Serum Adiponectin Is a Predictor of Coronary Heart Disease: A Population-Based 10-Year Follow-Up Study in Elderly Men
Abstract
CONTEXT: Cross-sectional and nested case-control studies indicate a relationship between adiponectin, obesity, and coronary heart disease (CHD). OBJECTIVE: Our objective was to investigate whether adiponectin could predict CHD in a population-based cohort of elderly men. DESIGN AND SETTING: From 1991-1995 a baseline investigation was carried out in 832 healthy men aged 70 yr in the Uppsala Longitudinal Study of Adult Men (ULSAM study). They were followed up to 10.4 yr using Swedish national registry data. The baseline investigation included anthropometry, blood pressure, smoking, serum lipids, a euglycemic insulin clamp, and fasting serum adiponectin. MAIN OUTCOME MEASURES: Main outcome measures were defined as death or first-time hospitalization for CHD (n = 116), recorded in the Cause of Death Registry or in the Hospital-Discharge Registry of the National Board of Health and Welfare, Sweden. Associations were analyzed using Cox's proportional hazards regression, presented as hazard ratios (HR) with 95% confidence intervals (CI) for 1 sd increase in the predictor variable. RESULTS: In a multivariable analysis including total cholesterol (HR, 1.24; CI, 1.02-1.50), high-density lipoprotein cholesterol (HR, 0.72; CI, 0.58-0.89), smoking (HR, 1.39; CI, 0.91-2.14), and systolic blood pressure (HR, 1.26; CI, 1.05-1.52), serum adiponectin was associated with lower risk for CHD (HR, 0.81; CI, 0.66-0.99). The association was independent of BMI and remained significant after adjustment for insulin sensitivity index. CONCLUSIONS: In this population-based cohort of healthy men, elevated serum levels of adiponectin were associated with a lower risk for CHD. Importantly, the association between adiponectin and CHD was independent of other well-known risk factors.
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Clinical studies have established correlations between plasma adiponectin levels and various aspects and severity of heart failure.
“First, an important pathophysiological contribution was suggested by the recent explosion in the number of clinical studies that have established correlations between plasma adiponectin levels and various aspects and severity of heart failure (107, 113, 143, 166, 172, 183, 198, 209, 251, 275, 282, 286, 303, 312, 366).”
From Cardiac remodeling in obesity (2008) · cites this paper as [107]
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- Authors
- Frystyk, J., Berne, C., Berglund, L., Jensevik, K., Flyvbjerg, A., & Zethelius, B.
- Affiliations
- Aarhus University Hospital (DK)
- Uppsala University (SE)
- Department of Public Health and Caring Sciences/Geriatrics (B.Z.), Uppsala University, 75125 Uppsala, Sweden
- Corresponding author
- Frystyk, Jan
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-11-21
- Volume
- 92
- Issue
- 2
- Pages
- 571-576
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2059393016
- Cited by
- 201
- References
- 36
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 4 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 10 · 2015: 12 · 2014: 15 · 2013: 28 · 2012: 11
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- adiponectin, coronary artery disease, cardiovascular risk prediction, older men, insulin sensitivity, obesity, serum lipids, smoking, blood pressure
- MeSH terms
- Aged, Coronary Disease, Cross-Sectional Studies, Follow-Up Studies, Humans, Longitudinal Studies, Male, Predictive Value of Tests, Registries, Risk Factors, Sweden, Cohort Studies, Multivariate Analysis, Proportional Hazards Models, Adiponectin
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