Hippocampal volume and cingulum bundle fractional anisotropy are independently associated with verbal memory in older adults
Open accessAbstract
The objective of this study was to investigate the relationship of medial temporal lobe and posterior cingulate cortex (PCC) volumetrics as well as fractional anisotropy of the cingulum angular bundle (CAB) and the cingulum cingulate gyrus (CCG) bundle to performance on measures of verbal memory in non-demented older adults. The participants were 100 non-demented adults over the age of 70 years from the Einstein Aging Study. Volumetric data were estimated from T1-weighted images. The entire cingulum was reconstructed using diffusion tensor MRI and probabilistic tractography. Association between verbal episodic memory and MRI measures including volume of hippocampus (HIP), entorhinal cortex (ERC), PCC and fractional anisotropy of CAB and CCG bundle were modeled using linear regression. Relationships between atrophy of these structures and regional cingulum fractional anisotropy were also explored. Decreased HIP volume on the left and decreased fractional anisotropy of left CAB were associated with lower memory performance. Volume changes in ERC, PCC and CCG disruption were not associated with memory performance. In regression models, left HIP volume and left CAB-FA were each independently associated with episodic memory. The results suggest that microstructural changes in the left CAB and decreased left HIP volume independently influence episodic memory performance in older adults without dementia. The importance of these findings in age and illness-related memory decline require additional exploration.
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To better reflect the cingulum's changing anatomical properties, reconstructions increasingly distinguished between the 'dorsal' and 'ventral' cingulum, i.e., above or below the splenium, which roughly corresponds to the distinction between cingulum cingulate gyrus and cingulum angular bundle.
“However, to better reflect its changing anatomical properties, reconstructions increasingly distinguished between the ‘dorsal’ and ‘ventral’ cingulum, i.e., above or below the splenium (e.g., Budisavljevic et al., 2015; Fig. 6B) which roughly corresponds to the distinction between cingulum cingulate gyrus and cingulum angular bundle (e.g., Ezzati et al., 2016).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Ezzati et al., 2016
Correlations between episodic memory and left parahippocampal cingulum FA that were independent of hippocampal volume were found in non-dementing elderly adults.
“Nevertheless, correlations between episodic memory and left parahippocampal cingulum FA that were independent of hippocampal volume were also found in non-dementing elderly adults (Ezzati et al., 2016).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Ezzati et al., 2016
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The cingulum bundle: Anatomy, function, and dysfunction
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- Authors
- Ezzati, A., Katz, M. J., Lipton, M. L., Zimmerman, M. E., & Lipton, R. B.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Ezzati, Ali
- Venue
- Brain Imaging and Behavior
- Published
- 2015-09-30
- Volume
- 10
- Issue
- 3
- Pages
- 652-659
- ISSN
- 1931-7557 (ISSN-L)
- 1931-7565
- PMC
- PMC4816657
- OpenAlex
- W1887045839
- Cited by
- 79
- References
- 5
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 8 · 2019: 14 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 1
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Imaging and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG026728, P01AG003949)
- National Center for Research Resources (M01RR012248)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hippocampal volume, cingulum, fractional anisotropy, verbal episodic memory, older adults, posterior cingulate cortex, entorhinal cortex, white matter microstructure, brain atrophy, non-demented elderly
- MeSH terms
- Aged, Aged, 80 and over, Atrophy, Female, Gyrus Cinguli, Hippocampus, Humans, Image Processing, Computer-Assisted, Male, Memory, Neuropsychological Tests, Organ Size, Linear Models, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging
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