Cited by 365Posttraumatic Stress Disorder ResearchFunctional Brain Connectivity StudiesTraumatic Brain Injury Research

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A Network-Based Neurobiological Model of PTSD: Evidence From Structural and Functional Neuroimaging Studies

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Akiki, Teddy J., Averill, Christopher L., Abdallah, Chadi G.·2017·Current Psychiatry Reports

DOI 10.1007/s11920-017-0840-4PMC PMC5960989

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Abstract

Purpose of review Although a fine-grained understanding of the neurobiology of posttraumatic stress disorder (PTSD) is yet to be elucidated, the last two decades have seen a rapid growth in the study of PTSD using neuroimaging techniques. The current review summarizes important findings from functional and structural neuroimaging studies of PTSD, by primarily focusing on their relevance towards an emerging network-based neurobiological model of the disorder.Recent findings PTSD may be characterized by a weakly connected and hypoactive default mode network (DMN) and central executive network (CEN) that are putatively destabilized by an overactive and hyperconnected salience network (SN), which appears to have a low threshold for perceived saliency, and inefficient DMN-CEN modulation. There is considerable evidence for large-scale functional and structural network dysfunction in PTSD. Nevertheless, several limitations and gaps in the literature need to be addressed in future research.

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Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182
The organization of the human cerebellum estimated by intrinsic functional connectivity
Buckner, R. L., Krienen, F. M., Castellanos, A., Diaz, J. C., & Yeo, B. T. T. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00339.2011 · Cited by 7,304
Large-scale brain networks and psychopathology: a unifying triple network model
Menon, V. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.08.003 · Cited by 4,168
Functional Network Organization of the Human Brain
Power, J. D., Cohen, A. L., Nelson, S. M., Wig, G. S., Barnes, K. A., Church, J. A., Vogel, A. C., Laumann, T. O., Miezin, F. M., Schlaggar, B. L., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.006 · Cited by 4,124
Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015
Functional-anatomic fractionation of the brain’s default network
Andrews-Hanna, J. R., Reidler, J. S., Sepulcre, J., Poulin, R., & Buckner, R. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.005 · Cited by 2,767
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Authors: Akiki, T. J., Averill, C. L., & Abdallah, C. G.
Affiliations: Yale University (US)
Corresponding author: Abdallah, Chadi G.
ORCID: Akiki, Teddy J.
Averill, Christopher L.
Abdallah, Chadi G.
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2017-09-19
Volume: 19
Issue: 11
Pages: 81-81
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-017-0840-4
PMC: PMC5960989
OpenAlex: W2756085351
Cited by: 365
References: 84
Citations by year: 2026: 35 · 2025: 44 · 2024: 46 · 2023: 52 · 2022: 53 · 2021: 39 · 2020: 41 · 2019: 31 · 2018: 20 · 2017: 2
FWCI: 3.89
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (unspecified)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Stanley Medical Research Institute
National Institutes of Health (5k23mh101498-05)
National Institute of Mental Health (K23MH-101498()
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Keywords: post-traumatic stress disorder, neurobiological model, brain networks, default mode network, frontoparietal network, salience network, network dysfunction, functional connectivity, structural neuroimaging, functional neuroimaging
MeSH terms: Brain, Humans, Magnetic Resonance Imaging, Models, Neurological, Nerve Net, Neurobiology, Stress Disorders, Post-Traumatic, Functional Neuroimaging

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A Network-Based Neurobiological Model of PTSD: Evidence From Structural and Functional Neuroimaging Studies

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