Immunology and clinical manifestations of non-clonal mast cell activation syndrome
Open accessAbstract
There is a spectrum of disorders that clinically manifest as a result of mast cell activation. A non-clonal form has emerged in the literature where many of the clinical features of systemic mastocytosis are shared despite having a distinct mast cell biology. In this review, we summarize key features of the science behind mast cell activation relevant to what is now known as non-clonal mast cell activation syndrome (nc-MCAS). We highlight the clinical manifestations of nc-MCAS with a focus on diagnosis and treatment.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic criteria and classification of mastocytosis: a consensus proposal
Valent, P., Horny, H., Escribano, L., Longley, B. J., Li, C. Y., Schwartz, L. B., Marone, G., Núñez, R., Akin, C., Sotlar, K., et al. (2001) · Leukemia Research · doi:10.1016/s0145-2126(01)00038-8 · Cited by 1,107 · see citing works
Integrated signalling pathways for mast-cell activation
Gilfillan, A. M., & Tkaczyk, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1782 · Cited by 955 · see citing works
Histamine and histamine intolerance
Maintz, L., & Novak, N. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1185 · Cited by 874 · see citing works
Nagata, H., Worobec, A. S., Oh, C. K., Chowdhury, B. A., Tannenbaum, S. H., Suzuki, Y., & Metcalfe, D. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10560 · Cited by 871 · see citing works
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis
Schwartz, L. B., Metcalfe, D. D., Miller, J. S., Earl, H., & Sullivan, T. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706253162603 · Cited by 784 · see citing works
Valent, P., Akin, C., Escribano, L., Födinger, M., Hartmann, K., Brockow, K., Castells, M., Sperr, W. R., Kluin‐Nelemans, H. C., Hamdy, N. A. T., et al. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01807.x · Cited by 750 · cited 3× · see citing works
“The collection of signs and symptoms that results from mast cell activation has been well documented in patients with systemic mastocytosis [1, 2].”
Self-citationImmunomodulatory mast cells: negative, as well as positive, regulators of immunity
Galli, S. J., Grimbaldeston, M. A., & Tsai, M. M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2327 · Cited by 738 · see citing works
Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells
Re, F., & Strominger, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105927200 · Cited by 691 · see citing works
Valent, P., Akin, C., Arock, M., Brockow, K., Butterfield, J. H., Carter, M. C., Castells, M., Escribano, L., Hartmann, K., Lieberman, P., et al. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000328760 · Cited by 654 · see citing works
Self-citationMetcalfe, D. D. (2008) · Blood · doi:10.1182/blood-2007-11-078097 · Cited by 536 · see citing works
Brockow, K., Jofer, C., Behrendt, H., & Ring, J. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01569.x · Cited by 523 · see citing works
García‐Montero, A. C. (2006) · Blood · doi:10.1182/blood-2006-04-015545 · Cited by 502 · see citing works
Molecular regulation of mast cell activation
Rivera, J. Á., & Gilfillan, A. M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.04.015 · Cited by 464 · see citing works
Differential release of mast cell mediators and the pathogenesis of inflammation
Theoharides, T. C., Kempuraj, D., Tagen, M., Conti, P., & Kalogeromitros, D. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00519.x · Cited by 425 · see citing works
Bodemer, C., Hermine, O., Palmérini, F., Yang, Y., Grandpeix-Guyodo, C., Leventhal, P. S., Hadj-Rabia, S., Nasca, L., Georgin-Lavialle, S., Cohen-Akenine, A., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.281 · Cited by 397 · see citing works
Kulka, M., Alexopoulou, L., Flavell, R. A., & Metcalfe, D. D. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.03.049 · Cited by 354 · see citing works
Mast cell activation syndrome: Proposed diagnostic criteria
Akin, C., Valent, P., & Metcalfe, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.035 · Cited by 327 · see citing works
Álvarez-Twose, I., González de Olano, D., Sánchez-Muñoz, L., Matito, A., Esteban-López, M. I., Vega, A., Mateo, M. B., Alonso Díaz de Durana, M. D., de la Hoz, B., del Pozo Gil, M. D., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.02.019 · Cited by 294 · see citing works
Toll‐like receptor 2 (TLR2) and TLR4 differentially activate human mast cells
Varadaradjalou, S., Féger, F., Thiéblemont, N., Benhamouda, N., Pléau, J., Dy, M., & Arock, M. (2003) · European Journal of Immunology · doi:10.1002/eji.200323830 · Cited by 293 · see citing works
The mast cell and allergic diseases: role in pathogenesis and implications for therapy
Brown, J. M., Wilson, T. M., & Metcalfe, D. D. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02886.x · Cited by 289 · see citing works
Akin, C., Scott, L. M., Kocabas, C. N., Kushnir-Sukhov, N., Brittain, E., Noel, P., & Metcalfe, D. D. (2007) · Blood · doi:10.1182/blood-2006-06-028100 · Cited by 240 · see citing works
IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells
Kandere‐Grzybowska, K., Létourneau, R., Kempuraj, D., Donelan, J., Poplawski, S. E., Boucher, W. S., Athanassiou, A., & Theoharides, T. C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4830 · Cited by 233 · see citing works
Hyperadrenergic Postural Tachycardia Syndrome in Mast Cell Activation Disorders
Shibao, C., Arzubiaga, C., Roberts, L. J., Raj, S., Black, B., Harris, P., & Biaggioni, I. (2005) · Hypertension · doi:10.1161/01.hyp.0000158259.68614.40 · Cited by 220 · see citing works
A Case of Intestinal Mastocytosis Misdiagnosed as Crohn's Disease
Reggiani, S., Cosso, L., Adriani, A., Pantaleoni, S., Risso, A., Vittone, F., Chiusa, L., Sapone, N., & Astegiano, M. (2015) · Case Reports in Gastroenterology · doi:10.1159/000430946 · Cited by 193 · see citing works
Diagnosis and Treatment of Cutaneous Mastocytosis in Children
Castells, M., Metcalfe, D. D., & Escribano, L. (2011) · American Journal of Clinical Dermatology · doi:10.2165/11588890-000000000-00000 · Cited by 193 · see citing works
Self-citationMarkers of Mast Cell Degranulation
Hogan, A. D., & Schwartz, L. B. (1997) · Methods · doi:10.1006/meth.1997.0494 · Cited by 178 · see citing works
Omalizumab for the treatment of unprovoked anaphylaxis in patients with systemic mastocytosis
Carter, M. C., Robyn, J. A., Bressler, P. B., Walker, J. C., Shapiro, G. G., & Metcalfe, D. D. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.03.032 · Cited by 172 · see citing works
Molderings, G. J., Brettner, S., Homann, J., & Afrin, L. B. (2011) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-4-10 · Cited by 149 · see citing works
Escribano, L., Dı́az-Agustı́n, B., López, A., Núñez, R., García‐Montero, A. C., Almeida, J., Prados, A., Angulo, M., Herrero, S., Órfão, A., et al. (2004) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.10072 · Cited by 148 · see citing works
Mastocytosis: Mediator-Related Signs and Symptoms
Castells, M., & Austen, K. F. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000048188 · Cited by 133 · see citing works
Self-citationMast cell activation syndrome: A newly recognized disorder with systemic clinical manifestations
Hamilton, M. J., Hornick, J. L., Akin, C., Castells, M. C., & Greenberger, N. J. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.037 · Cited by 132 · see citing works
Self-citationEscribano, L., Dı́az-Agustı́n, B., Bellas, C., Navalón, R., Núñez, R., Sperr, W. R., Schernthaner, G.-H., Valent, P., & Órfão, A. (2001) · Leukemia Research · doi:10.1016/s0145-2126(01)00050-9 · Cited by 132 · see citing works
Sonneck, K., Florian, S., Müllauer, L., Wimazal, F., Födinger, M., Sperr, W. R., & Valent, P. (2007) · International Archives of Allergy and Immunology · doi:10.1159/000096442 · Cited by 129 · see citing works
Sheffer, A. L., Tong, A. K. F., Murphy, G. F., Lewis, R. A., McFadden, E. R., & Austen, K. F. (1985) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(85)80021-x · Cited by 129 · see citing works
Activation of human mast cells by aggregated IgG through FcγRI: additive effects of C3a
Woolhiser, M. R. (2003) · Clinical Immunology · doi:10.1016/j.clim.2003.11.007 · Cited by 114 · see citing works
Mast cell mediators in allergic inflammation and mastocytosis
Castells, M. (2006) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2006.05.005 · Cited by 112 · see citing works
Self-citationFrieri, M., Alling, D. W., & Metcalfe, D. D. (1985) · The American Journal of Medicine · doi:10.1016/0002-9343(85)90454-1 · Cited by 110 · see citing works
Clinical utility of tryptase levels in systemic mastocytosis and associated hematologic disorders
Schwartz, L. B. (2001) · Leukemia Research · doi:10.1016/s0145-2126(01)00020-0 · Cited by 110 · see citing works
Dvořàk, A. M., McLeod, R. S., Onderdonk, A. B., Monahan-Earley, R. A., Cullen, J., Antonioli, D. A., Morgan, E. S., Blair, J. E., Estrella, P., Cisneros, R. L., et al. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236338 · Cited by 108 · see citing works
Dvořàk, A. M., Tepper, R., Weller, P. F., Morgan, E., Estrella, P., Monahan-Earley, R., & Galli, S. J. (1994) · Blood · doi:10.1182/blood.v83.12.3600.3600 · Cited by 95 · see citing works
Hahn, H. P., & Hornick, J. L. (2007) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318078ce7a · Cited by 93 · see citing works
gp49B1-αvβ3 interaction inhibits antigen-induced mast cell activation
Castells, M., Klickstein, L. B., Hassani, K., Cumplido, J., Lacouture, M. E., Austen, K. F., & Katz, H. R. (2001) · Nature Immunology · doi:10.1038/87749 · Cited by 91 · see citing works
Self-citationMolecular Diagnosis of Mast Cell Disorders
Akin, C. (2006) · Journal of Molecular Diagnostics · doi:10.2353/jmoldx.2006.060022 · Cited by 84 · see citing works
Butterfield, J. H., & Weiler, C. R. (2008) · International Archives of Allergy and Immunology · doi:10.1159/000144042 · Cited by 81 · see citing works
Inhibitory receptors and allergy
Katz, H. R. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00400-4 · Cited by 81 · see citing works
Biochemical Diagnosis of Systemic Mast Cell Disorders
Roberts, L. J., & Oates, J. A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12468945 · Cited by 74 · see citing works
Molderings, G. J., Kolck, U. W., Scheurlen, C., Brüss, M., Homann, J., & Von Kügelgen, I. (2007) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520701245744 · Cited by 73 · see citing works
Omalizumab is effective in treating systemic mastocytosis in a nonatopic patient
Douglass, J. A., Carroll, K., Voskamp, A. L., Bourke, P., Wei, A. H., & O’Hehir, R. E. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02259.x · Cited by 66 · see citing works
Awad, J. A., Morrow, J. D., & Roberts, L. J. (1994) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(94)90371-9 · Cited by 66 · see citing works
Omalizumab Treatment of Systemic Mast Cell Activation Disease: Experiences from Four Cases
Molderings, G. J., Raithel, M., Kratz, F., Azémar, M., Haenisch, B., Harzer, S., & Homann, J. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.4640 · Cited by 63 · see citing works
Molderings, G. J., Meis, K., Kolck, U. W., Homann, J., & Frieling, T. (2010) · Immunogenetics · doi:10.1007/s00251-010-0474-8 · Cited by 58 · see citing works
Drug allergy in mast cell disease
Brockow, K., & Bonadonna, P. (2012) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0b013e328355b7cb · Cited by 57 · see citing works
Mast Cell Activation Syndrome: A Review
Frieri, M., Patel, R., & Celestin, J. (2012) · Current Allergy and Asthma Reports · doi:10.1007/s11882-012-0322-z · Cited by 56 · see citing works
Anaphylaxis and Mast Cell Disease: What Is the Risk?
Akin, C. (2010) · Current Allergy and Asthma Reports · doi:10.1007/s11882-009-0080-8 · Cited by 55 · see citing works
Cutting the cord: is birth already too late for primary prevention of allergy?
Brown, M. A., Halonen, M. J., & Martínez, F. D. (1997) · PubMed · Cited by 55 · see citing works
Cutting the cord: is birth already too late for primary prevention of allergy?
Brown, M. A., Halonen, M. J., & Martínez, F. D. (1997) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1997.tb00665.x · Cited by 55 · see citing works
A morphometric study of neovascularization in colorectal carcinoma
Pavlopoulos, P. M., Konstantinidou, A. E., Agapitos, E. B., Kavantzas, N., Nikolopoulou, P., & Davaris, P. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981115)83:10 · Cited by 54 · see citing works
Differential Diagnosis of the Patient with Unexplained Flushing/Anaphylaxis
Metcalfe, D. D. (2000) · Allergy and Asthma Proceedings · doi:10.2500/108854100778249006 · Cited by 53 · see citing works
Prevention of anaphylaxis related to mast cell activation syndrome with omalizumab
Bell, M. C., & Jackson, D. J. (2012) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2012.02.021 · Cited by 50 · see citing works
Dvořàk, A. M. (2005) · KARGER eBooks · doi:10.1159/000086516 · Cited by 49 · see citing works
Mast cell-related disorders presenting with Kounis syndrome
González‐de‐Olano, D., Matito, A., Sánchez-López, P., Sánchez‐Muñoz, L., Morgado, J. M., Teodósio, C., Jara‐Acevedo, M., García‐Montero, A. C., Orfao, A., Escribano, L., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.06.041 · Cited by 30 · see citing works
Sargur, R. B., Cowley, D., Murng, S. H. K., Wild, G., Green, K., Shrimpton, A., & Egner, W. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04287.x · Cited by 26 · see citing works
Determination of histamine in human plasma: the European external quality control study 1988
COSTING, E., Neugebauer, E. A. M., Keyzer, J. J., & Lorenz, W. (1990) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1990.tb02793.x · Cited by 26 · see citing works
Weidner, N., Horan, R. F., & Austen, K. F. (1992) · PubMed · Cited by 22 · see citing works
Polycythemia From Mast Cell Activation Syndrome: Lessons Learned
Afrin, L. B., & Hamm, L. L. (2011) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e31821d41dd · Cited by 21 · see citing works
Evaluation of mast cell activation syndromes: impact of pathology and immunohistology
Horny, H.-P., Sotlar, K., & Valent, P. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000336374 · Cited by 21 · see citing works
Burning mouth syndrome and mast cell activation disorder
Afrin, L. B. (2011) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2010.11.030 · Cited by 17 · see citing works
Acute nonlymphocytic leukemia in systemic mastocytosis with biclonal gammopathy
Lindner, P. S., Pardanani, B., Angadi, C., & Frieri, M. (1992) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(05)80024-7 · Cited by 17 · see citing works
Lymphadenopathic mastocytosis with eosinophilia and biclonal gammopathy
Frieri, M., Linn, N., Schweitzer, M. E., Angadi, C., & Pardanani, B. (1990) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(05)80132-0 · Cited by 17 · see citing works
Sclerosing mediastinitis and mast cell activation syndrome
Afrin, L. B. (2012) · Pathology - Research and Practice · doi:10.1016/j.prp.2011.12.005 · Cited by 16 · see citing works
Cerra, F. B. (1987) · Cited by 16 · see citing works
Mast Cell Activation Syndrome Masquerading as Agranulocytosis
Afrin, L. B. (2012) · Military Medicine · doi:10.7205/milmed-d-11-00111 · Cited by 12 · see citing works
MAST CELL DISEASES AND THE SEVERITY AND COURSE OF INTRAOPERATIVE ANAPHYLAXIS
Bilò, M. B., Frontini, F., Massaccesi, C., Cinti, B., & Antonicelli, L. (2009) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)60173-1 · Cited by 10 · see citing works
Kassab, D., Koterba, A. P., Jiang, Y., & Akin, C. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.12.268 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [9]Frieri M Mahmoudi M Mastocytosis Challenges Cases in Allergy Immunology 2009 Humana Press 201 212
Cited by
Sorted by citations
Lyons, J. J., Yu, X., Hughes, J. D., Le, Q. T., Jamil, A., Bai, Y., Ho, N., Zhao, M., Liu, Y., O'Connell, M. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3696 · Cited by 394 · see citing works
Mast cell activation syndrome and mastocytosis: initial treatment options and long-term management
Castells, M., & Butterfield, J. (2019) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2019.02.002 · Cited by 135 · see citing works
Self-citationWeiler, C. R., Austen, K. F., Akin, C., Barkoff, M. S., Bernstein, J. A., Bonadonna, P., Butterfield, J. H., Carter, M., Fox, C. C., Maitland, A., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.08.023 · Cited by 123 · see citing works
Kucharik, A. H., & Chang, C. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08755-8 · Cited by 122 · see citing works
Theoharides, T. C., Tsilioni, I., & Ren, H. L. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1596800 · Cited by 124 · see citing works
Mast cell disorders in Ehlers-Danlos syndrome
Seneviratne, S. L., Maitland, A., & Afrin, L. (2017) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.31555 · Cited by 107 · see citing works
Clinical characteristics and risk profile of patients with elevated baseline serum tryptase
Fellinger, C., Hemmer, W., Wöhrl, S., Sesztak‐Greinecker, G., Jarisch, R., & Wantke, F. (2014) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2014.05.002 · Cited by 89 · see citing works
Picard, M., Junior, P. F. G.-B., Mezzano, V., & Castells, M. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.04.001 · Cited by 77 · see citing works
Self-citationAfrin, L. B., Butterfield, J. H., Raithel, M., & Molderings, G. J. (2016) · Annals of Medicine · doi:10.3109/07853890.2016.1161231 · Cited by 74 · see citing works
Presentation and Diagnosis of Hypersensitivity to Platinum Drugs
Caiado, J., & Castells, M. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0515-3 · Cited by 72 · see citing works
Self-citationAre Mast Cells Still Good Biomarkers for Bladder Pain Syndrome/Interstitial Cystitis?
Gamper, M., Regauer, S., Welter, J., Eberhard, J., & Viereck, V. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.01.036 · Cited by 69 · see citing works
Frieri, M. (2015) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8487-6 · Cited by 65 · see citing works
Spectrum of mast cell activation disorders
Petra, A. I., Panagiotidou, S., Stewart, J. M., Conti, P., & Theoharides, T. C. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.906302 · Cited by 54 · see citing works
Patient perceptions in mast cell disorders
Jennings, S. V., Slee, V. M., Zack, R. M., Verstovsek, S., George, T. I., Shi, H., Lee, P., & Castells, M. C. (2018) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2018.04.006 · Cited by 53 · see citing works
Self-citationMastocytosis: update on pharmacotherapy and future directions
Cardet, J. C., Akin, C., & Lee, M. J. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.824424 · Cited by 49 · see citing works
Self-citationThe genetic basis of mast cell activation disease - looking through a glass darkly
Molderings, G. J. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2014.09.001 · Cited by 50 · see citing works
Mast cell activation syndrome: Current understanding and research needs
Castells, M., Giannetti, M. P., Hamilton, M. J., Novak, P., Pozdnyakova, O., Nicoloro-SantaBarbara, J., Jennings, S. V., Francomano, C., Kim, B., Glover, S. C., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.05.025 · Cited by 45 · see citing works
Self-citationBrock, I., Prendergast, W., & Maitland, A. L. (2021) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31940 · Cited by 39 · see citing works
H1‐antihistamines for primary mast cell activation syndromes: a systematic review
Nurmatov, U. B., Rhatigan, E., Simons, F. E. R., & Sheikh, A. (2015) · Allergy · doi:10.1111/all.12672 · Cited by 39 · see citing works
Caiado, J., & Picard, M. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0451-7 · Cited by 36 · see citing works
The Role of Mast Cells in the Induction and Maintenance of Inflammation in Selected Skin Diseases
Woźniak, E., Owczarczyk-Saczonek, A. B., Lange, M., Czarny, J. H., Wygonowska, E., Placek, W. J., & Nedoszytko, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087021 · Cited by 35 · see citing works
Genetic characteristics of Jiaji Duck by whole genome re-sequencing
Gu, L., Wang, F., Lin, Z., Xu, T., Lin, D., Xing, M., Yang, S., Chao, Z., Ye, B., Lin, P., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228964 · Cited by 31 · see citing works
Drug Desensitizations for Chemotherapy: Safety and Efficacy in Preventing Anaphylaxis
Caiado, J., & Castells, M. (2021) · Current Allergy and Asthma Reports · doi:10.1007/s11882-021-01014-x · Cited by 29 · see citing works
Self-citationImpact of Probiotic Bacteria on Respiratory Allergy Disorders
Jakubczyk, D., & Górska, S. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.688137 · Cited by 28 · see citing works
Szukiewicz, D., Wojdasiewicz, P., Wątroba, M., & Szewczyk, G. (2022) · Journal of Immunology Research · doi:10.1155/2022/9534163 · Cited by 22 · see citing works
González‐de‐Olano, D., Matito, A., Órfão, A., & Escribano, L. (2016) · F1000Research · doi:10.12688/f1000research.9565.1 · Cited by 21 · see citing works
Bonadonna, P., Nalin, F., & Olivieri, F. (2022) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0000000000000849 · Cited by 18 · see citing works
Nicoloro SantaBarbara, J., & Lobel, M. (2022) · Journal of Health Psychology · doi:10.1177/13591053211014583 · Cited by 17 · see citing works
Survey of Mast Cell Mediator Levels from Patients Presenting with Symptoms of Mast Cell Activation
Butterfield, J. H. (2019) · International Archives of Allergy and Immunology · doi:10.1159/000503964 · Cited by 16 · see citing works
Successful treatment of idiopathic mast cell activation syndrome with low-dose omalizumab
Berry, R., Hollingsworth, P., & Lucas, M. (2019) · Clinical & Translational Immunology · doi:10.1002/cti2.1075 · Cited by 15 · see citing works
Jennings, S. V., Finnerty, C. C., Hobart, J. S., Martín‐Martinez, M., Sinclair, K. A., Slee, V. M., Agopian, J., Akin, C., Álvarez‐Twöse, I., Bonadonna, P., et al. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.06.018 · Cited by 12 · see citing works
Khokhar, D. S., & Akin, C. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2019.09.002 · Cited by 10 · see citing works
Cimolai, N. (2020) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-020-00494-8 · Cited by 9 · see citing works
Comparing histamine intolerance and non-clonal mast cell activation syndrome
Cimolai, N. (2020) · Intestinal Research · doi:10.5217/ir.2019.00087 · Cited by 8 · see citing works
Schäfer, D., Dreßen, P., Brettner, S., Rath, N.-F., Molderings, G. J., Jensen, K., & Ziemann, C. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0213-2 · Cited by 7 · see citing works
Mast Cell Activation Syndromes
Bonamichi-Santos, R., & Castells, M. (2016) · Current Treatment Options in Allergy · doi:10.1007/s40521-016-0100-6 · Cited by 9 · see citing works
Self-citationManagement of indolent mastocytosis and mast cell activation syndrome
Akin, C., Butterfield, J. H., Castells, M., & Lyons, J. J. (2025) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2025.06.032 · Cited by 4 · see citing works
Self-citationParasympathetic and Sympathetic Nervous System Dysfunction and Monitoring
DePace, N. L., Soloway, S., Yayac, M. F., & Colombo, J. (2025) · Springer eBooks · doi:10.1007/978-3-031-88769-7_13
- Authors
- Cardet, J.-C., Castells, M. C., & Hamilton, M. J.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Hamilton, Matthew J.
- Venue
- Current Allergy and Asthma Reports
- Published
- 2012-12-05
- Volume
- 13
- Issue
- 1
- Pages
- 10-18
- ISSN
- 1529-7322 (ISSN-L)
- 1534-6315
- PMC
- PMC3545645
- OpenAlex
- W2171209798
- Cited by
- 39
- References
- 74
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 2
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Allergy and Asthma Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK094971)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- mast cell activation, systemic mastocytosis, mast cell biology, clinical features, diagnosis, treatment, immunology
- MeSH terms
- Animals, Humans, Mast Cells, Syndrome, Mastocytosis, Systemic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review