Brief Depression Screening with the PHQ-2 Associated with Prognosis Following Percutaneous Coronary Intervention with Paclitaxel-Eluting Stenting
Open accessAbstract
BACKGROUND: Depression is associated with adverse prognosis in cardiac patients, warranting the availability of brief and valid instruments to identify depressed patients in clinical practice. OBJECTIVES: We examined whether the two-item Patient Health Questionnaire (PHQ-2) was associated with adverse events in percutaneous coronary intervention (PCI) patients treated with paclitaxel-eluting stenting (using the continuous score and various cutoffs), overall and by gender. DESIGN: Prospective follow-up study. PARTICIPANTS: Consecutive PCI patients (n = 796) seen at a university medical centre. MEASUREMENTS: PHQ-2 at baseline. The study endpoint was an adverse event, defined as a combination of death or non-fatal myocardial infarction (MI) at follow-up (mean of 1.4 years). RESULTS: At follow-up, 47 patients had experienced an adverse event. Using the continuous score of the PHQ-2 and the recommended cutoff > or =3, depressive symptoms were not associated with adverse events (ps > 0.05). Using a cutoff > or =2, depressive symptoms were significantly associated with adverse events (HR: 1.89; 95% CI: 1.06-3.35) and remained significant in adjusted analysis (HR: 1.90; 95% CI: 1.05-3.44). Depressive symptoms were associated with an increased risk of adverse events in men (HR: 2.69; 95% CI: 1.36-5.32) but not in women (HR: 0.76; 95% CI: 0.24-2.43); these results remained in adjusted analysis. CONCLUSIONS: Depression screening with a two-item scale and a cutoff score of > or =2 was independently associated with adverse events at follow-up. The PHQ-2 is a brief and valid measure that can easily be used post PCI to identify patients at risk for adverse health outcomes.
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The core symptoms of depression as assessed with the PHQ-2 or PHQ-9 predict new onset myocardial infarction and mortality.
“The core symptoms of depression as assessed with the PHQ-2 or PHQ-9 predict new onset myocardial infarction and mortality [42].”
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- Authors
- Pedersen, S. S., Denollet, J., de Jonge, P., Simsek, C., Serruys, P. W., & van Domburg, R. T.
- Affiliations
- Tilburg University (NL)
- Erasmus MC (NL)
- Corresponding author
- Pedersen, Susanne S.
- Venue
- Journal of General Internal Medicine
- Published
- 2009-07-05
- Volume
- 24
- Issue
- 9
- Pages
- 1037-1042
- ISSN
- 0884-8734 (ISSN-L)
- 1525-1497
- PMC
- PMC2726887
- OpenAlex
- W2125463360
- Cited by
- 31
- References
- 45
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Update notices
- correction (2009-08-19)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of General Internal Medicine (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- Research portal (Tilburg University) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- depression screening, PHQ-2, Patient Health Questionnaire, depressive symptoms, percutaneous coronary intervention, paclitaxel-eluting stents, cardiovascular adverse events, myocardial infarction, mortality, prognostic factors, sex differences, cut-off values
- MeSH terms
- Aged, Depression, Female, Follow-Up Studies, Humans, Male, Mass Screening, Middle Aged, Prognosis, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Angioplasty, Balloon, Coronary, Paclitaxel, Drug-Eluting Stents
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