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Effect of Bariatric Surgery on Liver Fibrosis
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Background Although bariatric surgery has been shown to improve hepatic steatosis in morbidly obese patients, the effect of weight loss on hepatic fibrosis has not been determined. Since the prognosis of patients with nonalcoholic fatty liver disease is closely related to the development of hepatic fibrosis, it is important to determine the hepatic histology of these patients after weight loss. We therefore evaluated the prevalence of hepatic fibrosis in morbidly obese patients undergoing bariatric surgery and assessed the correlation of histologic changes with weight loss. Methods We retrospectively evaluated 78 morbidly obese patients who underwent gastric bypass. Liver biopsies were taken during surgery and after weight loss, and the correlations between histologic findings and hepatic fibrosis were determined. Results Of the 78 patients, 35 (44.8%) had fibrosis at first biopsy, and 24 (30.8%) had hepatic fibrosis after weight loss, including 19 of the 35 patients (54.3%) with fibrosis at first biopsy and 5 of the 43 (11.6%) without hepatic fibrosis at first biopsy (P = 0.027). Conclusions Weight loss in morbidly obese patients was associated with a reduction in the prevalence of hepatic fibrosis.
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“Similarly, Moretto et al. observed substantial histological improvements in liver fibrosis, with over 70% of patients showing regression in fibrosis severity one year after RYGB surgery [31].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [31]
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Metadata
- Authors
- Moretto, M., Kupski, C., da Silva, V. D., Padoin, A. V., & Mottin, C. C.
- Affiliations
- Hospital São Lucas da PUCRS (BR)
- Corresponding author
- Moretto, Myriam
- Venue
- Obesity Surgery
- Published
- 2011-11-23
- Volume
- 22
- Issue
- 7
- Pages
- 1044-1049
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2055446509
- Cited by
- 110
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 11 · 2019: 4 · 2018: 5 · 2017: 13 · 2016: 11 · 2015: 15 · 2014: 9 · 2013: 13 · 2012: 2
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PUCRS Repository (Pontifical Catholic University of Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- bariatric surgery, liver fibrosis
- MeSH terms
- Adult, Fatty Liver, Female, Humans, Liver, Liver Cirrhosis, Male, Obesity, Morbid, Retrospective Studies, Gastric Bypass, Weight Loss, Prevalence, Treatment Outcome, Non-alcoholic Fatty Liver Disease
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