Cited by 206Vitamin D Research StudiesAdipokines, Inflammation, and Metabolic DiseasesMagnesium in Health and Disease

Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects

Bellia, Alfonso, Garcovich, Caterina, D’Adamo, Monica, Lombardo, Mauro, Tesauro, Manfredi, Donadel, Giulia, Gentileschi, Paolo, Lauro, Davide +3 more·2013·Internal and Emergency Medicine

Abstract

Obesity is frequently characterized by a reduced vitamin D bioavailability, as well as insulin-resistance and a chronic inflammatory response. We tested the hypothesis of an independent relationship between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and several circulating inflammatory markers in a cohort of severely obese individuals. Cross-sectional study was carried out among obese patients undergoing a clinical evaluation before bariatric surgery in our University Hospital. Serum 25(OH)D, fasting and post load glucose and insulin, high-sensitive C-reactive protein (hs CRP), fibrinogen, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin and lipid profile were collected. Insulin-resistance was assessed by insulin sensitivity index (ISI). Total body fat (FAT kg), total percent body fat (FAT%) and truncal fat mass (TrFAT) were assessed with dual-energy X-ray absorptiometry. A total of 147 obese subjects (89 women, 37.8 ± 7.1 years) with mean body mass index (BMI) of 43.6 ± 4.3 kg/m(2) were enrolled. Patients in the lowest tertile of 25(OH)D were significantly more obese with a higher amount of TrFAT, more insulin-resistant, and had higher levels of fasting and post-challenge glucose (p < 0.05 for all). In a multivariate regression analysis, serum 25(OH)D was inversely related to significant levels of hs CRP, IL-6 and TNF-α after accounting for age, gender, season of recruitment, BMI, FAT kg and TrFAT (p < 0.01 for all). In extremely obese subjects, 25(OH)D serum concentrations are inversely associated with several biomarkers of systemic inflammation, regardless of the total quantity of fat mass.

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Crossref · 10.1007/s11739-011-0559-x

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  • Vitamin D deficiency is associated with lower muscle strength, greater body instability, falls, and disability in the geriatric population.

    “several studies have suggested that vitamin D deficiency is associated with lower muscle strength, greater body instability, falls and disability in geriatric population (153).”

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Authors
Bellia, A., Garcovich, C., D’Adamo, M., Lombardo, M., Tesauro, M., Donadel, G., Gentileschi, P., Lauro, D., Federici, M., Lauro, R., & Sbraccia, P.
Affiliations
University of Rome Tor Vergata (IT)
Corresponding author
Sbraccia, Paolo
Venue
Internal and Emergency Medicine
Published
2011-03-25
Volume
8
Issue
1
Pages
33-40
ISSN
  • 1828-0447 (ISSN-L)
  • 1970-9366
OpenAlex
W2162663427
Cited by
206
References
33
Citations by year
2026: 1 · 2025: 6 · 2024: 13 · 2023: 17 · 2022: 8 · 2021: 17 · 2020: 17 · 2019: 10 · 2018: 16 · 2017: 19 · 2016: 19 · 2015: 19 · 2014: 9 · 2013: 22 · 2012: 13
FWCI
9.87
Type
journal article
Language
en
Open access
closed
Locations
  • Internal and Emergency Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Keywords
25-hydroxyvitamin D, vitamin D deficiency, obesity, systemic inflammation, insulin resistance, C-reactive protein, interleukin-6, TNF-α, bariatric surgery candidates, adipokines, leptin, adiponectin
MeSH terms
Adult, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Inflammation, Insulin Resistance, Male, Obesity, Tumor Necrosis Factor-alpha, Vitamin D, Cohort Studies, Interleukin-6, Body Mass Index, Multivariate Analysis

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