Depression, psychosocial correlates, and psychosocial resources in individuals with mast cell activation syndrome
Open accessAbstract
Individuals with Mast Cell Activation Syndrome (MCAS), a rare chronic disease, experience unpredictable physical symptoms and diagnostic challenges resulting in poor emotional states. The prevalence and correlates of depressive symptoms were examined among 125 participants who completed the CES-D and relevant instruments. The majority reported a clinically-significant level of depression which was especially common among younger participants and those who reported greater loneliness or more disease-specific stressors. Greater magnitude of depressive symptoms was associated with greater illness intrusiveness, less social support, and lower optimism. Results highlight the value of interventions targeting loneliness and stressors unique to this population.
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Almost three quarters of an MCAD sample reported clinically meaningful depressive symptoms, and most had substantially more symptoms than can be ascribed to MCAS.
“In fact, almost three quarters of the sample reported clinically meaningful levels of depressive symptoms, and most have substantially more symptoms than can be ascribed to MCAS.74”
From Mast cell activation syndrome: Current understanding and research needs (2024) · cites this paper as [74]
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Mast cell activation syndrome: Current understanding and research needs
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- Authors
- Nicoloro SantaBarbara, J., & Lobel, M.
- Affiliations
- University of California, Los Angeles, USA
- Stony Brook University (US)
- Venue
- Journal of Health Psychology
- Publisher
- SAGE Publications
- Published
- 2021-05-18
- Volume
- 27
- Issue
- 9
- Pages
- 2013-2026
- ISSN
- 1359-1053 (ISSN-L)
- 1461-7277
- PMC
- PMC10103633
- OpenAlex
- W3162629280
- Cited by
- 17
- References
- 84
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Health Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- national institute of mental health (T32MH015750)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- mast cell activation syndrome, depression, depressive symptoms, loneliness, illness intrusiveness, social support, optimism, psychosocial resources, chronic disease, young adults
- MeSH terms
- Mast Cell Activation Syndrome, Chronic Disease, Depression, Humans, Loneliness, Social Support
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