Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine
Open accessAbstract
We aimed to verify whether different levels of training performed regularly and voluntarily for many years could have an impact on one of the main issues of immunosenescence: the poor response to vaccines. We recruited 61 healthy elderly men (65-85 years old), 23 with a moderate training (MT) lifestyle (for 17.0 ± 3.2 years), 22 with an intense training (IT) lifestyle (for 25.9 ± 3.4 years), and 16 without a training lifestyle (NT). Fitness was evaluated through the IPAQ and VO2max consumption. The participants were evaluated regarding cognitive aspects, nutritional status, depression, and quality of life. Antibody titers were determined by hemagglutination inhibition assay prior to influenza vaccination and at 6 weeks and 6 months post-vaccination. Strains used were B, H3N2, and H1N1. Our groups were matched for most characteristics, except for those directly influenced by their lifestyles, such as BMI, VO2max, and MET. In general, MT and IT elderly men showed significantly higher antibody titers to the three vaccine strains post-vaccination than NT elderly men. There were also higher titers against B and H1N1 strains in the trained groups before vaccination. Additionally, there were higher proportions of seroprotected (titers ≥1:40) individuals in the pooled trained groups both at 6 weeks (B and H3N2, p < 0.05) and 6 months (H1N1, p < 0.05; B, p = 0.07). There were no significant differences between the MT and IT groups. Either a moderate or an intense training is associated with stronger and longstanding antibody responses to the influenza vaccine, resulting in higher percentages of seroprotected individuals.
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Even in vaccine studies that have not directly investigated, characterised or controlled for the degree of immunological ageing in the volunteers examined, acute and chronic exercise can improve the response to in vivo novel antigen challenge.
“Encouragingly though, even in vaccine studies that have not directly investigated, characterised or controlled for the degree of immunological ageing in the volunteers examined, it has been shown that acute and chronic exercise can improve the response to this in vivo novel antigen challenge (de Araujo et al. 2015; Pascoe et al. 2014).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as de Araujo et al. 2015
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- Authors
- de Araújo, A. L., Silva, L. C. R., Fernandes, J. R., Matias, M. D. S. T., Boas, L. S., Machado, C. M., Garcez-Leme, L. E., & Benard, G.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Benard, Gil
- Venue
- AGE
- Published
- 2015-10-19
- Volume
- 37
- Issue
- 6
- Pages
- 105-105
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC5005841
- OpenAlex
- W2172563285
- Cited by
- 67
- References
- 26
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 12 · 2020: 11 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2013: 1
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AGE (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2011/08817-0, 2011/18268-4)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (14952/13-0)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- influenza vaccination, antibody response, immunosenescence, exercise training, older men, long-term exercise, hemagglutination inhibition, influenza B, H3N2, H1N1, seroprotection, VO2max
- MeSH terms
- Aged, Aged, 80 and over, Aging, Antibodies, Viral, Antibody Formation, Cross-Sectional Studies, Hemagglutination Inhibition Tests, Humans, Influenza, Human, Influenza Vaccines, Life Style, Male, Exercise
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