The effects of aerobic exercise on the structure and function of DMN-related brain regions: a systematic review
Abstract
Physical activity may play a role in both the prevention and slowing of brain volume loss and may be beneficial in terms of improving the functional connectivity of brain regions. But much less is known about the potential benefit of aerobic exercise for the structure and function of the default mode network (DMN) brain regions. This systematic review examines the effects of aerobic exercise on the structure and function of DMN brain regions in human adulthood. Seven electronic databases were searched for prospective controlled studies published up to April 2015. The quality of the selected studies was evaluated with the Cochrane Collaboration's tool for assessing the risk of bias. RevMan 5.3 software was applied for data analysis. Finally, 14 studies with 631 participants were identified. Meta-analysis revealed that aerobic exercise could significantly increase right hippocampal volume (SMD = 0.26, 95% CI 0.01–0.51, p = 0.04, I2 = 7%, 4 studies), and trends of similar effects were observed in the total (SMD = 0.12, 95% CI –0.17 to 0.41, p = 0.43, I2 = 0%, 5 studies), left (SMD = 0.12, 95% CI −0.13 to 0.37, p = 0.33, I2 = 14%, 4 studies), left anterior (SMD = 0.12, 95% CI −0.16 to 0.40, p = 0.41, I2 = 74%, 2 studies) and right anterior (SMD = 0.10, 95% CI −0.17 to 0.38, p = 0.46, I2 = 76%, 4 studies) hippocampal volumes compared to the no-exercise interventions. A few studies reported that relative to no-exercise interventions, aerobic exercise could significantly decrease the atrophy of the medial temporal lobe, slow the anterior cingulate cortex (ACC) volume loss, increase functional connectivity within the hippocampus and improve signal activation in the cingulate gyrus and ACC. The current review suggests that aerobic exercise may have positive effects on the right hippocampus and potentially beneficial effects on the overall and other parts of the hippocampus, the cingulate cortex and the medial temporal areas of the DMN. Moreover, aerobic exercise may increase functional connectivity or activation in the hippocampus, cingulate cortex and parahippocampal gyrus regions of the DMN. However, considering the quantity and limitations of the included studies, the conclusion could not be drawn so far. Additional randomized controlled trials (RCTs) with rigorous designs and longer intervention periods are needed in the future.
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In one meta-analysis of 14 studies, nine in older adults, aerobic exercise increased right and left anterior hippocampal volumes.
“In one meta-analysis of 14 studies, nine of which were in older adults, aerobic exercise increased right and left anterior hippocampal volumes (71, 76).”
From Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines (2019) · cites this paper as [71]
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
<i>The Brain's Default Network</i>: <i>Anatomy, Function, and Relevance to Disease</i>
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761 · see citing works
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855 · see citing works
Greicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684 · see citing works
Gusnard, D. A., Akbudak, E., Shulman, G. L., & Raichle, M. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043098 · Cited by 2,997 · see citing works
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works
Squire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680 · see citing works
Kaiser, R. H., Andrews-Hanna, J. R., Wager, T. D., & Pizzagalli, D. A. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0071 · Cited by 2,281 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
The role of the posterior cingulate cortex in cognition and disease
Leech, R., & Sharp, D. J. (2014) · Brain · doi:10.1093/brain/awt162 · Cited by 2,247 · see citing works
Aerobic Exercise Training Increases Brain Volume in Aging Humans
Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Marquez, D. X., Hu, L., & Kramer, A. F. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.11.1166 · Cited by 2,134 · see citing works
Default-mode brain dysfunction in mental disorders: A systematic review
Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.002 · Cited by 1,675 · see citing works
Cardiovascular fitness, cortical plasticity, and aging
Colcombe, S. J., Kramer, A. F., Erickson, K. I., Scalf, P., McAuley, E., Cohen, N. J., Webb, A., Jerome, G. J., Marquez, D. X., & Elavsky, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400266101 · Cited by 1,648 · see citing works
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017 · see citing works
Inspired by Distraction: Mind Wandering Facilitates Creative Incubation
Baird, B., Smallwood, J., Mrazek, M. D., Kam, J. W. Y., Franklin, M. S., & Schooler, J. W. (2012) · Psychological Science · doi:10.1177/0956797612446024 · Cited by 975 · see citing works
Bherer, L., Erickson, K. I., & Liu-Ambrose, T. (2013) · Journal of Aging Research · doi:10.1155/2013/657508 · Cited by 899 · see citing works
Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882 · see citing works
Plasticity of brain networks in a randomized intervention trial of exercise training in older adults
Voss (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00032 · Cited by 841 · see citing works
Physical activity, fitness, and gray matter volume
Erickson, K. I., Leckie, R. L., & Weinstein, A. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.034 · Cited by 630 · see citing works
Hippocampal Plasticity in Response to Exercise in Schizophrenia
Pajonk, F.-G., Wobrock, T., Gruber, O., Scherk, H., Berner, D., Kaizl, I., Kierer, A., Müller, S., Oest, M., Meyer, T., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.193 · Cited by 592 · see citing works
Laird, A. R., Eickhoff, S. B., Li, K., Robin, D. A., Glahn, D. C., & Fox, P. T. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4004-09.2009 · Cited by 550 · see citing works
Physical activity predicts gray matter volume in late adulthood: The Cardiovascular Health Study
Erickson, K. I., Raji, C. A., Lopez, O. L., Becker, J. T., Rosano, C., Newman, A. B., Gach, H. M., Thompson, P. M., Ho, A. J., & Kuller, L. H. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f88359 · Cited by 508 · see citing works
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499 · see citing works
Voelcker‐Rehage, C., & Niemann, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.028 · Cited by 442 · see citing works
Cognitive Psychology: Mind and Brain
Smith, E. E., & Kosslyn, S. M. (2007) · Cited by 402 · see citing works
Suzuki, T., Shimada, H., Makizako, H., Doi, T., Yoshida, D., Ito, K., Shimokata, H., Washimi, Y., Endo, H., & Kato, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061483 · Cited by 390 · see citing works
ten Brinke, L. F., Bolandzadeh, N., Nagamatsu, L. S., Hsu, C. L., Davis, J. C., Miran-Khan, K., & Liu-Ambrose, T. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2013-093184 · Cited by 380 · see citing works
The structural–functional connectome and the default mode network of the human brain
Horn, A., Ostwald, D., Reisert, M., & Blankenburg, F. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.09.069 · Cited by 355 · see citing works
Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling
Phillips, C., Baktir, M. A., Srivatsan, M., & Salehi, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00170 · Cited by 330 · see citing works
Impairment and compensation coexist in amnestic MCI default mode network
Qi, Z., Wu, X., Wang, Z., Zhang, N., Dong, H., Yao, L., & Li, K. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.025 · Cited by 323 · see citing works
Using network science to evaluate exercise-associated brain changes in older adults.
Burdette (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00023 · Cited by 320 · see citing works
Lanius, R. A., Bluhm, R. L., Coupland, N. J., Hegadoren, K. M., Rowe, B., Théberge, J., Neufeld, R. W. J., Williamson, P. C., & Brimson, M. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01391.x · Cited by 273 · see citing works
Medial temporal theta state before an event predicts episodic encoding success in humans
Guderian, S., Schott, B. H., Richardson-Klavehn, A., & Düzel, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900289106 · Cited by 260 · see citing works
Flöel, A., Ruscheweyh, R., Krüger, K., Willemer, C., Winter, B., Völker, K., Lohmann, H., Zitzmann, M., Mooren, F. C., Breitenstein, C., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.043 · Cited by 243 · see citing works
Brain Changes in Older Adults at Very Low Risk for Alzheimer's Disease
Fjell, A. M., McEvoy, L. K., Holland, D., Dale, A. M., Walhovd, K. B., & Initiative, A. D. N. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5506-12.2013 · Cited by 227 · see citing works
Physical activity and the brain: A review of this dynamic, bi-directional relationship
Loprinzi, P. D., Herod, S. M., Cardinal, B. J., & Noakes, T. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.004 · Cited by 222 · see citing works
Niemann, C., Godde, B., & Voelcker-Rehage, C. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00170 · Cited by 190 · see citing works
Mining the posterior cingulate: Segregation between memory and pain components
Nielsen, F. Å., Balslev, D., & Hansen, L. K. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.04.034 · Cited by 185 · see citing works
Longitudinal Structure-Function Correlates in Elderly Reveal MTL Dysfunction with Cognitive Decline
Persson, J., Pudas, S., Lind, J., Kauppi, K., Nilsson, L.-G., & Nyberg, L. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr306 · Cited by 173 · see citing works
Psychomotor Speed and Functional Brain MRI 2 Years After Completing a Physical Activity Treatment
Rosano, C., Venkatraman, V. K., Guralnik, J. M., Newman, A. B., Glynn, N. W., Launer, L. J., Taylor, C. A., Williamson, J. D., Studenski, S. A., Pahor, M., et al. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq038 · Cited by 165 · see citing works
Moore, S. A., Hallsworth, K., Jakovljević, D. G., Blamire, A. M., He, J., Ford, G. A., Rochester, L., & Trenell, M. I. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314562116 · Cited by 161 · see citing works
The relation between structural and functional connectivity patterns in complex brain networks
Stam, C. J., van Straaten, E. C. W., van Dellen, E., Tewarie, P. K. B., Gong, G., Hillebrand, A., Meier, J. M., & Mieghem, P. V. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.02.011 · Cited by 157 · see citing works
Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease
Smith, J. C., Nielson, K. A., Woodard, J. L., Seidenberg, M., Durgerian, S., Hazlett, K. E., Figueroa, C. M., Kandah, C. C., Kay, C. D., Matthews, M. A., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00061 · Cited by 156 · see citing works
Scheewe, T. W., van Haren, N. E. M., Sarkisyan, G., Schnack, H. G., Brouwer, R. M., de Glint, M., Hulshoff Pol, H. E., Backx, F. J. G., Kahn, R. S., & Cahn, W. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.08.008 · Cited by 148 · see citing works
Leavitt, V. M., Cirnigliaro, C., Cohen, A., Farag, A., Brooks, M., Wecht, J. M., Wylie, G. R., Chiaravalloti, N. D., DeLuca, J., & Sumowski, J. F. (2014) · Neurocase · doi:10.1080/13554794.2013.841951 · Cited by 134 · see citing works
Krogh, J., Rostrup, E., Thomsen, C., Elfving, B., Videbech, P., & Nordentoft, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.041 · Cited by 123 · see citing works
Li, R., Zhu, X., Yin, S., Niu, Y., Zheng, Z., Huang, X., Wang, B., & Li, J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00039 · Cited by 120 · see citing works
Longitudinal assessment of default-mode brain function in aging
Persson, J., Pudas, S., Nilsson, L., & Nyberg, L. H. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.012 · Cited by 105 · see citing works
Default mode network as a potential biomarker of chemotherapy-related brain injury
Kesler, S. R. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.036 · Cited by 100 · see citing works
Physical activity and brain development
Gomes da Silva, S., & Arida, R. M. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1077115 · Cited by 89 · see citing works
Ezzati, A., Katz, M. J., Lipton, M. L., Zimmerman, M. E., & Lipton, R. B. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9452-y · Cited by 79 · see citing works
Bigger is better! Hippocampal volume and declarative memory performance in healthy young men
Pohlack, S. T., Meyer, P., Cacciaglia, R., Liebscher, C., Ridder, S., & Flor, H. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0497-z · Cited by 78 · see citing works
Physical activity and white matter hyperintensities: A systematic review of quantitative studies
Torres, E. R., Strack, E. F., Fernandez, C. E., Tumey, T. A., & Hitchcock, M. (2015) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2015.04.013 · Cited by 70 · see citing works
Physical Activity Predicts Microstructural Integrity in Memory-Related Networks in Very Old Adults
Tian, Q., Erickson, K. I., Simonsick, E. M., Aizenstein, H. J., Glynn, N. W., Boudreau, R. M., Newman, A. B., Kritchevsky, S. B., Yaffe, K. S., Harris, T. B., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt287 · Cited by 70 · see citing works
Falkai, P., Malchow, B., Wobrock, T., Gruber, O., Schmitt, A., Honer, W. G., Pajonk, F.-G., Sun, F., & Cannon, T. D. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0383-y · Cited by 68 · see citing works
Potential Moderators of Physical Activity on Brain Health
Leckie, R. L., Weinstein, A. M., Hodzic, J. C., & Erickson, K. I. (2012) · Journal of Aging Research · doi:10.1155/2012/948981 · Cited by 42 · see citing works
Drenowatz, C., Grieve, G. L., & DeMello, M. M. (2015) · SpringerPlus · doi:10.1186/s40064-015-1594-2 · Cited by 38 · see citing works
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Kandola, A., Ashdown-Franks, G., Hendrikse, J., Sabiston, C. M., & Stubbs, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.040 · Cited by 1,309 · see citing works
Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines
ERICKSON, K. I., HILLMAN, C., STILLMAN, C. M., BALLARD, R. M., BLOODGOOD, B., CONROY, D. E., MACKO, R., MARQUEZ, D. X., PETRUZZELLO, S. J., & POWELL, K. E. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001936 · Cited by 1,214 · see citing works
Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis
Firth, J., Stubbs, B., Vancampfort, D., Schuch, F., Lagopoulos, J., Rosenbaum, S., & Ward, P. B. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.11.007 · Cited by 526 · see citing works
The Role of Exercise in Management of Mental Health Disorders: An Integrative Review
Smith, P. J., & Merwin, R. M. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-060619-022943 · Cited by 360 · see citing works
Anderson‐Hanley, C., Barcelos, N. M., Zimmerman, E. A., Gillen, R. W., Dunnam, M., Cohen, B. D., Yerokhin, V., Miller, K. E., Hayes, D. J., Arciero, P. J., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00076 · Cited by 188 · see citing works
Kandola, A., Ashdown-Franks, G., Stubbs, B., Osborn, D. P. J., & Hayes, J. F. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.088 · Cited by 172 · see citing works
Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing
Tari, A. R., Walker, T. L., Huuha, A. M., Sando, S. B., & Wisløff, U. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00184-9 · Cited by 174 · see citing works
Liu, Y., Yan, T., Chu, J. M. T., Chen, Y., Dunnett, S. L., Ho, J. Y. S., Wong, G. T. C., & Chang, R. C. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0232-y · Cited by 161 · see citing works
Dance on the Brain: Enhancing Intra- and Inter-Brain Synchrony
Basso, J. C., Satyal, M. K., & Rugh, R. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.584312 · Cited by 162 · see citing works
Festa, F., Medori, S., & Macrì, M. (2023) · Biomedicines · doi:10.3390/biomedicines11061765 · Cited by 74 · see citing works
Jemni, M., Zaman, R., Carrick, F. R., Clarke, N. D., Marina, M., Bottoms, L. M., Matharoo, J. S., Ramsbottom, R., Hoffman, N., Groves, S. J., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1102526 · Cited by 77 · see citing works
Bhushan, D., Kotz, K. J., McCall, J., Wirtz, S., Gilgoff, R., Dube, S. R., Powers, C., Olson-Morgan, J., Galeste, M., Patterson, K., et al. (2020) · doi:10.48019/peam8812 · Cited by 71 · see citing works
Papiol, S., Popovic, D., Keeser, D., Hasan, A., Schneider-Axmann, T., Degenhardt, F., Rossner, M. J., Bickeböller, H., Schmitt, A., Falkai, P., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.131 · Cited by 62 · see citing works
Dhir, S., Teo, W., Chamberlain, S. R., Tyler, K., Yücel, M., & Segrave, R. A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.008 · Cited by 60 · see citing works
Moore, D., Jung, M., Hillman, C. H., Kang, M., & Loprinzi, P. D. (2022) · Psychophysiology · doi:10.1111/psyp.14014 · Cited by 60 · see citing works
Hvid, L. G., Harwood, D. S. L., Eskildsen, S. F., & Dalgas, U. (2021) · Sports Medicine · doi:10.1007/s40279-021-01453-6 · Cited by 52 · see citing works
Umegaki, H., Sakurai, T., & Arai, H. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.761674 · Cited by 51 · see citing works
Aerobic exercise promotes emotion regulation: a narrative review
Wang, X., Liu, T., Jin, X., & Zhou, C. (2024) · Experimental Brain Research · doi:10.1007/s00221-024-06791-1 · Cited by 49 · see citing works
Bray, N. W., Pieruccini‐Faria, F., Bartha, R., Doherty, T. J., Nagamatsu, L. S., & Montero‐Odasso, M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111493 · Cited by 42 · see citing works
Serra, L., Petrosini, L., Mandolesi, L., Bonarota, S., Balsamo, F., Bozzali, M., Caltagirone, C., & Gelfo, F. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192316310 · Cited by 43 · see citing works
Zheng, G., Ye, B., Xia, R., Qiu, P., Li, M., Zheng, Y., & Xiong, Z. (2021) · Brain Plasticity · doi:10.3233/bpl-210121 · Cited by 38 · see citing works
Self-citationGawryluk, J. R., Palombo, D. J., Curran, J., Parker, A. F., & Carlsten, C. (2023) · Environmental Health · doi:10.1186/s12940-023-00961-4 · Cited by 33 · see citing works
Papiol, S., Keeser, D., Hasan, A., Schneider-Axmann, T., Raabe, F. J., Degenhardt, F., Rossner, M. J., Bickeböller, H., Cantuti‐Castelvetri, L., Simons, M., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0618-z · Cited by 32 · see citing works
Balážová, Z., Mareček, R., Novakova, L., Elfmarková, N., Kropáčová, S., Brabenec, L., Grmela, R., Vaculíková, P., Svobodová, L., & Rektorová, I. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.724064 · Cited by 32 · see citing works
Morgan, J., Singhal, G., Corrigan, F., Jaehne, E. J., Jawahar, M. C., Breen, J., Pederson, S., & Baune, B. T. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.02.014 · Cited by 29 · see citing works
Static Stretching Reduces Motoneuron Excitability: The Potential Role of Neuromodulation
Trajano, G. S., & Blazevich, A. J. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000243 · Cited by 32 · see citing works
New principles, the benefits, and practices for fostering a physically active lifestyle
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The effects of physical exercise on parahippocampal function
Loprinzi, P. D. (2019) · Physiology International · doi:10.1556/2060.106.2019.10 · Cited by 26 · see citing works
Can exercise attenuate the negative effects of long COVID syndrome on brain health?
Teo, W., & Goodwill, A. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.986950 · Cited by 25 · see citing works
Chao, Y., Wu, C. W., Lin, L.-J., Lai, C., Wu, H.-Y., Hsu, A., & Chen, C.-N. (2020) · Journal of Medical and Biological Engineering · doi:10.1007/s40846-020-00522-x · Cited by 25 · see citing works
Budak, M., Bayraktaroğlu, Z., & Hanoğlu, L. (2022) · Cognitive Neurodynamics · doi:10.1007/s11571-022-09818-x · Cited by 25 · see citing works
Bray, N. W., Pieruccini‐Faria, F., Witt, S. T., Bartha, R., Doherty, T. J., Nagamatsu, L. S., Almeida, Q. J., Liu-Ambrose, T. Y. L., Middleton, L. E., Bherer, L., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00805-6 · Cited by 25 · see citing works
Krootnark, K., Chaikeeree, N., Saengsirisuwan, V., & Boonsinsukh, R. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1392429 · Cited by 28 · see citing works
Machida, M., Takamiya, T., Amagasa, S., Murayama, H., Fujiwara, T., Odagiri, Y., Kikuchi, H., Fukushima, N., Kouno, M., Saito, Y., et al. (2021) · Journal of Epidemiology · doi:10.2188/jea.je20200534 · Cited by 23 · see citing works
Novel Strategies for Healthy Brain Aging
Wahl, D., Cavalier, A. N., & LaRocca, T. J. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000242 · Cited by 23 · see citing works
Edgcumbe, D. R., Thoma, V., Rivolta, D., Nitsche, M. A., & Fu, C. H. Y. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.12.003 · Cited by 22 · see citing works
Dotson, V. M., Gradone, A. M., Bogoian, H. R., Minto, L. R., Taiwo, Z., & Salling, Z. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617721000710 · Cited by 19 · see citing works
Jia, Y., Yao, Y., Zhuo, L., Chen, X., Yan, C., Ji, Y., Tao, J., & Zhu, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.862078 · Cited by 20 · see citing works
Self-citationKerkenberg, N., Wachsmuth, L., Zhang, M., Schettler, C., Ponimaskin, E. G., Faber, C., Baune, B. T., Zhang, W., & Hohoff, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15415 · Cited by 20 · see citing works
Gilgoff, R., Mengelkoch, S., Elbers, J. M., Kotz, K. J., Radin, A. S., Pasumarthi, I., Murthy, R., Sindher, S., Harris, N. B., & Slavich, G. M. (2024) · Stress · doi:10.1080/10253890.2024.2327333 · Cited by 21 · see citing works
Effects of Exercise on Neural Changes in Inhibitory Control: An ALE Meta-Analysis of fMRI Studies
Wu, J., Xiao, W., Yip, J. Y. W., Peng, L. H., Zheng, K., Bentil, O. T., & Ren, Z. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.891095 · Cited by 18 · see citing works
Koevoets, E. W., Geerlings, M. I., Monninkhof, E. M., Mandl, R. C. W., Witlox, L., van der Wall, E., Stuiver, M. M., Sonke, G. S., Velthuis, M. J., Jobsen, J. J., et al. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103292 · Cited by 18 · see citing works
Physical Activity and Moving More for Health
Crooke, R., Haseler, C., Haseler, T. W. L., Collins, J., & Crockett, A. (2020) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.4997/jrcpe.2020.223 · Cited by 18 · see citing works
Maurus, I., Roell, L., Keeser, D., Papazov, B., Papazova, I., Lembeck, M., Roeh, A., Wagner, E. M., Hirjak, D., Malchow, B., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02155-x · Cited by 17 · see citing works
Wang, Y., Wang, L., Yan, J., Yuan, X., & Lou, Q. (2023) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-2105-0799 · Cited by 16 · see citing works
Swimming exercise improves short‐ and long‐term memories: Time‐course changes
Alomari, M. A., Alzoubi, K. H., & Khabour, O. F. (2021) · Physiological Reports · doi:10.14814/phy2.14851 · Cited by 16 · see citing works
Lin, M., Liu, W., Ma, C., Gao, J., Huang, L., Zhu, J., Liang, S., He, Y., Liu, J., Tao, J., et al. (2024) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2024.04.012 · Cited by 14 · see citing works
Self-citationJahrami, H., BaHammam, A. S., Stubbs, B., Sabah, A., Saif, Z., Bragazzi, N. L., & Vitiello, M. V. (2021) · Sleep And Breathing · doi:10.1007/s11325-021-02388-y · Cited by 15 · see citing works
Shared brain and genetic architectures between mental health and physical activity
Zhang, W., Paul, S. E., Winkler, A. M., Bogdan, R., & Bijsterbosch, J. D. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02172-w · Cited by 15 · see citing works
Peven, J. C., Litz, G. A., Brown, B. M., XiaoFeng, X., Grove, G., Watt, J. C., & Erickson, K. I. (2019) · Brain Plasticity · doi:10.3233/bpl-190085 · Cited by 14 · see citing works
Maurus, I., Röll, L., Keeser, D., Karali, T., Papazov, B., Hasan, A., Schmitt, A., Papazova, I., Lembeck, M., Hirjak, D., et al. (2022) · Schizophrenia · doi:10.1038/s41537-022-00269-1 · Cited by 13 · see citing works
Blumen, H., Ayers, E., Wang, C.-L., Ambrose, A., Jayakody, O., & Verghese, J. (2022) · Journal of Aging and Physical Activity · doi:10.1123/japa.2022-0176 · Cited by 13 · see citing works
Brown, B. M., de Frutos‐Lucas, J., Porter, T., Frost, N. J., Vacher, M. A., Peiffer, J. J., & Laws, S. M. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220114 · Cited by 13 · see citing works
Roell, L., Keeser, D., Papazov, B., Lembeck, M., Papazova, I., Greska, D., Muenz, S., Schneider-Axmann, T., Sykorova, E. B., Thieme, C. E., et al. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad113 · Cited by 13 · see citing works
Roell, L., Fischer, T., Keeser, D., Papazov, B., Lembeck, M., Papazova, I., Greska, D., Muenz, S., Schneider-Axmann, T., Sykorova, E. B., et al. (2024) · Psychological Medicine · doi:10.1017/s0033291724001867 · Cited by 13 · see citing works
Berns, C., Brüchle, W., Scho, S., Schneefeld, J., Schneider, U., & Rosenkranz, K. (2020) · Experimental Brain Research · doi:10.1007/s00221-020-05933-5 · Cited by 12 · see citing works
Hippocampal subfield plasticity is associated with improved spatial memory
Boecker, H., Daamen, M., Kunz, L., Geiß, M., Müller, M., Neuss, T., Henschel, L., Stirnberg, R., Upadhyay, N., Scheef, L., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05949-5 · Cited by 11 · see citing works
Rosso, C., Brustio, P. R., Manuello, J., & Rainoldi, A. (2025) · Sports · doi:10.3390/sports13080280 · Cited by 11 · see citing works
Tai Chi Practice Buffers Aging Effects in Functional Brain Connectivity
Cerna, J., Gupta, P., He, M., Ziegelman, L., Hu, Y., & Hernandez, M. E. (2024) · Brain Sciences · doi:10.3390/brainsci14090901 · Cited by 10 · see citing works
Schmill, M. P., Thompson, Z., Lee, D., Haddadin, L., Mitra, S., Ezzat, R., Shelton, S. M., Levin, P., Behnam, S., Huffman, K. J., et al. (2023) · Brain Behavior and Evolution · doi:10.1159/000533524 · Cited by 10 · see citing works
Lian, N., Lv, H., Guo, W., Shen, Y., Wu, R., Liu, Y. H., Zhu, F., Hu, M., Ou, J., & Zhao, J. (2018) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32644 · Cited by 10 · see citing works
Jennen, L., Mazereel, V., Lecei, A., Samaey, C., Vancampfort, D., & van Winkel, R. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0156 · Cited by 10 · see citing works
Xie, H., Zhang, F., Cao, Y., Long, X., Wu, B., Gong, Q., & Jia, Z. (2022) · Journal of Behavioral Addictions · doi:10.1556/2006.2022.00067 · Cited by 9 · see citing works
Bigliassi, M., Cabral, D. F., Kotler, S., Mannino, M., Mavrantza, A. M., Oparina, E., & Gomes‐Osman, J. (2023) · Psychophysiology · doi:10.1111/psyp.14437 · Cited by 9 · see citing works
Change in Cardiorespiratory Fitness and Risk of Depression, Anxiety, and Cerebrovascular Disease
Wiklund, C. A., Lindwall, M., Ekblom, Ö. B., Nyberg, J., Åberg, M., Paulsson, S. Å., & Ekblom‐Bak, E. (2024) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2024.07.012 · Cited by 9 · see citing works
Sport und körperliche Bewegung bei unipolarer Depression
Repple, J., & Opel, N. (2021) · Der Nervenarzt · doi:10.1007/s00115-021-01113-0 · Cited by 9 · see citing works
Physical activity and hippocampal volume in young adults
Cherednichenko, A., Miró‐Padilla, A., Adrián‐Ventura, J., Monzonís‐Carda, I., Beltran‐Valls, M. R., Moliner‐Urdiales, D., & Ávila, C. (2024) · Brain Imaging and Behavior · doi:10.1007/s11682-024-00916-4 · Cited by 8 · see citing works
Taking neurogenesis out of the lab and into the world with MAP Train My Brain™
Millon, E. M., & Shors, T. J. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112154 · Cited by 8 · see citing works
Yan, H., Xin, G., & Chen, R. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1623506 · Cited by 12 · see citing works
Dehsarvi, A., Al‐Wasity, S., Stefanov, K., Wiseman, S. J., Ralston, S. H., Wardlaw, J. M., Emsley, R., Bachmair, E., Cavanagh, J., Waiter, G. D., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42755 · Cited by 7 · see citing works
Hippocampal Subfield Volumes in Amateur Marathon Runners
Ao, Y.-W., LI, Y.-S., ZHAO, Y.-L., Zhang, L., YANG, R.-J., & Zha, Y. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003144 · Cited by 6 · see citing works
Holmlund, T., Blom, V., Hemmingsson, E., Ekblom, B. T., Andersson, G. B. J., Wallin, P., & Ekblom‐Bak, E. (2021) · Scandinavian Journal of Public Health · doi:10.1177/14034948211047140 · Cited by 6 · see citing works
Wang, H., Jülich, S. T., & Lei, X. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.10.023 · Cited by 6 · see citing works
Sun, R., Ma, P., He, Z., Yin, T., Qu, Y., Yin, S., Liu, X., Jin, L., Zhang, T., Huang, L., et al. (2020) · 世界针灸杂志:英文版 · doi:10.1016/j.wjam.2020.10.009 · Cited by 6 · see citing works
Rezavandzayeri, F., Vila, H., Khortabi, A., & Carral, J. M. C. (2024) · Retos · doi:10.47197/retos.v54.102554 · Cited by 5 · see citing works
Penukonda, S., Srinivasan, S., Tarumi, T., Tomoto, T., Sheng, M., Cullum, C. M., Zhang, R., Lu, H., & Thomas, B. P. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251325575 · Cited by 5 · see citing works
General Neural Process in Cycling Exercise
Scholler, V., Groslambert, A., Grappe, F., & Grosprêtre, S. (2022) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-022-00170-4 · Cited by 5 · see citing works
Cevada, T., Moreira, A., Vilete, L. M. P., Oertel‐Knöchel, V., & Deslandes, A. C. (2020) · The Open Sports Sciences Journal · doi:10.2174/1875399x02013010086 · Cited by 6 · see citing works
Randolph, J. J., Lacritz, L. H., Colvin, M. K., Espe‐Pfeifer, P., Carter, K. R., Arnett, P. A., Fox‐Fuller, J. T., Aduen, P. A., Cullum, C. M., & Sperling, S. A. (2023) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acad078 · Cited by 4 · see citing works
Vriend, C., Verhoeven, J. E., van Velzen, L. S., Schmaal, L., Penninx, B. W. J. H., & Han, L. K. M. (2025) · NeuroImage Clinical · doi:10.1016/j.nicl.2025.103812 · Cited by 4 · see citing works
Gust, C. J., Moe, E. N., Seals, D. R., Banich, M. T., Andrews‐Hanna, J. R., Hutchison, K. E., & Bryan, A. D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.858405 · Cited by 4 · see citing works
Lifestyle Factors and Successful Cognitive Aging in Older Adults
O’Connor, M. K., Kraft, M. L., & Randolph, J. J. (2022) · Springer eBooks · doi:10.1007/978-3-031-11389-5_3 · Cited by 4 · see citing works
Papiol, S., Roell, L., Maurus, I., Hirjak, D., Keeser, D., Schmitt, A., Meyer‐Lindenberg, A., & Falkai, P. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01841-9 · Cited by 4 · see citing works
Modifying modularity: aerobic exercise improves functional connectivity in breast cancer survivors
Page, L. L., Heller, A. M., Phipps, C. J., Berger, A. M., Reed, E. C., Warren, D. E., & Ehlers, D. K. (2024) · Frontiers in Cognition · doi:10.3389/fcogn.2024.1323438 · Cited by 3 · see citing works
Roell, L., & Maurus, I. (2023) · doi:10.31219/osf.io/y2phs · Cited by 3 · see citing works
Exercise-induced neuroplasticity
Neva, J. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00218-7 · Cited by 3 · see citing works
From hypoxic pockets to daily routines: linking brain oxygenation and cognitive resilience
Jiao, D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1534198 · Cited by 2 · see citing works
Physical and Cognitive Exercise for Patients with Dementia
Frederiksen, K. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-77904-7_13 · Cited by 1 · see citing works
Lee, J., Kim, Y., & An, D. (2025) · International Journal of Mental Health Promotion · doi:10.32604/ijmhp.2025.061234 · Cited by 1 · see citing works
O’Connor, M. K., Szemko, J. N., McLaren, J. E., Moo, L. R., Metcalf, E. E., Nguyen, A. H., Kraft, M. L., Frank, B. E., Salat, D. H., Randolph, J. J., et al. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06207-x · Cited by 1 · see citing works
Singh, S., Shaw, S. B., & Becker, S. (2026) · Cognitive Neurodynamics · doi:10.1007/s11571-026-10425-3 · Cited by 1 · see citing works
Centner, C., Ritzmann, R., Marušič, U., & Hughes, L. (2026) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2026.106189 · Cited by 1 · see citing works
Motif-aware brain functional connectivity network analysis for cognitive disorder diagnosis
Chen, D., Yao, L., Bai, L., Hancock, E. R., & Zhang, L. (2026) · Pattern Recognition · doi:10.1016/j.patcog.2026.113655 · Cited by 1 · see citing works
Cognitive Benefits of Physical Activity in the Elderly: A Narrative Review
Ghosh, A., Jagtap, T., & Issac, T. G. (2023) · Journal of Psychiatry Spectrum · doi:10.4103/jopsys.jopsys_40_23 · Cited by 1 · see citing works
Scientific Evidence of Baduanjin Improving Cognitive Function in Patients with Cognitive Impairment
唐, 琼. (2024) · Open Journal of Natural Science · doi:10.12677/ojns.2024.122032 · Cited by 1 · see citing works
Malchow, B., Lembeck, M., Maurus, I., Roeh, A., Papiol, S., Hasan, A., Falkai, P., & Schmitt, A. (2018) · Nervenheilkunde · doi:10.1055/s-0038-1651942
Exercise and brain function in obese & overweight people - a review
Ghosal, S., & Ghosal, A. K. (2021) · Journal of Diabetes Metabolic Disorders & Control · doi:10.15406/jdmdc.2021.08.00224
Shahidi, ., Rafiee, H., Sohrabi, S., Mohebi, N., Jahani, M., Sohrabi, F., Hakhamaneshi, E., Mohamadaiazar, S., Komaki, A., Afshar, S., et al. (2023) · Physiology and Pharmacology · doi:10.61186/phypha.27.2.161
Heller, A. M., Phipps, C. J., Sexton, J., Ramirez, M. K., & Warren, D. E. (2023) · Brain Sciences · doi:10.3390/brainsci13111558 · Cited by 2 · see citing works
- Authors
- Li, M.-Y., Huang, M.-M., Li, S.-Z., Tao, J., Zheng, G.-H., & Chen, L.-D.
- Affiliations
- Fujian University of Traditional Chinese Medicine (CN)
- ORCID
- Tao, Jing
- Venue
- International Journal of Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2016-08-05
- Volume
- 127
- Issue
- 7
- Pages
- 634-649
- ISSN
- 0020-7454 (ISSN-L)
- 1543-5245
- OpenAlex
- W2465904396
- Cited by
- 109
- References
- 58
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 15 · 2023: 19 · 2022: 17 · 2021: 18 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 2
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- aerobic exercise, default mode network, hippocampal volume, anterior cingulate cortex, medial temporal lobe atrophy, brain atrophy, functional connectivity, brain structure, physical activity, cognitive aging
- MeSH terms
- Brain, Brain Diseases, Exercise Therapy, Humans, Nerve Net, Exercise
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