Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer’s disease
Abstract
This study aimed to investigate the atrophy of the posterior cingulate cortex (PCC) and medical temporal lobe (MTL) structures (i.e., the entorhinal cortex (ERC) and hippocampus) and the regional disruption of the cingulum bundle in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients. The relationships between atrophy of these structures and regional cingulum disruption were also explored. Three-dimensional MRI and diffusion tensor imaging were applied to 19 MCI, 19 probable AD patients, and 18 normal controls (NC). Fractional anisotropy (FA) values were obtained from three different regions of the cingulum. Both MCI and AD patients showed decreased PCC volumes compared with NC. ERC atrophy was also significant in AD and MCI, while hippocampus atrophy was significant only in AD. MCI patients showed a significant FA decrease in the parahippocampal cingulum (PH-C), whereas AD patients had lower FA values in the posterior cingulate cingulum (PC-C) and PH-C, as compared with NC. However, the middle cingulate cingulum (MC-C) showed no significant FA differences between groups. Moreover, the volumes of MTL structures were significantly correlated with PH-C and PC-C FA values. In terms of PCC functional deficit in MCI or early AD, our results support both the direct effect of PCC atrophy itself and the indirect effect of cingulum fiber degeneration secondary to MTL atrophy.
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Choo et al. (2010) reported reduced FA in the parahippocampal cingulum in both MCI and Alzheimer's patients, with additional FA changes in the posterior retrosplenial cingulum in the Alzheimer's group.
“This study reported reduced FA in the parahippocampal cingulum in both MCI and Alzheimer’s patients, with additional FA changes in the posterior retrosplenial cingulum in the Alzheimer’s group (Choo et al., 2010; see also Ito et al., 2015).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Choo et al., 2010
A well-replicated finding concerns microstructural changes in the posterior and parahippocampal cingulum associated with both MCI and AD.
“A well-replicated finding concerns microstructural changes in the posterior and parahippocampal cingulum associated with both MCI and AD (Bozzali et al., 2012; Choo et al., 2010; Metzler-Baddeley et al., 2012a; Remy et al., 2015; Wang et al., 2017; Zhang et al., 2007; Zhuang et al., 2012; 2013, for review see Chua et al., 2008; Yu et al., 2017).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Choo et al., 2010
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“A well-replicated finding concerns microstructural changes in the posterior and parahippocampal cingulum associated with both MCI and AD (Bozzali et al., 2012; Choo et al., 2010; Metzler-Baddeley et al., 2012a; Remy et al., 2015; Wang et al., 2017; Zhang et al., 2007; Zhuang et al., 2012; 2013, for review see Chua et…”
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- Authors
- Choo, I. H., Lee, D. Y., Oh, J. S., Lee, J. S., Lee, D. S., Song, I. C., Youn, J. C., Kim, S. G., Kim, K. W., Jhoo, J. H., & Woo, J. I.
- Affiliations
- Seoul National University (KR)
- Seoul National University Bundang Hospital (KR)
- Kangwon National University Hospital (KR)
- Corresponding author
- Lee, Dong Young
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 31
- Issue
- 5
- Pages
- 772-779
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2083234722
- Cited by
- 211
- References
- 6
- Citations by year
- 2026: 3 · 2025: 18 · 2024: 12 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 14 · 2019: 12 · 2018: 10 · 2017: 12 · 2016: 18 · 2015: 12 · 2014: 12 · 2013: 11 · 2012: 13
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fonds National de la Recherche Luxembourg
- Seoul National University Hospital
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- cingulum, mild cognitive impairment, Alzheimer's disease, entorhinal cortex atrophy, hippocampal atrophy, medial temporal lobe, fractional anisotropy, diffusion tensor imaging
- MeSH terms
- Aged, Alzheimer Disease, Analysis of Variance, Atrophy, Cerebral Cortex, Cognition Disorders, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Chi-Square Distribution, Patient Selection
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