Roux-en-Y gastric bypass decreases pro-inflammatory and thrombotic biomarkers in individuals with extreme obesity

Netto, Bárbara Dal Molin; Bettini, Solange Cravo; Clemente, Ana Paula Grotti; de Carvalho Ferreira, Joana Pereira; Boritza, Katia; de Fátima Souza, Sandy; Von der Heyde, Maria Emilia; Earthman, Carrie P.; Dâmaso, Ana R.

doi:10.1007/s11695-014-1484-7

Cited by 74Bariatric Surgery and OutcomesAdipokines, Inflammation, and Metabolic DiseasesBody Contouring and Surgery

Roux-en-Y gastric bypass decreases pro-inflammatory and thrombotic biomarkers in individuals with extreme obesity

Netto, Bárbara Dal Molin, Bettini, Solange Cravo, Clemente, Ana Paula Grotti, de Carvalho Ferreira, Joana Pereira, Boritza, Katia, de Fátima Souza, Sandy, Von der Heyde, Maria Emilia, Earthman, Carrie P. +1 more·2015·Obesity Surgery

DOI 10.1007/s11695-014-1484-7

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Abstract

Background The low-grade inflammatory state in obesity leads to insulin resistance and endothelial dysfunction, which promote cardiovascular diseases in individuals with obesity. The purpose of this study was to evaluate the early effects of weight loss achieved through bariatric surgery on the inflammatory and prothrombotic states. This study also aimed to identify the role of hyperleptinemia on the prothrombotic state.Methods The sample was composed of 41 extremely obese who underwent Roux-en-Y gastric bypass (RYGB). Anthropometric and clinical data, and biochemical markers of inflammation were collected prior to surgery and 6 months post-RYGB.Results It was found that plasminogen activator inhibitor-1 (PAI-1) concentrations were higher among extremely obese individuals with hyperleptinemia than in those without hyperleptinemia (p < 0.01).In relation to the baseline, post-surgery body mass index (BMI) was reduced by 12.9 kg/m(2), corresponding to 63.50 % of excess weight loss. Additionally, waist circumference was found to decrease significantly from 126.2 to 101.4 cm. Plasma total cholesterol (p < 0.01), LDL cholesterol (p = 0.02), triglycerides (p < 0.01), and glucose (p = 0.01) were also found to decrease. Pro-inflammatory biomarkers were observed to decrease: PAI-1 by 55.9 ± 6.0 % (p < 0.01), C-reactive protein (CRP) by 18.8 ± 3.4 % (p < 0.01), intercellular adhesion molecule-1 (ICAM-1) by 89.9 ± 5.7 % (p < 0.01), leptin by 27.9 ± 3.2 % (p < 0.01), and resistin by 69.3 ± 5.8 % (p < 0.01). Additionally, significant decreases of tumor necrosis factor alpha (TNF-α) and leptin/adiponectin ratio were observed. Anti-inflammatory cytokines adiponectin and interleukin-10 (IL-10) were significantly increased (170.7 ± 82.5 %, p < 0.01; 122.7 ± 55.1 %, p = 0.02). CRP levels were predictive of ICAM-1 (p = 0.04), and changes in leptin concentrations were associated with decreased PAI-1 levels (p = 0.03).Conclusions We observed that individuals with obesity that have hyperleptinemia have higher circulating PAI-1 levels, which could indicate increased risk for cardiovascular disease. The biomarkers of inflammation and thrombosis measured in this study decreased after RYGB, suggesting that the surgery may be effective in reducing pro-inflammatory and thrombotic risk in individuals with extreme obesity.

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Weight-related reductions in PAI-1:Ag have previously been observed after bariatric surgery.
“weight-related reductions in PAI-1:Ag are of potential interest and have previously been observed after bariatric surgery. 15,40”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [40]
Several reviews of bariatric surgery found that E-selectin and sICAM-1 decreased after surgery, although this was not always consistent for sICAM-1.
“Several reviews of bariatric surgery found that E-selectin and sICAM-1 decreased after surgery, 15,39 although this was not always consistent for sICAM-1. 40”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [40]

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Is obesity an inflammatory disease?
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Authors: Netto, B. D. M., Bettini, S. C., Clemente, A. P. G., de Carvalho Ferreira, J. P., Boritza, K., de Fátima Souza, S., Von der Heyde, M. E., Earthman, C. P., & Dâmaso, A. R.
Affiliations: Universidade Federal de São Paulo (BR)
Hospital de Clínicas Universidade Federal do Paraná (BR)
University of Minnesota (US)
Corresponding author: Netto, Bárbara Dal Molin
Dâmaso, Ana R.
ORCID: Netto, Bárbara Dal Molin
Bettini, Solange Cravo
Clemente, Ana Paula Grotti
Earthman, Carrie P.
Dâmaso, Ana R.
Venue: Obesity Surgery
Publisher: Springer Science and Business Media LLC
Published: 2014-11-19
Volume: 25
Issue: 6
Pages: 1010-1018
ISSN: 0960-8923 (ISSN-L)
1708-0428
DOI: 10.1007/s11695-014-1484-7
OpenAlex: W1986056701
Cited by: 74
References: 38
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 4 · 2017: 9 · 2016: 8 · 2015: 3
FWCI: 6.61
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Obesity Surgery (publishedVersion)
PubMed (publishedVersion)
UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Surgery › Body Contouring and Surgery
Keywords: Roux-en-Y gastric bypass, morbid obesity
MeSH terms: Adult, C-Reactive Protein, Female, Humans, Inflammation, Insulin Resistance, Male, Middle Aged, Obesity, Triglycerides, Gastric Bypass, Biomarkers, Weight Loss, Body Mass Index, Interleukin-10, Treatment Outcome, Plasminogen Activator Inhibitor 1, Intercellular Adhesion Molecule-1, Leptin, Adiponectin, Young Adult

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Roux-en-Y gastric bypass decreases pro-inflammatory and thrombotic biomarkers in individuals with extreme obesity

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