CoChat
Sign Up
Cited by 33

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The impact of ursodeoxycholic acid on gallstone disease after bariatric surgery: a meta-analysis of randomized control trials

Fearon, Naomi M., Kearns, Emma C., Kennedy, Czara A., Conneely, John B., Heneghan, Helen M.·2022·Surgery for Obesity and Related Diseases
DOI 10.1016/j.soard.2021.10.004
Open this paper in CoChat — free account

Abstract

Background Ursodeoxycholic acid (UDCA) is a bile acid that has been shown to reduce the formation of gallstones after significant weight loss. Objective This study aimed to evaluate the impact of UDCA on the incidence of gallstones after bariatric surgery. Settings An electronic search of PubMed (Medline), Cochrane Central Register of Controlled Studies (CENTRAL), Scopus (Elsevier) databases, EMBASE, CINAHL, Clinicaltrials.gov, and Web of Science. Methods A meta-analysis of randomized control trials was performed. The primary outcome was the incidence of gallstones after bariatric surgery. Secondary outcomes included type of operation and time interval to and characteristics associated with gallstone formation. Results Ten randomized control trials including 2583 patients were included, 1772 patients (68.6%) receiving UDCA and 811 (31.4%) receiving placebo. There was a significant reduction in gallstone formation in patients who received UDCA postoperatively (risk ratio [RR] .36, 95% confidence interval [CI] .22-.41, P 600 mg/day) group (risk ratio .30; 95% CI, .09-1.01, P = .05). Conclusions UDCA significantly reduces the risk of both asymptomatic and symptomatic gallstones after bariatric surgery. A dose of 600 mg/day is associated with improved compliance and better outcomes regardless of type of surgery. UDCA should be considered part of a standard postoperative care bundle after bariatric surgery.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.soard.2021.10.004

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In a recent systematic review, the risk of de novo post-bariatric gallstones was 8.2%, not substantially higher than asymptomatic gallstone disease (20.7%).

    “In a recent systematic review, gallstone disease was classified as symptomatic or asymptomatic, and the risk of de novo post-bariatric gallstones was not substantially higher (8.2%) than that of asymptomatic gallstone disease (20.7%) [1617].”

    From Prevention of Gallstones After Bariatric Surgery using Ursodeoxycholic Acid: A Narrative Review of Literatures (2022) · cites this paper as [16]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 37

  1. Osland, 2017, Changes in non-diabetic comorbid disease status following laparoscopic vertical sleeve gastrectomy (LVSG) versus laparoscopic Roux-en-Y gastric bypass (LRYGB) procedures: a systematic review of randomized controlled trials, Obes Surg, 27, 1208, 10.1007/s11695-016-2469-5 · DOI
  2. Yuan S, Gill D, Giovannucci EL, Larsson SC. Obesity, type 2 diabetes, lifestyle factors and risk of gallstone disease: a Mendelian randomization investigation. Clin Gastroenterol Heptal. 2021 Jan 6:S1542-3565(21)00001-X. https://doi.org/10.1016/j.cgh.2020.12.034. Epub ahead of print. PMID: 33418132. · DOI
  3. Gustafsson, 2005, Changes in gallbladder bile composition and crystal detection time in morbidly obese subjects after bariatric surgery, Hepatology, 41, 1322, 10.1002/hep.20686 · DOI
  4. Tustumi, 2018, Cholecystectomy in patients submitted to bariatric procedure: a systematic review and meta-analysis, Obes Surg, 28, 3312, 10.1007/s11695-018-3443-1 · DOI
  5. Lam, 2021, Gallbladder disorders: a comprehensive review, Dis Mon, 67, 101130, 10.1016/j.disamonth.2021.101130 · DOI
  6. Abdallah, 2017, Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy, Surg Today, 47, 844, 10.1007/s00595-016-1446-x · DOI · Paper page
  7. Sioka, 2014, Complicated gallstones after laparoscopic sleeve gastrectomy, J Obes, 2014, 1, 10.1155/2014/468203 · DOI
  8. Oliveira CIB de, 2003, Impact of rapid weight reduction on risk of cholelithiasis after bariatric surgery, Obes Surg, 13, 625, 10.1381/096089203322190862 · DOI
  9. Warschkow, 2013, Concomitant cholecystectomy during laparoscopic roux-en-y gastric bypass in obese patients is not justified: a meta-analysis, Obes Surg, 23, 397, 10.1007/s11695-012-0852-4 · DOI · Paper page
  10. Paumgartner, 2002, Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited, Hepatology, 36, 525, 10.1053/jhep.2002.36088 · DOI · Paper page
  11. Guarino, 2007, Ursodeoxycholic acid improves muscle contractility and inflammation in symptomatic gallbladders with cholesterol gallstones, Gut, 56, 815, 10.1136/gut.2006.109934 · DOI
  12. Lazaridis, 2001, Ursodeoxycholic acid “mechanisms of action and clinical use in hepatobiliary disorders, J Hepatol, 35, 134, 10.1016/S0168-8278(01)00092-7 · DOI
  13. Uy, 2008, Ursodeoxycholic acid in the prevention of gallstone formation after bariatric surgery: a meta-analysis, Obes Surg, 18, 1532, 10.1007/s11695-008-9587-7 · DOI · Paper page
  14. Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, PLoS Med, 6, 10.1371/journal.pmed.1000097 · DOI · Paper page
  15. Duval, 2000, Trim and fill: a simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis, Biometrics, 56, 455, 10.1111/j.0006-341X.2000.00455.x · DOI · Paper page
  16. Jadad, 1996, Assessing the quality of reports of randomized clinical trials: Is blinding necessary?, Control Clin Trials, 17, 1, 10.1016/0197-2456(95)00134-4 · DOI · Paper page
  17. Worobetz, 1993, The effect of ursodeoxycholic acid therapy on gallstone formation in the morbidly obese during rapid weight loss, Am J Gastroenterol, 88, 1705
  18. Williams, 1993, A double-blind placebo-controlled trial of ursodeoxycholic acid in the prevention of gallstones during weight loss after vertical banded gastroplasty, Obes Surg, 3, 257, 10.1381/096089293765559278 · DOI · Paper page
  19. Sugerman, 1995, A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss, Am J Surg, 169, 91, 10.1016/S0002-9610(99)80115-9 · DOI · Paper page
  20. Wudel, 2002, Prevention of gallstone formation in morbidly obese patients undergoing rapid weight loss: results of a randomized controlled pilot study, J Surg Res, 102, 50, 10.1006/jsre.2001.6322 · DOI · Paper page
  21. Adams, 2016, Randomized, prospective comparison of ursodeoxycholic acid for the prevention of gallstones after sleeve gastrectomy, Obes Surg, 26, 990, 10.1007/s11695-015-1858-5 · DOI · Paper page
  22. Abouzeid, 2018, Should we prescribe ursodeoxycholic acid after laparoscopic sleeve gastrectomy? A two-center prospective randomized controlled trial, Egypt J Surg, 37, 349, 10.4103/ejs.ejs_29_18 · DOI
  23. Pizza, 2020, The role of ursodeoxycholic acid (UDCA) in cholelithiasis management after one anastomosis gastric bypass (OAGB) for morbid obesity: results of a monocentric randomized controlled trial, Obes Surg, 30, 4315, 10.1007/s11695-020-04801-z · DOI
  24. Sakran, 2020, The use of Ursolit for gallstone prophylaxis following bariatric surgery: a randomized-controlled trial, Updates Surg, 72, 1125, 10.1007/s13304-020-00850-2 · DOI · Paper page
  25. Talha, 2020, Cholelithiasis after bariatric surgery, incidence, and prophylaxis: randomized controlled trial, Surg Endosc, 34, 5331, 10.1007/s00464-019-07323-7 · DOI · Paper page
  26. Buchwald, 2014, The evolution of metabolic/bariatric surgery, Obes Surg, 24, 1126, 10.1007/s11695-014-1354-3 · DOI
  27. Lee, 2019, Randomized controlled trial of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity: comparison of the YOMEGA and Taiwan studies, Obes Surg, 29, 3047, 10.1007/s11695-019-04065-2 · DOI
  28. Docimo, 2021, One anastomosis gastric bypass versus Roux-en-Y gastric bypass: a 30-day follow-up review, Surg Endosc.
  29. Wu, 2020, Clinical outcomes of one anastomosis gastric bypass versus sleeve gastrectomy for morbid obesity, Obes Surg, 30, 1021, 10.1007/s11695-019-04303-7 · DOI
  30. Sneineh, 2020, Increased incidence of symptomatic cholelithiasis after bariatric Roux-en-Y gastric bypass and previous bariatric surgery: a single center experience, Obes Surg, 30, 846, 10.1007/s11695-019-04366-6 · DOI
  31. Cazzo, 2016, Influence of insulin resistance status on the development of gallstones following Roux-en-Y gastric bypass: a prospective cohort study, Obes Surg, 26, 769, 10.1007/s11695-015-1815-3 · DOI
  32. Chang, 2016, Predictive factors of biliary complications after bariatric surgery, Surg Obes Relat Dis, 12, 1706, 10.1016/j.soard.2015.11.004 · DOI · Paper page
  33. Coupaye, 2015, Comparison of the incidence of cholelithiasis after sleeve gastrectomy and Roux-en-Y gastric bypass in obese patients: a prospective study, Surg Obes Relat Dis, 11, 779, 10.1016/j.soard.2014.10.015 · DOI · Paper page
  34. Li, 2009, Predictors of gallstone formation after bariatric surgery: a multivariate analysis of risk factors comparing gastric bypass, gastric banding, and sleeve gastrectomy, Surg Endosc, 23, 1640, 10.1007/s00464-008-0204-6 · DOI · Paper page
  35. Anveden, 2020, Long-term incidence of gallstone disease after bariatric surgery results from the nonrandomized controlled Swedish Obese Subjects study, Surg Obes Relat Dis, 16, 1474, 10.1016/j.soard.2020.05.025 · DOI · Paper page
  36. Penna, 2019, Ursodeoxycholic acid for 6 months after bariatric surgery is impacting gallstone associated morbidity in patients with preoperative asymptomatic gallstones, Obes Surg, 29, 1216, 10.1007/s11695-018-03651-0 · DOI
  37. Cheng, 2021, Review of the endoscopic, surgical and radiological techniques of treating choledocholithiasis in bariatric Roux-en-Y gastric bypass patients and proposed management algorithm, Obes Surg, 31, 4993, 10.1007/s11695-021-05627-z · DOI

Cited by

Sorted by citations

Metadata

Authors
Fearon, N. M., Kearns, E. C., Kennedy, C. A., Conneely, J. B., & Heneghan, H. M.
Venue
Surgery for Obesity and Related Diseases
Publisher
Elsevier BV
Published
2022-01
Volume
18
Issue
1
Pages
77-84
ISSN
1550-7289
DOI
10.1016/j.soard.2021.10.004
Cited by
33
References
7
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review