Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications

SINHA, RAJITA; LI, C.‐S. R.

doi:10.1080/09595230601036960

Cited by 497Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications

SINHA, RAJITA, LI, C.‐S. R.·2007·Drug and Alcohol Review

DOI 10.1080/09595230601036960

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Abstract

Stress‐ and drug‐related cues are major factors contributing to high rates of relapse in addictive disorders. Brain imaging studies have begun to identify neural correlates of stress and drug cue‐induced craving states. Findings indicate considerable overlap in neural circuits involved in processing stress and drug cues with activity in the corticostriatal limbic circuitry underlying both affective and reward processing. More recent efforts have begun to identify the relationships between neural activity during stress and drug cue exposure and drug relapse outcomes. Findings suggest medial prefrontal, anterior and posterior cingulate, striatal and posterior insula regions to be associated with relapse outcomes. Altered function in these brain regions is associated with stress‐induced and drug cue‐induced craving states and an increased susceptibility to relapse. Such alterations can serve as markers to identify relapse propensity and a more severe course of addiction. Efficacy of pharmacological and behavioral treatments that specifically target stress and cue‐induced craving and arousal responses may also be assessed via alterations in these brain correlates.

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Chronic heavy alcohol use may dysregulate brain function in regions responsible for threat processing and impulse control, including the orbitofrontal area, anterior cingulate cortex, and subcortical and frontomesal regions.
“Chronic heavy alcohol use may dysregulate brain function in these regions alongside other regions that are responsible for both threat processing and impulse control, such as the orbitofrontal area, anterior cingulate cortex, as well as subcortical and frontomesal regions (Ochsner And Gross 2005; Bartholow and Heinz 2006; Sinha And Li 2007; Verdejo-García and Bechara 2009).”
From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Sinha And Li 2007
This pattern of reactivity to stress cues was associated with enhanced activation in regions linked to mesolimbic reward processing, including the medial prefrontal, anterior and posterior cingulate, striatal and posterior insula cortex.
“and this pattern of reactivity was associated with enhanced activation in regions linked to mesolimbic reward processing, including the medial prefrontal, anterior and posterior cingulate, striatal and posterior insula cortex (Sinha & Li, 2007).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Sinha & Li, 2007
Stress cues similarly elicit craving by inducing anxiety.
“Furthermore, there is evidence that stress cues similarly elicit craving by inducing anxiety (Coffey, Stasiewicz, Hughes, & Brimo, 2006; Fox, Bergquist, Hong, & Sinha, 2007; Sinha & Li, 2007; Sinha et al., 2009; 2003).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Sinha & Li, 2007
Responses to stress cues were on the whole comparable to those induced by alcohol-associated cues.
“These responses to stress cues were on the whole comparable to those induced by alcohol-associated cues (Fox et al., 2007; Sinha et al., 2009; Sinha & Li, 2007)”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Sinha & Li, 2007

Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793 · see citing works
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259 · see citing works
Treating tobacco use and dependence-Clinical practice guideline
Mc, F. (2000) · Medical Entomology and Zoology · Cited by 3,616 · see citing works
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502 · see citing works
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
Treating Tobacco Use and Dependence
(2008) · PEDIATRICS · doi:10.1542/peds.2008-1627 · Cited by 2,701 · see citing works
Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667 · see citing works
Clinical Practice Guideline: Otitis Media with Effusion (Update)
Rosenfeld, R. M., Shin, J. J., Schwartz, S. R., Coggins, R., Gagnon, L., Hackell, J. M., Hoelting, D., Hunter, L. L., Kummer, A. W., Payne, S. C., et al. (2016) · Otolaryngology–Head and Neck Surgery · doi:10.1177/0194599815623467 · Cited by 2,006 · see citing works
Pain and emotion interactions in subregions of the cingulate gyrus
Vogt, B. A. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1704 · Cited by 1,810 · see citing works
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513 · see citing works
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works
Self-citation
Dissociation of reward anticipation and outcome with event-related fMRI
Knutson, B., Fong, G. W., Adams, C. M., Varner, J. L., & Hommer, D. (2001) · Neuroreport · doi:10.1097/00001756-200112040-00016 · Cited by 1,300 · see citing works
Addiction, Dopamine, and the Molecular Mechanisms of Memory
Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,167 · see citing works
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076 · see citing works
Neural correlates of conscious self-regulation of emotion
Beauregard, M., Lévesque, J., & Bourgouin, P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-j0001.2001 · Cited by 1,033 · see citing works
Activation of memory circuits during cue-elicited cocaine craving.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.12040 · Cited by 936 · see citing works
Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli
Garavan, H., Pankiewicz, J., Bloom, A., Cho, J.-K., Sperry, L., Ross, T. J., Salmeron, B. J., Risinger, R., Kelley, D., & Stein, E. A. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1789 · Cited by 931 · see citing works
Neural substrates for voluntary suppression of negative affect: A functional magnetic resonance imaging study
Phan, K. L., Fitzgerald, D. A., Nathan, P. J., Moore, G. J., Uhde, T. W., & Tancer, M. E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.030 · Cited by 892 · see citing works
Toward a neurobiology of obsessive-compulsive disorder
Graybiel, A. M., & Rauch, S. L. (2000) · Neuron · doi:10.1016/s0896-6273(00)00113-6 · Cited by 864 · see citing works
Building neural representations of habits.
Jog, M. S., Kubota, Y., Connolly, C. I., Hillegaart, V., & Graybiel, A. M. (1999) · Science · doi:10.1126/science.286.5445.1745 · Cited by 834 · see citing works
Brain activity during transient sadness and happiness in healthy women
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.341 · Cited by 737 · see citing works
Drug addiction: the neurobiology of behaviour gone awry
Volkow, N. D., & Li, T. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1539 · Cited by 620 · see citing works
Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics
Gr�sser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., Weber-Fahr, W., Flor, H., Mann, K., Braus, D. F., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1828-4 · Cited by 598 · see citing works
Neural activity related to drug craving in cocaine addiction
Kilts, C. D., Schweitzer, J. B., Quinn, C. K., Gross, R. E., Faber, T. L., Muhammad, F., Ely, T. D., Hoffman, J. M., & Drexler, K. P. G. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.334 · Cited by 556 · see citing works
Cingulate Hypoactivity in Cocaine Users During a GO-NOGO Task as Revealed by Event-Related Functional Magnetic Resonance Imaging
Kaufman, J. N., Ross, T. J., Stein, E. A., & Garavan, H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07839.2003 · Cited by 553 · see citing works
Cocaine and Amphetamine Increase Extracellular Dopamine in the Nucleus Accumbens of Mice Lacking the Dopamine Transporter Gene
Carboni, E., Spielewoy, C., Vacca, C., Nosten‐Bertrand, M., Bruno Giros, A., & Chiara, G. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-j0001.2001 · Cited by 535 · see citing works
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha, R., Garcia, M., Paliwal, P., Kreek, M. J., & Rounsaville, B. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.324 · Cited by 528 · see citing works
Self-citation
Differential Brain Activity in Alcoholics and Social Drinkers to Alcohol Cues: Relationship to Craving
Myrick, H., Anton, R. F., Li, X., Henderson, S., Drobes, D., Voronin, K., & George, M. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300295 · Cited by 521 · see citing works
Neural systems and cue-induced cocaine craving
Bonson, K. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00371-2 · Cited by 507 · see citing works
Reward Circuitry Activation by Noxious Thermal Stimuli
Becerra, L. R., Breiter, H. C., Wise, R. A., González, R., & Borsook, D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00533-5 · Cited by 489 · see citing works
Appetitive and Aversive Olfactory Learning in Humans Studied Using Event-Related Functional Magnetic Resonance Imaging
Gottfried, J. A., O’Doherty, J. P., & Dolan, R. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10829.2002 · Cited by 474 · see citing works
Direct Activation of the Ventral Striatum in Anticipation of Aversive Stimuli
Jensen, J., McIntosh, A. R., Crawley, A. P., Mikulis, D. J., Remington, G., & Kapur, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00724-4 · Cited by 455 · see citing works
Functional Magnetic Resonance Imaging of Human Brain Activation During Cue-Induced Cocaine Craving
Maas, L. C., Lukas, S. E., Kaufman, M. J., Weiss, R. D., Daniels, S. L., Rogers, V. W., Kukes, T. J., & Renshaw, P. F. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.124 · Cited by 434 · see citing works
Human Striatal Responses to Monetary Reward Depend On Saliency
Zink, C. F., Pagnoni, G., Martin-Skurski, M. E., Chappelow, J., & Berns, G. S. (2004) · Neuron · doi:10.1016/s0896-6273(04)00183-7 · Cited by 432 · see citing works
Activation in Mesolimbic and Visuospatial Neural Circuits Elicited by Smoking Cues: Evidence From Functional Magnetic Resonance Imaging
Due, D. L., Huettel, S. A., HALL, W. G., & Rubin, D. C. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.6.954 · Cited by 429 · see citing works
Decision-making and impulse control after frontal lobe injuries
Bechara, A., & der Linden, M. V. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000194141.56429.3c · Cited by 426 · see citing works
Brain metabolic changes during cigarette craving
Brody, A. L., Mandelkern, M. A., London, E. D., Childress, A. R., Lee, G. S., Bota, R. G., Ho, M. L., Saxena, S., Baxter, L. R., Madsen, D., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.12.1162 · Cited by 425 · see citing works
Functional Magnetic Resonance Imaging of Cocaine Craving
Wexler, B. E., Gottschalk, C. H., Fulbright, R. K., Prohovnik, I., Lacadie, C. M., Rounsaville, B. J., & Gore, J. C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.1.86 · Cited by 420 · see citing works
A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats
Capriles, N., Rodaros, D., Sorge, R. E., & Stewart, J. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1283-z · Cited by 414 · see citing works
Correlation Between Dopamine D<sub>2</sub> Receptors in the Ventral Striatum and Central Processing of Alcohol Cues and Craving
Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Klein, S., Grüsser-Sinopoli, S. M., Flor, H., Braus, D. F., Buchholz, H. G., Gründer, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1783 · Cited by 408 · see citing works
Stress-induced craving and stress response in cocaine dependent individuals
Sinha, R., Catapano, D., & O’Malley, S. S. (1999) · Psychopharmacology · doi:10.1007/s002130050898 · Cited by 403 · see citing works
Self-citation
Activation of Prefrontal Cortex and Anterior Thalamus in Alcoholic Subjects on Exposure to Alcohol-Specific Cues
George, M. S., Anton, R. F., Bloomer, C., Tenebäck, C. C., Drobes, D. J., Lorberbaum, J. P., Nahas, Z. H., & Vincent, D. J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.345 · Cited by 382 · see citing works
Cue-Induced Brain Activity in Pathological Gamblers
Crockford, D. N., Goodyear, B., Edwards, J., Quickfall, J., & el-Guebaly, N. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.037 · Cited by 375 · see citing works
Neural Response to Alcohol Stimuli in Adolescents With Alcohol Use Disorder
Tapert, S. F., Cheung, E. H., Brown, G. G., Frank, L. R., Paulus, M. P., Schweinsburg, A. D., Meloy, M. J., & Brown, S. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.7.727 · Cited by 372 · see citing works
Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states
Sinha, R., Talih, M., Malison, R. T., Cooney, N. L., Anderson, G. M., & Kreek, M. J. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1525-8 · Cited by 366 · see citing works
Self-citation
Regional brain metabolic activation during craving elicited by recall of previous drug experiences
Wang, G.-J., Volkow, N. D., Fowler, J. S., Cervany, P., Hitzemann, R. J., Pappas, N. R., Wong, C. T., & Felder, C. (1999) · Life Sciences · doi:10.1016/s0024-3205(98)00619-5 · Cited by 336 · see citing works
Subcortical Correlates of Craving in Recently Abstinent Alcoholic Patients
Schneider, F. W., Habel, U., Wagner, M., Franke, P. E., Salloum, J. B., Shah, N. J., Toni, I., Sulzbach, C., Hönig, K., Maier, W., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1075 · Cited by 319 · see citing works
Human striatal response to salient nonrewarding stimuli
Zink, C. F., Pagnoni, G., Martin, M. E., Dhamala, M., & Berns, G. S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-22-08092.2003 · Cited by 312 · see citing works
Cue-Induced Brain Activity Changes and Relapse in Cocaine-Dependent Patients
Kosten, T. R., Scanley, B. E., Tucker, K. A., Oliveto, A. H., Prince, C. N., Sinha, R., Potenza, M. N., Skudlarski, P., & Wexler, B. E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300851 · Cited by 306 · see citing works
Self-citation
Ventral Striatum/Nucleus Accumbens Activation to Smoking-Related Pictorial Cues in Smokers and Nonsmokers: A Functional Magnetic Resonance Imaging Study
David, S. P., Munafo, M. R., Johansen‐Berg, H., Smith, S. M., Rogers, R. D., Matthews, P. M., & Walton, R. T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.028 · Cited by 275 · see citing works
The Neural Correlates of Cue-Induced Craving in Cocaine-Dependent Women
Kilts, C. D., Gross, R. E., Ely, T. D., & Drexler, K. P. G. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.233 · Cited by 252 · see citing works
Neural responses associated with cue evoked emotional states and heroin in opiate addicts
Sell, L., Morris, J. S., Bearn, J., Frackowiak, R. S. J., Friston, K. J., & Dolan, R. J. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(99)00158-1 · Cited by 238 · see citing works
Severity of nicotine dependence modulates cue-induced brain activity in regions involved in motor preparation and imagery
Smolka, M. N., Bühler, M., Klein, S., Zimmermann, U., Mann, K., Heinz, A., & Braus, D. F. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0080-x · Cited by 230 · see citing works
Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues
McClernon, F. J., Hiott, F. B., Huettel, S. A., & Rose, J. E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300780 · Cited by 216 · see citing works
fMRI BOLD response to alcohol stimuli in alcohol dependent young women
Tapert, S. F., Brown, G. G., Baratta, M. V., & Brown, S. A. (2003) · Addictive Behaviors · doi:10.1016/j.addbeh.2003.07.003 · Cited by 211 · see citing works
Brain Systems for the Mediation of Social Separation‐Distress and Social‐Reward Evolutionary Antecedents and Neuropeptide Intermediaries<sup>a</sup>
PANKSEPP, J., NELSON, E., & BEKKEDAL, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51914.x · Cited by 210 · see citing works
Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study
Sinha, R., Lacadie, C., Skudlarski, P., Fulbright, R. K., Rounsaville, B. J., Kosten, T. R., & Wexler, B. E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0147-8 · Cited by 192 · see citing works
Self-citation
Development of alcohol-associated cues and cue-induced brain activation in alcoholics
Wrase, J., Grüsser, S. M., Vollstädt‐Klein, S., Diener, C., Hermann, D., Flor, H., Mann, K. F., Braus, D. F., & Heinz, A. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00676-4 · Cited by 192 · see citing works
Changes in Regional Cerebral Blood Flow Elicited by Craving Memories in Abstinent Opiate-Dependent Subjects
Daglish, M. R. C., Weinstein, A. M., Malizia, A. L., Wilson, S., Melichar, J., Britten, S., Brewer, C. L., Lingford-Hughes, A. R., Myles, J. S., Grasby, P. M., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.10.1680 · Cited by 171 · see citing works
Human striatal activation reflects degree of stimulus saliency
Zink, C. F., Pagnoni, G., Chappelow, J., Martin-Skurski, M. E., & Berns, G. S. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.006 · Cited by 169 · see citing works
Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study
Brody, A. L., Mandelkern, M. A., Lee, G., Smith, E. C., Sadeghi, M., Saxena, S., Jarvik, M. E., & London, E. D. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2003.12.006 · Cited by 153 · see citing works
Activation of reward circuitry in human opiate addicts
Sell, L., Morris, J., Bearn, J., Frackowiak, R. S. J., Friston, K. J., & Dolan, R. J. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00522.x · Cited by 148 · see citing works
Instructed smoking expectancy modulates cue‐elicited neural activity: A preliminary study
Wilson, S. J., Sayette, M. A., Delgado, M. R., & Fiez, J. A. (2005) · Nicotine & Tobacco Research · doi:10.1080/14622200500185520 · Cited by 143 · see citing works
Neural Circuits Underlying Emotional Distress in Humans
SINHA, R., LACADIE, C., SKUDLARSKI, P., & WEXLER, B. E. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.032 · Cited by 121 · see citing works
Self-citation
Sex differences in brain activation during stress imagery in abstinent cocaine users: A functional magnetic resonance imaging study
Li, C.-S. R., Kosten, T. R., & Sinha, R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.048 · Cited by 114 · see citing works
Self-citation
Will, Anterior Cingulate Cortex, and Addiction
Peoples, L. L. (2002) · Science · doi:10.1126/science.1072997 · Cited by 82 · see citing works
Functional connectivity analysis of the neural circuits of opiate craving: “more” rather than “different”?
Daglish, M. R. C. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.025 · Cited by 77 · see citing works
Effect of sustained-release (SR) bupropion on craving and withdrawal in smokers deprived of cigarettes for 72 h
Teneggi, V., Tiffany, S. T., Squassante, L., Milleri, S., Ziviani, L., & Bye, A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0145-x · Cited by 39 · see citing works
Pathways to relapse: factors controlling the reinitiation of drug seeking after abstinence.
Stewart, J. (2004) · PubMed · Cited by 32 · see citing works
Stress and drug abuse
Sinha, R. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80063-x · Cited by 22 · see citing works
Self-citation

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Witkiewitz, K., Bowen, S., Douglas, H., & Hsu, S. H. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.04.001 · Cited by 337 · see citing works
Modeling stress and drug craving in the laboratory: implications for addiction treatment development
Sinha, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00134.x · Cited by 314 · see citing works
Self-citation
Interoception and drug addiction
Paulus, M. P., & Stewart, J. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.002 · Cited by 281 · see citing works
Mindful attention reduces neural and self-reported cue-induced craving in smokers
Westbrook, C., Creswell, J. D., Tabibnia, G., Julson, E., Kober, H., & Tindle, H. A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr076 · Cited by 278 · see citing works
Clinical and laboratory assessment of the subjective experience of drug craving
Rosenberg, H. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.06.002 · Cited by 251 · see citing works
Classic hallucinogens in the treatment of addictions
Bogenschutz, M. P., & Johnson, M. W. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.002 · Cited by 226 · see citing works
Multiple roles for orexin/hypocretin in addiction
Mahler, S. V., Smith, R. J., Moorman, D. E., Sartor, G. C., & Aston-Jones, G. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59489-1.00007-0 · Cited by 215 · see citing works
Neural circuitry of impaired emotion regulation in substance use disorders
Wilcox, C. E., Pommy, J. M., & Adinoff, B. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15060710 · Cited by 213 · see citing works
Retraining the addicted brain: A review of hypothesized neurobiological mechanisms of mindfulness-based relapse prevention.
Witkiewitz, K., Lustyk, M. K. B., & Bowen, S. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0029258 · Cited by 207 · see citing works
Chronic stress exposure may affect the brain’s response to high calorie food cues and predispose to obesogenic eating habits
Tryon, M. S., Carter, C. S., DeCant, R., & Laugero, K. D. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.08.010 · Cited by 191 · see citing works
Increased ventral striatal BOLD activity during non-drug reward anticipation in cannabis users
Nestor, L., Hester, R., & Garavan, H. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.07.022 · Cited by 186 · see citing works
Striatal sensitivity to reward deliveries and omissions in substance dependent patients
Bjork, J. M., Smith, A. R., & Hommer, D. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.035 · Cited by 154 · see citing works
Neuroimaging for drug addiction and related behaviors
Parvaz, M. A., Alia-Klein, N., Woicik, P. A., Volkow, N. D., & Goldstein, R. Z. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.055 · Cited by 151 · see citing works
Co-occurrence of alcohol use disorder and behavioral addictions: relevance of impulsivity and craving
Di Nicola, M., Tedeschi, D., De Risio, L., Pettorruso, M., Martinotti, G., Ruggeri, F., Swierkosz-Lenart, K., Guglielmo, R., Callea, A., Ruggeri, G., et al. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.12.028 · Cited by 143 · see citing works
Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems
Rutherford, H. J. V., Williams, S. K., Moy, S., Mayes, L. C., & Johns, J. M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00037 · Cited by 140 · see citing works
21st century neurobehavioral theories of decision making in addiction: Review and evaluation
Bickel, W. K., Mellis, A. M., Snider, S. E., Athamneh, L. N., Stein, J. S., & Pope, D. A. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.09.009 · Cited by 134 · see citing works
Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity
Graziane, N. M., Polter, A. M., Briand, L. A., Pierce, R. C., & Kauer, J. A. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.034 · Cited by 121 · see citing works
Regional gray matter deficits in alcohol dependence: A meta-analysis of voxel-based morphometry studies
Xiao, P., Dai, Z., Zhong, J., Zhu, Y., Shi, H., & Pan, P. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.05.030 · Cited by 120 · see citing works
Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
Fox, H. C., Seo, D., Tuit, K., Hansen, J., Kimmerling, A., Morgan, P. T., & Sinha, R. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111430746 · Cited by 112 · see citing works
Self-citation
Longitudinal effects of interoceptive awareness training through Mindful Awareness in Body-oriented Therapy (MABT) as an adjunct to women’s substance use disorder treatment: A randomized controlled trial
Price, C. J., Thompson, E. A., Crowell, S., & Pike, K. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.02.012 · Cited by 111 · see citing works
DEVICE-BASED BRAIN STIMULATION TO AUGMENT FEAR EXTINCTION: IMPLICATIONS FOR PTSD TREATMENT AND BEYOND: Review: Device-Based Brain Stimulation to Augment Fear Extinction
Marin, M.-F., Camprodon, J. A., Dougherty, D. D., & Milad, M. R. (2014) · Depression and Anxiety · doi:10.1002/da.22252 · Cited by 106 · see citing works
Using fMRI to study reward processing in humans: past, present, and future
Wang, K. S., Smith, D. V., & Delgado, M. R. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00333.2015 · Cited by 105 · see citing works
Immediate Effects of Interoceptive Awareness Training through Mindful Awareness in Body-Oriented Therapy (Mabt) for Women in Substance Use Disorder Treatment
Price, C. J., Thompson, E. A., Crowell, S. E., Pike, K., Cheng, S. C., Parent, S., & Hooven, C. (2019) · Substance Abuse · doi:10.1080/08897077.2018.1488335 · Cited by 94 · see citing works
Sex differences in behavioral and neural cross-sensitization and escalated cocaine taking as a result of episodic social defeat stress in rats
Holly, E. N., Shimamoto, A., DeBold, J. F., & Miczek, K. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2846-2 · Cited by 98 · see citing works
Pharmacological approaches to reducing craving in patients with alcohol use disorders
Haass-Koffler, C. L., Leggio, L., & Kenna, G. A. (2014) · CNS Drugs · doi:10.1007/s40263-014-0149-3 · Cited by 83 · see citing works
Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments
Kober, H., Brewer, J. A., Height, K. L., & Sinha, R. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.09.042 · Cited by 75 · see citing works
Self-citation
Repetitive transcranial magnetic stimulation and drug addiction
Barr, M. S., Farzan, F., Wing, V. C., George, T. P., Fitzgerald, P. B., & Daskalakis, Z. J. (2011) · International Review of Psychiatry · doi:10.3109/09540261.2011.618827 · Cited by 78 · see citing works
Inhibitory control in excessive social networking users: Evidence from an event-related potential-based Go-Nogo task
Gao, Q., Jia, G., Zhao, J., & Zhang, D. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01810 · Cited by 71 · see citing works
“1 https://www.qq.com/pdf/2017s01.htm The Go-Nogo task is a frequently used paradigm in the investigation of inhibitory control (Spinella, 2002; Dinn et al., 2004; Gotlib et al., 2004; Monterosso et al., 2005; Reynolds et al., 2007; Luijten et al., 2011; Messerotti Benvenuti et al., 2015,…”
Method
Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior
Hellberg, S. N., Russell, T. I., & Robinson, M. J. F. (2019) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-018-00662-3 · Cited by 65 · see citing works
“These responses to stress cues were on the whole comparable to those induced by alcohol-associated cues (Fox et al., 2007; Sinha et al., 2009; Sinha & Li, 2007), and support the evidence that the physiological reactivity elicited by stress cues may serve as a powerful catalyst for craving and…”
Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety
Knapp, D. J., Whitman, B. A., Wills, T. A., Angel, R. A., Overstreet, D. H., Criswell, H. E., Ming, Z., & Breese, G. R. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.02.018 · Cited by 60 · see citing works
Cocaine cue-induced dopamine release in the human prefrontal cortex
Milella, M. S., Fotros, A., Gravel, P., Casey, K. F., Larcher, K., Verhaeghe, J. A. J., Cox, S. M. L., Reader, A. J., Dagher, A., Benkelfat, C., et al. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.150207 · Cited by 56 · see citing works
Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times
Wang, G.-B., Zhang, X.-L., Zhao, L.-Y., Sun, L.-L., Wu, P., Lu, L., & Shi, J. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2617-5 · Cited by 46 · see citing works
Ultra-Brief Mindfulness Training Reduces Alcohol Consumption in At-Risk Drinkers: A Randomized Double-Blind Active-Controlled Experiment
Kamboj, S. K., Irez, D., Serfaty, S., Thomas, E., Das, R. K., & Freeman, T. P. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx064 · Cited by 41 · see citing works
Midbrain-Driven Emotion and Reward Processing in Alcoholism
Müller-Oehring, E. M., Jung, Y.-C., Sullivan, E. V., Hawkes, W. C., Pfefferbaum, A., & Schulte, T. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.102 · Cited by 38 · see citing works
Cue-induced craving and physiological reactions in recently and long-abstinent heroin-dependent patients
Zhao, M., Fan, C., Du, J., Jiang, H., Chen, H., & Sun, H. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2011.11.030 · Cited by 37 · see citing works
How Long Does Craving Predict Use of Methamphetamine? Assessment of Use One to Seven Weeks after the Assessment of Craving
Galloway, G. P., Singleton, E. G., The Methamphetamine Treatment Project Corporate Authors, Anglin, M. D., Rawson, R. A., Patricia, M.-C., Joseph, B., Richard, B., Alison Hamilton, B., Cynthia, B., et al. (2008) · Substance Abuse: Research and Treatment · doi:10.4137/sart.s775 · Cited by 24 · see citing works
Dorsolateral caudate nucleus differentiates cocaine from natural reward-associated contextual cues
Liu, H.-S., Chefer, S., Lu, H., Guillem, K., Rea, W., Kurup, P., Yang, Y., Peoples, L., & Stein, E. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207531110 · Cited by 23 · see citing works
A Review of Preclinical Research Demonstrating that Drug and Non-Drug ReinforcersDifferentially Affect Behavior
N. Kearns, D., A. Gomez-Serrano, M., & J. Tunstall, B. (2011) · Current Drug Abuse Reviewse · doi:10.2174/1874473711104040261 · Cited by 22 · see citing works
Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework
Russell, N. M., Frier, M. D., Bortolato, M., & Mangieri, R. A. (2026) · Psychopharmacology · doi:10.1007/s00213-025-06938-0 · Cited by 3 · see citing works

Review for "Posterior cingulate cortex targeted real‐time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default‐mode network in PTSD"
(2022) · doi:10.1002/brb3.2883/v2/review1
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Frankort, A., Roefs, A., Siep, N., Roebroeck, A. F., Havermans, R. C., & Jansen, A. T. M. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht016 · Cited by 37 · see citing works
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Decision letter for "Posterior cingulate cortex targeted real‐time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default‐mode network in PTSD"
(2022) · doi:10.1002/brb3.2883/v2/decision1
Review for "Posterior cingulate cortex targeted real‐time fMRI neurofeedback recalibrates functional connectivity with the amygdala, posterior insula, and default‐mode network in PTSD"
(2022) · doi:10.1002/brb3.2883/v1/review2

Authors: SINHA, R., & LI, C. ‐. R.
Affiliations: Yale University (US)
Corresponding author: SINHA, RAJITA
ORCID: SINHA, RAJITA
LI, C.‐S. R.
Venue: Drug and Alcohol Review
Publisher: Wiley
Published: 2007-01
Volume: 26
Issue: 1
Pages: 25-31
ISSN: 0959-5236 (ISSN-L)
1465-3362
DOI: 10.1080/09595230601036960
OpenAlex: W2133559478
Cited by: 497
References: 70
Citations by year: 2026: 15 · 2025: 15 · 2024: 11 · 2023: 15 · 2022: 17 · 2021: 20 · 2020: 41 · 2019: 26 · 2018: 34 · 2017: 37 · 2016: 36 · 2015: 35 · 2014: 34 · 2013: 29 · 2012: 34
FWCI: 2.04
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 879 d)
Locations: Drug and Alcohol Review (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA013892, R01-AA-13892)
National Institute on Drug Abuse (K02 DA17232, P50DA016556, K02DA017232, P50-DA16556)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: drug craving, alcohol craving, stress, drug-related cues, relapse, addiction, medial prefrontal cortex, cingulate cortex, striatum, posterior insula, neural correlates, treatment response
MeSH terms: Ethanol, Alcoholism, Animals, Brain, Cues, Emotions, Humans, Magnetic Resonance Imaging, Motivation, Nerve Net, Prognosis, Recurrence, Risk Factors, Illicit Drugs, Stress, Psychological, Substance Withdrawal Syndrome, Substance-Related Disorders

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Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications

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