Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects
Abstract
Obesity is frequently characterized by a reduced vitamin D bioavailability, as well as insulin-resistance and a chronic inflammatory response. We tested the hypothesis of an independent relationship between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and several circulating inflammatory markers in a cohort of severely obese individuals. Cross-sectional study was carried out among obese patients undergoing a clinical evaluation before bariatric surgery in our University Hospital. Serum 25(OH)D, fasting and post load glucose and insulin, high-sensitive C-reactive protein (hs CRP), fibrinogen, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin and lipid profile were collected. Insulin-resistance was assessed by insulin sensitivity index (ISI). Total body fat (FAT kg), total percent body fat (FAT%) and truncal fat mass (TrFAT) were assessed with dual-energy X-ray absorptiometry. A total of 147 obese subjects (89 women, 37.8 ± 7.1 years) with mean body mass index (BMI) of 43.6 ± 4.3 kg/m(2) were enrolled. Patients in the lowest tertile of 25(OH)D were significantly more obese with a higher amount of TrFAT, more insulin-resistant, and had higher levels of fasting and post-challenge glucose (p < 0.05 for all). In a multivariate regression analysis, serum 25(OH)D was inversely related to significant levels of hs CRP, IL-6 and TNF-α after accounting for age, gender, season of recruitment, BMI, FAT kg and TrFAT (p < 0.01 for all). In extremely obese subjects, 25(OH)D serum concentrations are inversely associated with several biomarkers of systemic inflammation, regardless of the total quantity of fat mass.
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Vitamin D deficiency is associated with lower muscle strength, greater body instability, falls, and disability in the geriatric population.
“several studies have suggested that vitamin D deficiency is associated with lower muscle strength, greater body instability, falls and disability in geriatric population (153).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [153]
Cites
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720 · see citing works
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works
Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204 · see citing works
Vitamin D Deficiency and Risk of Cardiovascular Disease
Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K. J., Benjamin, E. J., D’Agostino, R. B., Wolf, M. S., & Vasan, R. S. (2008) · Circulation · doi:10.1161/circulationaha.107.706127 · Cited by 2,394 · see citing works
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works
Adipose Tissue, Inflammation, and Cardiovascular Disease
Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113 · see citing works
Serum 25-Hydroxyvitamin D Levels and Risk of Multiple Sclerosis
Munger, K. L., Levin, L. I., Hollis, B. W., Howard, N. S., & Ascherio, A. (2006) · JAMA · doi:10.1001/jama.296.23.2832 · Cited by 1,899 · see citing works
Hypovitaminosis D is associated with insulin resistance and β cell dysfunction
Chiu, K. C., Chu, A. Y., Go, V. L. W., & Saad, M. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.820 · Cited by 1,648 · see citing works
Scragg, R. K. R., Sowers, M. R., & Bell, C. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2813 · Cited by 964 · see citing works
Schleithoff, S. S., Zittermann, A., Tenderich, G., Berthold, H. K., Stehle, P., & Koerfer, R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.754 · Cited by 924 · see citing works
Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System
Veldman, C. M., Cantorna, M. T., & DeLuca, H. F. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1605 · Cited by 712 · see citing works
Evidence for alteration of the vitamin D-endocrine system in obese subjects.
Bell, N. H., Epstein, S., Greene, A. S., Shary, J., Oexmann, M. J., & Shaw, S. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111971 · Cited by 685 · see citing works
Concentrations of Serum Vitamin D and the Metabolic Syndrome Among U.S. Adults
Ford, E. S., Ajani, U. A., McGuire, L. C., & Liu, S. (2005) · Diabetes Care · doi:10.2337/diacare.28.5.1228 · Cited by 667 · see citing works
The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults
Parikh, S. J., Edelman, M., Uwaifo, G. I., Freedman, R. J., Semega‐Janneh, M., Reynolds, J. C., & Yanovski, J. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031398 · Cited by 659 · see citing works
D’Ambrosio, D., Cippitelli, M., Cocciolo, M., Mazzeo, D., Lucia, P. D., Lang, R., Sinigaglia, F., & Panina‐Bordignon, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1050 · Cited by 649 · see citing works
Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects
ClÉment, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., Sicard, A., Rome, S., Benis, A., Zucker, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2204com · Cited by 640 · see citing works
Body Fat Content and 25-Hydroxyvitamin D Levels in Healthy Women
Arunabh, S., Pollack, S. Z., Yeh, J. K., & Aloia, J. F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020978 · Cited by 623 · see citing works
Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance
Forouhi, N. G., Luan, J., Cooper, A., Boucher, B. J., & Wareham, N. J. (2008) · Diabetes · doi:10.2337/db08-0593 · Cited by 613 · see citing works
Maestro, B., Campión, J., Dávila, N., & Calle, C. (2000) · Endocrine Journal · doi:10.1507/endocrj.47.383 · Cited by 435 · see citing works
Borissova, A.-M., Tankova, T. I., Кirilov, G., Dakovska, L. N., & Kovatcheva, R. D. (2003) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2003.tb10480.x · Cited by 427 · see citing works
McGill, A., STEWART, J. M., Lithander, F. E., Strik, C. M., & Poppitt, S. D. (2008) · Nutrition Journal · doi:10.1186/1475-2891-7-4 · Cited by 314 · see citing works
Bone Turnover in Prolonged Critical Illness: Effect of Vitamin D
den Berghe, G. V., Roosbroeck, D. V., Vanhove, P., Wouters, P. J., Pourcq, L. D., & Bouillon, R. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030358 · Cited by 254 · see citing works
Hp, K., AMATRUDA, T. T., IKEKAWA, N., Kobayashi, Y., & Hf, D. (1984) · PubMed · Cited by 230 · see citing works
Gysemans, C. A., Cardozo, A. K., Callewaert, H. I., Giulietti, A., Hulshagen, L., Bouillon, R., Eizirik, D. L., & Mathieu, C. (2005) · Endocrinology · doi:10.1210/en.2004-1322 · Cited by 213 · see citing works
Sex Differences in the Relationship between C-Reactive Protein and Body Fat
Khera, A., Vega, G. L., Das, S. R., Ayers, C. R., McGuire, D. K., Grundy, S. M., & de Lemos, J. A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2406 · Cited by 191 · see citing works
Vilarrasa, N., Maravall, J., Estepa, A., Sánchez, R., Masdevall, C., Navarro, M. A., Alia, P. J., Soler, J., & Gómez, J. M. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03347445 · Cited by 134 · see citing works
Extrarenal Production of Calcitriol in Normal and Uremic Humans*
Dusso, A., Finch, J. L., Brown, A. D. H., Ritter, C. S., Delmez, J. A., Schreiner, G. F., & Slatopolsky, E. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-157 · Cited by 132 · see citing works
Chiu, K. C., Chuang, L., & Yoon, C. (2001) · BMC Medical Genetics · doi:10.1186/1471-2350-2-2 · Cited by 121 · see citing works
Willheim, M., Thien, R., Schrattbauer, K., Bajna, E., Holub, M., Gruber, R., Baier, K., Pietschmann, P., Reinisch, W., Scheiner, O., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6054 · Cited by 106 · see citing works
Willheim, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.10.3739 · Cited by 39 · see citing works
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Vitamin D status and ill health: a systematic review
Autier, P., Boniol, M., Pizot, C., & Mullie, P. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70165-7 · Cited by 1,106 · see citing works
Vekić, J., Zeljković, A., Stefanović, A., Jelić‐Ivanović, Z., & Spasojević‐Kalimanovska, V. (2018) · Metabolism · doi:10.1016/j.metabol.2018.11.005 · Cited by 623 · see citing works
Daneshkhah, A., Agrawal, V., Eshein, A., Subramanian, H., Roy, H. K., & Backman, V. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01677-y · Cited by 358 · see citing works
An Update on Vitamin D Metabolism
Saponaro, F., Saba, A., & Zucchi, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186573 · Cited by 325 · see citing works
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
Cannell, J. J., Grant, W. B., & Holick, M. F. (2014) · Dermato-Endocrinology · doi:10.4161/19381980.2014.983401 · Cited by 227 · see citing works
Focus on Vitamin D, Inflammation and Type 2 Diabetes
Chagas, C. E. A., Borges, M. C., Martini, L. A., & Rogero, M. M. (2012) · Nutrients · doi:10.3390/nu4010052 · Cited by 217 · see citing works
Gut microbiota interactions with the immunomodulatory role of vitamin D in normal individuals
Lüthold, R. V., Fernandes, G. D. R., de Moraes, A. C. F., Folchetti, L. G. D., & Ferreira, S. R. G. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.007 · Cited by 195 · see citing works
Low vitamin D status and obesity: Role of nutritionist
Savastano, S., Barrea, L., Savanelli, M. C., Nappi, F., Somma, C. D., Orio, F., & Colao, A. (2017) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-017-9410-7 · Cited by 166 · see citing works
Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects
Caprio, M., Infante, M., Calanchini, M., Mammi, C., & Fabbri, A. (2016) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-016-0312-6 · Cited by 165 · see citing works
Inflammatory markers and bariatric surgery: a meta-analysis
Rao, S. R. (2012) · Inflammation Research · doi:10.1007/s00011-012-0473-3 · Cited by 162 · see citing works
Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes
Marcotorchino, J., Gouranton, E., Romier, B., Tourniaire, F., Astier, J., Malezet‐Desmoulins, C., Amiot, M. J., & Landrier, J. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200383 · Cited by 155 · see citing works
Chen, N., Wan, Z., Han, S.-F., Li, B., Zhang, Z.-L., & Qin, L.-Q. (2014) · Nutrients · doi:10.3390/nu6062206 · Cited by 150 · see citing works
The link between vitamin D metabolism and sleep medicine
McCarty, D. E., Chesson, A. L., Jain, S. K., & Marino, A. A. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.07.001 · Cited by 144 · see citing works
Akbari, M., Ostadmohammadi, V., Lankarani, K. B., Tabrizi, R., Kolahdooz, F., Heydari, S. T., Kavari, S. H., Mirhosseini, N. Z., Mafi, A., Dastorani, M., et al. (2018) · Hormone and Metabolic Research · doi:10.1055/s-0044-101355 · Cited by 122 · see citing works
A Genome-Wide Methylation Study of Severe Vitamin D Deficiency in African American Adolescents
Zhu, H., Wang, X., Shi, H., Su, S., Harshfield, G. A., Gutin, B., Snieder, H., & Dong, Y. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.10.059 · Cited by 105 · see citing works
Jafari, T., Faghihimani, E., Feizi, A., Iraj, B., Javanmard, S. H., Esmaillzadeh, A., Fallah, A. A., & Askari, G. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.02.014 · Cited by 100 · see citing works
Vitamin D-Binding Protein in Pregnancy and Reproductive Health
Fernando, M., Ellery, S. J., Marquina, C., Lim, S. S., Naderpoor, N., & Mousa, A. (2020) · Nutrients · doi:10.3390/nu12051489 · Cited by 99 · see citing works
Jamka, M., Woźniewicz, M., Walkowiak, J., Bogdański, P., Jeszka, J., & Stelmach-Mardas, M. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1089-5 · Cited by 96 · see citing works
Krajewska, M., Witkowska–Sędek, E., Rumińska, M., Stelmaszczyk‐Emmel, A., Sobol, M., Majcher, A., & Pyrżak, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.920340 · Cited by 102 · see citing works
Mackawy, A. M. H., & Badawy, M. E.-S. (2014) · Meta Gene · doi:10.1016/j.mgene.2014.07.002 · Cited by 93 · see citing works
Chang, E., & Kim, Y. (2017) · Nutrients · doi:10.3390/nu9040338 · Cited by 93 · see citing works
Chandler, P. D., Scott, J. B., Drake, B. F., Ng, K., Manson, J. E., Rifai, N., Chan, A. T., Bennett, G. G., Hollis, B. W., Giovannucci, E. L., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0338-t · Cited by 84 · see citing works
Akbaş, E. M., Güngör, Â., Özçiçek, A., Akbaş, N., Aşkın, S., & Polat, M. (2016) · Archives of Medical Science · doi:10.5114/aoms.2015.50625 · Cited by 78 · see citing works
Low 25-hydroxyvitamin D level is independently associated with non-alcoholic fatty liver disease
Jablonski, K., Jovanovich, A. J., Holmen, J. R., Targher, G., McFann, K., Kendrick, J., & Chonchol, M. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.12.006 · Cited by 75 · see citing works
Mansournia, M. A., Ostadmohammadi, V., Doosti‐Irani, A., Ghayour‐Mobarhan, M., Ferns, G. A., Akbari, H., Ghaderi, A., Talari, H. R., & Asemi, Z. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0630-1303 · Cited by 72 · see citing works
Pu, D., Luo, J., Wang, Y., Ju, B., Lv, X., Fan, P., & He, L. (2017) · Clinical Rheumatology · doi:10.1007/s10067-017-3874-4 · Cited by 69 · see citing works
Wamberg, L., Pedersen, S. B., Rejnmark, L., & Richelsen, B. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0176-5 · Cited by 66 · see citing works
Parikh, S. J., Guo, D.-H., Pollock, N. K., Petty, K., Bhagatwala, J., Gutin, B., Houk, C., Zhu, H., & Dong, Y. (2012) · Diabetes Care · doi:10.2337/dc11-1944 · Cited by 65 · see citing works
The Role of Vitamin D in the Prevention of Type 2 Diabetes: To D or Not to D?
Angellotti, E., & Pittas, A. G. (2017) · Endocrinology · doi:10.1210/en.2017-00265 · Cited by 66 · see citing works
Mazidi, M., Rezaie, P., & Vatanparast, H. (2018) · BMC Nutrition · doi:10.1186/s40795-017-0207-6 · Cited by 64 · see citing works
Bose, S., Diette, G. B., Woo, H., Koehler, K., Romero, K. M., Rule, A. M., Detrick, B., Brigham, E. P., McCormack, M. C., & Hansel, N. N. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.01.051 · Cited by 63 · see citing works
Vitamin D deficiency and Alzheimer disease: Common links
Keeney, J. T. R., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.06.020 · Cited by 59 · see citing works
Enrique Lanzarini, S., Nogués, X., Goday, A., Benaiges, D., Ramón, M., Villatoro, M., Pera, M., Grande, L., & Ramón, J. M. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1572-3 · Cited by 59 · see citing works
Mokhtari‐Zaer, A., Hosseini, M., Salmani, H., Arab, Z., & Zareian, P. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117703 · Cited by 59 · see citing works
Negative association between trunk fat, insulin resistance and skeleton in obese women
Greco, E. A. (2013) · World Journal of Diabetes · doi:10.4239/wjd.v4.i2.31 · Cited by 57 · see citing works
Vitamin D deficiency increases blood-brain barrier dysfunction after ischemic stroke in male rats
Sayeed, I., Turan, N., Stein, D. G., & Wali, B. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.11.005 · Cited by 58 · see citing works
Titmarsh, H. F., Gow, A. G., Kilpatrick, S., Cartwright, J. A., Milne, E., Philbey, A., Berry, J., Handel, I. G., & Mellanby, R. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137377 · Cited by 51 · see citing works
Barker, T., Martins, T. B., Hill, H. R., Kjeldsberg, C. R., Dixon, B. M., Schneider, E. D., Henriksen, V. T., & Weaver, L. K. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2582-7 · Cited by 51 · see citing works
Mousa, A., Naderpoor, N., Johnson, J., Sourris, K. C., de Courten, M., Wilson, K., Scragg, R. K. R., Plebanski, M., & de Courten, B. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-15264-1 · Cited by 51 · see citing works
Abiri, B., Sarbakhsh, P., & Vafa, M. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.1945859 · Cited by 50 · see citing works
Barker, T., Henriksen, V. T., Rogers, V. E., Aguirre, D., Trawick, R. H., Rasmussen, G. L., & Momberger, N. G. (2014) · Redox Biology · doi:10.1016/j.redox.2014.01.024 · Cited by 49 · see citing works
Vitamin D, vitamin D binding protein, lung function and structure in COPD
Berg, I., Hanson, C., Sayles, H. R., Romberger, D. J., Nelson, A. J., Meza, J. L., Miller, B. E., Wouters, E. F. �., MacNee, W., Rutten, E. P. A., et al. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2013.05.010 · Cited by 49 · see citing works
Nonalcoholic Fatty Liver Disease in Children
Selvakumar, P. K. C., Kabbany, M. N., Nobili, V., & Alkhouri, N. (2017) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2017.01.008 · Cited by 49 · see citing works
Association of body mass index and serum vitamin D level in healthy Iranian adolescents.
Baradaran, A., Behradmanesh, S., & Nasri, H. (2012) · PubMed · Cited by 47 · see citing works
Iolascon, G., Mauro, G. L., Fiore, P., Cisari, C., Benedetti, M. G., Panella, L., Alessandro de, S. I. R. E., Calafiore, D., Moretti, A., & Gimigliano, F. (2018) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.17.04533-6 · Cited by 47 · see citing works
Relation Between Vitamin D Status and Nonalcoholic Fatty Liver Disease in Children
Hourigan, S. K., Abrams, S. H., Yates, K. P., Pfeifer, K., Torbenson, M. S., Murray, K. F., Roth, C. L., Kowdley, K. V., Scheimann, A. O., & CRN, N. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000598 · Cited by 46 · see citing works
Severe hypovitaminosis D correlates with increased inflammatory markers in HIV infected patients
Ansemant, T., Mahy, S., Piroth, C., Ornetti, P., Lemaire‐Ewing, S., Guilland, J.-C., Croisier, D., Duvillard, L., Chavanet, P., Maillefert, J.-F., et al. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-7 · Cited by 46 · see citing works
Correlation between vitamin D and cardiovascular disease predictors in overweight and obese Koreans
Kim, M., Na, W., & Sohn, C. (2013) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.12-81 · Cited by 45 · see citing works
Zuk, A. M., Fitzpatrick, T., & Rosella, L. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154215 · Cited by 43 · see citing works
Poudel‐Tandukar, K., Poudel, K. C., Jimba, M., Kobayashi, J., Johnson, C. A., & Palmer, P. H. (2012) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2012.0120 · Cited by 44 · see citing works
Serum Vitamin D Increases with Weight Loss in Obese Subjects 6 Months After Roux-en-Y Gastric Bypass
Coupaye, M., Breuil, M. C., Rivière, P., Castel, B., Bogard, C., Dupré, T., Msika, S., & Ledoux, S. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0813-y · Cited by 44 · see citing works
Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns
Tao, R., Zhou, Q., Xu, Z., Hao, J., Huang, K., Mou, Z., Jiang, X.-M., Tao, F., & Zhu, P. (2015) · Nutrients · doi:10.3390/nu7115468 · Cited by 44 · see citing works
Holick, M. F., Mazzei, L. J., Menéndez, S. G., Giménez, V. M. M., Anouti, F. A., & Manucha, W. A. (2023) · Nutrients · doi:10.3390/nu15030767 · Cited by 42 · see citing works
Hajimohammadi, M., Shab‐Bidar, S., & Neyestani, T. R. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.245 · Cited by 42 · see citing works
Chang, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810915 · Cited by 39 · see citing works
Zhu, D., Liu, Y., Zhang, A., Chu, Z.-X., Wu, Q. Y., Li, H., Ge, J., Dong, Y., & Zhu, P. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.051 · Cited by 39 · see citing works
Vitamin D and Immune Response: Implications for Prostate Cancer in African Americans
Batai, K., Murphy, A. B., Nonn, L., & Kittles, R. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00053 · Cited by 39 · see citing works
Amani, R., Fazelian, S., Paknahad, Z., Kheiri, S., & Khajehali, L. (2019) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_174_18 · Cited by 38 · see citing works
Huang, X. L., Yang, Y., Jiang, Y., Zhou, Z., & Zhang, J. (2023) · BMC Public Health · doi:10.1186/s12889-023-16447-4 · Cited by 46 · see citing works
Pergola, G. D., Nitti, A., Bartolomeo, N., Gesuita, A., Giagulli, V. A., Triggiani, V., Guastamacchia, E., & Silvestris, F. (2013) · BioMed Research International · doi:10.1155/2013/921348 · Cited by 37 · see citing works
Ability of vitamin D to reduce inflammation in adults without acute illness
Zanetti, M., Harris, S. S., & Dawson‐Hughes, B. (2013) · Nutrition Reviews · doi:10.1111/nure.12095 · Cited by 35 · see citing works
Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle
Pojednic, R. M., Ceglia, L., Lichtenstein, A. H., Dawson‐Hughes, B., & Fielding, R. A. (2014) · Endocrine · doi:10.1007/s12020-014-0505-6 · Cited by 35 · see citing works
Waterhouse, M. A., Tran, B. N. H., Ebeling, P. R., English, D. R., Lucas, R. M., Venn, A., Webb, P. M., Whiteman, D. C., & Neale, R. Ε. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002366 · Cited by 33 · see citing works
Yodoshi, T., Orkin, S. H., Arce‐Clachar, A. C., Bramlage, K., Liu, C., Fei, L., El-Khider, F. A., Dasarathy, S., Xanthakos, S. A., & Mouzaki, M. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-019-0493-y · Cited by 33 · see citing works
Vitamin D supplementation increases adipokine concentrations in overweight or obese adults
Mousa, A., Naderpoor, N., Wilson, K., Plebanski, M., de Courten, M., Scragg, R. K. R., & de Courten, B. V. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01899-5 · Cited by 32 · see citing works
de Souza, W. N., Norde, M. M., Oki, É., Rogero, M. M., Marchioni, D. M. L., Fisberg, R. M., & Martini, L. A. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.10.006 · Cited by 30 · see citing works
Low serum levels of vitamin D are associated with anxiety in children and adolescents with dialysis
Han, B., Zhu, F., Yu, H., Liu, S., & Zhou, J.-L. (2018) · Scientific Reports · doi:10.1038/s41598-018-24451-7 · Cited by 30 · see citing works
Beyond the skeleton: the role of vitamin D in companion animal health
Mellanby, R. J. (2016) · Journal of Small Animal Practice · doi:10.1111/jsap.12458 · Cited by 29 · see citing works
Vitamina D–importância da avaliação laboratorial
Alves, M., Bastos, M., Leitão, F., Marques, G., Ribeiro, G., & Carrilho, F. (2013) · Revista Portuguesa de Endocrinologia Diabetes e Metabolismo · doi:10.1016/j.rpedm.2012.12.001 · Cited by 29 · see citing works
Jia, X., Wang, Y., Zhang, N., Guo, L., Zhen, X., Li, H., & Wei, L. (2015) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12793 · Cited by 29 · see citing works
Zhang, M., Gao, Y., Tian, L., Li, Z., Wang, X., Liu, W., Zhang, Y., & Huang, G. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.02.022 · Cited by 29 · see citing works
Itariu, B. K., Zeyda, M., Leitner, L., Marculescu, R., & Stulnig, T. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054634 · Cited by 28 · see citing works
Association Between Serum Levels of Vitamin D and the Risk of Post-Stroke Anxiety
Wu, C., Ren, W., Cheng, J., Zhu, B., Jin, Q., Wang, L., Chen, C., Zhu, L., Chang, Y., Gu, Y., et al. (2016) · Medicine · doi:10.1097/md.0000000000003566 · Cited by 28 · see citing works
Prandota, J. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000241 · Cited by 27 · see citing works
Wesselink, E., Balvers, M. G. J., Bours, M. J. L., de Wilt, J. H. W., Witkamp, R. F., van Baar, H., Geijsen, A. J. M. R., van Halteren, H., Keulen, E. T. P., Kok, D. E. G., et al. (2020) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284820923922 · Cited by 26 · see citing works
Stein, D. G., & Sayeed, I. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.006 · Cited by 26 · see citing works
de Menezes-Júnior, L. A. A., Sabião, T. D. S., de Moura, S. S., Batista, A. P., de Menezes, M. C., Carraro, J. C. C., Andrade, A. C. D. S., Machado-Coelho, G. L. L., & Meireles, A. L. (2023) · Nutrition · doi:10.1016/j.nut.2023.112008 · Cited by 25 · see citing works
García‐Bailo, B., Roke, K., Mutch, D. M., El‐Sohemy, A., & Badawi, A. F. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-102 · Cited by 25 · see citing works
Mieszkowski, J., Borkowska, A., Stankiewicz, B., Kochanowicz, A., Niespodziński, B., Surmiak, M., Waldziński, T., Rola, R., Petr, M., & Antosiewicz, J. (2021) · Nutrients · doi:10.3390/nu13041280 · Cited by 29 · see citing works
Nutritional and Hormonal Modulation of Adiponectin and its Receptors adipoR1 and adipoR2
de Oliveira, C., de Mattos, A. B. M., Silva, C. B. R., Mota, J. F., & Zemdegs, J. C. S. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-398313-8.00003-8 · Cited by 23 · see citing works
Nguyen, V. T., Li, X., Elli, E. F., Ayloo, S. M., Castellanos, K. J., Fantuzzi, G., Freels, S. A., & Braunschweig, C. L. (2015) · Obesity · doi:10.1002/oby.21131 · Cited by 22 · see citing works
Pesarini, J. R., Oliveira, R. J., Pessatto, L. R., Antoniolli‐Silva, A. C. M. B., Felicidade, I., Nardi, N. B., Camassola, M., Mantovani, M. S., & Ribeiro, L. R. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.013 · Cited by 21 · see citing works
Cătoi, A. F., Iancu, M., Pârvu, A. E., Cecan, A. D., Bidian, C., Chera, E. I., Pop, I., & MACRI, A. M. (2021) · Nutrients · doi:10.3390/nu13082889 · Cited by 22 · see citing works
Matteis, C. D., Crudele, L., Cariello, M., Battaglia, S., Piazzolla, G., Suppressa, P., Sabbà, C., Piccinin, E., & Moschetta, A. (2022) · Nutrients · doi:10.3390/nu14020347 · Cited by 21 · see citing works
Zhou, W. P., & Ye, S. (2015) · Journal of Diabetes Research · doi:10.1155/2015/815949 · Cited by 21 · see citing works
Guglielmi, V., Bellia, A., Gentileschi, P., Lombardo, M., D’Adamo, M., Lauro, D., & Sbraccia, P. (2017) · Endocrine · doi:10.1007/s12020-017-1477-0 · Cited by 20 · see citing works
Self-citationCosendey-Menegati, G., de Oliveira, L. C., Santos, A. L. A., Cohen, L., Magno, F. C. C. M., de Mendonça, L. M. C., Carneiro, J. R. I., Farias, M. L. F., & Rosado, E. L. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1910-5 · Cited by 20 · see citing works
Sphingolipid serum profiling in vitamin D deficient and dyslipidemic obese dimorphic adults
Al‐Daghri, N. M., Torretta, E., Barbacini, P., Asare, H., Ricci, C., Capitanio, D., Guerini, F. R., Sabico, S., Alokail, M. S., Clerici, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-53122-4 · Cited by 17 · see citing works
Prevalence of vitamin D deficiency in adults presenting for bariatric surgery in Lebanon
Aridi, H. D., Alami, R. S., Fouani, T., Shamseddine, G. A., Tamim, H., & Safadi, B. Y. (2015) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2015.09.022 · Cited by 19 · see citing works
Formica, V., Morelli, C., Ferroni, P., Nardecchia, A., Tesauro, M., Pellicori, S., Cereda, V., Russo, A. D., Riondino, S., Guadagni, F., et al. (2016) · Cancer Biomarkers · doi:10.3233/cbm-160645 · Cited by 17 · see citing works
Self-citationBabatunde, O. A., Adams, S. A., Truman, S. C., Sercy, E., Murphy, A. E., Khan, S., Hurley, T. G., Wirth, M. D., Choi, S. K., Johnson, H., et al. (2020) · Women & Health · doi:10.1080/03630242.2020.1746950 · Cited by 17 · see citing works
Latifi-Pupovci, H., Namani, S. A., Pajaziti, A., Ahmetaj‐Shala, B., Berisha, L. A., Kotori, A., Haxhibeqiri, V., Gegaj, V., & Bunjaku, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-09785-7 · Cited by 16 · see citing works
Wakolbinger, M., Kruschitz, R., Marculescu, R., Haslacher, H., Hoppichler, F., Kállay, E., Kienbacher, C., Klammer, C., Kral, M., Langer, F. B., et al. (2015) · Trials · doi:10.1186/s13063-015-0877-9 · Cited by 16 · see citing works
Low Vitamin D Level in Saudi Women With Polycystic Ovary Syndrome
Bindayel, I. A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.611351 · Cited by 16 · see citing works
Ahmed, A., Ghany, M. A., Hakeem, G. L. A., Kamal, A., Khattab, R. A., Abdalla, A., Aboul-Fotoh, L. E.-M., Mazary, A. A. E., Sayed, M. A., & Fadil, A. M. A. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0112-z · Cited by 16 · see citing works
A meta‐analysis: Does vitamin D play a promising role in sleep disorders?
Yan, S., Tian, Z., Zhao, H., Wang, C., Pan, Y., Yao, N., Guo, Y., Wang, H., Li, B., & Cui, W. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1867 · Cited by 16 · see citing works
The constellation of vitamin D, the acute-phase response, and inflammation
Antonelli, M. J., Kushner, I., & Epstein, M. (2023) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.90a.22048 · Cited by 15 · see citing works
Vitamin D status and insulin resistance among young obese Saudi females
Abdelkarem, H. M., Elsherif, M. A., & Gomaa, S. B. (2016) · Saudi Medical Journal · doi:10.15537/smj.2016.5.13581 · Cited by 15 · see citing works
Vitamin D3 alleviates cognitive impairment through regulating inflammatory stress in db/db mice
Tan, X., Gao, L., Cai, X., Zhang, M., Huang, D., Dang, Q., & Bao, L. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2397 · Cited by 15 · see citing works
- Authors
- Bellia, A., Garcovich, C., D’Adamo, M., Lombardo, M., Tesauro, M., Donadel, G., Gentileschi, P., Lauro, D., Federici, M., Lauro, R., & Sbraccia, P.
- Affiliations
- University of Rome Tor Vergata (IT)
- Corresponding author
- Sbraccia, Paolo
- ORCID
- Venue
- Internal and Emergency Medicine
- Published
- 2011-03-25
- Volume
- 8
- Issue
- 1
- Pages
- 33-40
- ISSN
- 1828-0447 (ISSN-L)
- 1970-9366
- OpenAlex
- W2162663427
- Cited by
- 206
- References
- 33
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 13 · 2023: 17 · 2022: 8 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 16 · 2017: 19 · 2016: 19 · 2015: 19 · 2014: 9 · 2013: 22 · 2012: 13
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Internal and Emergency Medicine (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Keywords
- 25-hydroxyvitamin D, vitamin D deficiency, obesity, systemic inflammation, insulin resistance, C-reactive protein, interleukin-6, TNF-α, bariatric surgery candidates, adipokines, leptin, adiponectin
- MeSH terms
- Adult, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Inflammation, Insulin Resistance, Male, Obesity, Tumor Necrosis Factor-alpha, Vitamin D, Cohort Studies, Interleukin-6, Body Mass Index, Multivariate Analysis
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