Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes
Abstract
The purpose of the current study was to test the hypothesis that an altered fat distribution in elderly healthy subjects and in patients with type-2 diabetes contributes to high circulating levels of interleukin (IL)-6 and tumor necrotic factor (TNF)-alpha, which secondly is related to lower muscle mass. Twenty young controls, (20-35 yr), 20 healthy elderly subjects (65-80 yr) and 16 elderly patients with type 2 diabetes (65-80 yr) were included in a cross sectional study. Plasma levels of TNF-alpha and IL-6 were measured after an overnight fast. Dual-energy X-ray absorptiometry and total body potassium counting measured truncal fat, appendicular skeletal muscle mass (ASM) and body cell mass (BCM), respectively. TNF-alpha, IL-6 and the relative truncal fat mass were higher in elderly compared with young controls. ASM was lower in diabetic men than in young controls and BCM was lower in elderly men compared with young men. TNF-alpha and IL-6 were correlated with the absolute as well as the relative truncal fat mass in univariate regression analyses. Similar results were found in multivariate linear regression analyses after adjusting for the effect of age and gender. TNF-alpha was related to lower ASM and BCM in elderly men both in a univariate regression analysis and a multivariate regression analysis. In conclusion, high plasma levels of TNF-alpha and IL-6 in elderly healthy people and in patients with type 2 diabetes are associated with increased truncal fat mass, suggesting that cytokines are partly derived from this adipose tissue bed. Furthermore, TNF-alpha was related to lower ASM and BCM, suggesting that TNF-alpha contributes to sarcopenia in ageing.
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In vitro, acute hyperglycaemia leads to a significant decrease in leucocyte vitamin C content.
“Accordingly, Chen et al. (668) provided evidence in vitro that acute hyperglycaemia leads to a significant decrease in leucocyte vitamin C content.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [668]
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- Authors
- Pedersen, M., Bruunsgaard, H., Weis, N., Hendel, H. W., Andreassen, B. U., Eldrup, E., Dela, F., & Pedersen, B. K.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Mechanisms of Ageing and Development
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 124
- Issue
- 4
- Pages
- 495-502
- ISSN
- 0047-6374 (ISSN-L)
- OpenAlex
- W2092390633
- Cited by
- 342
- References
- 39
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 16 · 2023: 19 · 2022: 10 · 2021: 18 · 2020: 16 · 2019: 21 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 17 · 2014: 9 · 2013: 16 · 2012: 18
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mechanisms of Ageing and Development (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- TNF-α, interleukin-6, appendicular skeletal muscle mass, body cell mass, type 2 diabetes, sarcopenia, aging, body fat distribution, older adults
- MeSH terms
- Adipose Tissue, Adult, Aged, Aging, Body Composition, Diabetes Mellitus, Type 2, Female, Humans, Male, Muscular Atrophy, Tumor Necrosis Factor-alpha, Interleukin-6, Muscle, Skeletal
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