The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Ursodeoxycholic Acid in the Prevention of Gallstone Formation After Bariatric Surgery: an Updated Systematic Review and Meta-analysis
Abstract
We aim to review the available literature on obese patients treated with ursodeoxycholic acid (UDCA) in order to prevent gallstone formation after bariatric surgery. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Eight studies met the inclusion criteria incorporating 1355 patients. Random-effects meta-analysis showed a lower incidence of gallstone formation in patients taking UDCA. Subgroup analysis reported fewer cases of gallstone disease in the UDCA group in relation to different bariatric procedures, doses of administered UDCA, and time from bariatric surgery. Adverse events were similar in both groups. Fewer patients required cholecystectomy in UDCA group. No deaths were reported. The administration of UDCA after bariatric surgery seems to prevent gallstone formation.
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“Consequently, similar incidences of symptomatic gallstone disease, 40 and a similar effect of ursodeoxycholic acid on gallstone formation are reported.7,23,24,26”
In the citing paper
“A meta-analysis of 6 RCTs and two observational studies found that ursodeoxycholic acid treatment versus no treatment was associated with lower odds of gallstone formation (OR 0.20, 95% CI 0.13 to 0.33) [129].”
From Clinical practice guidelines of the European Association for Endoscopic Surgery (EAES) on bariatric surgery: update 2020 endorsed by IFSO-EC, EASO and ESPCOP (2020) · cites this paper as [129]
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Metadata
- Authors
- Magouliotis, D. E., Tasiopoulou, V. S., Svokos, A. A., Svokos, K. A., Chatedaki, C., Sioka, E., & Zacharoulis, D.
- Affiliations
- University Hospital of Larissa (GR)
- University of Thessaly (GR)
- Riverside Regional Medical Center (US)
- Brown University (US)
- Corresponding author
- Magouliotis, Dimitrios E.
- ORCID
- Venue
- Obesity Surgery
- Published
- 2017-09-09
- Volume
- 27
- Issue
- 11
- Pages
- 3021-3030
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2755711258
- Cited by
- 108
- References
- 36
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 3 · 2023: 16 · 2022: 18 · 2021: 20 · 2020: 19 · 2019: 10 · 2018: 7
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
- Health Sciences › Medicine › Gastroenterology › Biliary and Gastrointestinal Fistulas
- Keywords
- ursodeoxycholic acid, gallstone prevention
- MeSH terms
- Adult, Cholecystectomy, Humans, Obesity, Morbid, Ursodeoxycholic Acid, Chemoprevention, Gallstones, Bariatric Surgery
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