Cited by 159Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsNatural Antidiabetic Agents Studies

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Insulin signaling and glucose transport in insulin resistant human skeletal muscle

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Karlsson, Håkan K. R., Zierath, Juleen R.·2007·Cell Biochemistry and Biophysics

DOI 10.1007/s12013-007-0030-9

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Abstract

Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This review summarizes recent work to identify downstream intermediates in the insulin signaling pathways governing glucose homeostasis, in an attempt to characterize the molecular mechanism accounting for skeletal muscle insulin resistance in Type 2 diabetes. Furthermore, the effects of pharmaceutical treatment of Type 2 diabetic patients on insulin signaling and glucose uptake are discussed. The identification and characterization of pathways governing insulin action on glucose metabolism will facilitate the development of strategies to improve insulin sensitivity in an effort to prevent and treat Type 2 diabetes mellitus.

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Global Prevalence of Diabetes
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Real time quantitative PCR.Preprint
Heid, C., Stevens, J., Livak, K. J., & Williams, P. (1996) · Genome Research · doi:10.1101/gr.6.10.986 · Cited by 6,180
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522

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Rozentul, N., Avrahami, Y., Shubely, M., Levy, L., Munder, A., Cohen, G., Cerasi, E., Sasson, S., & Gruzman, A. (2017) · Pharmaceutical Research · doi:10.1007/s11095-017-2271-7 · Cited by 10
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Authors: Karlsson, H. K. R., & Zierath, J. R.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Zierath, Juleen R.
ORCID: Karlsson, Håkan K. R.
Zierath, Juleen R.
Venue: Cell Biochemistry and Biophysics
Publisher: Springer Science and Business Media LLC
Published: 2007-04-17
Volume: 48
Issue: 2-3
Pages: 103-113
ISSN: 1085-9195 (ISSN-L)
1559-0283
DOI: 10.1007/s12013-007-0030-9
OpenAlex: W2159080529
Cited by: 159
References: 231
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 16 · 2020: 12 · 2019: 5 · 2018: 13 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 10
FWCI: 4.20
Type: journal article
Language: en
Open access: green
figshare.com
Licence: cc-by
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cell Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by)
Open Archive (Karolinska Institutet) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords: insulin signaling, glucose transport, skeletal muscle, insulin resistance, type 2 diabetes, glucose uptake, signal transduction, protein phosphorylation, glucose homeostasis, antidiabetic drugs, insulin sensitivity
MeSH terms: Diabetes Mellitus, Type 2, Glucose, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Models, Biological, Phosphoproteins, Signal Transduction, Muscle, Skeletal, Insulin Receptor Substrate Proteins

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Insulin signaling and glucose transport in insulin resistant human skeletal muscle

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