Cited by 423Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.

The role of stress in addiction relapse

Sinha, Rajita·2007·Current Psychiatry Reports

DOI 10.1007/s11920-007-0050-6

Open this paper in CoChat — free account

Abstract

Stress is an important factor known to increase alcohol and drug relapse risk. This paper examines the stress-related processes that influence addiction relapse. First, individual patient vignettes of stress- and cue-related situations that increase drug seeking and relapse susceptibility are presented. Next, empirical findings from human laboratory and brain-imaging studies that are consistent with clinical observations and support the specific role of stress processes in the drug-craving state are reviewed. Recent findings on differences in stress responsivity in addicted versus matched community social drinkers are reviewed to demonstrate alterations in stress pathways that could explain the significant contribution of stress-related mechanisms on craving and relapse susceptibility. Finally, significant implications of these findings for clinical practice are discussed, with a specific focus on the development of novel interventions that target stress processes and drug craving to improve addiction relapse outcomes.

Integrity signals

Registry

Crossref · 10.1007/s11920-007-0050-6

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Emotion circuits in the brain
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638 · cited 1×
“These findings validate a host of human laboratory studies documenting that exposure to external drug-related stimuli, which may include people and places associated with drug use or drug paraphernalia such as needles, drug pipes, cocaine powder, or beer cans, and in vivo exposure to drug itself can result in increase…”
Background
The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes
Tiffany, S. T. (1990) · Psychological Review · doi:10.1037/0033-295x.97.2.147 · Cited by 1,554
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505
Self-citation

Show all 93 references

Sorted by citations

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749
Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904
Self-citation
Cognitive neuroscience of self-regulation failure
Heatherton, T. F., & Wagner, D. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.12.005 · Cited by 1,033
Gene–Stress–Epigenetic regulation of FKBP5: clinical and translational implications
Zannas, A. S., Wiechmann, T., Gassen, N. C., & Binder, E. B. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.235 · Cited by 622
Stress and the HPA axis: role of glucocorticoids in alcohol dependence
Stephens, M. (2012) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v34.4.11 · Cited by 571
Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals
Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.78 · Cited by 466
Self-citation
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li, C.-S. R., & Sinha, R. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.003 · Cited by 345
Self-citation
Ghrelin mediates stress-induced food-reward behavior in mice
Chuang, J.-C., Perelló, M., Sakata, I., Osborne-Lawrence, S. L., Savitt, J. M., Lutter, M. L., & Zigman, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57660 · Cited by 347
Mindfulness Training Modifies Cognitive, Affective, and Physiological Mechanisms Implicated in Alcohol Dependence: Results of a Randomized Controlled Pilot Trial
Garland, E. L., Gaylord, S. A., Boettiger, C. A., & Howard, M. O. (2010) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2010.10400690 · Cited by 319
Modeling stress and drug craving in the laboratory: implications for addiction treatment development
Sinha, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00134.x · Cited by 314
Self-citation
Depression, loneliness and Internet addiction: How important is low self-control?
Özdemir, Y., Kuzucu, Y., & Ak, Ş. (2014) · Computers in Human Behavior · doi:10.1016/j.chb.2014.02.009 · Cited by 312
Systematic Review of Electronic Cigarette Use (Vaping) and Mental Health Comorbidity Among Adolescents and Young Adults
Becker, T. D., Arnold, M. K., Ro, V., Martin, L. K., & Rice, T. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa171 · Cited by 323
Neural Correlates of Stress-Induced and Cue-Induced Drug Craving: Influences of Sex and Cocaine Dependence
Potenza, M. N., Hong, K., Lacadie, C., Fulbright, R. K., Tuit, K. L., & Sinha, R. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020289 · Cited by 300
Self-citation
Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265
Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse
Breese, G. R., Sinha, R., & Heilig, M. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.007 · Cited by 274
Self-citation
The effect of job loss on overweight and drinking
Deb, P., Gallo, W. T., Ayyagari, P., Fletcher, J. M., & Sindelar, J. L. (2011) · Journal of Health Economics · doi:10.1016/j.jhealeco.2010.12.009 · Cited by 229
Pain and suicidality: Insights from reward and addiction neuroscience
Elman, I., Borsook, D., & Volkow, N. D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.003 · Cited by 226
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence
Smith, R. J., & Aston-Jones, G. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0191-3 · Cited by 206
Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study
Rando, K., Hong, K.-I., Bhagwagar, Z., Li, C.-S. R., Bergquist, K., Guarnaccia, J., & Sinha, R. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10020233 · Cited by 189
Self-citation
Psychostimulant abuse and neuroinflammation: emerging evidence of their interconnection.
Clark, K. H., Wiley, C. A., & Bradberry, C. W. (2013) · Neurotoxicity Research · doi:10.1007/s12640-012-9334-7 · Cited by 194
A Gender Perspective of Addictive Disorders
Fonseca, F., Robles-Martínez, M., Tirado-Muñoz, J., Alías-Ferri, M., Mestre-Pintó, J. I., Coratu, A. M., & Torrens, M. (2021) · Current Addiction Reports · doi:10.1007/s40429-021-00357-9 · Cited by 192
Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment
Garland, E. L., Franken, I. H. A., & Howard, M. O. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2618-4 · Cited by 170
Bi-directional associations of electronic and combustible cigarette use onset patterns with depressive symptoms in adolescents
Lechner, W. V., Janssen, T., Kahler, C. W., Audrain-McGovern, J. E., & Leventhal, A. M. (2016) · Preventive Medicine · doi:10.1016/j.ypmed.2016.12.034 · Cited by 189
Simultaneous Glucocorticoid and Noradrenergic Activity Disrupts the Neural Basis of Goal-Directed Action in the Human Brain
Schwabe, L., Tegenthoff, M., Höffken, O., & Wolf, O. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1304-12.2012 · Cited by 162
Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings
Fox, H. C., Anderson, G. M., Tuit, K. L., Hansen, J., Kimmerling, A., Siedlarz, K. M., MORGAN, P. T., & Sinha, R. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01628.x · Cited by 159
Self-citation
A Corticotropin Releasing Factor Pathway for Ethanol Regulation of the Ventral Tegmental Area in the Bed Nucleus of the Stria Terminalis
Silberman, Y., Matthews, R. T., & Winder, D. G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2949-12.2013 · Cited by 144
Engaging women with an embodied conversational agent to deliver mindfulness and lifestyle recommendations: A feasibility randomized control trial
Gardiner, P. M., McCue, K. D., Negash, L. M., Cheng, T., White, L. F., Yinusa-Nyahkoon, L., Jack, B. W., & Bickmore, T. W. (2017) · Patient Education and Counseling · doi:10.1016/j.pec.2017.04.015 · Cited by 139
Dopamine and addiction: what have we learned from 40 years of research
Solinas, M., Belujon, P., Fernagut, P., Jaber, M., & Thiriet, N. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1957-2 · Cited by 163
Sex Differences in Drug-Related Stress-System Changes
Fox, H. C., & Sinha, R. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902899680 · Cited by 160
Self-citation
How does stress lead to risk of alcohol relapse?
Sinha, R. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.07 · Cited by 148
Self-citation
Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats
Lê, A. D., Funk, D. R., Juzytsch, W., Coen, K. M., Navarre, B. M., Cifani, C., & Shaham, Y. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2178-7 · Cited by 132
Resting-State Synchrony During Early Alcohol Abstinence Can Predict Subsequent Relapse
Camchong, J., Stenger, A., & Fein, G. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs190 · Cited by 131
Making a bad thing worse: adverse effects of stress on drug addiction
Cleck, J. N., & Blendy, J. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33946 · Cited by 122
The effects of psychosocial stress on dopaminergic function and the acute stress response
Bloomfield, M. A., McCutcheon, R. A., Kempton, M., Freeman, T. P., & Howes, O. (2019) · eLife · doi:10.7554/elife.46797 · Cited by 112
“Our findings may be highly relevant in terms of our understanding of addiction, as a history of exposure to aversive stimuli is strongly associated with later addictive behaviour, with both clinical and preclinical work demonstrating that stress plays a powerful role in the initiation, escalation, and relapse to drug…”
Background
How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.
Clapp, P., Bhave, S. V., & Hoffman, P. L. (2008) · PubMed Central · Cited by 116
Memory under stress: from single systems to network changes
Schwabe, L. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13478 · Cited by 121
How emotionally intelligent are pre-service teachers?
Corcoran, R. P., & Tormey, R. (2012) · Teaching and Teacher Education · doi:10.1016/j.tate.2012.02.007 · Cited by 130
Memory dynamics under stress
Quaedflieg, C. W. E. M., & Schwabe, L. (2017) · Memory · doi:10.1080/09658211.2017.1338299 · Cited by 110
Epigenetic mechanisms of alcoholism and stress-related disorders
Palmisano, M., & Pandey, S. C. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.001 · Cited by 108
Immediate Effects of Interoceptive Awareness Training through Mindful Awareness in Body-Oriented Therapy (Mabt) for Women in Substance Use Disorder Treatment
Price, C. J., Thompson, E. A., Crowell, S. E., Pike, K., Cheng, S. C., Parent, S., & Hooven, C. (2019) · Substance Abuse · doi:10.1080/08897077.2018.1488335 · Cited by 94
Self-medication among traumatized youth: structural equation modeling of pathways between trauma history, substance misuse, and psychological distress
Garland, E. L., Pettus‐Davis, C., & Howard, M. O. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9413-5 · Cited by 114
Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand
Cox, B. M., Bentzley, B. S., Regen-Tuero, H. C., See, R. E., Reichel, C. M., & Aston‐Jones, G. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.011 · Cited by 98
Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats
Anker, J. J., & Carroll, M. E. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.11.002 · Cited by 98
Inducing Negative Affect Increases the Reward Value of Appetizing Foods in Dieters
Wagner, D. D., Boswell, R. G., Kelley, W. M., & Heatherton, T. F. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00238 · Cited by 95
Resting‐State Synchrony in Long‐Term Abstinent Alcoholics
Camchong, J., Stenger, A., & Fein, G. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01859.x · Cited by 97
Attentional bias, inhibitory control and acute stress in current and former opiate addicts
Constantinou, N., Morgan, C. J. A., Battistella, S., O’Ryan, D., Davis, P. W., & Curran, H. V. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.01.012 · Cited by 92
Predicting Internet Gaming Disorder symptoms in young adolescents: A one-year follow-up study
Peeters, M., Koning, I. M., & van den Eijnden, R. J. J. M. (2017) · Computers in Human Behavior · doi:10.1016/j.chb.2017.11.008 · Cited by 98
Emerging Role for Corticotropin Releasing Factor Signaling in the Bed Nucleus of the Stria Terminalis at the Intersection of Stress and Reward
Silberman, Y., & Winder, D. G. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00042 · Cited by 96
Stress-Induced Potentiation of Cocaine Reward: A Role for CRFR1 and CREB
Kreibich, A. S., Briand, L., Cleck, J. N., Ecke, L., Rice, K. C., & Blendy, J. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.91 · Cited by 89
Dopaminergic control of anxiety in young and aged zebrafish
Kacprzak, V., Patel, N. A., Riley, E., Yu, L., Yeh, J.-R. J., & Zhdanova, I. V. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.01.005 · Cited by 88
Motivational and mindfulness intervention for young adult female marijuana users
de Dios, M. A., Herman, D. S., Britton, W. B., Hagerty, C. E., Anderson, B. J., & Stein, M. D. (2012) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2011.08.001 · Cited by 86
Behavioral and neural mechanisms underlying habitual and compulsive drug seeking
Smith, R. J., & Laiks, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.003 · Cited by 93
Mindfulness and alcohol problems in college students: the mediating effects of stress
Bodenlos, J. S., Noonan, M., & Wells, S. Y. (2013) · Journal of American College Health · doi:10.1080/07448481.2013.805714 · Cited by 81
Stress-Induced and Cue-Induced Craving for Alcohol in Heavy Drinkers: Preliminary Evidence of Genetic Moderation by the OPRM1 and CRH-BP Genes
Ray, L. A. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01333.x · Cited by 83
The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder
Arnsten, A. F. T. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.133 · Cited by 83
Amygdala involvement in human avoidance, escape and approach behavior
Schlund, M. W., & Cataldo, M. F. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.058 · Cited by 81
Substance use modulates stress reactivity: Behavioral and physiological outcomes
Fosnocht, A. Q., & Briand, L. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.024 · Cited by 80
Dark Times: The Role of Negative Reinforcement in Methamphetamine Addiction
May, A. C., Aupperle, R. L., & Stewart, J. L. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00114 · Cited by 84
Personal support networks, social capital, and risk of relapse among individuals treated for substance use issues
Panebianco, D., Gallupe, O., Carrington, P. J., & Colozzi, I. (2015) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2015.09.009 · Cited by 79
Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments
Kober, H., Brewer, J. A., Height, K. L., & Sinha, R. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.09.042 · Cited by 75
Self-citation
Neural pathways of stress integration: relevance to alcohol abuse
Herman, J. P. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.08 · Cited by 79
Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species
Arnsten, A. F. T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107327 · Cited by 75
“Stress exposure is also often a cause of substance abuse, which in turn further weakens PFC abilities, creating a vicious cycle (Sinha, 2007).”
Fish oil supplementation reduces cortisol basal levels and perceived stress: A randomized, placebo‐controlled trial in abstinent alcoholics
Barbadoro, P., Annino, I., Ponzio, E., Romanelli, R. M. L., D’Errico, M. M., Prospero, E., & Minelli, A. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200676 · Cited by 76
Conceptualising social media addiction: a longitudinal network analysis of social media addiction symptoms and their relationships with psychological distress in a community sample of adults
Tullett-Prado, D., Doley, J. R., Zarate, D., Gomez, R., & Stavropoulos, V. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04985-5 · Cited by 77
Nothing to fear? Neural systems supporting avoidance behavior in healthy youths
Schlund, M. W., Siegle, G. J., Ladouceur, C. D., Silk, J. S., Cataldo, M. F., Forbes, E. E., Dahl, R. E., & Ryan, N. D. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.244 · Cited by 74
The genetics of alcoholism
Stacey, D., Clarke, T., & Schumann, G. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0055-4 · Cited by 67
Avoidance-based human Pavlovian-to-instrumental transfer
Lewis, A. H., Niznikiewicz, M. A., Delamater, A., & Delgado, M. R. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12377 · Cited by 75
A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment
Wemm, S., Larkin, C., Hermes, G., Tennen, H. A., & Sinha, R. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107569 · Cited by 66
Self-citation
Psychosocial Stress and Its Relationship to Gambling Urges in Individuals with Pathological Gambling
Elman, I., Tschibelu, E., & Borsook, D. (2010) · American Journal on Addictions · doi:10.1111/j.1521-0391.2010.00055.x · Cited by 64
The therapeutic potential of GLP-1 analogues for stress-related eating and role of GLP-1 in stress, emotion and mood: a review
Guerrero-Hreins, E., Goldstone, A. P., Brown, R. M., & Sumithran, P. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110303 · Cited by 62
From personal tragedy to personal challenge: responses to stigma among sober living home residents and operators
Heslin, K. C., Singzon, T. K., Aimiuwu, O., Sheridan, D., & Hamilton, A. (2011) · Sociology of Health & Illness · doi:10.1111/j.1467-9566.2011.01376.x · Cited by 63
Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF
Newman, E. L., Leonard, M. Z., Arena, D. T., de Almeida, R. M. M., & Miczek, K. A. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.09.007 · Cited by 70
Thought suppression, impaired regulation of urges, and Addiction-Stroop predict affect-modulated cue-reactivity among alcohol dependent adults
Garland, E. L., Carter, K., Ropes, K., & Howard, M. O. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2011.09.010 · Cited by 62
A Clinical Trial with Combined Transcranial Direct Current Stimulation and Attentional Bias Modification in Alcohol‐Dependent Patients
den Uyl, T. E., Gladwin, T. E., Lindenmeyer, J., & Wiers, R. W. H. J. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13841 · Cited by 72
The detrimental effects of emotional process dysregulation on decision-making in substance dependence
Murphy, A., Taylor, E., & Elliott, R. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00101 · Cited by 69
Sex-Specific Dissociations in Autonomic and HPA Responses to Stress and Cues in Alcohol-Dependent Patients with Cocaine Abuse
Fox, H. C., Hong, K.-I. A., Siedlarz, K. M., Bergquist, K. L., Anderson, G. M., Kreek, M. J., & Sinha, R. (2009) · Alcohol and Alcoholism · doi:10.1093/alcalc/agp060 · Cited by 59
Self-citation
Neural Activity to a Partner's Facial Expression Predicts Self-Regulation After Conflict
Hooker, C. I., Gyurak, A., Verosky, S. C., Miyakawa, A., & Ayduk, Ö. N. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.014 · Cited by 57
Event-related potentials in a Go/Nogo task of abnormal response inhibition in heroin addicts
Yang, B., Yang, S., Zhao, L., Yin, L., Liu, X., & An, S. (2009) · Science in China Series C Life Sciences · doi:10.1007/s11427-009-0106-4 · Cited by 60
Self-regulation and its failure: The seven deadly threats to self-regulation.
Wagner, D. D., & Heatherton, T. F. (2014) · American Psychological Association eBooks · doi:10.1037/14341-026 · Cited by 66
For better or for worse? A pre–post exploration of the impact of the COVID‐19 lockdown on cannabis users
Cousijn, J., Kuhns, L., Larsen, H., & Kroon, E. (2021) · Addiction · doi:10.1111/add.15387 · Cited by 56
Perceived control alters the effect of acute stress on persistence.
Bhanji, J. P., Kim, E. S., & Delgado, M. R. (2016) · Journal of Experimental Psychology General · doi:10.1037/xge0000137 · Cited by 66
Sleep disturbance as a therapeutic target to improve opioid use disorder treatment.
Huhn, A. S., & Finan, P. H. (2021) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000477 · Cited by 60
The influence of stress on the transition from drug use to addiction.
Wand, G. S. (2008) · Europe PMC (PubMed Central) · Cited by 55
The Role of the Glucocorticoids in Developing Resilience to Stress and Addiction
Srinivasan, S., Shariff, M. R., & Bartlett, S. E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00068 · Cited by 62
Opioid withdrawal, craving, and use during and after outpatient buprenorphine stabilization and taper: A discrete survival and growth mixture model
Northrup, T. F., Stotts, A. L., Green, C., Potter, J. S., Marino, E. N., Walker, R., Weiss, R. D., & Trivedi, M. H. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.09.021 · Cited by 57
Perceived Control Influences Neural Responses to Setbacks and Promotes Persistence
Bhanji, J. P., & Delgado, M. R. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.012 · Cited by 60
Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine
de la Fuente, A., Sedeño, L., Vignaga, S. S., Ellmann, C., Sonzogni, S., Belluscio, L., García-Cordero, I., Castagnaro, E., Boano, M., Cetkovich, M., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0370-3 · Cited by 55
Human Laboratory Paradigms in Alcohol Research
Plebani, J. G., Ray, L. A., Morean, M. E., Corbin, W. R., MacKillop, J. M., Amlung, M. T., & King, A. C. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01704.x · Cited by 58
Chronic Corticosterone Exposure during Adolescence Reduces Impulsive Action but Increases Impulsive Choice and Sensitivity to Yohimbine in Male Sprague-Dawley Rats
Torregrossa, M. M., Xie, M., & Taylor, J. R. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.11 · Cited by 55
Blunted vagal reactivity predicts stress-precipitated tobacco smoking
Ashare, R. L., Sinha, R., Lampert, R. J., Weinberger, A. H., Anderson, G. M., Lavery, M. E., Yanagisawa, K., & McKee, S. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2473-3 · Cited by 57
Self-citation
The role of lifestyle in perpetuating substance use disorder: the Lifestyle Balance Model
Davies, G., Elison, S., Ward, J., & Laudet, A. B. (2015) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/1747-597x-10-2 · Cited by 55
Mechanisms Underlying the Comorbidity Between Depressive and Addictive Disorders in Adolescents: Interactions Between Stress and HPA Activity
Rao, U., Hammen, C. L., & Poland, R. E. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08030412 · Cited by 55
Predicting abstinence from methamphetamine use after residential rehabilitation: Findings from the Methamphetamine Treatment Evaluation Study
McKetin, R., Kothe, A., Baker, A. L., Lee, N. K., Ross, J., & Lubman, D. I. (2018) · Drug and Alcohol Review · doi:10.1111/dar.12528 · Cited by 53
Intermittent social defeat stress enhances mesocorticolimbic ΔFosB/BDNF co-expression and persistently activates corticotegmental neurons: Implication for vulnerability to psychostimulants
Nikulina, E. M., Lacagnina, M. J., Fanous, S., Wang, J., & Hammer, R. P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.012 · Cited by 59
Behavioral economic analysis of stress effects on acute motivation for alcohol
Owens, M. M., Ray, L. A., & MacKillop, J. M. (2014) · Journal of the Experimental Analysis of Behavior · doi:10.1002/jeab.114 · Cited by 51
Elevated Glucocorticoid Levels Are Responsible for Induction of Tyrosine Hydroxylase mRNA Expression, Phosphorylation, and Enzyme Activity in the Nucleus of the Solitary Tract during Morphine Withdrawal
Núñez, C., Földes, A., Pérez-Flores, D., García-Borrón, J. C., Laorden, M. L., Kovács, K., & Milanés, M. V. (2009) · Endocrinology · doi:10.1210/en.2008-1732 · Cited by 51
The Impact of Adolescent Binge Drinking and Sustained Abstinence on Affective State
Bekman, N. M., Winward, J. L., Lau, L. L., Wagner, C., & Brown, S. A. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12096 · Cited by 52
Nerve Growth Factor, Stress and Diseases
Ceci, F. M., Ferraguti, G., Petrella, C., Greco, A., Tirassa, P., Iannitelli, A., Ralli, M., Vitali, M., Ceccanti, M., Chaldakov, G. N., et al. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200818111654 · Cited by 53
Efficacy of Cognitive Behavioral Therapy on Opiate Use and Retention in Methadone Maintenance Treatment in China: A Randomised Trial
Pan, S., Jiang, H., Du, J., Chen, H., Li, Z., Ling, W., & Zhao, M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0127598 · Cited by 49
The Resurrection of Phenotypic Drug Discovery
Childers, W. E., Elokely, K. M., & Abou-Gharbia, M. A. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.0c00006 · Cited by 48

Authors: Sinha, R.
Affiliations: Yale University (US)
Corresponding author: Sinha, Rajita
ORCID: Sinha, Rajita
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 9
Issue: 5
Pages: 388-395
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-007-0050-6
OpenAlex: W2043621158
Cited by: 423
References: 93
Citations by year: 2026: 17 · 2025: 13 · 2024: 21 · 2023: 24 · 2022: 23 · 2021: 30 · 2020: 39 · 2019: 23 · 2018: 29 · 2017: 26 · 2016: 15 · 2015: 24 · 2014: 17 · 2013: 16 · 2012: 27
FWCI: 2.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA013892, R01-AA-13892)
National Institute on Drug Abuse (K02 DA17232, P50DA016556, K02DA017232, R01-DA18219, R01DA018219, P50-DA16556)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: stress, addiction relapse, drug craving, alcohol relapse, drug-seeking behavior, stress responsivity, stress response pathways
MeSH terms: Alcoholism, Arousal, Brain, Conditioning, Psychological, Humans, Magnetic Resonance Imaging, Motivation, Illicit Drugs, Stress, Psychological, Substance Withdrawal Syndrome, Neurotransmitter Agents, Substance-Related Disorders, Secondary Prevention

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of stress in addiction relapse

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks