Cited by 39Mast cells and histamineAsthma and respiratory diseasesFood Allergy and Anaphylaxis Research

Immunology and clinical manifestations of non-clonal mast cell activation syndrome

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Cardet, Juan-Carlos, Castells, Mariana C., Hamilton, Matthew J.·2013·Current Allergy and Asthma Reports

Abstract

There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize key features of the science behind mast cell activation relevant to what is now known as non-clonal mast cell activation syndrome (nc-MCAS). We highlight the clinical manifestations of nc-MCAS with a focus on diagnosis and treatment.

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  1. [9]Frieri M Mahmoudi M Mastocytosis Challenges Cases in Allergy Immunology 2009 Humana Press 201 212

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Authors
Cardet, J.-C., Castells, M. C., & Hamilton, M. J.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Hamilton, Matthew J.
Venue
Current Allergy and Asthma Reports
Published
2012-12-05
Volume
13
Issue
1
Pages
10-18
ISSN
  • 1529-7322 (ISSN-L)
  • 1534-6315
OpenAlex
W2171209798
Cited by
39
References
74
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 2
FWCI
0.32
Type
journal article
Language
en
Open access
Locations
  • Current Allergy and Asthma Reports (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (K08DK094971)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
mast cell activation, systemic mastocytosis, mast cell biology, clinical features, diagnosis, treatment, immunology
MeSH terms
Animals, Humans, Mast Cells, Syndrome, Mastocytosis, Systemic

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