Cited by 822Hypothalamic control of reproductive hormonesRegulation of Appetite and ObesityReproductive Biology and Fertility

Early onset of reproductive function in normal female mice treated with leptin

Chehab, Farid F., Mounzih, Khalid, Lu, Ronghua, Lim, Mary E.·1997·Science

Abstract

Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract.

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Crossref · 10.1126/science.275.5296.88

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12 of 12 references verified0 citation errors · 0 not checkable

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Authors
Chehab, F. F., Mounzih, K., Lu, R., & Lim, M. E.
Affiliations
University of California, San Francisco (US)
Venue
Science
Published
1997-01-03
Volume
275
Issue
5296
Pages
88-90
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2073828263
Cited by
822
References
12
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 11 · 2020: 11 · 2019: 13 · 2018: 17 · 2017: 12 · 2016: 13 · 2015: 14 · 2014: 27 · 2013: 20 · 2012: 18
FWCI
87.16
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HLS-53762)
  • National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007636, DK 07636)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
leptin, puberty onset, adipose tissue, nutritional status, adiposity, growth rate, reproductive function
MeSH terms
Animals, Body Weight, Eating, Estradiol, Estrus, Female, Genitalia, Female, Luteinizing Hormone, Mice, Inbred C57BL, Organ Size, Proteins, Recombinant Proteins, Reproduction, Sexual Maturation, Leptin, Mice

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