Cited by 423Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

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The role of stress in addiction relapse

Sinha, Rajita·2007·Current Psychiatry Reports

DOI 10.1007/s11920-007-0050-6

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Abstract

Stress is an important factor known to increase alcohol and drug relapse risk. This paper examines the stress-related processes that influence addiction relapse. First, individual patient vignettes of stress- and cue-related situations that increase drug seeking and relapse susceptibility are presented. Next, empirical findings from human laboratory and brain-imaging studies that are consistent with clinical observations and support the specific role of stress processes in the drug-craving state are reviewed. Recent findings on differences in stress responsivity in addicted versus matched community social drinkers are reviewed to demonstrate alterations in stress pathways that could explain the significant contribution of stress-related mechanisms on craving and relapse susceptibility. Finally, significant implications of these findings for clinical practice are discussed, with a specific focus on the development of novel interventions that target stress processes and drug craving to improve addiction relapse outcomes.

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“These findings validate a host of human laboratory studies documenting that exposure to external drug-related stimuli, which may include people and places associated with drug use or drug paraphernalia such as needles, drug pipes, cocaine powder, or beer cans, and in vivo exposure to drug itself can result in increase…”
Background
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Self-citation

Authors: Sinha, R.
Affiliations: Yale University (US)
Corresponding author: Sinha, Rajita
ORCID: Sinha, Rajita
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 9
Issue: 5
Pages: 388-395
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-007-0050-6
OpenAlex: W2043621158
Cited by: 423
References: 93
Citations by year: 2026: 17 · 2025: 13 · 2024: 21 · 2023: 24 · 2022: 23 · 2021: 30 · 2020: 39 · 2019: 23 · 2018: 29 · 2017: 26 · 2016: 15 · 2015: 24 · 2014: 17 · 2013: 16 · 2012: 27
FWCI: 2.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA013892, R01-AA-13892)
National Institute on Drug Abuse (K02 DA17232, P50DA016556, K02DA017232, R01-DA18219, R01DA018219, P50-DA16556)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: stress, addiction relapse, drug craving, alcohol relapse, drug-seeking behavior, stress responsivity, stress response pathways
MeSH terms: Alcoholism, Arousal, Brain, Conditioning, Psychological, Humans, Magnetic Resonance Imaging, Motivation, Illicit Drugs, Stress, Psychological, Substance Withdrawal Syndrome, Neurotransmitter Agents, Substance-Related Disorders, Secondary Prevention

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The role of stress in addiction relapse

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