Age-related changes in the regulation of transcription factor NF-κB in rat brain

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Dexamethasone attenuates NF-κ B DNA binding activity without inducing I κ B levels in rat brain in vivo

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SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

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NF-κB inhibition delays DNA damage–induced senescence and aging in mice

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Microglia Priming with Aging and Stress

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Increased mitochondrial H 2 O 2 production promotes endothelial NF-κB activation in aged rat arteries

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Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype: Astrocyte senescence in aging brain

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The UPRER: Sensor and Coordinator of Organismal Homeostasis.

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NF-κB in Aging and Disease.

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HEAT SHOCK RESPONSE AND AGEING: MECHANISMS AND APPLICATIONS

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Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases

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Blueberry Supplemented Diet: Effects on Object Recognition Memory and Nuclear Factor-kappa B Levels in Aged Rats

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The role of free radicals in the aging brain and Parkinson’s Disease: Convergence and parallelism

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Interleukin-6 in the aging brain

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NF-κB Signaling in the Aging Process

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Alveolar Cell Senescence Exacerbates Pulmonary Inflammation in Patients with Chronic Obstructive Pulmonary Disease

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Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

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ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

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Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury

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Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

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Ceramide-induced and Age-associated Increase in Macrophage COX-2 Expression Is Mediated through Up-regulation of NF-κB Activity

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Influence of Age on Brain Edema Formation, Secondary Brain Damage and Inflammatory Response after Brain Trauma in Mice

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Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor κB

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Reversal of aging by NFκB blockade

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Loss of Nfkb1 leads to early onset aging

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Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

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Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand

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Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1

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Down-regulation of iNOS and TNF-α expression by kaempferol via NF-κB inactivation in aged rat gingival tissues

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Aging and Inflammation: Etiological Culprits of Cancer

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ISSLS Prize Winner

Nasto, L. A., Seo, H.-Y., Robinson, A. R., Tilstra, J. S., Clauson, C. L., Sowa, G., Ngo, K., Dong, Q. D., Pola, E., Lee, J. Y., et al. (2012) · Spine · doi:10.1097/brs.0b013e31824ee8f7 · Cited by 83 · see citing works

Molecular exploration of age-related NF-κB/IKK downregulation by calorie restriction in rat kidney

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The effect of ageing on macrophage Toll-like receptor-mediated responses in the fight against pathogens

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Atypical pathways of NF-κB activation and aging

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Modulating T cell signals using CD3/CD28 Xcyte™ Dynabeads® allows for selective expansion or deletion of antigen-specific T cells

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Differential expression of cytokines and chemokines during secondary neuron death following brain injury in old and young mice

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NF-κB signaling as a driver of ageing

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Genetics vs. entropy: Longevity factors suppress the NF-κB-driven entropic aging process

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NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss

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Age‐related differences in cellular and molecular profiles of inflammatory responses after spinal cord injury

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Cellular Mechanisms of Somatic Stem Cell Aging

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Transcriptional impact of dietary methionine restriction on systemic inflammation: Relevance to biomarkers of metabolic disease during aging

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Effects of moderate exercise over different phases on age-related physiological dysfunction in testes of SAMP8 mice

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HIF‐1α cytoplasmic accumulation is associated with cell death in old rat cerebral cortex exposed to intermittent hypoxia

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Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

Ungvari, Z., Krasnikov, B. F., Csiszar, A., Labinskyy, N., Mukhopadhyay, P., Pacher, P., Cooper, A. J. L., Podlutskaya, N., Austad, S. N., & Podlutsky, A. (2008) · AGE · doi:10.1007/s11357-008-9059-y · Cited by 56 · see citing works

Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging

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Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity

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Chronic lung inflammation in aging mice

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Stabilization of telomere by the antioxidant property of polyphenols: Anti-aging potential

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Development of age-dependent glomerular lesions in galectin-3/AGE-receptor-3 knockout mice

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Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer

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Age-Associated Alterations in Splenic iNOS Regulation: Influence of Constitutively Expressed IFN-γ and Correction Following Supplementation with PPARα Activators or Vitamin E

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Involvement of Rel/NF-κB transcription factors in senescence

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Signal Transduction, Ageing and Disease

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Influence of Age on Cerebral Housekeeping Gene Expression for Normalization of Quantitative Polymerase Chain Reaction after Acute Brain Injury in Mice

Timaru‐Kast, R., Herbig, E. L., Luh, C., Engelhard, K., & Thal, S. C. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2014.3784 · Cited by 33 · see citing works

Delayed neurodegeneration and early astrogliosis after excitotoxicity to the aged brain

Castillo-Ruiz, M. D. M., Campuzano, Ó., Acarín, L., Castellano, B., & González, B. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.10.008 · Cited by 33 · see citing works

Klotho deficiency aggravates sepsis-related multiple organ dysfunction

Jorge, L., Coelho, F. O., Sanches, T. R., Malheiros, D. M. A. C., Souza, L., dos Santos, F., Lima, L. D. S., Scavone, C., Irigoyen, M. C., Kuro‐o, M., et al. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00625.2017 · Cited by 32 · see citing works

Lifelong Aspirin Supplementation as a Means to Extending Life Span

Phillips, T., & Leeuwenburgh, C. (2004) · Rejuvenation Research · doi:10.1089/rej.2004.7.243 · Cited by 30 · see citing works

The role of the nuclear pore complex in aging of post-mitotic cells

Hetzer, M. W. (2010) · Aging · doi:10.18632/aging.100125 · Cited by 28 · see citing works

Prednisolone suppresses adriamycin-induced vascular smooth muscle cell senescence and inflammatory response via the SIRT1-AMPK signaling pathway

Sung, J. Y., Kim, S. G., Kim, J.-R., & Choi, H. C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239976 · Cited by 27 · see citing works

p75 Neurotrophin receptor mediates neurotrophin activation of NF‐kappa B and induction of iNOS expression in P19 neurons

Burke, M. A., & Bothwell, M. A. (2003) · Journal of Neurobiology · doi:10.1002/neu.10174 · Cited by 27 · see citing works

Club cell protein 16 (Cc16) deficiency increases inflamm‐aging in the lungs of mice

Laucho-Contreras, M. E., Polverino, F., Rojas, J., Wang, X., & Owen, C. A. (2018) · Physiological Reports · doi:10.14814/phy2.13797 · Cited by 26 · see citing works

Sustained NF κB inhibition improves insulin sensitivity but is detrimental to muscle health

Zhang, N., Valentine, J. M., Zhou, Y., Li, M. E., Zhang, Y., Bhattacharya, A., Walsh, M. E., Fischer, K. E., Austad, S. N., Osmulski, P. A., et al. (2017) · Aging Cell · doi:10.1111/acel.12613 · Cited by 26 · see citing works

Free radical-dependent changes in constitutive Nuclear factor kappa B in the aged hippocampus

Kaufmann, J. A., Bickford, P. C., & Taglialatela, G. (2002) · Neuroreport · doi:10.1097/00001756-200210280-00017 · Cited by 26 · see citing works

The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats

AKBULUT, K. G., Aktaş, S. H., & Akbulut, H. (2014) · Biogerontology · doi:10.1007/s10522-014-9540-1 · Cited by 25 · see citing works

Role of Redox Imbalance in the Molecular Mechanisms Responsible for Immunosenescence

Daynes, R. A., Enioutina, E. Y., & Jones, D. C. (2003) · Antioxidants & Redox Signaling · doi:10.1089/152308603770310185 · Cited by 27 · see citing works

The Frequency of 4 Common Gene Polymorphisms in Nonagenarians, Centenarians, and Average Life Span Individuals

Kolovou, G. D., Kolovou, V., Vasiliadis, I. K., Giannakopoulou, V., Mihas, C. C., Bilianou, H. I., Kollia, A., Papadopoulou, E., Marvaki, A., Goumas, G., et al. (2013) · Angiology · doi:10.1177/0003319712475075 · Cited by 22 · see citing works

Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol

Sinha, M. S., Bir, A., Banerjee, A., Bhowmick, P., & Chakrabarti, S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.10.003 · Cited by 22 · see citing works

Korean Red ginseng prevents endothelial senescence by downregulating the HO-1/NF-κB/miRNA-155-5p/eNOS pathway

Kim, T. H., Kim, J.-Y., Bae, J., Kim, Y. M., Won, M., Ha, K., Kwon, Y., & Kim, Y. (2020) · Journal of Ginseng Research · doi:10.1016/j.jgr.2020.08.002 · Cited by 22 · see citing works

Hyperglycemia and advanced glycation end products (AGEs) suppress the differentiation of 3T3-L1 preadipocytes

Chang, C., Chen, C., Chang, G.-D., Chen, W.-L., Chen, W.-L., Wen, H., Chang, C.-H., & Chang, C.-H. (2017) · Oncotarget · doi:10.18632/oncotarget.18993 · Cited by 21 · see citing works

Differential Effects of In Vitro Zinc Treatment on Gene Expression in Peripheral Blood Mononuclear Cells Derived from Young and Elderly Individuals

Mazzatti, D. J., Malavolta, M., White, A., Costarelli, L., Giacconi, R., Muti, E., Cipriano, C., Powell, J. R., & Mocchegiani, E. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0553 · Cited by 21 · see citing works

Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages

Babagana, M., Oh, K., Chakraborty, S., Pacholewska, A., Aqdas, M., & Sung, M. (2021) · Aging · doi:10.18632/aging.203422 · Cited by 19 · see citing works

cRel induces mitochondrial alterations in correlation with proliferation arrest

Bernard, D., Slomianny, C., Vandenbunder, B., & Abbadie, C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00668-2 · Cited by 20 · see citing works

Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation

Tsuchiya, T., Higami, Y., Komatsu, T., Tanaka, K., Honda, S., Yamaza, H., Chiba, T., Ayabe, H., & Shimokawa, I. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.11.007 · Cited by 19 · see citing works

Chronic Inflammation as an Underlying Mechanism of Ageing and Ageing-Related Diseases

Chung, K. W., Kim, D. H., Jung, H. J., Arulkumar, R., Chung, H. Y., & Yu, B. P. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_3 · Cited by 18 · see citing works

Methods to Quantify the NF-κB Pathway During Senescence

Zhang, L. J., Zhao, J., Gurkar, A. U., Niedernhofer, L. J., & Robbins, P. D. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8931-7_18 · Cited by 18 · see citing works

Developmental patterns of NF-κB activation during acute hypoxia in the caudal brainstem of the rat

Simakajornboon, N., Gozal, E., & Gozal, D. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00132-8 · Cited by 18 · see citing works

Dysregulated expression of miR-101b and miR-26b lead to age-associated increase in LPS-induced COX-2 expression in murine macrophage

Liu, D., Wang, D., Xu, Z., Gao, J., Liu, M., Liu, Y., Jiang, M., & Zheng, D. (2015) · AGE · doi:10.1007/s11357-015-9836-3 · Cited by 17 · see citing works

Reduced Neuroinflammation Via Astrocytes and Neutrophils Promotes Regeneration After Spinal Cord Injury in Neonatal Mice

Kitade, K., Kobayakawa, K., Saiwai, H., Matsumoto, Y., Kawaguchi, K., Iida, K., Kijima, K., Iura, H., Tamaru, T., Haruta, Y., et al. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0044 · Cited by 17 · see citing works

Systems Biology of Parkinson's Disease

Wellstead, P. E., & Cloutier, M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3411-5 · Cited by 17 · see citing works

Resveratrol improves episodic-like memory and motor coordination through modulating neuroinflammation in old rats

Sarubbo, F., Ramis, M. R., Tejada, S., Jiménez‐García, M., Esteban, S., Miralles, A., & Moranta, D. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105533 · Cited by 16 · see citing works

NF-κB Activation with Aging: Characterization and Therapeutic Inhibition

Zhao, J., Li, X., McGowan, S. J., Niedernhofer, L. J., & Robbins, P. D. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2422-6_32 · Cited by 16 · see citing works

Characterization of Aging-Associated Up-Regulation of Constitutive Nuclear Factor-κB Binding Activity

Helenius, M., Kyrylenko, S., Vehviläinen, P., & Salminen, A. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100669 · Cited by 97 · see citing works

Aging-associated changes in NF-kappa Β signaling

Helenius, M. (2000) · Jyväskylä University Digital Archive (University of Jyväskylä)

Age-dependent modulation of NF-κB expression in rat adrenal gland

Medicherla, R., Leers‐Sucheta, S., Luo, Y., & Azhar, S. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00015-5 · Cited by 11 · see citing works

Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB

Helenius, M., Hänninen, M., Lehtinen, S. K., & Salminen, A. (1996) · Biochemical Journal · doi:10.1042/bj3180603 · Cited by 232 · see citing works

Free radical-dependent changes in constitutive Nuclear factor kappa B in the aged hippocampus

Kaufmann, J. A., Bickford, P. C., & Taglialatela, G. (2002) · Neuroreport · doi:10.1097/00001756-200210280-00017 · Cited by 26 · see citing works