A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome
Open accessAbstract
Individuals with Williams syndrome (WS) demonstrate an abnormally positive social bias. However, the neural substrates of this hypersociability, i.e., positive attribution bias and increased drive toward social interaction, have not fully been elucidated. Methods: We performed an event-related functional magnetic resonance imaging study while individuals with WS and typically developing controls (TD) matched positive and negative emotional faces. WS compared to TD showed reduced right amygdala activation during presentation of negative faces, as in the previous literature. In addition, WS showed a unique pattern of right orbitofrontal cortex activation. While TD showed medial orbitofrontal cortex activation in response to positive, and lateral orbitofrontal cortex activation to negative, WS showed the opposite pattern. In light of the general notion of a medial/lateral gradient of reward/punishment processing in the orbitofrontal cortex, these findings provide an additional biological explanation for, or correlate of positive attribution bias and hypersociability in WS.
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Another study found that individuals with WS show reduced amygdala activity in response to sad faces and comparable activity in the orbitofrontal cortex for happy and sad faces, whereas TS individuals show a heightened orbitofrontal cortex response to sad faces.
“Another study found that individuals with WS show reduced amygdala activity in response to sad faces and comparable activity in the orbitofrontal cortex for happy and sad faces, whereas TS individuals show a heightened orbitofrontal cortex response to sad faces [690].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [690]
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- Authors
- Mimura, M., Hoeft, F., Kato, M., Kobayashi, N., Sheau, K., Piggot, J., Mills, D., Galaburda, A., Korenberg, J. R., Bellugi, U., & Reiss, A. L.
- Affiliations
- SHOWA Medical University (JP)
- Stanford Medicine (US)
- Keio University (JP)
- University of California, Los Angeles (US)
- Bangor University (GB)
- Beth Israel Deaconess Medical Center (US)
- University of Utah (US)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Reiss, Allan L.
- Venue
- Journal of Neurodevelopmental Disorders
- Published
- 2010-01-26
- Volume
- 2
- Issue
- 2
- Pages
- 93-98
- ISSN
- 1866-1947 (ISSN-L)
- 1866-1955
- PMC
- PMC3034146
- OpenAlex
- W2144890266
- Cited by
- 38
- References
- 26
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neurodevelopmental Disorders (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Child Health and Human Development (HD049653)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD049653, P01HD033113)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- Williams syndrome, hypersociability, orbitofrontal cortex, amygdala, emotional face processing
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