The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
The role of stress in addiction relapse
Abstract
Stress is an important factor known to increase alcohol and drug relapse risk. This paper examines the stress-related processes that influence addiction relapse. First, individual patient vignettes of stress- and cue-related situations that increase drug seeking and relapse susceptibility are presented. Next, empirical findings from human laboratory and brain-imaging studies that are consistent with clinical observations and support the specific role of stress processes in the drug-craving state are reviewed. Recent findings on differences in stress responsivity in addicted versus matched community social drinkers are reviewed to demonstrate alterations in stress pathways that could explain the significant contribution of stress-related mechanisms on craving and relapse susceptibility. Finally, significant implications of these findings for clinical practice are discussed, with a specific focus on the development of novel interventions that target stress processes and drug craving to improve addiction relapse outcomes.
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“Furthermore, mindfulness training has been shown to help decrease stress levels and as a result, may partially decrease engagement in alcohol use [52–55].”
From Engaging women with an embodied conversational agent to deliver mindfulness and lifestyle recommendations: A feasibility randomized control trial (2017) · cites this paper as [54]
Citations
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Metadata
- Authors
- Sinha, R.
- Affiliations
- Yale University (US)
- Corresponding author
- Sinha, Rajita
- ORCID
- Sinha, Rajita
- Venue
- Current Psychiatry Reports
- Published
- 2007-10
- Volume
- 9
- Issue
- 5
- Pages
- 388-395
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- OpenAlex
- W2043621158
- Cited by
- 423
- References
- 93
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 21 · 2023: 24 · 2022: 23 · 2021: 30 · 2020: 39 · 2019: 23 · 2018: 29 · 2017: 26 · 2016: 15 · 2015: 24 · 2014: 17 · 2013: 16 · 2012: 27
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (R01AA013892, R01-AA-13892)
- National Institute on Drug Abuse (K02 DA17232, P50DA016556, K02DA017232, R01-DA18219, R01DA018219, P50-DA16556)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- stress, addiction relapse, drug craving, alcohol relapse, drug-seeking behavior, stress responsivity, stress response pathways
- MeSH terms
- Alcoholism, Arousal, Brain, Conditioning, Psychological, Humans, Magnetic Resonance Imaging, Motivation, Illicit Drugs, Stress, Psychological, Substance Withdrawal Syndrome, Neurotransmitter Agents, Substance-Related Disorders, Secondary Prevention
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