β-amyloid cytotoxicity is prevented by natural achillolide A

Elmann, Anat; Telerman, Alona; Ofir, Rivka; Kashman, Yoel; Lazarov, Orly

doi:10.1007/s11418-018-1191-0

Cited by 14Alzheimer's disease research and treatmentsSesquiterpenes and Asteraceae StudiesMedicinal Plants and Neuroprotection

β-amyloid cytotoxicity is prevented by natural achillolide A

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Elmann, Anat, Telerman, Alona, Ofir, Rivka, Kashman, Yoel, Lazarov, Orly·2018·Journal of Natural Medicines

DOI 10.1007/s11418-018-1191-0PMC PMC5960475

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Abstract

Alzheimer's disease (AD) is the most prevalent cause of dementia in adults. Current available drugs for AD transiently alleviate some of the symptoms, but do not modify the disease mechanism or cure it. Therefore, new drugs are desperately needed. Key contributors to AD are amyloid beta (Aβ)- and reactive oxygen species (ROS)-induced cytotoxicities. Plant-derived substances have been shown to affect various potential targets in various diseases including AD. Therefore, phytochemicals which can protect neuronal cells against these insults might help in preventing and treating this disease. In the following research, we have isolated the sesquiterpene lactone achillolide A from the plant Achillea fragrantissima and, for the first time, characterized its effects on Aβ-treated neuroblastoma cells. Aβ is a peptide derived from the sequential cleavage of amyloid precursor protein, and is part of the pathogenesis of AD. Our current study aimed to determine whether achillolide A can interfere with Aβ-induced processes in Neuro2a cells, and protect them from its toxicity. Our results show that achillolide A decreased Aβ-induced death and enhanced the viability of Neuro2a cells. In addition, achillolide A reduced the accumulation of Aβ-induced ROS and inhibited the phosphorylation of stress-activated protein kinase/c-Jun N-terminal kinase and p44/42 mitogen-activated protein kinase in these cells. We therefore suggest that achillolide A may have therapeutic potential for the treatment of AD.

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Cytotoxicity of neuroblastoma cells by Aβ deposition decreased significantly by sesquiterpene lactones.
“In addition, the cytotoxicity of neuroblastoma cells by Aβ deposition decreased significantly by sesquiterpene lactones [63].”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [63]

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“In addition, the cytotoxicity of neuroblastoma cells by Aβ deposition decreased significantly by sesquiterpene lactones [63].”
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Authors: Elmann, A., Telerman, A., Ofir, R., Kashman, Y., & Lazarov, O.
Affiliations: Agricultural Research Organization (IL)
Dead Sea and Arava Science Center (IL)
Tel Aviv University (IL)
University of Illinois Chicago (US)
Corresponding author: Elmann, Anat
ORCID: Elmann, Anat
Ofir, Rivka
Lazarov, Orly
Venue: Journal of Natural Medicines
Publisher: Springer Science and Business Media LLC
Published: 2018-03-15
Volume: 72
Issue: 3
Pages: 626-631
ISSN: 1340-3443 (ISSN-L)
1861-0293
DOI: 10.1007/s11418-018-1191-0
PMC: PMC5960475
OpenAlex: W2792542624
Cited by: 14
References: 38
Citations by year: 2026: 2 · 2025: 4 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1
FWCI: 0.86
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
Locations: Journal of Natural Medicines (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: United States - Israel Binational Agricultural Research and Development Fund (IS-4473-11)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: amyloid-beta, Alzheimer's disease, sesquiterpene lactones, Achillea fragrantissima, neuroprotection, reactive oxygen species, JNK phosphorylation, MAPK signaling, neuroblastoma cells, cytotoxicity
MeSH terms: Alzheimer Disease, Humans, Plant Extracts, Sesquiterpenes, Amyloid beta-Peptides, Reactive Oxygen Species

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β-amyloid cytotoxicity is prevented by natural achillolide A

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