Cited by 94Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

Adiponectin: Protection of the endothelium

Lam, Karen S. L., Xu, Aimin·2005·Current Diabetes Reports

Abstract

Low levels of adiponectin, a fat-derived hormone, are found in coronary heart disease, type 2 diabetes, obesity, and other insulin-resistant states. Conversely, high adiponectin levels are predictive of reduced coronary risk in long-term epidemiologic studies. A close association between hypoadiponectinemia and endothelial dysfunction has also been demonstrated. The various mechanisms through which adiponectin may protect the endothelium, via its insulin-sensitizing, antiatherogenic, anti-inflammatory, and antioxidant properties, are reviewed.

Integrity signals

Registry

Crossref · 10.1007/s11892-005-0019-y

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Adiponectin mediates a variety of cardiovascular effects including anti-atherogenic effects via a combination of effects on endothelial cells, macrophages, and vascular smooth muscle cells.

    “Adiponectin mediates a variety of cardiovascular effects including anti-atherogenic effects via a combination of effects on endothelial cells, macrophages, and vascular smooth muscle cells (195).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [195]

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Authors
Lam, K. S. L., & Xu, A.
Affiliations
University of Hong Kong (HK)
Venue
Current Diabetes Reports
Published
2005-07
Volume
5
Issue
4
Pages
254-259
ISSN
  • 1534-4827 (ISSN-L)
  • 1539-0829
OpenAlex
W2158372214
Cited by
94
References
48
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 9
FWCI
1.38
Type
journal article
Language
en
Open access
closed
Locations
  • Current Diabetes Reports (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adiponectin, endothelial dysfunction, hypoadiponectinemia, coronary artery disease, type 2 diabetes, obesity, insulin resistance, insulin sensitivity, atherosclerosis, inflammation, antioxidant activity
MeSH terms
Animals, Antioxidants, Coronary Disease, Diabetes Mellitus, Type 2, Endothelium, Vascular, Humans, Insulin Resistance, Obesity, Adiponectin

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