Evaluation of bone mineral density loss in morbidly obese women after gastric bypass: 3-year follow-up
Open accessAbstract
Studies that evaluate the influence of gastric bypass (RYGP) on bone mass are limited to short-term follow-up. We analysed changes in bone mineral density (BMD) three years after surgery and evaluated the main determinants of the development of bone disease. Prospective study of 59 morbidly obese white women aged 46 ± 8 years. BMD scanning using DEXA and plasma determinations of calcium, parathyroid hormone, 25-hydroxyvitamin D and insulin-like growth factor-I were made prior, at 12 months and 3 years after surgery. In the first postoperative year BMD decreased at femoral neck (FN) 10.2 % and in the lumbar spine (LS) 3.2 %, in the third year it additionally decreased 2.7 % and 3.1 %, respectively. BMD at both sites remained above the values of women of the same age. In the follow-up, 1.7 % developed osteoporosis at FN and 6.8 % at LS. Patients with bone disease were older, the percentage of women with menopause was greater in this group and had lower initial and final values of lean mass. The percentage of BMD loss at FN remained positively associated with the percentage of lean mass loss [β 0.304, p=0.045], and menopause [β 0.337, p=0.025]. Major osteoporotic fracture and hip fracture risk was low even in menopausal patients (3.1 % and 0.40 %, respectively). After RYGP menopausal women and those with greater lean mass loss are at higher risk of BMD loss but progression to osteoporosis is uncommon and the risk of fracture is low.
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Hip BMD declines after RYGB range between 8% and 11%.
“Declines in hip BMD range between 8-11%17, 52-54, 62, 67-69.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [62]
A strong association between extent of weight loss after bariatric surgery and amount of bone loss has been documented by most but not all studies.
“A strong association between extent of weight loss after bariatric surgery and amount of bone loss has been documented bymost40, 45, 51-53, 62, 67 but not all studies.63”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [62]
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- Authors
- Vilarrasa, N., San José, P., García, I., Gómez-Vaquero, C., Medina Miras, P., de Gordejuela, A. G. R., Masdevall, C., Pujol, J., Soler, J., & Gómez, J. M.
- Affiliations
- Bellvitge University Hospital (ES)
- ORCID
- Gómez, José Manuel
- Venue
- Obesity Surgery
- Published
- 2010-12-29
- Volume
- 21
- Issue
- 4
- Pages
- 465-472
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2088448704
- Cited by
- 129
- References
- 43
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 12 · 2019: 8 · 2018: 10 · 2017: 14 · 2016: 8 · 2015: 13 · 2014: 16 · 2013: 13 · 2012: 5
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Hispana (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- bariatric surgery, Roux-en-Y gastric bypass
- MeSH terms
- Adult, Bone Diseases, Metabolic, Female, Humans, Middle Aged, Osteoporosis, Cohort Studies, Gastric Bypass, Weight Loss, Bone Density, Body Mass Index
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