Cited by 79Bariatric Surgery and OutcomesBone health and osteoporosis researchBone Metabolism and Diseases

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Changes in Bone Mineral Density in Women Following 1-Year Gastric Bypass Surgery

Casagrande, Daniela Schaan, Repetto, Giuseppe, Mottin, Claudio Corá, Shah, Jatin, Pietrobon, Ricardo, Worni, Mathias, Schaan, Beatriz D.·2012·Obesity Surgery

DOI 10.1007/s11695-012-0687-z

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Abstract

Background Roux-en-Y gastric bypass (RYGB) surgery is the gold standard surgical treatment for obesity. However, unintended nutritional deficiencies following this surgery are common, including changes in bone metabolism. We assessed changes in bone mineral density (BMD), nutritional compounds, and bone resorption markers before and 1 year following RYGB surgery.Methods Our study included 22 female patients with class II/III obesity. A clinical questionnaire, a 24-h recall, blood and urine samples, and dual-energy X-ray absorptiometry were provided.Results Mean age was 37.2 ± 9.6 years; 86 % were Caucasian and 77.2 % were premenopausal. Mean preoperative body mass index was 44.4 ± 5.0 and 27.5 ± 4.5 kg/m(2) at 1-year follow-up (p < 0.001). 25-OH-vitamin D-levels were similar in both periods [11.7 (9.7-18.0) vs. 15.7 (10.2-2.7) pg/dL, p = 0.327]. Serum N-telopeptide (16.3 ± 3.4 vs. 38.2 ± 7.0 nM BCE, p < 0.001) and parathyroid hormone (45.4 ± 16.7 vs. 62.7 ± 28.9 pg/mL, p = 0.026) increased after RYGB surgery, reflecting bone resorption. BMD decreased after RYGB surgery in the lumbar spine (1.13 ± 0.11 vs. 1.04 ± 0.09 g/cm(2), p = 0.001), femoral neck (1.03 ± 0.15 vs. 0.94 ± 0.16 g/cm(2), p = 0.001), and total femur (1.07 ± 0.11 vs. 0.97 ± 0.15 g/cm(2), p = 0.003).Conclusions Decreased BMD in the lumbar spine, femoral neck, and total femur is detectable in women 1 year after RYGB surgery. Calcium malabsorption, caused by vitamin D deficiency and increased bone resorption, is partially responsible for these outcomes and should be targeted in future clinical trials.

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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204
Calcium plus Vitamin D Supplementation and the Risk of Fractures
Jackson, R. D., LaCroix, A. Z., Gass, M. L. S., Wallace, R. B., Robbins, J. A., Lewis, C. E., Bassford, T. L., Beresford, S. A. A., Black, H. R., Blanchette, P. L., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055218 · Cited by 1,876
Gastrointestinal surgery for severe obesity: National Institutes of Health Consensus Development Conference statement.
(1992) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.2.615s · Cited by 748
Vitamin D Deficiency
Lee, J. H., O’Keefe, J. H., Bell, D. S. H., Hensrud, D. D., & Holick, M. F. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.08.050 · Cited by 744
Official Positions of the International Society for Clinical Densitometry and Executive Summary of the 2007 ISCD Pediatric Position Development Conference
Baim, S., Leonard, M. B., Bianchi, M.-L., Hans, D. B., Kalkwarf, H. J., Langman, C. B., & Rauch, F. (2008) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2007.12.002 · Cited by 708
Surgery for obesity
Colquitt, J. L., Picot, J., Loveman, E., & Clegg, A. J. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003641.pub3 · Cited by 650
The levelling off of the obesity epidemic since the year 1999 – a review of evidence and perspectives
Rokholm, B., Baker, J. L., & Sørensen, T. I. A. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00810.x · Cited by 601
ASMBS Allied Health Nutritional Guidelines for the Surgical Weight Loss Patient
Aills, L., Blankenship, J. D., Buffington, C. K., Furtado, M. M., & Parrott, J. M. (2008) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.03.002 · Cited by 600
Official Positions of the International Society for Clinical Densitometry and Executive Summary of the 2007 ISCD Position Development Conference
Baim, S., Binkley, N., Bilezikian, J. P., Kendler, D. L., Hans, D. B., Lewiecki, E. M., & Silverman, S. (2008) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2007.12.007 · Cited by 418
Laparoscopic Roux-en-Y gastric bypass: 10-year follow-up
Higa, K. D., Ho, T., Tercero, F. M., Yunus, T. E., & Boone, K. B. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.10.019 · Cited by 412
Impact of micronutrient deficiencies on obesity
García, O. P., Long, K. Z., & Rosado, J. L. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00228.x · Cited by 398
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Whitehead, C. C., & Fleming, R. H. (2000) · Poultry Science · doi:10.1093/ps/79.7.1033 · Cited by 386
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Mezquita‐Raya, P., Muñoz‐Torres, M., Luna, J. D. D., Luna, V., Lopez-Rodriguez, F., Torres-Vela, E. M., & Escobar‐Jiménez, F. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.8.1408 · Cited by 213
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Ricci, T. A., Heymsfield, S. B., Pierson, R. N., Stahl, T. J., Chowdhury, H. A., & Shapses, S. A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.347 · Cited by 195
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Authors: Casagrande, D. S., Repetto, G., Mottin, C. C., Shah, J., Pietrobon, R., Worni, M., & Schaan, B. D.
Affiliations: Universidade Federal do Rio Grande do Sul (BR)
Pontifícia Universidade Católica do Rio Grande do Sul (BR)
Duke University (US)
Corresponding author: Schaan, Beatriz D.
ORCID: Casagrande, Daniela Schaan
Shah, Jatin
Pietrobon, Ricardo
Worni, Mathias
Schaan, Beatriz D.
Venue: Obesity Surgery
Publisher: Springer Science and Business Media LLC
Published: 2012-06-13
Volume: 22
Issue: 8
Pages: 1287-1292
ISSN: 0960-8923 (ISSN-L)
1708-0428
DOI: 10.1007/s11695-012-0687-z
OpenAlex: W1998242188
Cited by: 79
References: 46
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 11
FWCI: 10.42
Type: journal article
Language: en
Update notices: correction (2015-07-15)
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Obesity Surgery (publishedVersion)
PubMed (publishedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords: Roux-en-Y gastric bypass, bariatric surgery
MeSH terms: Adult, Bone Resorption, Brazil, Calcium, Dietary, Female, Femur, Follow-Up Studies, Humans, Lumbar Vertebrae, Obesity, Morbid, Prospective Studies, Surveys and Questionnaires, Vitamin D Deficiency, Gastric Bypass, Weight Loss, Absorptiometry, Photon, Bone Density, Body Mass Index, Premenopause

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Changes in Bone Mineral Density in Women Following 1-Year Gastric Bypass Surgery

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