Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies
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The objective of this study was to evaluate the effects of steroid anabolic androgenic hormones use on lean mass gain in elderly men through a systematic review with a meta-analysis of randomized controlled studies. We systematically searched PubMed database until 4th October 2013. We included randomized placebo-controlled trials (RCT) that studied testosterone replacement therapy in men over 60 years of age, with total testosterone levels ≤550 ng/dl, observing gains in weight, lean mass tissue and fat mass as outcome. We excluded duplicated studies, studies which mixed men and women, and studies using weak androgens such as dehydroepiandrosterone or androstenedione. The initial search yielded 2681 articles, of which 26 were selected for full text analysis. In the end, 11 studies were included. However, 3 studies were not included in the meta-analysis. Meta-analysis showed that mean weight increased (lean mass), ranging from 1.65 (95 % CI, 1.61-1.69) to 6.20 (95 % CI, 5.22-7.18) kg, although it was heterogeneous (I (2) = 98 %). Effect estimate was 3.59 [2.38-4.81]. Androgen therapy decreased fat mass; effect estimate was -1.78 [-2.57, -0.99] that analysis had also a high level of heterogeneity (I (2) = 81 %). The results suggest that testosterone replacement therapy is able to increase muscle mass in elderly men and that is affected by the time that the treatment is carried out and the method of administration of the drug.
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In men over 60 years with low testosterone, testosterone supplementation increased lean mass by 1.6 to 6.20 kg.
“in men over 60 years with low testosterone, gains in lean mass following testosterone supplementation ranged from 1.6 kg to 6.20 kg (REF407).”
From Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies (2018) · cites this paper as [407]
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Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954 · see citing works
(2018) · doi:10.1001/jama · Cited by 932 · see citing works
Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
Iannuzzi-Sucich, M., Prestwood, K. M., & Kenny, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.12.m772 · Cited by 890 · cited 1× · see citing works
“Prevalence studies suggest that androgen therapy strategies may be of interest in reducing the rate of muscle wasting seen during aging (Iannuzzi-Sucich et al. 2002).”
BackgroundCalof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.11.1451 · Cited by 728 · see citing works
Isidori, A. M., Giannetta, E., Greco, E. A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., & Fabbri, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02339.x · Cited by 695 · see citing works
Page, S. T., Amory, J. K., Bowman, F. D., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1933 · Cited by 566 · see citing works
Xu, L., Freeman, G., Cowling, B. J., & Schooling, C. M. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-108 · Cited by 562 · see citing works
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Mac, R. P., Lee, M., Yarasheski, K. E., Sinha-Hikim, I., Dzekov, C., Dzekov, J., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1184 · Cited by 544 · see citing works
Effect of Testosterone Treatment on Body Composition and Muscle Strength in Men Over 65 Years of Age
Snyder, P. J. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.8.2647 · Cited by 531 · see citing works
Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai Pour, H. R., Aleman, A., Lock, T. M. T. W., Bosch, J. L. H. R., Grobbee, D. E., & van der Schouw, Y. T. (2008) · JAMA · doi:10.1001/jama.2007.51 · Cited by 518 · see citing works
Kenny, A. M., Prestwood, K. M., Gruman, C. A., Marcello, K. M., & Raisz, L. G. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.5.m266 · Cited by 456 · see citing works
Blackman, M. R. (2002) · JAMA · doi:10.1001/jama.288.18.2282 · Cited by 455 · see citing works
Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. C. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00507.x · Cited by 418 · see citing works
Steidle, C. P., Schwartz, S. L., Jacoby, K., Sebree, T. B., Smith, T. P. L., & Bachand, R. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021058 · Cited by 406 · see citing works
Wittert, G., Chapman, I. M., Haren, M. T., Mackintosh, S. F., Coates, P. S., & Morley, J. E. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.7.m618 · Cited by 342 · see citing works
Classical and/or alternative NF-κB pathway activation in multiple myeloma
Demchenko, Y. N., Glebov, O. K., Zingone, A., Keats, J. J., Bergsagel, P. L., & Kuehl, W. M. (2010) · Blood · doi:10.1182/blood-2009-09-243535 · Cited by 289 · see citing works
Kenny, R. A., Kleppinger, A., Annis, K., Rathier, M., Browner, B., Judge, J. O., & McGee, D. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02865.x · Cited by 250 · see citing works
Testosterone and Growth Hormone Improve Body Composition and Muscle Performance in Older Men
Sattler, F. R., Castaneda-Sceppa, C., Binder, E. F., Schroeder, E. T., Wang, Y., Bhasin, S., Kawakubo, M., Stewart, Y., Yarasheski, K. E., Ulloor, J., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2338 · Cited by 194 · see citing works
Androgen Treatment and Muscle Strength in Elderly Men: A Meta‐Analysis
Ottenbacher, K. J., Ottenbacher, M. E., Ottenbacher, A. J., Acha, A. A., & Ostir, G. V. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00938.x · Cited by 173 · see citing works
Morley, J. S., Bridson, J. D., Nash, T. P., Miles, J. B., White, S. J., & Makin, M. K. (2003) · Palliative Medicine · doi:10.1191/0269216303pm815oa · Cited by 157 · see citing works
Differential Anabolic Effects of Testosterone and Amino Acid Feeding in Older Men
Ferrando, A. A., Sheffield‐Moore, M., Paddon‐Jones, D., Wolfe, R. R., & Urban, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021041 · Cited by 155 · see citing works
MALE HORMONE REPLACEMENT THERAPY INCLUDING “ANDROPAUSE”
Tenover, J. L. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70050-5 · Cited by 114 · see citing works
NF-κB–inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
Aya, K., Alhawagri, M., Hagen-Stapleton, A., Kitaura, H., Kanagawa, O., & Novack, D. V. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23763 · Cited by 110 · see citing works
Abbasi, A. A., Drinka, P. J., Mattson, D. E., & Rudman, D. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb06764.x · Cited by 93 · see citing works
Effects of an oral androgen on muscle and metabolism in older, community-dwelling men
Schroeder, E. T., Singh, A. B., Bhasin, S., Storer, T. W., Azen, C. G., Davidson, T., Martinez, C., Sinha‐Hikim, I., Jaque, S. V., Terk, M. R., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00363.2002 · Cited by 67 · see citing works
Qin, W., Pan, J., Wu, Y., Bauman, W. A., & Cardozo, C. P. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.061 · Cited by 66 · see citing works
Allan, C. A., Forbes, E. A., Strauss, B. J., & McLachlan, R. I. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.22 · Cited by 65 · see citing works
Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies
Schroeder, E. T., Terk, M. R., & Sattler, F. R. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00032.2003 · Cited by 65 · see citing works
Diabetes-Induced Activation of Canonical and Noncanonical Nuclear Factor-κB Pathways in Renal Cortex
Starkey, J. M., Haidacher, S. J., LeJeune, W. S., Zhang, X., Tieu, B. C., Choudhary, S., Brasier, A. R., Denner, L. A., & Tilton, R. G. (2006) · Diabetes · doi:10.2337/db05-1554 · Cited by 65 · see citing works
Androgens affect myogenesis in vitro and increase local igf-1 expression
SCULTHORPE, N., SOLOMON, A. M., SINANAN, A. C. M., BOULOUX, P.-M. G., GRACE, F., & LEWIS, M. P. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318237c5c0 · Cited by 59 · see citing works
Testosterone-induced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR
Wu, Y., Bauman, W. A., Blitzer, R. D., & Cardozo, C. P. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.127 · Cited by 56 · see citing works
Sheffield‐Moore, M., Dillon, E. L., Casperson, S. L., Gilkison, C. R., Paddon‐Jones, D., Durham, W. J., Grady, J. J., & Urban, R. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1262 · Cited by 54 · see citing works
Yang, D., Li, J., Yuan, Z., & Liu, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062329 · Cited by 43 · see citing works
Kenny, R. A., Prestwood, K. M., & Raisz, L. G. (2000) · Endocrine Research · doi:10.3109/07435800009066159 · Cited by 43 · see citing works
Treatment with oxandrolone and the durability of effects in older men
Schroeder, E. T., Zheng, L., Yarasheski, K. E., Qian, D., Stewart, Y., Flores, C., Martinez, C., Terk, M. R., & Sattler, F. R. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00808.2003 · Cited by 40 · see citing works
Translational studies in older men using testosterone to treat sarcopenia.
Urban, R. J., Dillon, E. L., Choudhary, S., Zhao, Y., Horstman, A. M. H., Tilton, R. G., & Sheffield‐Moore, M. (2014) · Europe PMC (PubMed Central) · Cited by 39 · see citing works
Six-Week Improvements in Muscle Mass and Strength During Androgen Therapy in Older Men
Schroeder, E. T., Vallejo, A. F., Zheng, L., Stewart, Y., Flores, C., Nakao, S., Martinez, C., & Sattler, F. R. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.12.1586 · Cited by 36 · see citing works
Growth hormone and sex steroid administration in healthy aged women and men
(2003) · Obstetrics and Gynecology · doi:10.1097/00006250-200303000-00032 · Cited by 35 · see citing works
McGill, J., Shoskes, D. A., & Sabanegh, E. S. (2012) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.79a.12010 · Cited by 33 · see citing works
Flagged first, then by citations
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- [17]17. Liverman C, Blazer D (2005) Testosterone in aging: directions for clinical research. National Academy Press, Washington, DC
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797 · see citing works
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works
Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship
Mesinovic, J., Zengin, A., de Courten, B. V., Ebeling, P. R., & Scott, D. S. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s186600 · Cited by 584 · see citing works
Brook, M. S., Wilkinson, D. J., Mitchell, W. K., Lund, J. N., Phillips, B. E., Szewczyk, N. J., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2016) · The Journal of Physiology · doi:10.1113/jp272857 · Cited by 204 · see citing works
Sarcopenic Obesity: Epidemiologic Evidence, Pathophysiology, and Therapeutic Perspectives
Koliaki, C., Liatis, S., Dalamaga, M., & Kokkinos, A. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00359-9 · Cited by 176 · see citing works
Klaver, M., Dekker, M. J. H. J., de Mutsert, R., Twisk, J. W. R., & den Heijer, M. (2016) · Andrologia · doi:10.1111/and.12660 · Cited by 165 · see citing works
Chen, H., Huang, X., Dong, M., Wen, S., Zhou, L., & Yuan, X. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s410834 · Cited by 180 · see citing works
Isidori, A., Aversa, A., Calogero, A., Ferlin, A., Francavilla, S., Lanfranco, F., Pivonello, R., Rochira, V., Corona, G., & Maggi, M. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01859-7 · Cited by 135 · see citing works
Espino-González, E., Dalbram, E., Mounier, R., Gondin, J., Farup, J., Jessen, N., & Treebak, J. T. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.02.014 · Cited by 132 · see citing works
Sarcopenic Obesity: An Emerging Public Health Problem
Ji, T., Li, Y., & Ma, L. (2022) · Aging and Disease · doi:10.14336/ad.2021.1006 · Cited by 126 · see citing works
Cardiovascular Risks of Exogenous Testosterone Use Among Men: A Systematic Review and Meta-Analysis
Alexander, G. C., Iyer, G. S., Lucas, E. J., Lin, D. H., & Singh, S. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.09.017 · Cited by 120 · see citing works
Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age
Rezuş, E., Burlui, A., Cardoneanu, A., Rezuș, C., Codreanu, C., Parvu, M., Zota, G. R., & Tamba, B.-I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020592 · Cited by 117 · see citing works
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Barone, B., Napolitano, L., Abate, M., Cirillo, L., Reccia, P., Passaro, F., Turco, C., Morra, S., Mastrangelo, F., Scarpato, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073535 · Cited by 120 · see citing works
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Liu, J., & Wu, Y. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000407 · Cited by 118 · see citing works
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Roberts, B. M., Lavin, K. M., Many, G. M., Thalacker‐Mercer, A. E., Merritt, E. K., Bickel, C. S., Mayhew, D. L., Tuggle, S. C., Cross, J. M., Kosek, D. J., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.02.023 · Cited by 110 · see citing works
Aging of the endocrine system and its potential impact on sarcopenia
Vitale, G., Cesari, M., & Mari, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.017 · Cited by 106 · see citing works
Shadid, S., Abosi-Appeadu, K., Maertelaere, A.-S. D., Defreyne, J., Veldeman, L., Holst, J. J., Lapauw, B., Vilsbøll, T., & T'Sjoen, G. G. (2019) · Diabetes Care · doi:10.2337/dc19-1061 · Cited by 82 · see citing works
Skinner, J. W., Otzel, D. M., Bowser, A., Nargi, D., Agarwal, S., Peterson, M. D., Zou, B., Borst, S. E., & Yarrow, J. F. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12291 · Cited by 76 · see citing works
Sarcopenia: An Endocrine Disorder?
McKee, A. M., Morley, J. E., Matsumoto, A. M., & Vinik, A. I. (2017) · Endocrine Practice · doi:10.4158/ep171795.ra · Cited by 70 · see citing works
Parahiba, S. M., Ribeiro, É. C. T., Corrêa, C., Bieger, P., Perry, I. D. S., & Souza, G. C. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111106 · Cited by 59 · see citing works
Rahman, F. A., Angus, S. A., Stokes, K., Karpowicz, P. A., & Krause, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134575 · Cited by 55 · see citing works
Choi, S. M., & Lee, B. (2015) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2015.1094052 · Cited by 37 · see citing works
Oliveira, A., Fidalgo, A., Farinatti, P., & Monteiro, W. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105451 · Cited by 36 · see citing works
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Damluji, A. A., Tomczak, C. R., Hiser, S. L., O’Neill, D. E., Goyal, P., Pack, Q. R., Foulkes, S., Brown, T. M., Haykowsky, M. J., Needham, D. M., et al. (2025) · Circulation Research · doi:10.1161/circresaha.125.325705 · Cited by 45 · see citing works
Fode, M. M., Salonia, A., Minhas, S., Burnett, A. L. “., & Shindel, A. W. (2019) · European Urology Focus · doi:10.1016/j.euf.2019.02.021 · Cited by 36 · see citing works
Nightingale, T. E., Moore, P. D., Harman, J., Khalil, R. E., Gill, R. S., Castillo, T. A., Adler, R. A., & Gorgey, A. S. (2017) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2017.1357917 · Cited by 36 · see citing works
Zhang, J., Li, X., Cai, Z., Li, H., & Yang, B. (2019) · The Aging Male · doi:10.1080/13685538.2018.1557139 · Cited by 32 · see citing works
Stanozolol promotes osteogenic gene expression and apposition of bone mineral in vitro
Ghiacci, G., Lumetti, S., Manfredi, E., Mori, D., Macaluso, G. M., & Sala, R. (2018) · Journal of Applied Oral Science · doi:10.1590/1678-7757-2018-0014 · Cited by 29 · see citing works
Theodorakis, N., Feretzakis, G., Vamvakou, G., Verykios, V. S., Polymeris, A., & Nikolaou, M. (2024) · Hormones · doi:10.1007/s42000-024-00587-2 · Cited by 28 · see citing works
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Morley, J. E., & Anker, S. D. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12231 · Cited by 26 · see citing works
Haring, R., Ghannad, M., Bertizzolo, L., & Page, M. J. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2020.02.004 · Cited by 24 · see citing works
Kazemi, M., Pierson, R. A., Parry, S. A., Kaviani, M., & Chilibeck, P. D. (2021) · Obesity Reviews · doi:10.1111/obr.13255 · Cited by 24 · see citing works
Buratto, J., Kirk, B., Phu, S., Vogrin, S., & Duque, G. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.04.013 · Cited by 20 · see citing works
Sarcopenia in cirrhosis: From pathophysiology to interventional therapy
Chen, H., Yang, C., Yan, S., Liu, X., Zhou, L., & Yuan, X. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112571 · Cited by 23 · see citing works
Robledo, K. P., Marschner, I. C., Handelsman, D. J., Bracken, K., Stuckey, B. G. A., Yeap, B. B., Inder, W. J., Grossmann, M., Jesudason, D. R., Allan, C. A., et al. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad074 · Cited by 18 · see citing works
Lee, T.-W., Kao, P., Chen, Y., & Wang, S. (2023) · Gerontology · doi:10.1159/000532062 · Cited by 19 · see citing works
Alrabadi, N., Al-Rabadi, G. J., Maraqa, R., Sarayrah, H., Alzoubi, K. H., Alqudah, M., & Al-U'datt, D. G. F. (2020) · Andrologia · doi:10.1111/and.13730 · Cited by 18 · see citing works
Varanoske, A. N., Margolis, L. M., & Pasiakos, S. M. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa090 · Cited by 17 · see citing works
Neto, W. K., Silva, W. D. A., Ciena, A. P., Nucci, R. A. B., Anaruma, C. A., & Gama, E. F. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00205 · Cited by 16 · see citing works
Self-citationLópez, D. S., Qiu, X., Advani, S., Tsilidis, K. K., Khera, M., Kim, J. J., Morgentaler, A., Wang, R. J., & Canfield, S. E. (2017) · Clinical Endocrinology · doi:10.1111/cen.13501 · Cited by 17 · see citing works
Activation of the apelin/APJ system by vitamin D attenuates age-related muscle atrophy
Lee, Y. J., Kim, G. H., Lee, D. S., Jeong, H., & Lim, J. H. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123205 · Cited by 13 · see citing works
Muscedere, J., Kim, P. M., Afilalo, J., Balion, C. M., Baracos, V. E., Bowdish, D. M. E., Cesari, M., Erusalimsky, J. D., Fülöp, T., Heckman, G. A., et al. (2019) · The Journal of Frailty & Aging · doi:10.14283/jfa.2019.12 · Cited by 12 · see citing works
Management of male obesity-related secondary hypogonadism: A clinical update
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Fenton, J. M., King, J. A., Hoekstra, S. P., Valentino, S. E., Phillips, S. M., & Goosey-Tolfrey, V. L. (2022) · Disability and Rehabilitation · doi:10.1080/09638288.2022.2063420 · Cited by 10 · see citing works
Varanoske, A. N., Harris, M. N., Hebert, C., Howard, E. E., Johannsen, N. M., Heymsfield, S. B., Greenway, F. L., Margolis, L. M., Lieberman, H. R., Beyl, R. A., et al. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00190.2022 · Cited by 8 · see citing works
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Herrera‐Perez, J. J., Martı́nez-Mota, L., Jiménez-Rubio, G., Ortiz-López, L. I., Cabrera-Muñoz, E. A., Galindo-Sevilla, N., Zambrano, E., Hernández‐Luis, F., Ramírez-Rodríguez, G. B., & Flores‐Ramos, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.007 · Cited by 6 · see citing works
Neto, W. K., Silva, W. D. A., Ciena, A. P., Anaruma, C. A., & Gama, E. F. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.018 · Cited by 6 · see citing works
Self-citationLópez, D. S., Kim, H., Polychronopoulou, E., Torres‐Sánchez, L., Tezanos, A. G. V., Baillargeon, J., Canfield, S. E., & Kuo, Y. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04778-z · Cited by 5 · see citing works
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Gavrilov, Z., & Lojk, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146924 · Cited by 5 · see citing works
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Amundson, J. R., Williams, J. K., Benjamin, A. J., Witmer, H. D. D., & Roggin, K. K. (2020) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000046 · Cited by 5 · see citing works
Coşkun, A., Carobene, A., Demirelce, Ö., Mussap, M., Braga, F., Sezer, E., Aarsand, A. K., Sandberg, S., Fernández–Calle, P., Díaz–Garzón, J., et al. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117632 · Cited by 4 · see citing works
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Ismaeel, N., & Wang, R. (2016) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2016.06.002 · Cited by 4 · see citing works
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Čeponis, J., Swerdloff, R. S., & Wang, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-53298-1_18 · Cited by 2 · see citing works
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López, D. S. (2017) · Energy balance and cancer · doi:10.1007/978-3-319-64940-5_2 · Cited by 1 · see citing works
Nucci, R. A. B., Tanasov, V. S., Neto, W. K., de Souza, R., & Gama, E. F. (2018) · Journal of Morphological Sciences · doi:10.1055/s-0038-1669470 · Cited by 1 · see citing works
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Janek, N. (2022) · doi:10.53846/goediss-9087 · Cited by 1 · see citing works
Graber, T. G. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)
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Solsrud, E., Louters, M. M., & Pearlman, A. M. (2023) · Current Sexual Health Reports · doi:10.1007/s11930-022-00351-w
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- Authors
- Neto, W. K., Gama, E. F., Rocha, L. Y., Ramos, C. C., Taets, W., Scapini, K. B., Ferreira, J. B., Rodrigues, B., & Caperuto, É.
- Affiliations
- Universidade São Judas Tadeu (BR)
- Universidade Presbiteriana Mackenzie (BR)
- Corresponding author
- Caperuto, Érico
- Venue
- AGE
- Published
- 2015-02
- Volume
- 37
- Issue
- 1
- Pages
- 9742-9742
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC4312307
- OpenAlex
- W2080456154
- Cited by
- 64
- References
- 40
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 2
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AGE (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- testosterone replacement therapy, lean mass gain, older men, anabolic steroids, fat mass, muscle mass, androgen therapy
- MeSH terms
- Aged, Aged, 80 and over, Androgens, Body Weight, Humans, Male, Middle Aged, Testosterone, Body Mass Index, Hormone Replacement Therapy
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