Cited by 167Parkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

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The Role of Oxidative Stress, Metabolic Compromise, and Inflammation in Neuronal Injury Produced by Amphetamine-Related Drugs of Abuse

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Yamamoto, Bryan K., Raudensky, Jamie·2008·Journal of Neuroimmune Pharmacology

DOI 10.1007/s11481-008-9121-7PMC PMC3955110

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Abstract

Methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are amphetamine derivatives with high abuse liability. These amphetamine-related drugs of abuse mediate their effects through the acute activation of both dopaminergic and serotonergic neurons. Long-term abuse of these amphetamine derivatives, however, results in damage to both dopaminergic and serotonergic terminals throughout the brain. This toxicity is mediated in part by oxidative stress, metabolic compromise, and inflammation. The overall objective of this review is to highlight experimental evidence that METH and MDMA increase oxidative stress, produce mitochondrial dysfunction, and increase inflammation that converge and culminate in the long-term toxicity to dopaminergic and serotonergic neurons.

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Authors: Yamamoto, B. K., & Raudensky, J.
Affiliations: Boston University (US)
Corresponding author: Yamamoto, Bryan K.
ORCID: Yamamoto, Bryan K.
Venue: Journal of Neuroimmune Pharmacology
Publisher: Springer Science and Business Media LLC
Published: 2008-08-15
Volume: 3
Issue: 4
Pages: 203-217
ISSN: 1557-1890 (ISSN-L)
1557-1904
DOI: 10.1007/s11481-008-9121-7
PMC: PMC3955110
OpenAlex: W2135980918
Cited by: 167
References: 168
Citations by year: 2026: 5 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 18 · 2021: 10 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 16
FWCI: 1.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Neuroimmune Pharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (R01DA007606)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: methamphetamine, MDMA, ecstasy, oxidative stress, mitochondrial dysfunction, neuroinflammation, dopaminergic neurons, serotonergic neurons, neuronal injury, neurotoxicity, drug abuse
MeSH terms: Amphetamines, Animals, Brain, Humans, Inflammation, Neurons, Illicit Drugs, Oxidative Stress

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The Role of Oxidative Stress, Metabolic Compromise, and Inflammation in Neuronal Injury Produced by Amphetamine-Related Drugs of Abuse

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