Early onset of reproductive function in normal female mice treated with leptin
Abstract
Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract.
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A high-fat diet increases hypothalamic gnrh expression in prepubescent gilts, where this treatment also advances puberty onset, a result observed also in female mice injected with leptin and in obese girls.
“In line with this, a high-fat diet increases hypothalamic gnrh expression in prepubescent gilts (50), where this treatment also advances puberty onset, a result observed also in female mice injected with leptin and in obese girls (50–52).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [51]
In rodents, injecting leptin in juvenile mice advances puberty onset.
“In rodents, injecting leptin (a hormone released by adipose tissue) in juvenile mice advances puberty onset”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Chehab et al., 1997
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- Authors
- Chehab, F. F., Mounzih, K., Lu, R., & Lim, M. E.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Lu, Ronghua
- Venue
- Science
- Published
- 1997-01-03
- Volume
- 275
- Issue
- 5296
- Pages
- 88-90
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073828263
- Cited by
- 822
- References
- 12
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 17 · 2017: 12 · 2016: 13 · 2015: 14 · 2014: 27 · 2013: 20 · 2012: 18
- FWCI
- 87.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HLS-53762)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007636, DK 07636)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- leptin, puberty onset, adipose tissue, nutritional status, adiposity, growth rate, reproductive function
- MeSH terms
- Animals, Body Weight, Eating, Estradiol, Estrus, Female, Genitalia, Female, Luteinizing Hormone, Mice, Inbred C57BL, Organ Size, Proteins, Recombinant Proteins, Reproduction, Sexual Maturation, Leptin, Mice
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