J. (2004) · Systematic Biology · doi:10.1080/10635150490468701 · Cited by 553 · see citing works
Superoxide Excess in Hypertension and Aging
Hamilton, C., Brosnan, M. J., McIntyre, M., Graham, D., & Dominiczak, A. F. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.529 · Cited by 438 · see citing works
Roubenoff, R., Parise, H., Payette, H., Abad, L. W., D’Agostino, R. B., Jacques, P. F., Wilson, P. W. F., Dinarello, C. A., & Harris, T. B. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.05.001 · Cited by 397 · see citing works
Mukhopadhyay, P., Rajesh, M., Haskó, G., Hawkins, B. J., Madesh, M., & Pacher, P. (2007) · Nature Protocols · doi:10.1038/nprot.2007.327 · Cited by 373 · see citing works
Self-citationHeme oxygenase and the cardiovascular–renal system
Abraham, N. G., & Kappas, A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.010 · Cited by 356 · see citing works
Ungvari, Z. I., Orosz, Z. Z., Labinskyy, N., Rivera, A., Xiangmin, Z., Smith, K. E., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01346.2006 · Cited by 347 · see citing works
Self-citationPedersen, M., Bruunsgaard, H., Weis, N., Hendel, H. W., Andreassen, B. U., Eldrup, E., Dela, F., & Pedersen, B. K. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00027-7 · Cited by 342 · see citing works
Simple quantitative detection of mitochondrial superoxide production in live cells
Mukhopadhyay, P., Rajesh, M., Kashiwaya, Y., Haskó, G., & Pacher, P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.106 · Cited by 328 · see citing works
Self-citationLee, C.-K., Allison, D. B., Brand, J., Weindruch, R., & Prolla, T. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232308999 · Cited by 314 · see citing works
Cernadas, M. R., de Miguel, L. S., Garcı́a-Durán, M., González-Fernández, F., Millás, I., Montón, M., Rodrigo, J., Rico, L., Fernández, A. P., de Frutos, T., et al. (1998) · Circulation Research · doi:10.1161/01.res.83.3.279 · Cited by 310 · see citing works
Cellular machineries for chromosomal DNA repairPreprint
Peterson, C. L., & Côté, J. (2004) · Genes & Development · doi:10.1101/gad.1182704 · Cited by 287 · see citing works
Phillips, T., & Leeuwenburgh, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2870fje · Cited by 283 · see citing works
Aging‐induced proinflammatory shift in cytokine expression profile in rat coronary arteries
Csiszár, A., Ungvari, Z. I., Koller, Á., Edwards, J. G., & Kaley, G. (2003) · The FASEB Journal · doi:10.1096/fj.02-1049fje · Cited by 266 · see citing works
Self-citationLass, A., Sohal, B. H., Weindruch, R. H., Forster, M. J., & Sohal, R. S. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00144-0 · Cited by 251 · see citing works
Ran, Q.-T., Liang, H.-Y., Gu, M., Qi, W., Walter, C., Roberts, L., Herman, B., Richardson, A., & Remmen, H. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410387200 · Cited by 242 · see citing works
Ku, H., & Sohal, R. S. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90132-b · Cited by 240 · see citing works
Propagation of the apoptotic signal by mitochondrial waves
Pacher, P., & Hajnóczky, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.4107 · Cited by 240 · see citing works
Self-citationResveratrol increases vascular oxidative stress resistance
Ungvari, Z. I., Orosz, Z. Z., Rivera, A., Labinskyy, N., Xiangmin, Z., Olson, S. C., Podlutsky, A. J., & Csiszár, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01258.2006 · Cited by 238 · see citing works
Self-citationOxidative damage to mitochondria and aging
Remmen, H. V. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00093-6 · Cited by 233 · see citing works
Mansouri, A., Muller, F. L., Liu, Y., Ng, R., Faulkner, J., Hamilton, M., Richardson, A., Huang, T.-T., Epstein, C. J., & Van Remmen, H. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.11.004 · Cited by 227 · see citing works
Forte, M., Gold, B., Marracci, G., Chaudhary, P., Basso, E., Johnsen, D., Yu, X.-L., Fowlkes, J., Rahder, M., Stem, K., et al. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0702228104 · Cited by 222 · see citing works
Helenius, M. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0045 · Cited by 217 · see citing works
Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
Csiszár, A., Ungvari, Z. I., Koller, Á., Edwards, J. G., & Kaley, G. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2003 · Cited by 217 · see citing works
Self-citationVasculoprotective Effects of Anti-Tumor Necrosis Factor-α Treatment in Aging
Csiszár, A., Labinskyy, N., Smith, K. E., Rivera, A., Orosz, Z. Z., & Ungvari, Z. I. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060708 · Cited by 214 · see citing works
Self-citationSentman, M.-L., Granström, M., Jakobson, H., Reaume, A. G., Basu, S., & Marklund, S. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510764200 · Cited by 181 · see citing works
Brunet-Rossinni, A. K. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.09.003 · Cited by 181 · see citing works
Relationship between antioxidant defenses and longevity in different mammalian species
Sohal, R. S., Sohal, B. H., & Brunk, U. T. (1990) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(90)90040-m · Cited by 175 · see citing works
Radak, Z. O., Chung, H. Y., Naıto, H., Takahashi, R., Jung, K. J., Kim, H., & Goto, S. (2004) · The FASEB Journal · doi:10.1096/fj.03-0509fje · Cited by 173 · see citing works
Harper, J. M., Salmon, A. B., Leiser, S. F., Gałecki, A. T., & Miller, R. A. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00255.x · Cited by 156 · see citing works
Ca 2+ marks: Miniature calcium signals in single mitochondria driven by ryanodine receptors
Pacher, P., Thomas, A. P., & Hajnóczky, G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032423699 · Cited by 152 · see citing works
Self-citationAge-related changes in the regulation of transcription factor NF-κB in rat brain
Korhonen, P., Helenius, M., & Salminen, A. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00190-0 · Cited by 138 · see citing works
Vascular Dysfunction in Aging: Potential Effects of Resveratrol, an Anti- Inflammatory Phytoestrogen
Labinskyy, N., Csiszár, A., Veress, G., Stef, G., Pacher, P., Oroszi, G., WU, J. M., & Ungvari, Z. I. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706776360987 · Cited by 138 · see citing works
Self-citationMitochondrial production of pro-oxidants and cellular senescence
Sohal, R. S., & Brunk, U. T. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90033-l · Cited by 135 · see citing works
Remmen, H. V., Qi, W., Sabia, M., Freeman, G. L., Estlack, L. E., Yang, H. C., Guo, Z. M., Huang, T., Strong, R., Lee, S., et al. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.03.016 · Cited by 130 · see citing works
Vascular aging in the longest-living rodent, the naked mole rat
Csiszár, A., Labinskyy, N., Orosz, Z. Z., Xiangmin, Z., Buffenstein, R., & Ungvari, Z. I. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01287.2006 · Cited by 129 · see citing works
Self-citationRelationship between Antioxidants, Prooxidants, and the Aging Processa
Sohal, R. S., & Orr, W. C. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38651.x · Cited by 125 · see citing works
Biochemical Correlates of Longevity in Two Closely Related Rodent Species
Sohal, R. S., Ku, H.-H., & Agarwal, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2208 · Cited by 114 · see citing works
Csiszár, A., Pacher, P., Kaley, G., & Ungvari, Z. I. (2005) · Current Vascular Pharmacology · doi:10.2174/1570161054368616 · Cited by 112 · see citing works
Self-citationCsiszár, A., Labinskyy, N., Xiangmin, Z., Hu, F., Serpillon, S., Huang, Z., Ballabh, P., Levy, R. J., Hintze, T. H., Wolin, M. S., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00339.x · Cited by 111 · see citing works
Self-citationKruger, A. L., Peterson, S. J., Schwartzman, M. L., Fusco, H. N., McClung, J. A., Weiss, M. B., Shenouda, S. K., Goodman, A. I., Goligorsky, M. S., Kappas, A., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.107482 · Cited by 109 · see citing works
Bátkai, S., Rajesh, M., Mukhopadhyay, P., Haskó, G., Liaudet, L., Cravatt, B. F., Csiszár, A., Ungvari, Z. I., & Pacher, P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00373.2007 · Cited by 106 · see citing works
Self-citationSacher, G. A., & Hart, R. W. (1978) · PubMed · Cited by 102 · see citing works
Labinskyy, N., Csiszár, A., Orosz, Z. Z., Smith, K. E., Rivera, A., Buffenstein, R., & Ungvari, Z. I. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00534.2006 · Cited by 102 · see citing works
Self-citationOxidative stress in vascular senescence: lessons from successfully aging species
Ungvari, Z. I. (2008) · Frontiers in bioscience · doi:10.2741/3064 · Cited by 100 · see citing works
Self-citationAdler, A., Messina, E. J., Sherman, B., Wang, Z., Huang, H., Linke, A., & Hintze, T. H. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01047.2002 · Cited by 100 · see citing works
Mitochondria Revisited. Alternative Functions of Mitochondria
Zorov, D. B., Krasnikov, B. F., Kuzminova, A. E., Vysokikh, M. Y., & Zorova, L. D. (1997) · Bioscience Reports · doi:10.1023/a:1027304122259 · Cited by 98 · see citing works
Self-citationChanges in membrane potential during calcium ion influx and efflux across the mitochondrial membrane
Åkerman, K. E. O. (1978) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(78)90056-7 · Cited by 88 · see citing works
DNA Repair in a Short-and a Long-lived Rodent Species
Hart, R. W., Sacher, G. A., & Hoskins, T. L. (1979) · Journal of Gerontology · doi:10.1093/geronj/34.6.808 · Cited by 85 · see citing works
Bayne, A.-C. V., Mockett, R. J., Orr, W. C., & Sohal, R. S. (2005) · Biochemical Journal · doi:10.1042/bj20041872 · Cited by 84 · see citing works
Novgorodov, S. A., & Gudz, T. I. (1996) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf02110644 · Cited by 78 · see citing works
Longevity, stability and DNA repair
Hart, R. W., D’Ambrosio, S. M., Ng, K., & Modak, S. P. (1979) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(79)90100-3 · Cited by 76 · see citing works
Oxidative Damage to DNA and Aging
Remmen, H. V., Hamilton, M. L., & Richardson, A. G. (2003) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200307000-00009 · Cited by 76 · see citing works
Vascular Inflammation in Aging
Ungvari, Z., Csiszar, A., & Kaley, G. (2004) · Herz · doi:10.1007/s00059-004-2625-x · Cited by 75 · see citing works
Self-citationMarklund, S. L., Westman, N. G., Roos, G., Carlsson, J., Roos, G., & Carlsson, J. (1984) · Radiation Research · doi:10.2307/3576527 · Cited by 70 · see citing works
The mitochondrion as Janus Bifrons
Zorov, D. B., Исаев, Н. К., Plotnikov, E. Y., Zorova, L. D., Stelmashook, E. V., Vasileva, A. K., Arkhangelskaya, A. A., & Khryapenkova, T. G. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907100094 · Cited by 59 · see citing works
Mitochondrial Ca2+ Signaling and Cardiac Apoptosis
Pacher, P., Csordás, G., & Hajnóczky, G. (2001) · Neurosignals · doi:10.1159/000046888 · Cited by 40 · see citing works
Self-citationKrasnikov, B. F., Zorov, D. B., Antonenko, Y. N., Zaspa, A. A., Kulikov, I. V., Kristal, B. S., Cooper, A. J. L., & Brown, A. M. (2005) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2005.05.009 · Cited by 35 · see citing works
Self-citationGuo, Z., Wang, M., Tian, G., Burger, J., Gochfeld, M., & Yang, C. S. (1993) · PubMed · Cited by 34 · see citing works
Zhang, J., Dai, J., Lu, Y. H., Yao, Z., O’Brien, C. A., Murtha, J., Qi, W., Hall, D. E., Manolagas, S. C., Ershler, W. B., et al. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.024 · Cited by 33 · see citing works
Survival and reproduction in Peromyscus leucopus in the laboratory: viable model for aging studies.
Burger, J., & Gochfeld, M. (1992) · PubMed · Cited by 24 · see citing works
Longevity-dependent organ-specific accumulation of DNA damage in two closely related murine species
Su, C. M., Brash, D. E., Turturro, A., & Hart, R. W. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90049-6 · Cited by 19 · see citing works
Steger, R. W., Peluso, J. J., Huang, H. H., Hodson, C. A., Leung, F. C.-C., Meites, J., & Sacher, G. A. (1980) · Experimental Aging Research · doi:10.1080/03610738008258368 · Cited by 17 · see citing works
Kuzminova, A. E., Zhuravleva, A., Vyssokikh, M. Y., Zorova, L. D., Krasnikov, B. F., & Zorov, D. B. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01005-9 · Cited by 16 · see citing works
Self-citationRole of oxidative stress in senescence.
Rs, S., & Wc, O. (1998) · PubMed · Cited by 15 · see citing works
King, T. S., Karasek, M., Petterborg, L. J., Hansen, J. T., & Reiter, R. J. (1982) · Journal of Experimental Zoology · doi:10.1002/jez.1402240202 · Cited by 15 · see citing works
The Ca2+‐induced pore opening in mitochondria energized by succinate‐ferricyanide electron transport
Krasnikov, B. F., Kuzminova, A. E., & Zorov, D. B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01450-6 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Ungvari Z, Orosz Z, Labinskyy N et al (2007b) Increased mitochondrial H2O2 production promotes endothelial NF- kB activation in aged rat arteries. Am J Physiol Heart Circ Physiol 293(1):H37-H47
Cited by
Sorted by citations
Ungvari, Z., Tarantini, S., Donato, A. J., Galvan, V., & Csiszar, A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311378 · Cited by 919 · see citing works
Self-citationCross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program
Geirsdottir, L., David, E., Keren-Shaul, H., Weiner, A., Bohlen, S. C., Neuber, J., Balic, A., Giladi, A., Sheban, F., Dutertre, C.-A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.010 · Cited by 461 · see citing works
Inflammation and endothelial dysfunction during aging: role of NF-κB
Csiszar, A., Wang, M., Lakatta, E. G., & Ungvari, Z. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90470.2008 · Cited by 441 · see citing works
Self-citationResveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
Ungvari, Z. I., Labinskyy, N., Mukhopadhyay, P., Pinto, J. T., Bagi, Z. A., Ballabh, P., Zhang, C., Pacher, P., & Csiszár, A. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00375.2009 · Cited by 343 · see citing works
Self-citationHardeland, R. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12090 · Cited by 285 · see citing works
Ungvari, Z. I., Bailey‐Downs, L. C., Sosnowska, D., Gautam, T., Koncz, P., Losonczy, G., Ballabh, P., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01134.2010 · Cited by 274 · see citing works
Self-citationPeromyscus mice as a model for studying natural variation
Bedford, N. L., & Hoekstra, H. E. (2015) · eLife · doi:10.7554/elife.06813 · Cited by 235 · see citing works
Gadd45 proteins: Relevance to aging, longevity and age-related pathologies
Moskalev, A., Smit‐McBride, Z., Shaposhnikov, M. V., Николаевна, П. Е., Zhavoronkov, A. A., Budovsky, A., Tăcutu, R., & Fraifeld, V. E. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.09.003 · Cited by 168 · see citing works
Mitochondrial uncoupling and lifespan
Mookerjee, S. A., Divakaruni, A. S., Jastroch, M., & Brand, M. D. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.03.010 · Cited by 169 · see citing works
Ungvari, Z. I., Bailey‐Downs, L. C., Gautam, T., Jiménez, R., Losonczy, G., Zhang, C., Ballabh, P., Recchia, F. A., Wilkerson, D. C., Sonntag, W. E., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00402.2010 · Cited by 162 · see citing works
Self-citationRobert, K. A., & Bronikowski, A. M. (2010) · The American Naturalist · doi:10.1086/649595 · Cited by 99 · see citing works
Harris, S. E., Munshi‐South, J., Obergfell, C. J., & O'Neill, R. J. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074938 · Cited by 89 · see citing works
Coletta, C., Módis, K., Oláh, G., Brunyánszki, A., Herzig, D. S., Sherwood, E. R., Ungvari, Z. I., & Szabó, C. (2014) · Critical Care · doi:10.1186/s13054-014-0511-3 · Cited by 87 · see citing works
Self-citationHeisey, D. M., Mickelsen, N. A., Schneider, J. R., Johnson, C. J., Johnson, C. J., Langenberg, J. A., Bochsler, P. N., Keane, D. P., & Barr, D. J. (2009) · Journal of Virology · doi:10.1128/jvi.00560-09 · Cited by 76 · see citing works
Increase of Drosophila melanogaster lifespan due to D-GADD45 overexpression in the nervous system
Plyusnina, E., Shaposhnikov, M. V., & Moskalev, A. (2010) · Biogerontology · doi:10.1007/s10522-010-9311-6 · Cited by 63 · see citing works
Csiszár, A., Podlutsky, A. J., Podlutskaya, N., Sonntag, W. E., Merlin, S. Z., Philipp, E. E. R., Doyle, K. P., Dávila, A., Recchia, F. A., Ballabh, P., et al. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr216 · Cited by 61 · see citing works
Self-citationLabinskyy, N., Mukhopadhyay, P., Toth, J., Szalai, G., Veres, M., Losonczy, G., Pinto, J. T., Pacher, P., Ballabh, P., Podlutsky, A. J., et al. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00693.2008 · Cited by 60 · see citing works
Self-citationSchwanz, L. E., Warner, D. A., McGaugh, S. E., Terlizzi, R. D., & Bronikowski, A. M. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.046813 · Cited by 58 · see citing works
Bronikowski, A. M., & Vleck, D. B. V. (2010) · Integrative and Comparative Biology · doi:10.1093/icb/icq132 · Cited by 53 · see citing works
Comparative Studies of Oxidative Stress and Mitochondrial Function in Aging
Shi, Y., Buffenstein, R., Pulliam, D. A., & Remmen, H. V. (2010) · Integrative and Comparative Biology · doi:10.1093/icb/icq079 · Cited by 52 · see citing works
Vijver, M. G., & Peijnenburg, W. J. G. M. (2011) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/978160805121210043 · Cited by 52 · see citing works
Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes
Zhang, Y., Zhang, Y., Zhong, C., & Xiao, F. (2016) · Scientific Reports · doi:10.1038/srep34578 · Cited by 49 · see citing works
Shi, Y., Pulliam, D. A., Liu, Y., Hamilton, R. T., Jernigan, A., Bhattacharya, A., Sloane, L. B., Qi, W., Chaudhuri, A. R., Buffenstein, R., et al. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00139.2012 · Cited by 44 · see citing works
Self-citationUngvari, Z. I., Sosnowska, D., Podlutsky, A. J., Koncz, P., Sonntag, W. E., & Csiszár, A. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr004 · Cited by 44 · see citing works
Self-citationXiao, F., Li, Y., DAI, L., Deng, Y., Zou, Y., Peng, L., Yuan, Y., & Zhong, C. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1031 · Cited by 41 · see citing works
Bacolla, A., Wang, G., Jain, A., Chuzhanova, N. A., Cer, R. Z., Collins, J., Cooper, D. N., Bohr, V. A., & Vásquez, K. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.176636 · Cited by 38 · see citing works
Conserved signaling pathways genetically associated with longevity across the species
Khan, A. H., Zou, Z., Yang, X. D., Chen, S., & Tian, X. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.001 · Cited by 37 · see citing works
Ungvari, Z. I., Sosnowska, D., Mason, J. B., Gruber, H., Lee, S. W., Schwartz, T. S., Brown, M. K., Storm, N. J., Fortney, K., Sowa, J. N., et al. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls193 · Cited by 34 · see citing works
Self-citationKo, K. M., Chen, N., Leung, H. Y., Leong, E. P. K., Poon, M. K. T., & Chiu, P. Y. (2008) · BioFactors · doi:10.1002/biof.5520340408 · Cited by 33 · see citing works
Peromyscus as a model of human disease
Havighorst, A., Crossland, J. P., & Kiaris, H. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.06.020 · Cited by 30 · see citing works
Sosnowska, D., Richardson, C., Sonntag, W. E., Csiszár, A., Ungvari, Z. I., & Ridgway, I. D. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt201 · Cited by 29 · see citing works
Self-citationValencak, T. G., Csiszár, A., Szalai, G., Podlutsky, A. J., Tarantini, S., Fazekas‐Pongor, V., Papp, M., & Ungvari, Z. I. (2021) · GeroScience · doi:10.1007/s11357-021-00444-9 · Cited by 27 · see citing works
Self-citationAge-related cellular changes in the long-lived bivalve A. islandica
Gruber, H., Weßels, W., Boynton, P. J., Xu, J., Wohlgemuth, S. E., Leeuwenburgh, C., Qi, W., Austad, S. N., Schaible, R., & Philipp, E. E. R. (2015) · AGE · doi:10.1007/s11357-015-9831-8 · Cited by 25 · see citing works
Self-citationZou, S., Carey, J. R., Liedo, P., Ingram, D. K., Yu, B., & Ghaedian, R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp176 · Cited by 25 · see citing works
The crucial role of diverse animal models to investigate cochlear aging and hearing loss
Castaño-González, K., Köppl, C., & Pyott, S. J. (2024) · Hearing Research · doi:10.1016/j.heares.2024.108989 · Cited by 24 · see citing works
New Vistas on Oxidative Damage and Aging
Hardeland, R., & Coto‐Montes, A. M. (2010) · The Open Biology Journal · doi:10.2174/18741967010030100039 · Cited by 29 · see citing works
New Vistas on Oxidative Damage and Aging~!2009-08-18~!2009-11-25~!2010-04-21~!
Hardeland, R., & Coto‐Montes, A. M. (2010) · The Open Biology Journal · doi:10.2174/1874196701003010039 · Cited by 24 · see citing works
Regulation of Age-Related Protein Toxicity
Pras, A., & Nollen, E. A. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637084 · Cited by 22 · see citing works
Capshaw, G., Vicencio-Jiménez, S., Screven, L. A., Burke, K., Weinberg, M. M., & Lauer, A. M. (2022) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-022-00860-4 · Cited by 17 · see citing works
Mukli, P., Wu, D. H., Csípő, T., Owens, C. D., Lipécz, Á., Rácz, F. S., Zouein, F. A., Tabák, Á. G., Csiszár, A., Ungvari, Z. I., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6110226 · Cited by 15 · see citing works
Self-citationBiology and Diseases of Other Rodents
Donnelly, T. M., Bergin, I. L., & Ihrig, M. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-409527-4.00007-9 · Cited by 13 · see citing works
An updated genetic map of Peromyscus with chromosomal assignment of linkage groups
Brown, J., Crivello, J., & O'Neill, R. J. W. (2018) · Mammalian Genome · doi:10.1007/s00335-018-9754-7 · Cited by 10 · see citing works
Cellular and Molecular Determinants of Arterial Aging
Lacolley, P. J., Challande, P., Regnault, V., Lakatta, E. G., & Wang, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801387-8.00002-8 · Cited by 9 · see citing works
Barbour, A. G., Shao, H., Cook, V. J., Baldwin-Brown, J. G., Tsao, J. I., & Long, A. D. (2019) · Scientific Reports · doi:10.1038/s41598-019-54389-3 · Cited by 8 · see citing works
Podlutsky, A. J. (2019) · GeroScience · doi:10.1007/s11357-019-00060-8 · Cited by 5 · see citing works
Self-citationMitochondrial dysfunction drives age-related degeneration of the thoracic aorta
Dhanekula, A., Harrison, B. R., Pharaoh, G. A., Mattson-Hughes, A., Tarantini, S., Stuppard, R. S., DeRoo, S. C., Burke, C. R., Hwang, B., Pal, J. D., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01937-7 · Cited by 5 · see citing works
Oxidative Stress in Vascular Aging
Csiszár, A., & Ungvari, Z. I. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-600-9_13 · Cited by 4 · see citing works
Self-citationWang, M., Monticone, R. E., & Lakatta, E. G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00013-7 · Cited by 2 · see citing works
Verlekar, M. M., Sinha, A., & D’Costa, A. (2025) · Drug and Chemical Toxicology · doi:10.1080/01480545.2025.2609951 · Cited by 1 · see citing works
Xiao, F., Hu, Q., Zeng, M., Guan, L., Liu, X., Yuan, Y., & Zhong, C. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.04.044 · Cited by 1 · see citing works
Windon, C., & Elahi, F. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-49963-0_30 · Cited by 1 · see citing works
Free Radicals in Aging – An Evolutionary Perspective
Csiszár, A., & Ungvari, Z. I. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_14 · Cited by 1 · see citing works
Self-citationSonntag, W. E., Pearson, K. J., de Cabo, R., Csiszar, A., Zhang, C., Ballabh, P., Recchia, F. A., Ungvari, D. C. Z., Bailey‐Downs, L. C., Gautam, T., et al. (2011)
Self-citationLong Live The Queen: influence of membrane phospholipids on longevity of honey bees
Martin, N. (2019) · Research Online (University of Wollongong)
Wimer, L. A., Davis-Castillo, A., Galkina, S. A., Ciotlos, S., Patterson, C., Prado, L., Munoz, M. C., Martin, N., Epstein, S., Schaum, N., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01175-3
Wolmarans, D. W., Stroebel, J.-A., van der Sluis, R., Sampson, T. R., Jaspan, H. B., & Happel, A. (2026) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2026.106966
- Authors
- Ungvari, Z., Krasnikov, B. F., Csiszar, A., Labinskyy, N., Mukhopadhyay, P., Pacher, P., Cooper, A. J. L., Podlutskaya, N., Austad, S. N., & Podlutsky, A.
- Affiliations
- New York Medical College (US)
- National Institutes of Health (US)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Ungvari, Zoltan
- Podlutsky, Andrej
- ORCID
- Venue
- AGE
- Published
- 2008-06-14
- Volume
- 30
- Issue
- 2-3
- Pages
- 121-133
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC2527628
- OpenAlex
- W2081992084
- Cited by
- 56
- References
- 79
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 2 · 2019: 4 · 2018: 3 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AGE (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- Funders
- American Heart Association (0435140N)
- San Antonio Area Foundation
- Philip Morris International
- National Institutes of Health (Z99‐AA999999, 5k07ag025063-05, HL-43023)
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000375)
- National Institute on Aging (R01AG022873, K07-AG-025063)
- National Heart, Lung, and Blood Institute (P01HL043023, R01HL077256)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- white-footed mouse, deer mouse, house mouse, maximum lifespan, theories of aging, oxidative stress, reactive oxygen species scavenging, DNA repair, antioxidant defense, mitochondrial ROS production, apoptosis resistance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review