Adiponectin: Protection of the endothelium
Abstract
Low levels of adiponectin, a fat-derived hormone, are found in coronary heart disease, type 2 diabetes, obesity, and other insulin-resistant states. Conversely, high adiponectin levels are predictive of reduced coronary risk in long-term epidemiologic studies. A close association between hypoadiponectinemia and endothelial dysfunction has also been demonstrated. The various mechanisms through which adiponectin may protect the endothelium, via its insulin-sensitizing, antiatherogenic, anti-inflammatory, and antioxidant properties, are reviewed.
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Adiponectin mediates a variety of cardiovascular effects including anti-atherogenic effects via a combination of effects on endothelial cells, macrophages, and vascular smooth muscle cells.
“Adiponectin mediates a variety of cardiovascular effects including anti-atherogenic effects via a combination of effects on endothelial cells, macrophages, and vascular smooth muscle cells (195).”
From Cardiac remodeling in obesity (2008) · cites this paper as [195]
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- Authors
- Lam, K. S. L., & Xu, A.
- Affiliations
- University of Hong Kong (HK)
- Venue
- Current Diabetes Reports
- Published
- 2005-07
- Volume
- 5
- Issue
- 4
- Pages
- 254-259
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- OpenAlex
- W2158372214
- Cited by
- 94
- References
- 48
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 9
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- adiponectin, endothelial dysfunction, hypoadiponectinemia, coronary artery disease, type 2 diabetes, obesity, insulin resistance, insulin sensitivity, atherosclerosis, inflammation, antioxidant activity
- MeSH terms
- Animals, Antioxidants, Coronary Disease, Diabetes Mellitus, Type 2, Endothelium, Vascular, Humans, Insulin Resistance, Obesity, Adiponectin
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