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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Ursodeoxycholic acid for the prevention of gallstones and subsequent cholecystectomy after bariatric surgery: a meta-analysis of randomized controlled trials

Mulliri, Andrea, Menahem, Benjamin, Alves, Arnaud, Dupont, Benoît·2022·Journal of Gastroenterology
DOI 10.1007/s00535-022-01886-4
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Abstract

Background This meta-analysis aimed to compare the incidence of gallstone formation, subsequent biliary disease and the need for cholecystectomy in untreated patients and patients treated with ursodeoxycholic acid (UDCA) following bariatric surgery. Methods Randomized controlled trials (RCTs) comparing UDCA and controls for the prevention of gallstone formation after bariatric surgery published until February 2022 were selected and subjected to a systematic review and meta-analysis. Articles were searched in the MEDLINE, Web of Science and Cochrane Trials Register databases. Meta-analysis was performed with Review Manager 5.0. Results Eleven randomized controlled studies were included, with a total of 2363 randomized patients and 2217 patients analysed in the UDCA group versus 1415 randomized patients and 1257 patients analysed in the control group. Considering analysed patients, prophylactic use of UDCA was significantly associated with decreased (i) gallstone formation (OR = 0.25, 95% CI = 0.21-0.31), (ii) symptomatic gallstone disease (GD) (OR = 0.29, 95% CI = 0.20-0.42) and consequently (iii) cholecystectomy rate (OR = 0.33, 95% CI = 0.20-0.55). The results were similar in ITT analysis, in the subgroup of patients undergoing sleeve gastrectomy or considering only randomized versus placebo studies. Conclusions Prophylactic use of UDCA after bariatric surgery prevents both gallstone formation and symptomatic GD and reduces the need for cholecystectomy.

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  • A recent meta-analysis of randomized controlled trials reported that UDCA decreases bile lithogenicity, concluding that UDCA can effectively prevent gallstones and reduce the risk of cholecystectomy after bariatric surgery.

    “A recent meta-analysis of these randomized controlled trials has reported that UDCA decreases bile lithogenicity, concluding that UDCA can effectively prevent gallstones and reduce the risk of cholecystectomy after bariatric surgery [3].”

    From Prevention of Gallstones After Bariatric Surgery using Ursodeoxycholic Acid: A Narrative Review of Literatures (2022) · cites this paper as [3]

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Research works printed but not linked: 34

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Metadata

Authors
Mulliri, A., Menahem, B., Alves, A., & Dupont, B.
Venue
Journal of Gastroenterology
Publisher
Springer Science and Business Media LLC
Published
2022-06-15
Volume
57
Issue
8
Pages
529-539
ISSN
  • 0944-1174
  • 1435-5922
DOI
10.1007/s00535-022-01886-4
Cited by
52
References
7
Language
en
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