Cited by 56Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and PathologyTelomeres, Telomerase, and Senescence

Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

Open access
Ungvari, Zoltan, Krasnikov, Boris F., Csiszar, Anna, Labinskyy, Nazar, Mukhopadhyay, Partha, Pacher, Pal, Cooper, Arthur J. L., Podlutskaya, Natalia +2 more·2008·AGE

Abstract

In the present review we discuss the potential use of two long-lived mice of the genus Peromyscus--the white-footed mouse (P. leucopus) and the deer mouse (P. maniculatus) maximum lifespan potential approximately 8 years for both--to test predictions of theories about aging from the oxidative stress theory, mitochondrial theory and inflammatory theory. Previous studies have shown that P. leucopus cells exhibit superior antioxidant defense mechanisms and lower cellular production of reactive oxygen species (ROS) than do cells of the house mouse, Mus musculus (maximum lifespan approximately 3.5 years). We present new data showing that mitochondria in P. leucopus cells produce substantially less ROS than mitochondria in M. musculus cells, and that P. leucopus mitochondria exhibit superior stress resistance to those of M. musculus. We also provide evidence that components of the DNA repair system (e.g., pathways involved in repair of DNA damage induced by gamma-irradiation) are likely to be more efficient in P. leucopus than in M. musculus. We propose that mitochondrial stress resistance, ROS detoxification pathways and more efficient DNA repair contribute to the previously documented resistance of P. leucopus cells toward oxidative stress-induced apoptosis. The link between these three pathways and species longevity is discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s11357-008-9059-y

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Ungvari Z, Orosz Z, Labinskyy N et al (2007b) Increased mitochondrial H2O2 production promotes endothelial NF- kB activation in aged rat arteries. Am J Physiol Heart Circ Physiol 293(1):H37-H47

Cited by

Sorted by citations

Authors
Ungvari, Z., Krasnikov, B. F., Csiszar, A., Labinskyy, N., Mukhopadhyay, P., Pacher, P., Cooper, A. J. L., Podlutskaya, N., Austad, S. N., & Podlutsky, A.
Affiliations
  • New York Medical College (US)
  • National Institutes of Health (US)
  • The University of Texas at San Antonio Health Science Center (US)
Corresponding author
  • Ungvari, Zoltan
  • Podlutsky, Andrej
Venue
AGE
Published
2008-06-14
Volume
30
Issue
2-3
Pages
121-133
ISSN
  • 0161-9152 (ISSN-L)
  • 1574-4647
OpenAlex
W2081992084
Cited by
56
References
79
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2022: 2 · 2021: 2 · 2019: 4 · 2018: 3 · 2016: 2 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 4
FWCI
2.16
Type
journal article
Language
en
Open access
Locations
  • AGE (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Touro Scholar (Touro College) (submittedVersion)
Funders
  • American Heart Association (0435140N)
  • San Antonio Area Foundation
  • Philip Morris International
  • National Institutes of Health (Z99‐AA999999, 5k07ag025063-05, HL-43023)
  • National Institute on Alcohol Abuse and Alcoholism (Z01AA000375)
  • National Institute on Aging (R01AG022873, K07-AG-025063)
  • National Heart, Lung, and Blood Institute (P01HL043023, R01HL077256)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
white-footed mouse, deer mouse, house mouse, maximum lifespan, theories of aging, oxidative stress, reactive oxygen species scavenging, DNA repair, antioxidant defense, mitochondrial ROS production, apoptosis resistance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review