Cited by 110Bariatric Surgery and OutcomesGallbladder and Bile Duct DisordersBiliary and Gastrointestinal Fistulas

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Ursodeoxycholic Acid in the Prevention of Gallstone Formation After Bariatric Surgery: an Updated Systematic Review and Meta-analysis

Magouliotis, Dimitrios E., Tasiopoulou, Vasiliki S., Svokos, Alexis A., Svokos, Konstantina A., Chatedaki, Christina, Sioka, Eleni, Zacharoulis, Dimitris·2017·Obesity Surgery

DOI 10.1007/s11695-017-2924-y

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Abstract

We aim to review the available literature on obese patients treated with ursodeoxycholic acid (UDCA) in order to prevent gallstone formation after bariatric surgery. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Eight studies met the inclusion criteria incorporating 1355 patients. Random-effects meta-analysis showed a lower incidence of gallstone formation in patients taking UDCA. Subgroup analysis reported fewer cases of gallstone disease in the UDCA group in relation to different bariatric procedures, doses of administered UDCA, and time from bariatric surgery. Adverse events were similar in both groups. Fewer patients required cholecystectomy in UDCA group. No deaths were reported. The administration of UDCA after bariatric surgery seems to prevent gallstone formation.

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Authors: Magouliotis, D. E., Tasiopoulou, V. S., Svokos, A. A., Svokos, K. A., Chatedaki, C., Sioka, E., & Zacharoulis, D.
Affiliations: University Hospital of Larissa (GR)
University of Thessaly (GR)
Riverside Regional Medical Center (US)
Brown University (US)
Corresponding author: Magouliotis, Dimitrios E.
ORCID: Magouliotis, Dimitrios E.
Tasiopoulou, Vasiliki S.
Svokos, Alexis A.
Svokos, Konstantina A.
Zacharoulis, Dimitris
Venue: Obesity Surgery
Publisher: Springer Science and Business Media LLC
Published: 2017-09-09
Volume: 27
Issue: 11
Pages: 3021-3030
ISSN: 0960-8923 (ISSN-L)
1708-0428
DOI: 10.1007/s11695-017-2924-y
OpenAlex: W2755711258
Cited by: 108
References: 36
Citations by year: 2026: 5 · 2025: 8 · 2024: 3 · 2023: 16 · 2022: 18 · 2021: 20 · 2020: 19 · 2019: 10 · 2018: 7
FWCI: 2.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Obesity Surgery (publishedVersion)
PubMed (publishedVersion)
University of Thessaly Institutional Repository (University of Thessaly) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
Health Sciences › Medicine › Gastroenterology › Biliary and Gastrointestinal Fistulas
Keywords: ursodeoxycholic acid, gallstone prevention
MeSH terms: Adult, Cholecystectomy, Humans, Obesity, Morbid, Ursodeoxycholic Acid, Chemoprevention, Gallstones, Bariatric Surgery

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Ursodeoxycholic Acid in the Prevention of Gallstone Formation After Bariatric Surgery: an Updated Systematic Review and Meta-analysis

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