The gut microbiome as a target for IBD treatment: are we there yet

Knox, Natalie C.; Forbes, Jessica D.; Van Domselaar, Gary; Bernstein, Charles N.

doi:10.1007/s11938-019-00221-w

Cited by 119Inflammatory Bowel DiseaseGut microbiota and healthProbiotics and Fermented Foods

The gut microbiome as a target for IBD treatment: are we there yet

Knox, Natalie C., Forbes, Jessica D., Van Domselaar, Gary, Bernstein, Charles N.·2019·Current Treatment Options in Gastroenterology

DOI 10.1007/s11938-019-00221-w

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Abstract

Purpose of review This review aims to highlight recent research on the gut microbiome in IBD and the application of microbiome-modulating therapies for the treatment of IBD including the use of the microbiome as an indicator for disease severity and treatment response. Recent findings Despite the high number of gut microbiome studies and emerging evidence supporting the gut microbiome's involvement in disease pathogenesis, no single microorganism has been identified as a pathogenic agent in IBD. Retrospective studies and meta-analyses on antibiotic use in ulcerative colitis and Crohn's disease and long-term outcomes are conflicting. Similarly, the use of probiotics for the treatment of IBD remains inconclusive; however, some encouraging results are emerging as microbial concoctions are optimized to include beneficial bacterial strains. Fecal microbial transplantation (FMT) is currently emerging as one of the more promising microbiome-modulating IBD therapies. FMT studies in ulcerative colitis have shown improved remission rates compared to placebo; however, relatively small study sample sizes and varied treatment methods, limit definitive conclusions. With clear evidence of an IBD gut dysbiosis, novel therapies to treat and prevent disease relapse will undoubtedly require a microbiome-modulating approach. The complexity and variability of IBD disease pathogenesis (disease phenotype, gut microbiome, host genetic susceptibility, and environmental factors) will likely require a personalized and multidimensional treatment approach where microbiome-modulating therapy is coupled with other therapies to target other IBD disease components.

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Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies
Ng, S. C., Shi, H. Y., Hamidi, N., Underwood, F. E., Tang, W., Benchimol, E. I., Panaccione, R., Ghosh, S., Wu, J. C. Y., Chan, F. K. L., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32448-0 · Cited by 6,087 · see citing works
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220 · see citing works
Environment dominates over host genetics in shaping human gut microbiota
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859 · see citing works
Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
Dethlefsen, L., & Relman, D. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000087107 · Cited by 2,421 · see citing works
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277 · see citing works
Immunopathogenesis of IBD: current state of the art
de Souza, H. S. P., & Fiocchi, C. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.186 · Cited by 1,551 · see citing works
Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial
Moayyedi, P., Surette, M. G., Kim, P. T., Libertucci, J., Wolfe, M., Onischi, C., Armstrong, D., Marshall, J. K., Kassam, Z., Reinisch, W., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.001 · Cited by 1,499 · see citing works
Fungal microbiota dysbiosis in IBD
Sokol, H., Leducq, V., Aschard, H., Pham, H., Jégou, S., Landman, C., Cohen, D., Liguori, G., Bourrier, A., Nion–Larmurier, I., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310746 · Cited by 1,321 · see citing works
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285 · see citing works
Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial
Paramsothy, S., Kamm, M. A., Kaakoush, N. O., Walsh, A. J., van den Bogaerde, J., Samuel, D., Leong, R. W. L., Connor, S., Ng, W., Paramsothy, R., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30182-4 · Cited by 1,276 · see citing works
The resilience of the intestinal microbiota influences health and disease
Sommer, F., Anderson, J. M., Bharti, R., Raes, J., & Rosenstiel, P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.58 · Cited by 1,058 · see citing works
A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes
Willing, B. P., Dicksved, J., Halfvarson, J., Andersson, A. F., Lucio, M., Zheng, Z., Järnerot, G., Tysk, C., Jansson, J. K., & Engstrand, L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.08.049 · Cited by 1,032 · see citing works
Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis
Rossen, N. G., Fuentes, S., van der Spek, M. J., Tijssen, J. G., Hartman, J. H. A., Duflou, A., Löwenberg, M., van den Brink, G. R., Mathus-Vliegen, E. M. H., de Vos, W. M., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.03.045 · Cited by 921 · see citing works
A microbial signature for Crohn's disease
Pascal, V., Pozuelo, M., Borruel, N., Casellas, F., Campos, D., Santiago, A., Martínez, X., Varela, E., Sarrabayrouse, G., Machiels, K., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313235 · Cited by 842 · see citing works
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
Imhann, F., Vich Vila, A., Bonder, M. J., Fu, J., Gevers, D., Visschedijk, M. C., Spekhorst, L. M., Alberts, R., Franke, L., van Dullemen, H. M., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-312135 · Cited by 788 · see citing works
Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum
Baumgart, M., Dogan, B., Rishniw, M., Weitzman, G., Bosworth, B. P., Yantiss, R. K., Orsi, R. H., Wiedmann, M., McDonough, P. L., Kim, S. G., et al. (2007) · The ISME Journal · doi:10.1038/ismej.2007.52 · Cited by 630 · see citing works
Effect of Oral Capsule– vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent <i>Clostridium difficile</i> Infection: A Randomized Clinical Trial
Kao, D., Roach, B., Silva, M., Beck, P., Rioux, K., Kaplan, G. G., Chang, H.-J., Coward, S., Goodman, K. J., Xu, H., et al. (2017) · JAMA · doi:10.1001/jama.2017.17077 · Cited by 615 · see citing works
Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease
Takahashi, K., Nishida, A., Fujimoto, T., Fujii, M., Shioya, M., Imaeda, H., Inatomi, O., Bamba, S., Andoh, A., & Sugimoto, M. (2016) · Digestion · doi:10.1159/000441768 · Cited by 599 · see citing works
Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host
Strauss, J., Kaplan, G. G., Beck, P. L., Rioux, K. P., Panaccione, R., DeVinney, R., Lynch, T., & Allen‐Vercoe, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21606 · Cited by 574 · see citing works
Dynamics of metatranscription in the inflammatory bowel disease gut microbiome
Schirmer, M., Franzosa, E. A., Lloyd‐Price, J., McIver, L. J., Schwager, R., Poon, T. W., Ananthakrishnan, A. N., Andrews, E., Barron, G., Lake, K., et al. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0089-z · Cited by 570 · see citing works
Antibiotic therapy in inflammatory bowel disease: A systematic review and meta-analysis
Khan, K. J., Ullman, T. A., Ford, A. C., Abreu, M. T., Abadir, A., Marshall, J. K., Talley, N. J., & Moayyedi, P. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.72 · Cited by 569 · see citing works
Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohnʼs disease
Willing, B., Halfvarson, J., Dicksved, J., Rosenquist, M., Järnerot, G., Engstrand, L., Tysk, C., & Jansson, J. K. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20783 · Cited by 455 · see citing works
Gut microbiome function predicts response to anti-integrin biologic therapy in Inflammatory Bowel diseases
Ananthakrishnan, A. N., Luo, C., Yajnik, V., Khalili, H., Garber, J. J., Stevens, B. W., Cleland, T., & Xavier, R. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.04.010 · Cited by 451 · see citing works
Faecal microbiota transplantation for inflammatory bowel disease: a systematic review and meta-analysis
Paramsothy, S., Paramsothy, R., Rubin, D. T., Kamm, M. A., Kaakoush, N. O., Mitchell, H. M., & Castaño-Rodríguez, N. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx063 · Cited by 436 · see citing works
High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
Kotłowski, R., Bernstein, C. N., Sepehri, S., & Krause, D. O. (2006) · Gut · doi:10.1136/gut.2006.099796 · Cited by 422 · see citing works
Self-citation
Systematic review with meta-analysis: The efficacy of probiotics in inflammatory bowel disease
Derwa, Y., Gracie, D. J., Hamlin, P. J., & Ford, A. C. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14203 · Cited by 393 · see citing works
Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn’s Disease Patients
Liguori, G., Lamas, B., Richard, M. L., Brandi, G., Costa, G. D., Hoffmann, T. W., Simone, M. P. D., Calabrese, C., Poggioli, G., Langella, P., et al. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv209 · Cited by 332 · see citing works
Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis
Ohkusa, T., Okayasu, I., Ogihara, T., Morita, K., Ogawa, M., & Sato, N. (2002) · Gut · doi:10.1136/gut.52.1.79 · Cited by 300 · see citing works
Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease
Chehoud, C., Albenberg, L. G., Judge-Golden, C. P., Hoffmann, C., Grunberg, S., Bittinger, K. L., Baldassano, R. N., Lewis, J. D., Bushman, F. D., & Wu, G. D. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000454 · Cited by 265 · see citing works
Fungi of the Murine Gut: Episodic Variation and Proliferation during Antibiotic Treatment
Dollive, S., Chen, Y., Grunberg, S., Bittinger, K. L., Hoffmann, C., Vandivier, L. E., Cuff, C. F., Lewis, J. D., Wu, G. D., & Bushman, F. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071806 · Cited by 236 · see citing works
Decline in Presumptively Protective Gut Bacterial Species and Metabolites Are Paradoxically Associated with Disease Improvement in Pediatric Crohn’s Disease During Enteral Nutrition
Gerasimidis, K., Bertz, M., Hanske, L., Junick, J., Biskou, O., Aguilera, J., Garrick, V., Russell, R. K., Blaut, M., McGrogan, P., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000023 · Cited by 230 · see citing works
The microbiota in inflammatory bowel disease: Current and therapeutic insights
Lane, E. R., Zisman, T., & Suskind, D. (2017) · Journal of Inflammation Research · doi:10.2147/jir.s116088 · Cited by 226 · see citing works
Systematic Review and Meta-analysis
Narula, N., Kassam, Z., Yuan, Y., Colombel, J., Ponsioen, C. Y., Reinisch, W., & Moayyedi, P. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001228 · Cited by 206 · see citing works
Tiny microbes, enormous impacts: what matters in gut microbiome studies?
Debelius, J. W., Song, S. J., Vázquez‐Baeza, Y., Xu, Z. Z., González, A., & Knight, R. D. (2016) · Genome biology · doi:10.1186/s13059-016-1086-x · Cited by 148 · see citing works
Clinical and Fecal Microbial Changes With Diet Therapy in Active Inflammatory Bowel Disease
Suskind, D. L., Cohen, S. A., Brittnacher, M., Wahbeh, G. T., Lee, D. Y., Shaffer, M. L., Braly, K., Hayden, H. S., Klein, J., Gold, B. D., et al. (2017) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000772 · Cited by 146 · see citing works
Transcriptional activity of the dominant gut mucosal microbiota in chronic inflammatory bowel disease patients
Rehman, A., Lepage, P., Nolte, A., Hellmig, S., Schreiber, S., & Ott, S. J. (2010) · Journal of Medical Microbiology · doi:10.1099/jmm.0.021170-0 · Cited by 137 · see citing works
Safety, Clinical Response, and Microbiome Findings Following Fecal Microbiota Transplant in Children With Inflammatory Bowel Disease
Goyal, A., Yeh, A., Bush, B. R., Firek, B., Siebold, L., Rogers, M. B., Kufen, A., & Morowitz, M. J. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx035 · Cited by 134 · see citing works
The risk of inflammatory bowel disease flares after fecal microbiota transplantation: Systematic review and meta-analysis
Qazi, T., Amaratunga, T., Barnes, E. L., Fischer, M., Kassam, Z., & Allegretti, J. R. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1353848 · Cited by 123 · see citing works
Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease
Moustafa, A. M., Li, W., Anderson, E. L., Wong, E., Dulai, P. S., Sandborn, W. J., Biggs, W., Yooseph, S., Jones, M. B., Venter, C. J., et al. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2017.58 · Cited by 117 · see citing works
Metagenomic analysis of intestinal mucosa revealed a specific eukaryotic gut virome signature in early-diagnosed inflammatory bowel disease
Ungaro, F., Massimino, L., Furfaro, F., Rimoldi, V., Peyrin‐Biroulet, L., D’Alessio, S., & Danese, S. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1511664 · Cited by 111 · see citing works
Saccharomyces cerevisiae CNCM I-3856 Prevents Colitis Induced by AIEC Bacteria in the Transgenic Mouse Model Mimicking Crohnʼs Disease
Sivignon, A., de Vallée, A., Barnich, N., Denizot, J., Darcha, C., Pignède, G., Vandekerckove, P., & Darfeuille–Michaud, A. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000280 · Cited by 99 · see citing works
Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages
Seider, K., Gerwien, F., Kasper, L., Allert, S., Brunke, S., Jablonowski, N., Schwarzmüller, T., Barz, D., Rupp, S., Kuchler, K., et al. (2014) · Eukaryotic Cell · doi:10.1128/ec.00262-13 · Cited by 91 · see citing works
Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Paramsothy, S., Paramsothy, R., Kamm, M. A., Kaakoush, N. O., Mitchell, H. M., Rubin, D. T., & Castaño‐Rodríguez, N. (2017) · Gastroenterology · doi:10.1016/s0016-5085(17)33417-0 · Cited by 87 · see citing works
Antibiotics in IBD: Still a Role in the Biological Era?
Ledder, O., & Turner, D. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy067 · Cited by 81 · see citing works
The fungal microbiota of de-novo paediatric inflammatory bowel disease
Mukhopadhya, I., Hansen, R., Meharg, C., Thomson, J., Russell, R. K., Berry, S. H., El-Omar, E. M., & Hold, G. L. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.12.001 · Cited by 78 · see citing works
Fusobacterium Detected in Colonic Biopsy and Clinicopathological Features of Ulcerative Colitis in Japan
Tahara, T., Shibata, T., Kawamura, T., Okubo, M., Ichikawa, Y., Sumi, K., Miyata, M., Ishizuka, T., Nakamura, M., Nagasaka, M., et al. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3316-y · Cited by 68 · see citing works
Metagenomics-Based, Strain-Level Analysis of Escherichia coli From a Time-Series of Microbiome Samples From a Crohn's Disease Patient
Fang, X. D., Monk, J. M., Nurk, S., Akseshina, M., Zhu, Q., Gemmell, C., Gianetto-Hill, C., Leung, N., Szubin, R., Sanders, J. G., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02559 · Cited by 57 · see citing works
Fungal Microbiota Profile in Newly Diagnosed Treatment-naïve Children with Crohn’s Disease
Mouzan, M. I. E., Wang, F., Mofarreh, M. A. A., Menon, R., Barrag, A. A., Korolev, K. S., Sarkhy, A. A. A., Alasmi, M., Hamed, Y. M., Saeed, A., et al. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw197 · Cited by 56 · see citing works
A Microbiome Foundation for the Study of Crohn’s Disease
Gevers, D., Kugathasan, S., Knights, D., Kostic, A. D., Knight, R. D., & Xavier, R. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.02.012 · Cited by 51 · see citing works
Azithromycin and metronidazole versus metronidazole-based therapy for the induction of remission in mild to moderate paediatric Crohn’s disease : a randomised controlled trial
Levine, A., Kori, M., Kierkus, J., Boneh, R. S., Sładek, M., Escher, J. C., Wine, E., Yerushalmi, B., Dias, J. A., Shaoul, R. R., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315199 · Cited by 46 · see citing works
16S sequencing and functional analysis of the fecal microbiome during treatment of newly diagnosed pediatric inflammatory bowel disease
Ashton, J. J., Colquhoun, C. M., Cleary, D. W., Coelho, T. A. F., Haggarty, R., Mulder, I. E., Batra, A., Afzal, N. A., Beattie, R. M., Scott, K. P., et al. (2017) · Medicine · doi:10.1097/md.0000000000007347 · Cited by 41 · see citing works
Antibiotics, Probiotics and Prebiotics in IBD
Bernstein, C. N. (2014) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000360713 · Cited by 36 · see citing works
Self-citation
Adjuvant use of antibiotics with corticosteroids in inflammatory bowel disease exacerbations requiring hospitalisation: a retrospective cohort study and meta‐analysis
Gupta, V., Rodrigues, R., Nguyen, D. D., Sauk, J. S., Khalili, H., Yajnik, V., & Ananthakrishnan, A. N. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13454 · Cited by 28 · see citing works
Sa1163 Its Gene Sequencing Reveals a Unique Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease
Albenberg, L. G., Chehoud, C., Judge-Golden, C. P., Grunberg, S., Bittinger, K. L., Baldassano, R. N., Lewis, J. D., Bushman, F. D., & Wu, G. D. (2014) · Gastroenterology · doi:10.1016/s0016-5085(14)60767-8 · Cited by 5 · see citing works

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Hul, M. V., & Cani, P. D. (2019) · Current Nutrition Reports · doi:10.1007/s13668-019-00281-5 · Cited by 79 · see citing works
Role of Carbon Monoxide in Host–Gut Microbiome Communication
Hopper, C., Cruz, L. K. D. L., Lyles, K. V. M., Wareham, L. K., Gilbert, J. A., Eichenbaum, Z., Magierowski, M., Poole, R. K., Wollborn, J., & Wang, B. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00586 · Cited by 72 · see citing works
Bacterial and Fungal Profiles as Markers of Infliximab Drug Response in Inflammatory Bowel Disease
Ventin-Holmberg, R., Eberl, A., Saqib, S., Korpela, K., Virtanen, S., Sipponen, T. M., Salonen, A., Saavalainen, P., & Nissilä, E. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa252 · Cited by 72 · see citing works
Drug delivery to the inflamed intestinal mucosa – targeting technologies and human cell culture models for better therapies of IBD
Hartwig, O., Boushehri, M. A. S., Shalaby, K. S., Loretz, B., Lamprecht, A., & Lehr, C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113828 · Cited by 72 · see citing works
The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease
Xu, X., Ocansey, D. K. W., Hang, S., Wang, B., Amoah, S., Yi, C., Zhang, X., Liu, L., & Mao, F. (2022) · Gut Pathogens · doi:10.1186/s13099-022-00499-9 · Cited by 67 · see citing works
Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits
Hanscom, M., Loane, D. J., Aubretch, T., Leser, J. M., Molesworth, K., Hedgekar, N., Ritzel, R. M., Abulwerdi, G. A., Shea‐Donohue, T., & Faden, A. I. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02067-x · Cited by 61 · see citing works
Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
Wipperman, M. F., Bhattarai, S. K., Vorkas, C. K., Maringanti, V. S., Taur, Y., Mathurin, L. D., McAulay, K., Vilbrun, S. C., Francois, D., Bean, J. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21475-y · Cited by 60 · see citing works
Homeostasis and Dysbiosis of the Intestinal Microbiota: Comparing Hallmarks of a Healthy State with Changes in Inflammatory Bowel Disease
Talapko, J., Včev, A., Meštrović, T., Pustijanac, E., Jukić, M., & Škrlec, I. (2022) · Microorganisms · doi:10.3390/microorganisms10122405 · Cited by 61 · see citing works
Fucose Ameliorate Intestinal Inflammation Through Modulating the Crosstalk Between Bile Acids and Gut Microbiota in a Chronic Colitis Murine Model
Ke, J., Li, Y., Han, C., He, R., Lin, R., Qian, W., & Hou, X. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa007 · Cited by 57 · see citing works
Searching for a Consensus Among Inflammatory Bowel Disease Studies: A Systematic Meta-Analysis
Abdel-Rahman, L. I. H., & Morgan, X. C. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac194 · Cited by 51 · see citing works
Novel Gut Microbiota Patterns Involved in the Attenuation of Dextran Sodium Sulfate-Induced Mouse Colitis Mediated by Glycerol Monolaurate via Inducing Anti-inflammatory Responses
Mo, Q., Liu, T., Fu, A., Ruan, S., Zhong, H., Tang, J., Zhao, M., Li, Y., Zhu, S., Cai, H., et al. (2021) · mBio · doi:10.1128/mbio.02148-21 · Cited by 49 · see citing works
Comparative of the Effectiveness and Safety of Biological Agents, Tofacitinib, and Fecal Microbiota Transplantation in Ulcerative Colitis: Systematic Review and Network Meta-Analysis
Zhou, H., Guo, B., Lufumpa, E., Li, X., Chen, L., Meng, X. L., & Li, B. (2020) · Immunological Investigations · doi:10.1080/08820139.2020.1714650 · Cited by 45 · see citing works
The effectiveness of multi-session FMT treatment in active ulcerative colitis patients: A pilot study
Mańkowska-Wierzbicka, D., Stelmach-Mardas, M., Gabryel, M., Tomczak, H., Skrzypczak-Zielińska, M., Zakerska-Banaszak, O., Sowińska, A., Mahadea, D., Baturo, A., Wolko, Ł., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8080268 · Cited by 39 · see citing works
Management of Clostridioides difficile infection in patients with inflammatory bowel disease
Khanna, S. (2020) · Intestinal Research · doi:10.5217/ir.2020.00045 · Cited by 40 · see citing works
m6A modification in inflammatory bowel disease provides new insights into clinical applications
Zhang, J., Song, B., Zeng, Y., Xu, C., Gao, L., Guo, Y., & Liu, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114298 · Cited by 33 · see citing works
Diosmin alleviates ulcerative colitis in mice by increasing Akkermansia muciniphila abundance, improving intestinal barrier function, and modulating the NF-κB and Nrf2 pathways
Salem, M. B., El-Lakkany, N. M., el-Din, S. H. S., Hammam, O. A., & Samir, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27527 · Cited by 33 · see citing works
Complex Responses to Hydrogen Peroxide and Hypochlorous Acid by the Probiotic Bacterium Lactobacillus reuteri
Thakur, P. B., Long, A. R., Nelson, B. J., Kumar, R., Rosenberg, A. F., & Gray, M. J. (2019) · mSystems · doi:10.1128/msystems.00453-19 · Cited by 32 · see citing works
Microbiota-targeted therapies in inflammation resolution
Strati, F., Lattanzi, G., Amoroso, C., & Facciotti, F. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101599 · Cited by 30 · see citing works
Microbes with higher metabolic independence are enriched in human gut microbiomes under stressPreprint
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2023) · eLife · doi:10.7554/elife.89862 · Cited by 32 · see citing works
Bacterial cross talk with gut microbiome and its implications: a short review
Shastry, R. P., & Rekha, P. D. (2020) · Folia Microbiologica · doi:10.1007/s12223-020-00821-5 · Cited by 29 · see citing works
Changes in the Intestinal Microbiota Are Seen Following Treatment with Infliximab in Children with Crohn’s Disease
Kowalska‐Duplaga, K., Kapusta, P., Gosiewski, T., Sroka-Oleksiak, A., Ludwig‐Słomczyńska, A. H., Wołkow, P. P., & Fyderek, K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030687 · Cited by 28 · see citing works
Changes in the Intestinal Microbiota of Patients with Inflammatory Bowel Disease with Clinical Remission during an 8-Week Infliximab Infusion Cycle
Seong, G., Kim, N., Joung, J., Kim, E. R., Chang, D. K., Chun, J., Hong, S. N., & Kim, Y. (2020) · Microorganisms · doi:10.3390/microorganisms8060874 · Cited by 27 · see citing works
Lactobacillus rhamnosus 1.0320 Postbiotics Ameliorate Dextran Sodium Sulfate-Induced Colonic Inflammation and Oxidative Stress by Regulating the Intestinal Barrier and Gut Microbiota
Zhang, J., Duan, X., Chen, X., Qian, S., Ma, J., Jiang, Z., & Hou, J. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06303 · Cited by 26 · see citing works
Gastrointestinal microbiota-directed nutritional and therapeutic interventions for inflammatory bowel disease: opportunities and challenges
Paudel, D., Nair, D. V. T., Joseph, G., Castro, R., Tiwari, A. K., & Singh, V. (2023) · Gastroenterology report · doi:10.1093/gastro/goae033 · Cited by 23 · see citing works
Diversion Colitis and Probiotic Stimulation: Effects of Bowel Stimulation Prior to Ileostomy Closure
Rodríguez-Padilla, Á., Morales-Martín, G., Quintero, R. P., Rada, R., Gómez-Salgado, J. C., & Ruíz-Frutos, C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.654573 · Cited by 23 · see citing works
Microbes with higher metabolic independence are enriched in human gut microbiomes under stress
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2025) · eLife · doi:10.1101/2023.05.10.540289 · Cited by 26 · see citing works
Methodology for biomarker discovery with reproducibility in microbiome data using machine learning
Rojas-Velázquez, D., Kidwai, S., Kraneveld, A. D., Tonda, A. P., Oberski, D. L., Garssen, J., & Lopez‐Rincon, A. (2024) · BMC Bioinformatics · doi:10.1186/s12859-024-05639-3 · Cited by 23 · see citing works
Microbiome-Mediated Immune Signaling in Inflammatory Bowel Disease and Colorectal Cancer: Support From Meta-omics Data
Pratt, M., Forbes, J. D., Knox, N., Bernstein, C. N., & Domselaar, G. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716604 · Cited by 22 · see citing works
Self-citation
Enteral Nutrition Supplemented with Transforming Growth Factor-β, Colostrum, Probiotics, and Other Nutritional Compounds in the Treatment of Patients with Inflammatory Bowel Disease
Triantafillidis, J. K., Tzouvala, M., & Triantafyllidi, E. (2020) · Nutrients · doi:10.3390/nu12041048 · Cited by 23 · see citing works
Specific Bacterial Cell Wall Components Influence the Stability of Coxsackievirus B3
Dhalech, A. H., Fuller, T. D., & Robinson, C. M. (2021) · Journal of Virology · doi:10.1128/jvi.01424-21 · Cited by 20 · see citing works
Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients
Lucafò, M., Franzin, M., Lagatolla, C., Franca, R., Bramuzzo, M., Stocco, G., & Decorti, G. (2019) · Clinical and Translational Science · doi:10.1111/cts.12722 · Cited by 20 · see citing works
Dextran Sulphate Sodium Acute Colitis Rat Model: A Suitable Tool for Advancing Our Understanding of Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease
Adamkova, P., Hradická, P., Skalníková, H. K., Cizkova, V., Vodička, P., Iannaccone, S. F., Kassayová, M., Gancarčíková, S., & Demečková, V. (2022) · Veterinary Sciences · doi:10.3390/vetsci9050238 · Cited by 19 · see citing works
Tetragenococcus halophilus Alleviates Intestinal Inflammation in Mice by Altering Gut Microbiota and Regulating Dendritic Cell Activation via CD83
Islam, S. M. S., Ryu, H.-M., & Sohn, S. (2022) · Cells · doi:10.3390/cells11121903 · Cited by 19 · see citing works
Tieguanyin extracts ameliorated DSS-induced mouse colitis by suppressing inflammation and regulating intestinal microbiota
Zhang, Y., Feng, X., Lin, H., Chen, X., He, P., Wang, Y., & Chu, Q. (2022) · Food & Function · doi:10.1039/d2fo02781j · Cited by 17 · see citing works
Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-κB/MAPK pathway
Qin, X., Liu, Z., Nong, K., Fang, X., Chen, W., Zhang, B., Wu, Y., Wang, Z., Shi, H., Wang, X., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111385 · Cited by 19 · see citing works
Emerging concepts and shifting paradigms for understanding the microbial basis of inflammatory bowel diseases
Kennedy, M. S., & Chang, E. B. (2025) · Journal of Clinical Investigation · doi:10.1172/jci193969 · Cited by 16 · see citing works
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion
Wang, W., Zhai, D., Bai, Y., Xue, K., Deng, L., Ma, L., Du, T., Ye, Z., Qu, D., An, X., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00444-w · Cited by 16 · see citing works
Determine independent gut microbiota-diseases association by eliminating the effects of human lifestyle factors
Zhu, C., Wang, X., Li, J., Jiang, R., Chen, H., Chen, T., & Yang, Y. (2022) · BMC Microbiology · doi:10.1186/s12866-021-02414-9 · Cited by 17 · see citing works
A Review of Hyperbaric Oxygen Therapy for Inflammatory Bowel Disease
Alenazi, N., Alsaeed, H., Alsulami, A., & Alanzi, T. M. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s336678 · Cited by 15 · see citing works
Diversion Colitis: Macro and Microscopic Findings after Probiotics Stimulation
Rodríguez-Padilla, Á., Morales-Martín, G., Quintero, R. P., Gómez-Salgado, J. C., Rada, R., & Ruíz-Frutos, C. (2021) · Biology · doi:10.3390/biology10040303 · Cited by 15 · see citing works
Downregulation of METTL3 enhances TRADD-mediated apoptosis in inflammatory bowel disease
Gong, T., Zeng, Z., Huang, Z., Luo, Y., Cao, X., Li, Z., Zhao, Y., Han, D., Li, D., & Zhong, M. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2799-6 · Cited by 13 · see citing works
Microbial Modulation in Inflammatory Bowel Diseases
Yu, J., & Cheon, J. H. (2022) · Immune Network · doi:10.4110/in.2022.22.e44 · Cited by 13 · see citing works
Candida gut commensalism and inflammatory disease
Gu, Z.-Q., Tseng, K.-Y., & Tsai, Y.-H. (2020) · Medicine in Microecology · doi:10.1016/j.medmic.2020.100008 · Cited by 13 · see citing works
Incorporating plasmid biology and metagenomics into a holistic model of the human gut microbiome
Stockdale, S. R., & Hill, C. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102307 · Cited by 12 · see citing works
Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy
Forte, A., Balistreri, C. R., FEO, M. D., Corte, A. D., Hellstrand, P., Persson, L., & Nilsson, B. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.02.014 · Cited by 13 · see citing works
Unmet needs of drugs for irritable bowel syndrome and inflammatory bowel diseases: interest of vagus nerve stimulation and hypnosis
Bonaz, B. L. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01446-7 · Cited by 13 · see citing works
Nanoparticles as Budding Trends in Colon Drug Delivery for the Management of Ulcerative Colitis
Singh, A., Kaur, K., Mandal, U. K., & Narang, R. K. (2020) · Current Nanomedicine · doi:10.2174/2468187310999200621200615 · Cited by 12 · see citing works
H89 Treatment Reduces Intestinal Inflammation and Candida albicans Overgrowth in Mice
Dumortier, C., Charlet, R., Bettaı̈eb, A., & Jawhara, S. (2020) · Microorganisms · doi:10.3390/microorganisms8122039 · Cited by 11 · see citing works
Intestinal retentive systems – recent advances and emerging approaches
Naik, D. A., Matonis, S., Balakrishnan, G., & Bettinger, C. J. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01842c · Cited by 11 · see citing works
Payload‐free protein nanoparticles target inflamed colons to restore intestinal barrier integrity for effectively treating inflammatory bowel diseases
Yang, M., Shen, H., Zhong, S., Xu, Z., Liu, X., Wu, W., Mao, C., & Yang, M. (2024) · Aggregate · doi:10.1002/agt2.515 · Cited by 11 · see citing works
Beneficial Effect of Faecal Microbiota Transplantation on Mild, Moderate and Severe Dextran Sodium Sulphate-Induced Ulcerative Colitis in a Pseudo Germ-Free Animal Model
Lauko, S., Gancarčíková, S., Hrčková, G., Hajdučková, V., Andrejčáková, Z., Fecskeová, L. K., Bertková, I., Hijová, E., Kamlárová, A., Janíčko, M., et al. (2023) · Biomedicines · doi:10.3390/biomedicines12010043 · Cited by 10 · see citing works
Integrated microbiomic and metabolomics insight into the ameliorating mechanisms of dietary Polygonatum cyrtonema saponin on ulcerative colitis
Xiao, J., Xie, L., Zheng, B., Chen, Y., Xie, J., Huang, H., Hu, X., & Yu, Q. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103871 · Cited by 10 · see citing works
Alternative Therapy in the Prevention of Experimental and Clinical Inflammatory Bowel Disease. Impact of Regular Physical Activity, Intestinal Alkaline Phosphatase and Herbal Products
Bilski, J., Wójcik-Grzybek, D., Danielak, A., Mazur-Biały, A. I., Magierowski, M., Tønnesen, K., Brzozowski, B., Surmiak, M., Magierowska, K., Pajdo, R., et al. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200427090127 · Cited by 10 · see citing works
Microbes with higher metabolic independence are enriched in human gut microbiomes under stressPreprint
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2023) · eLife · doi:10.7554/elife.89862.1 · Cited by 10 · see citing works
Intestinal protozoa and helminths in ulcerative colitis and the influence of anti-parasitic therapy on the course of the disease
Toychiev, A., Navruzov, B., Пазылова, Д. У., Davis, N., Badalova, N., & Осипова, С. О. (2020) · Acta Tropica · doi:10.1016/j.actatropica.2020.105755 · Cited by 11 · see citing works
Single Donor FMT Reverses Microbial/Immune Dysbiosis and Induces Clinical Remission in a Rat Model of Acute Colitis
Adámková, P., Hradicka, P., Gancarčíková, S., Kassayová, M., Ambro, Ľ., Bertková, I., Marônek, M., Iannaccone, S. F., & Demeckova, V. (2021) · Pathogens · doi:10.3390/pathogens10020152 · Cited by 9 · see citing works
IMOVNN: incomplete multi-omics data integration variational neural networks for gut microbiome disease prediction and biomarker identification
Hu, M. Y., Zhu, J., Peng, G., Lu, W., Wang, H., & Xie, Z. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad394 · Cited by 9 · see citing works
Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices
Naik, D. A., Balakrishnan, G., Rajagopalan, M., Huang, X., Trivedi, N., Bhat, A., & Bettinger, C. J. (2023) · Advanced Science · doi:10.1002/advs.202301084 · Cited by 8 · see citing works
Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect
Jirků, M., Lhotská, Z., Frgelecová, L., Kadlecová, O., Petrželková, K. J., Morien, E., & Jirků‐Pomajbíková, K. (2021) · Microorganisms · doi:10.3390/microorganisms9020226 · Cited by 8 · see citing works
ORAL AND ENTERAL NUTRITION THERAPY IN INFLAMMATORY BOWEL DISEASES AMONG THE PEDIATRIC POPULATION: A LITERATURE REVIEW
Souza, G. N., Draghi, P. F., & Yonamine, G. H. (2020) · Revista Paulista de Pediatria · doi:10.1590/1984-0462/2020/38/2019032 · Cited by 8 · see citing works
Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment
Thomas, S., Mercogliano, G., & Prendergast, G. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276910 · Cited by 7 · see citing works
Intestinale Mikrobiota — ein lebenswichtiges „Organ“ mit vielfältigen Funktionen
Konturek, P. C., Konturek, K., Zopf, Y., & Harsch, I. A. (2020) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-020-0228-y · Cited by 7 · see citing works
Small intestinal bacterial overgrowth in inflammatory bowel disease
Shah, A., & Holtmann, G. (2022) · Indian Journal of Gastroenterology · doi:10.1007/s12664-021-01235-y · Cited by 7 · see citing works
Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease
Budzinski, L., Kang, G.-U., Riedel, R., Sempert, T., Lietz, L., Maier, R., Büttner, J., Bochow, B., Tordai, M. T., Shah, A., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2452250 · Cited by 6 · see citing works
Early fecal microbiome transfer after donor defecation determines response in patients with moderate to severe ulcerative colitis
Singh, A., Mahajan, R., Kahlon, B. K., Dhaliwal, A. S., Midha, V., Mehta, V., Bansal, N., Singh, D., & Sood, A. (2022) · Indian Journal of Gastroenterology · doi:10.1007/s12664-022-01257-0 · Cited by 6 · see citing works
Microbes with higher metabolic independence are enriched in human gut microbiomes under stressPreprint
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2024) · eLife · doi:10.7554/elife.89862.2 · Cited by 8 · see citing works
Assessing the Resolution of Methyltransferase-Mediated DNA Optical Mapping
D’Huys, L., Vitale, R., Ruppeka‐Rupeika, E., Goyvaerts, V., Ruckebusch, C., & Hofkens, J. (2021) · ACS Omega · doi:10.1021/acsomega.1c01381 · Cited by 5 · see citing works
Dietary Administration of Black Raspberries and Arsenic Exposure: Changes in the Gut Microbiota and Its Functional Metabolites
Tu, P., Tang, Q., Mo, Z., Niu, H., Hu, Y., Wu, L., Chen, Z., Wang, X., & Gao, B. (2023) · Metabolites · doi:10.3390/metabo13020207 · Cited by 5 · see citing works
Gut Microbes: The Gut Brain Connection
Lynch, C. M. K., O’Riordan, K. J., Clarke, G. A., & Cryan, J. F. (2023) · Springer eBooks · doi:10.1007/978-3-031-46712-7_4 · Cited by 5 · see citing works
Perioperative Considerations for the Surgical Treatment of Crohn’s Disease with Discussion on Surgical Antibiotics Practices and Impact on the Gut Microbiome
Olson, S. L., Welton, L. L., & Jahansouz, C. (2024) · Antibiotics · doi:10.3390/antibiotics13040317 · Cited by 5 · see citing works
Assessing the effects of tofacitinib on the gut microbiome in inflammatory bowel disease.
Favaron, A., Sangfuang, N., McCoubrey, L. E., Awad, A., Ghyselinck, J., Marzorati, M., Verstrepen, L., Munck, J. D., Medts, J. D., Basit, A. W., et al. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107365 · Cited by 5 · see citing works
Gut Microbiota-Mediated Immunomodulatory Effects of Lactobacillus rhamnosus HDB1258 Cultured in the Lava Seawater in the Colitis Mouse Model
Kim, K., Song, J., Yang, S.-J., Choi, J.-W., Sohn, J., Han, S., Shin, Y.-J., Lee, D.-Y., Lee, S., & Kim, D. (2021) · Journal of Medicinal Food · doi:10.1089/jmf.2021.k.0103 · Cited by 4 · see citing works
Complementary and Alternative Medicine
Hay, W., Steinke, L., & Foster, L. (2022) · Springer eBooks · doi:10.1007/978-3-030-54441-6_143 · Cited by 4 · see citing works
Are We Ready to Reclassify Crohn’s Disease Using Molecular Classification?
Kamal, S., Parkash, N., Beattie, W., Christensen, B., & Segal, J. P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12185786 · Cited by 4 · see citing works
L-arginine as a novel target for clinical intervention in inflammatory bowel disease
Nüse, B., & Mattner, J. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00008 · Cited by 4 · see citing works
Complex responses to inflammatory oxidants by the probiotic bacterium Lactobacillus reuteriPreprint
Thakur, P. B., Long, A. R., Nelson, B. J., Kumar, R., Rosenberg, A. F., & Gray, M. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/605881 · Cited by 4 · see citing works
Systematic interrogation of the distinct metabolic potential in gut microbiomes of inflammatory bowel disease patients with dysbiosisPreprint
Heinken, A., & Thiele, I. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/640649 · Cited by 5 · see citing works
High-resolution QTL mapping with Diversity Outbred mice identifies genetic variants that impact gut microbiome compositionPreprint
Schlamp, F., Zhang, D. Y., Beltrán, J. F., Cosgrove, E. J., Šimeček, P., Edwards, M. M., Goodrich, J. K., Ley, R. E., Pack, A. I., Churchill, G. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/722744 · Cited by 3 · see citing works
Current insight into enteropathogens in flare-up ulcerative colitis. An observational study
Hassan, E. A., Rehim, A. S. E.-D. A., Ahmed, A. O., Salim, S. M. A. E., Soliman, A. M. A., Rashed, H. G., & El‐Kareem, D. M. A. (2023) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002563 · Cited by 2 · see citing works
The role of the yycF gene in regulating biofilm formation and probiotic properties in Lactobacillus reuteri.
Wang, X., Bai, M., Li, J., Yu, X., Li, P., Ding, X., & Duan, J. (2026) · Food Research International · doi:10.1016/j.foodres.2025.117950 · Cited by 1 · see citing works
Advances in Gut Microbiome and Metabolomics Research in the Comorbidity of Inflammatory Bowel Disease and Depressive Disorder
Zhao, C., Lao, J., Cao, J., Yang, Y., Liu, C., & Tang, F. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.70173 · Cited by 1 · see citing works
Probiotics, Prebiotics, and Synbiotics in Human Health
Wells, O. L., Mishra, S. P., & Yadav, H. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160950-00086 · Cited by 1 · see citing works
Complementary and Alternative Medicine
Hay, W., Steinke, L., & Foster, L. (2020) · Springer eBooks · doi:10.1007/978-1-4939-0779-3_143-1 · Cited by 1 · see citing works
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Das, K., Upadhyay, S., & Oli, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99988-5.00021-8 · Cited by 1 · see citing works
Gut microbiome–based therapeutics in inflammatory bowel disease
Hu, K. A., & Gubatan, J. M. B. (2023) · Clinical and Translational Discovery · doi:10.1002/ctd2.182 · Cited by 25 · see citing works

Authors: Knox, N. C., Forbes, J. D., Van Domselaar, G., & Bernstein, C. N.
Affiliations: Public Health Agency of Canada (CA)
University of Toronto (CA)
University of Manitoba (CA)
Corresponding author: Bernstein, Charles N.
ORCID: Knox, Natalie C.
Bernstein, Charles N.
Venue: Current Treatment Options in Gastroenterology
Publisher: Springer Science and Business Media LLC
Published: 2019-01-19
Volume: 17
Issue: 1
Pages: 115-126
ISSN: 1092-8472 (ISSN-L)
1534-309X
DOI: 10.1007/s11938-019-00221-w
OpenAlex: W2911082921
Cited by: 117
References: 54
Citations by year: 2026: 1 · 2025: 7 · 2024: 10 · 2023: 19 · 2022: 19 · 2021: 28 · 2020: 22 · 2019: 11
FWCI: 2.65
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Treatment Options in Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, inflammatory bowel disease, fecal microbiota transplantation, probiotics, antibiotic use, ulcerative colitis, Crohn's disease, gut dysbiosis, disease severity markers, treatment response, personalized medicine, relapse prevention

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The gut microbiome as a target for IBD treatment: are we there yet

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