RNA m6A modification and its function in diseases

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

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A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

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N6-methyladenosine Modulates Messenger RNA Translation Efficiency

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A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

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Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

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Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

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Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing

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5′ UTR m6A Promotes Cap-Independent Translation

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Identification of Methylated Nucleosides in Messenger RNA from Novikoff Hepatoma Cells

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m6A RNA methylation promotes XIST-mediated transcriptional repression

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Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

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Variation in FTO contributes to childhood obesity and severe adult obesity

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Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

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m 6 A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

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HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

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FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

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YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

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m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program

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RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

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HITS-CLIP yields genome-wide insights into brain alternative RNA processing

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N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

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m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

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Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

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m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

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The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

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Dynamic m6A mRNA methylation directs translational control of heat shock response

Zhou, J. L., Wan, J., Gao, X., Zhang, X., Jaffrey, S. R., & Qian, S. (2015) · Nature · doi:10.1038/nature15377 · Cited by 1,228 · see citing works

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

Wang, X., Feng, J. Q., Xue, Y. C., Guan, Z., Zhang, D., Liu, Z., Gong, Z., Wang, Q., Huang, J. B., Tang, C., et al. (2016) · Nature · doi:10.1038/nature18298 · Cited by 1,218 · see citing works

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

Schwartz, S., Mumbach, M. R., Jovanović, M., Wang, T., Maciag, K., Bushkin, G. G., Mertins, P., Ter‐Ovanesyan, D., Habib, N., Cacchiarelli, D., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.048 · Cited by 1,213 · see citing works

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Su, R., Dong, L., Li, C., Nachtergaele, S., Wunderlich, M., Qing, Y., Deng, X., Wang, Y., Weng, X., Hu, C., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.031 · Cited by 1,137 · see citing works

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

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The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention

Pendleton, K. E., Chen, B., Liu, K., Hunter, O. V., Xie, Y., Tu, B. P., & Conrad, N. K. (2017) · Cell · doi:10.1016/j.cell.2017.05.003 · Cited by 1,095 · see citing works

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

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Reversible methylation of m6Am in the 5′ cap controls mRNA stability

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m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

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Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.

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RNA m6A methylation regulates the ultraviolet-induced DNA damage response

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Structural imprints in vivo decode RNA regulatory mechanisms

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Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

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MTA Is an Arabidopsis Messenger RNA Adenosine Methylase and Interacts with a Homolog of a Sex-Specific Splicing Factor

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High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis

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m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination

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m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

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m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

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m6A modulates neuronal functions and sex determination in Drosophila

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The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

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m 6 A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnoverPreprint

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Structural insights into the molecular mechanism of the m6A writer complex

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N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection

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Grand Challenge Commentary: RNA epigenetics?

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Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation

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Oxidative demethylation of 3‐methylthymine and 3‐methyluracil in single‐stranded DNA and RNA by mouse and human FTO

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Dynamics of Human and Viral RNA Methylation during Zika Virus Infection

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Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex

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Posttranscriptional m6A Editing of HIV-1 mRNAs Enhances Viral Gene Expression

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m6A mRNA methylation sustains Treg suppressive functions

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IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

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N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression

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RNA Methylation by the MIS Complex Regulates a Cell Fate Decision in Yeast

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RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated

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Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain

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Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA

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The m6A pathway facilitates sex determination in Drosophila

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RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

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The absolute frequency of labeled N-6-methyladenosine in HeLa cell messenger RNA decreases with label time

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The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila

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Our views of dynamic N6-methyladenosine RNA methylation

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Probing RNA Modification Status at Single-Nucleotide Resolution in Total RNA

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The gene fl(2)d is needed for the sex-specific splicing of transformer pre-mRNA but not for double-sex pre-mRNA in Drosophila melanogaster

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Methylation and processing of transfer ribonucleic acid in mammalian and bacterial cells.

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m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

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METTL3-mediated m 6 A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance

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METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

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Role of m6A RNA methylation in cardiovascular disease (Review)

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Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

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N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2

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Naturally occurring modified ribonucleosides

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Pooled CRISPR screening identifies m 6 A as a positive regulator of macrophage activation

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METTL3-mediated m6A modification of TIMP2 mRNA promotes podocyte injury in diabetic nephropathy

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m 6 A demethylase ALKBH5 controls CD4 + T cell pathogenicity and promotes autoimmunity

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METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway

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m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma

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3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line

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Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

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RNA modifications and cancer

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Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage

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IGF2BP2 Promotes Liver Cancer Growth Through an m6A-FEN1-Dependent Mechanism

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m6A-YTHDF1-mediated TRIM29 upregulation facilitates the stem cell-like phenotype of cisplatin-resistant ovarian cancer cells

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Functions, mechanisms, and therapeutic implications of METTL14 in human cancer

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Function and evolution of RNA N6-methyladenosine modification

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YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA

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METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte

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METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway

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IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome

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The essential roles of m6A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma

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Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke

Si, W., Li, Y., Ye, S., Li, Z., Liu, Y., Kuang, W., Chen, D., & Zhu, M. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00103 · Cited by 111 · see citing works

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling

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Multiple Functions and Mechanisms Underlying the Role of METTL3 in Human Cancers

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Emerging role of m6A RNA methylation in nutritional physiology and metabolism

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microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation

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m6A RNA methylation regulators could contribute to the occurrence of chronic obstructive pulmonary disease

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The emerging molecular mechanism of m6A modulators in tumorigenesis and cancer progression

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VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer

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Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm

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Potential roles of N6-methyladenosine (m6A) in immune cells

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The Emerging Role of m6A Modification in Regulating the Immune System and Autoimmune Diseases

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METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma

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Identification of the Role and Clinical Prognostic Value of Target Genes of m6A RNA Methylation Regulators in Glioma

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Connecting METTL3 and intratumoural CD33+ MDSCs in predicting clinical outcome in cervical cancer

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Significance of RNA N6-Methyladenosine Regulators in the Diagnosis and Subtype Classification of Childhood Asthma Using the Gene Expression Omnibus Database

Dai, B., Sun, F., Cai, X., Li, C., Liu, H., & Shang, Y. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.634162 · Cited by 77 · see citing works

METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response

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Long Non-Coding RNA Epigenetics

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METTL3 expression is associated with glycolysis metabolism and sensitivity to glycolytic stress in hepatocellular carcinoma

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TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2

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Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications

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Genome-Wide Screening of Altered m6A-Tagged Transcript Profiles in the Hippocampus after Traumatic Brain Injury in Mice

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m6A RNA Methylation Regulators Participate in the Malignant Progression and Have Clinical Prognostic Value in Lung Adenocarcinoma

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Structures and target RNA preferences of the RNA-binding protein family of IGF2BPs: An overview

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Discovery of Pyrazolo[1,5-a]pyrimidine Derivative as a Novel and Selective ALKBH5 Inhibitor for the Treatment of AML

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eIF-Three to Tango: emerging functions of translation initiation factor eIF3 in protein synthesis and disease

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The molecular structure and biological functions of RNA methylation, with special emphasis on the roles of RNA methylation in autoimmune diseases

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Identification of METTL14 in Kidney Renal Clear Cell Carcinoma Using Bioinformatics Analysis

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Resveratrol Attenuates Aflatoxin B1-Induced ROS Formation and Increase of m6A RNA Methylation

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Regulation of RNA N6-methyladenosine modification and its emerging roles in skeletal muscle development

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Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury

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ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction

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METTL3 potentiates progression of cervical cancer by suppressing ER stress via regulating m6A modification of TXNDC5 mRNA

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N 6 ‐methyladenosine (m 6 A) RNA modification in human cancer

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RNA Biology Provides New Therapeutic Targets for Human Disease

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Recent developments of small molecules targeting RNA m6A modulators

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Insights into roles of METTL14 in tumors

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TGF-β signaling promotes cervical cancer metastasis via CDR1as

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Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA

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LncRNA CACNA1G-AS1 up-regulates FTH1 to inhibit ferroptosis and promote malignant phenotypes in ovarian cancer cells

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mRNA Metabolism in Cardiac Development and Disease: Life After Transcription

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Reprogramming of m 6 A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia

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Multiple Functions of RNA Methylation in T Cells: A Review

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miR-338-5p inhibits cell growth and migration via inhibition of the METTL3/m6A/c-Myc pathway in lung cancer

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TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4

Wang, H., Wei, W., Zhang, Z., Liu, Y., Shi, B., Zhong, W., Zhang, H.-S., Fang, X., Sun, C., Wang, J., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04459-0 · Cited by 41 · see citing works

N6‑methyladenine RNA modification and cancer (Review)

Jun, Y., Chen, J., Fei, X., Wang, X., & Wang, K. (2020) · Oncology Letters · doi:10.3892/ol.2020.11739 · Cited by 41 · see citing works

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Li, J., Dai, Y., Wu, L., Zhang, M., Ouyang, W., Huang, J., & Chen, S. (2021) · Frontiers of Medicine · doi:10.1007/s11684-020-0821-6 · Cited by 43 · see citing works

N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4

van den Homberg, D. A. L., van der Kwast, R. V. C. T., Quax, P. H. A., & Nossent, A. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031057 · Cited by 41 · see citing works

M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis

Guo, W., Zhang, C., Feng, P., Li, M., Wang, X., Xia, Y., Chen, D., & Li, J. (2021) · Oncogene · doi:10.1038/s41388-021-01987-z · Cited by 40 · see citing works

FTO-mediated m6A modification alleviates autoimmune uveitis by regulating microglia phenotypes via the GPC4/TLR4/NF-κB signaling axis

He, S., Li, W., Wang, G., Wang, X., Fan, W., Zhang, Z., Li, N., & Hou, S. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.09.008 · Cited by 39 · see citing works

METTL16 inhibits papillary thyroid cancer tumorigenicity through m6A/YTHDC2/SCD1-regulated lipid metabolism

Li, Q., Wang, Y., Meng, X., Wang, W., Duan, F., Chen, S., Zhang, Y., Sheng, Z., Gao, Y., & Zhou, L. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05146-x · Cited by 39 · see citing works

Involvement of YTHDF1 in renal fibrosis progression via up‐regulating YAP

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The Emerging Role of RNA Modifications in the Regulation of Antiviral Innate Immunity

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Fat mass and obesity–associated protein promotes liver steatosis by targeting PPARα

Wei, X., Zhang, J., Tang, M. M., Wang, X., Fan, N., & Peng, Y. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01640-y · Cited by 39 · see citing works

Prognostic Value of an m6A RNA Methylation Regulator‐Based Signature in Patients with Hepatocellular Carcinoma

Wu, X., Zhang, X., Tao, L., Dai, X., & Chen, P. (2020) · BioMed Research International · doi:10.1155/2020/2053902 · Cited by 36 · see citing works

METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial–mesenchymal transition

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IGF2BP2 knockdown suppresses thyroid cancer progression by reducing the expression of long non-coding RNA HAGLR

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m6A RNA methylation facilitates pre-mRNA 3’-end formation and is essential for viability of Toxoplasma gondii

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METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury

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The role m6A RNA methylation is CNS development and glioma pathogenesis

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Long non-coding RNA ILF3-AS1 facilitates hepatocellular carcinoma progression by stabilizing ILF3 mRNA in an m6A-dependent manner

Bo, C., Li, N., Li, H., Zhang, S., & An, Y. (2021) · Human Cell · doi:10.1007/s13577-021-00608-x · Cited by 34 · see citing works

The RNA Methyltransferase METTL3 Promotes Endothelial Progenitor Cell Angiogenesis in Mandibular Distraction Osteogenesis via the PI3K/AKT Pathway

Jiang, W., Zhu, P., Huang, F., Zhao, Z., Zhang, T., An, X., Liao, F., Guo, L., Liu, Y., Zhou, N., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720925 · Cited by 33 · see citing works

IGF2BP1-mediated N6-methyladenosine modification promotes intrahepatic cholangiocarcinoma progression

Xiao, P., Meng, Q., Liu, Q., Lang, Q., Yin, Z., Li, G., Li, Z., Xu, Y., Yu, Z., Geng, Q., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216075 · Cited by 33 · see citing works

Epigenetic regulation of N6‐methyladenosine modifications in obesity

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The regulatory role of N6 ‐methyladenosine modification in the interaction between host and microbes

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Research progress on N6-adenosylate methylation RNA modification in heart failure remodeling

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Differential m6A methylomes between two major life stages allows potential regulations in Trypanosoma brucei

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N6-methyladenosine (m6A) methyltransferase WTAP-mediated miR-92b-5p accelerates osteoarthritis progression

Lin, Z., Jiang, T., Zheng, W., Zhang, J., Li, A., Lu, C., & Liu, W. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01228-8 · Cited by 31 · see citing works

METTL14 promotes lipid metabolism reprogramming and sustains nasopharyngeal carcinoma progression via enhancing m6A modification of ANKRD22 mRNA

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METTL14 Overexpression Promotes Osteosarcoma Cell Apoptosis and Slows Tumor Progression via Caspase 3 Activation

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RNA N6-Methyladenosine Regulator-Mediated Methylation Modifications Pattern and Immune Infiltration Features in Glioblastoma

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