The DOI matches its Crossref record; 236 of the 236 references it cites were found in a registry or an index.
Insulin signaling and glucose transport in insulin resistant human skeletal muscle
Open accessAbstract
Insulin increases glucose uptake and metabolism in skeletal muscle by signal transduction via protein phosphorylation cascades. Insulin action on signal transduction is impaired in skeletal muscle from Type 2 diabetic subjects, underscoring the contribution of molecular defects to the insulin resistant phenotype. This review summarizes recent work to identify downstream intermediates in the insulin signaling pathways governing glucose homeostasis, in an attempt to characterize the molecular mechanism accounting for skeletal muscle insulin resistance in Type 2 diabetes. Furthermore, the effects of pharmaceutical treatment of Type 2 diabetic patients on insulin signaling and glucose uptake are discussed. The identification and characterization of pathways governing insulin action on glucose metabolism will facilitate the development of strategies to improve insulin sensitivity in an effort to prevent and treat Type 2 diabetes mellitus.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Real time quantitative PCR.Preprint
Heid, C., Stevens, J., Livak, K. J., & Williams, P. (1996) · Genome Research · doi:10.1101/gr.6.10.986 · Cited by 6,180
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Randle, P. J., Garland, P. B., Hales, C. N., & Newsholme, E. A. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91500-9 · Cited by 5,093
Follow-up report on the diagnosis of diabetes mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3160 · Cited by 3,784
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,645
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Mechanism of activation of protein kinase B by insulin and IGF‐1.
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014
Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874
Type 2 diabetes: principles of pathogenesis and therapy
Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
Chiasson, J.-L., Josse, R. G., Gomis, R., Hanefeld, M., Karasik, A., & Laakso, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08905-5 · Cited by 2,543
Characterization of Mammalian Selenoproteomes
Kryukov, G. V., Castellano, S., Novoselov, S. V., Lobanov, A. V., Zehtab, O., Guigó, R., & Gladyshev, V. N. (2003) · Science · doi:10.1126/science.1083516 · Cited by 2,385
Inflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170
Pathogenesis of NIDDM. A balanced overview.
DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
Burgering, B. M. T., & Coffer, P. J. (1995) · Nature · doi:10.1038/376599a0 · Cited by 2,076
Franke, T. F., Yang, S., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., & Tsichlis, P. N. (1995) · Cell · doi:10.1016/0092-8674(95)90534-0 · Cited by 2,001
Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860
Comment on the provisional report from the WHO consultation
(1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00059.x · Cited by 1,820
Disruption of IRS-2 causes type 2 diabetes in mice
Withers, D. J., Gutierrez, J. S., Towery, H. H., Burks, D. J., Ren, J., Previs, S. F., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,775
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,756
Bailey, C. J., & Turner, R. C. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602293340906 · Cited by 1,726
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Buchanan, T. A., Xiang, A. H., Peters, R. K., Kjos, S. L., Marroquin, A., Goico, J., Ochoa, C., Tan, S., Berkowitz, K., Hodis, H. N., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2796 · Cited by 1,339
Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus
Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295
Kohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31372 · Cited by 1,284
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,246
DeFronzo, R. A., Gunnarsson, R., Björkman, O., Olsson, M., & Wahren, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111938 · Cited by 1,167
Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
Stumvoll, M., Nurjhan, N., Perriello, G., Dailey, G., & Gerich, J. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199508313330903 · Cited by 1,148
Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., & Mandarino, L. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7535 · Cited by 1,139
Cushman, S. W., & Wardzala, L. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85561-8 · Cited by 1,088
Schmidt, M. I., Duncan, B. B., Sharrett, A. R., Lindberg, G., Savage, P. J., Offenbacher, S., Azambuja, M. I. R., Tracy, R. P., & HEISS, G. M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01046-6 · Cited by 1,080
Mechanism by which metformin reduces glucose production in type 2 diabetes.
Hundal, R. S., Krssak, M., Dufour, S., Laurent, D., Lebon, V, Chandramouli, V, Inzucchi, S. E., Schumann, W. C., Petersen, K. F., Landau, B. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2063 · Cited by 1,052 · cited 1×
“This is consistent with previous studies of poorly controlled obese Type 2 diabetic patients [88, 89 ].”
ResultLow-Grade Systemic Inflammation and the Development of Type 2 Diabetes
Duncan, B. B., Schmidt, M. I., Pankow, J. S., Ballantyne, C. M., Couper, D., Vigo, A., Hoogeveen, R., Folsom, A. R., & Heiss, G. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1799 · Cited by 1,036
Suzuki, K. T., & Kôno, T. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2542 · Cited by 1,030
Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m101521200 · Cited by 1,010
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation
Sano, H., Kane, S., Sano, E., Mı̂inea, C. P., Asara, J. M., Lane, W. S., Garner, C. W., & Lienhard, G. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300063200 · Cited by 964
Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., & Birnbaum, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100462200 · Cited by 959
NAVÉ, B. T., Ouwens, D. M., Withers, D. J., Alessi, D. R., & Shepherd, P. R. (1999) · Biochemical Journal · doi:10.1042/bj3440427 · Cited by 926
Laaksonen, D. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf145 · Cited by 916
Molecular cloning and characterization of an insulin-regulatable glucose transporter
James, D. E., Strube, M., & Muecdler, M. (1989) · Nature · doi:10.1038/338083a0 · Cited by 901
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875
Wardzala, L. J., & Jeanrenaud, B. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68926-x · Cited by 839
Borkman, M., Storlien, L. H., Pan, D. A., Jenkins, A. B., Chisholm, D. J., & Campbell, L. V. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301283280404 · Cited by 835
Rossetti, L., Smith, D. J., Shulman, G. I., Papachristou, D. N., & DeFronzo, R. A. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112981 · Cited by 824
PDK1, the master regulator of AGC kinase signal transduction
Mora, A., Komander, D., van Aalten, D. M. F., & Alessi, D. R. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2003.12.022 · Cited by 818
Early Metabolic Defects in Persons at Increased Risk for Non-Insulin-Dependent Diabetes Mellitus
Eriksson, J., Franssila-Kallunki, A., Ekstrand, A., Saloranta, C., Widén, E., Schalin, C., & Groop, L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908103210601 · Cited by 807
Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus
Inzucchi, S. E., Maggs, D. G., Spollett, G. R., Page, S. L., Rife, F. S., Walton, V., & Shulman, G. I. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803263381303 · Cited by 794
Goldberg, R. B., Kendall, D. M., Deeg, M. A., Buse, J. B., Zagar, A. J., Pinaire, J. A., Tan, M. H., Khan, M. A., Perez, A. T., Jacober, S. J., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1547 · Cited by 790
Stanley, J. C. (1981) · British Journal of Anaesthesia · doi:10.1093/bja/53.2.123 · Cited by 731
Yu, J. G., Javorschi, S., Hevener, A. L., Kruszynska, Y. T., Norman, R. A., Sinha, M. K., & Olefsky, J. M. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2968 · Cited by 726
How Selenium Has Altered Our Understanding of the Genetic Code
Hatfield, D. L., & Gladyshev, V. N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3565-3576.2002 · Cited by 681
Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D. L., & Shulman, G. I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410404 · Cited by 675
Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein
James, D. E., Brown, R., Navarro, J., & Pilch, P. F. (1988) · Nature · doi:10.1038/333183a0 · Cited by 666
Parental transmission of type 2 diabetes: the Framingham Offspring Study
Meigs, J. B., Cupples, L. A., & Wilson, P. W. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2201 · Cited by 666
Mayerson, A. B., Hundal, R. S., Dufour, S., Lebon, V., Befroy, D., Cline, G. W., Enocksson, S., Inzucchi, S. E., Shulman, G. I., & Petersen, K. F. (2002) · Diabetes · doi:10.2337/diabetes.51.3.797 · Cited by 647
Metabolic Syndrome: A Clinical and Molecular Perspective
Moller, D. E., & Kaufman, K. D. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104751 · Cited by 636
Role of AMP-activated protein kinase in mechanism of metformin action
Zhou, G., Myers, R., Li, Y., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113505 · Cited by 635
Aronoff, S., Rosenblatt, S., Braithwaite, S. S., Egan, J. W., Mathisen, A. L., & Schneider, R. (2000) · Diabetes Care · doi:10.2337/diacare.23.11.1605 · Cited by 626
Regulation of protein kinase C ζ by PI 3-kinase and PDK-1
Chou, M. M., Hou, W., Johnson, J. E., Graham, L. K., Lee, M. H., Chen, C., Newton, A. C., Schaffhausen, B. S., & Toker, A. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70444-0 · Cited by 608
Identification of a novel gene encoding an insulin-responsive glucose transporter protein
Birnbaum, M. J. (1989) · Cell · doi:10.1016/0092-8674(89)90968-9 · Cited by 598
Components of the “Metabolic Syndrome” and Incidence of Type 2 Diabetes
Hanson, R. L., Imperatore, G., Bennett, P. H., & Knowler, W. C. (2002) · Diabetes · doi:10.2337/diabetes.51.10.3120 · Cited by 590
Phosphoinositide 3-kinase signalling pathways
Cantrell, D. A. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.8.1439 · Cited by 539
Effect of Metformin and Rosiglitazone Combination Therapy in Patients With Type 2 Diabetes Mellitus
Fonseca, V. A., Rosenstock, J., Patwardhan, R., & Salzman, A. (2000) · JAMA · doi:10.1001/jama.283.13.1695 · Cited by 538
A Method to Identify Serine Kinase Substrates
Kane, S., Sano, H., Liu, S. C. H., Asara, J. M., Lane, W. S., Garner, C. C., & Lienhard, G. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200198200 · Cited by 529
Goodyear, L. J., Giorgino, F., Sherman, L., Carey, J., Smith, R. J., & Dohm, G. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117909 · Cited by 527
Rosiglitazone Monotherapy Is Effective in Patients with Type 2 Diabetes
Lebovitz, H. E., Dole, J., Patwardhan, R., Rappaport, E. B., & Freed, M. I. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7157 · Cited by 520
Lund, S., Holman, G. D., Schmitz, O., & Pedersen, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5817 · Cited by 492
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
Kido, Y., Burks, D. J., Withers, D. J., Brüning, J. C., Kahn, C. R., White, M. F., & Accili, D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7917 · Cited by 491
Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase
Feng, J., Park, J., Cron, P. D., Heß, D., & Hemmings, B. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406731200 · Cited by 488
Kim, Y.-B., Nikoulina, S. E., Ciaraldi, T. P., Henry, R. R., & Kahn, B. B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6928 · Cited by 487
The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function
Scheepers, A., Joost, H., & Schurmann, A. (2004) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607104028005364 · Cited by 476 · cited 2×
“The GLUT’s have different tissue expression and different affinity for glucose [ 6 ].”
BackgroundFukumoto, H., Kayano, T., Buse, J. B., Edwards, Y. H., Pilch, P. F., Bell, G. I., & Seino, S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83106-4 · Cited by 474
Douen, A. G., Ramlal, T., Rastogi, S., Bilan, P. J., Cartee, G. D., Vranić, M., Holloszy, J. O., & Klip, A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77362-6 · Cited by 471
Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
Katz, E. B., Stenbit, A. E., Hatton, K. S., DePinho, R. A., & Charron, M. J. (1995) · Nature · doi:10.1038/377151a0 · Cited by 467
Garvey, W. T., Maianu, L., Zhu, J. H., Brechtel-Hook, G., Wallace, P., & Baron, A. D. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1557 · Cited by 459
Mîinea, C. P., Sano, H., Kane, S., Sano, E., Fukuda, M., Peränen, J., Lane, W. S., & Lienhard, G. E. (2005) · Biochemical Journal · doi:10.1042/bj20050887 · Cited by 449
Phosphoinositide 3-kinase signalling pathways
Domin, J. (2006) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860948091_0003 · Cited by 444
c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade
Lee, Y. H., Giraud, J., Davis, R. J., & White, M. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208359200 · Cited by 441
Klippel, A., Reinhard, C., Kavanaugh, W. M., Apell, G., Escobedo, M.-A., & Williams, L. T. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4117 · Cited by 440
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators
Joost, H., Bell, G. I., Best, J. D., Birnbaum, M. J., Charron, M. J., Chen, Y. T., Doege, H., James, D. E., Lodish, H. F., Moley, K. H., et al. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00407.2001 · Cited by 421
Zierath, J. R., He, L., Gumà, A., Wahlström, E. O., Klip, A., & Wallberg-Henriksson, H. (1996) · Diabetologia · doi:10.1007/bf02658504 · Cited by 402
Self-citationYang, W., Jeng, C.-Y., Wu, T.-J., Tanaka, S., Funahashi, T., Matsuzawa, Y., Wang, J.-P., Chen, C., Tai, T., & Chuang, L. (2002) · Diabetes Care · doi:10.2337/diacare.25.2.376 · Cited by 402
A glucose transport protein expressed predominately in insulin-responsive tissues.
Charron, M. J., Brosius, F. C., Alper, S. L., & Lodish, H. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2535 · Cited by 390
Krook, A., Björnholm, M., Galuska, D., Jiang, X. J., Fahlman, R., Myers, M. G., Wallberg-Henriksson, H., & Zierath, J. R. (2000) · Diabetes · doi:10.2337/diabetes.49.2.284 · Cited by 375
Self-citationMetformin: its botanical background
Bailey, C. J., & Day, C. (2004) · Practical Diabetes · doi:10.1002/pdi.606 · Cited by 370
Björnholm, M., Kawano, Y., Lehtihet, M., & Zierath, J. R. (1997) · Diabetes · doi:10.2337/diab.46.3.524 · Cited by 361
Self-citationNikoulina, S. E., Ciaraldi, T. P., Mudaliar, S., Mohideen, P., Carter, L., & Henry, R. R. (2000) · Diabetes · doi:10.2337/diabetes.49.2.263 · Cited by 357
Ueki, K., Yamamoto‐Honda, R., Kaburagi, Y., Yamauchi, T., Tobe, K., Burgering, B. M. T., Coffer, P. J., Komuro, I., Akanuma, Y., Yazaki, Y., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5315 · Cited by 357
Bajaj, M. S., Suraamornkul, S., Piper, P. K., Hardies, L. J., Glass, L. C., Cersósimo, E., Pratipanawatr, T., Miyazaki, Y., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031315 · Cited by 355
Kohn, A. D., Kovacina, K. S., & Roth, R. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00103.x · Cited by 352
Saad, M. J., Folli, F., Kahn, J. A., & Kahn, C. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116803 · Cited by 349
Raskin, P., Rendell, M., Riddle, M. C., Dole, J., Freed, M. I., & Rosenstock, J. (2001) · Diabetes Care · doi:10.2337/diacare.24.7.1226 · Cited by 345
Way, J. M., Harrington, W. W., Brown, K. K., Gottschalk, W. K., Sundseth, S. S., Mansfield, T. A., Ramachandran, R. K., Willson, T. M., & Kliewer, S. A. (2001) · Endocrinology · doi:10.1210/endo.142.3.8037 · Cited by 342
Caro, J. F., Sinha, M. K., Raju, S. M., Ittoop, O., Pories, W. J., Flickinger, E. G., Meelheim, D., & Dohm, G. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112958 · Cited by 341
Insulin‐induced translocation of glucose transporters in rat hindlimb muscles
Klip, A., Ramlal, T., Young, D. A., & Holloszy, J. O. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80452-0 · Cited by 334
Holman, G. D., Kozka, I. J., CLARK, A. E., Flower, C. J., Saltis, J., Habberfield, A. D., Simpson, I. A., & Cushman, S. W. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44734-x · Cited by 329
Pedersen, O., Bak, J. F., Andersen, P. H., Lund, S., Moller, D. E., Flier, J. S., & Kahn, B. B. (1990) · Diabetes · doi:10.2337/diab.39.7.865 · Cited by 329
Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load.
Kelley, D. E., Mitrakou, A., Marsh, H. W., Schwenk, F. W., Benn, J., Sonnenberg, G. E., Arcangeli, M. A., Aoki, T. T., Sorensen, J., & Berger, M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113489 · Cited by 327
Saad, M. J. A., Araki, E., Miralpeix, M., Rothenberg, P., White, M. F., & Kahn, C. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116060 · Cited by 321
Kelly, I. E., Han, T. S., Walsh, K., & Lean, M. E. J. (1999) · Diabetes Care · doi:10.2337/diacare.22.2.288 · Cited by 314
Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM Subjects
Krook, A., Roth, R. A., Jiang, X. J., Zierath, J. R., & Wallberg‐Henriksson, H. (1998) · Diabetes · doi:10.2337/diab.47.8.1281 · Cited by 309
Self-citationStimulation of glucose transport in skeletal muscle by hypoxia
Cartee, G. D., Douen, A. G., Ramlal, T., Klip, A., & Holloszy, J. O. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.4.1593 · Cited by 305
Bouzakri, K., Roques, M., Gual, P., Espinosa, S., Guebre-Egziabher, F., Riou, J.-P., Laville, M., Le Marchand-Brustel, Y., Tanti, J.-F., & Vidal, H. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1319 · Cited by 305
Phillips, L. S., Grunberger, G., Miller, E., Patwardhan, R., Rappaport, E. B., & Salzman, A. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.308 · Cited by 301
Karlsson, H., Zierath, J. R., Kane, S., Krook, A., Lienhard, G. E., & Wallberg‐Henriksson, H. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1692 · Cited by 299
Self-citationDohm, G. L., Tapscott, E. B., Pories, W. J., Dabbs, D. J., Flickinger, E. G., Meelheim, D., Fushiki, T., Atkinson, S., Elton, C. W., & Caro, J. F. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113622 · Cited by 296
Metabolic Effects of Troglitazone Monotherapy in Type 2 Diabetes Mellitus
Maggs, D. G., Buchanan, T. A., Burant, C., Cline, G. W., Gumbiner, B., Hsueh, W. A., Inzucchi, S., Kelley, D., Nolan, J., Olefsky, J. M., et al. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-3-199802010-00002 · Cited by 283
Ren, J., Marshall, B. A., Gulve, E. A., Gao, J., Johnson, D. W., Holloszy, J. O., & Mueckler, M. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85395-4 · Cited by 274
Miyazaki, Y., Glass, L. C., Triplitt, C. L., Matsuda, M., Cusi, K. J., Mahankali, A., Mahankali, S., Mandarino, L. J., & DeFronzo, R. A. (2001) · Diabetologia · doi:10.1007/s001250100031 · Cited by 274
Bruss, M. D., Arias, E. B., Lienhard, G. E., & Cartee, G. D. (2005) · Diabetes · doi:10.2337/diabetes.54.1.41 · Cited by 273 · cited 1×
“In addition, AS160 is phosphorylated in response to insulin in a dose-dependent fashion in rat skeletal muscle [46, 47 ].”
BackgroundWolffenbuttel, B. H. R., Gomis, R., Squatrito, S., Jones, N. P., & Patwardhan, R. (2000) · Diabetic Medicine · doi:10.1046/j.1464-5491.2000.00224.x · Cited by 263
Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes
Tanti, J., Grillo, S., Grémeaux, T., Coffer, P. J., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1997) · Endocrinology · doi:10.1210/endo.138.5.5136 · Cited by 260
Khan, M. A., Peter, J. V. S., & Xue, J. L. (2002) · Diabetes Care · doi:10.2337/diacare.25.4.708 · Cited by 250
�stenson, C. G., Khan, A. W., Abdel‐Halim, S. M., Guenifi, A., Suzuki, K., Goto, Y., & Efendić, S. (1993) · Diabetologia · doi:10.1007/bf00399086 · Cited by 246
Hirshman, M. F., Goodyear, L. J., Wardzala, L. J., Horton, E. D., & Horton, E. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40147-6 · Cited by 243
High-Fat Feeding Impairs Insulin-Stimulated GLUT4 Recruitment via an Early Insulin-Signaling Defect
Zierath, J. R., Houseknecht, K. L., Gnudi, L., & Kahn, B. B. (1997) · Diabetes · doi:10.2337/diab.46.2.215 · Cited by 238
Self-citation“Semi-open” muscle biopsy technique A SIMPLE OUTPATIENT PROCEDURE
Henriksson, K. G. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1979.tb02942.x · Cited by 233
Koistinen, H. A., Galuska, D., Chibalin, A., Yang, J., Zierath, J. R., Holman, G. D., & Wallberg‐Henriksson, H. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1066 · Cited by 232
Self-citationKelley, D. E., Mintun, M. A., Watkins, S. C., Simoneau, J. A., Jadali, F., Fredrickson, A., Beattie, J., & Thériault, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118724 · Cited by 228
Glucose tolerance in young and older athletes and sedentary men
Seals, D. R., Hagberg, J. M., Allen, W. K., Hurley, B. F., Dalsky, G. P., Ehsani, A. A., & Holloszy, J. O. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.6.1521 · Cited by 228
Gibbs, E. M., Stock, J. L., McCoid, S. C., Stukenbrok, H., Pessin, J. E., Stevenson, R. W., Milici, A. J., & McNeish, J. D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117823 · Cited by 226
Zeigerer, A., McBrayer, M. K., & McGraw, T. E. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0333 · Cited by 226
Camp, H. S., Li, O., Wise, S., Hong, Y., Frankowski, C., Shen, X., Vanbogelen, R., & Leff, T. (2000) · Diabetes · doi:10.2337/diabetes.49.4.539 · Cited by 224
Folli, F. B., Saad, M. J. A., Backer, J., & Kahn, C. R. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116768 · Cited by 220
Bandyopadhyay, G. K., Standaert, M. L., Galloway, L. C., Moscat, J., & Farese, R. V. (1997) · Endocrinology · doi:10.1210/endo.138.11.5473 · Cited by 218
Ryder, J. W., Yang, J., Galuska, D., Rincón, J., Björnholm, M., Krook, A., Lund, S., Pedersen, O., Wallberg-Henriksson, H., Zierath, J. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.4.647 · Cited by 216
Self-citationRaskin, P., Rappaport, E. B., Cole, S. T., Yan, Y., Patwardhan, R., & Freed, M. I. (2000) · Diabetologia · doi:10.1007/s001250050045 · Cited by 214
Effect of Rosiglitazone on Insulin Sensitivity and Body Composition in Type 2 Diabetic Patients
Carey, D., Cowin, G., Galloway, G. J., Jones, N. P., Richards, J. C., Biswas, N., & Doddrell, D. M. (2002) · Obesity Research · doi:10.1038/oby.2002.137 · Cited by 210
Hyperglycemia Decreases Glucose Uptake in Type I Diabetes
Yki‐Järvinen, H., Helve, E., & Koivisto, V. A. (1987) · Diabetes · doi:10.2337/diab.36.8.892 · Cited by 208
Enhanced Insulin Action Due to Targeted GLUT4 Overexpression Exclusively in Muscle
Tsao, T., Burcelin, R., Katz, E. B., Huang, L., & Charron, M. J. (1996) · Diabetes · doi:10.2337/diab.45.1.28 · Cited by 201
Gerhold, D. L., Liu, F., Jiang, G., Li, Z., Xu, J. Y., Lu, M., Sachs, J. R., Bagchi, A., Fridman, A., Holder, D., et al. (2002) · Endocrinology · doi:10.1210/endo.143.6.8842 · Cited by 191
Glucose uptake in human adipose tissue
Mårin, P., Rebuffé-Scrive, M., Smith, U., & Björntorp, P. A. (1987) · Metabolism · doi:10.1016/0026-0495(87)90242-3 · Cited by 183
Huang, C., Thirone, A. C. P., Huang, X., & Klip, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412317200 · Cited by 181
Patel, J., Anderson, R. J., & Rappaport, E. B. (1999) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.1999.00020.x · Cited by 180
Arner, P., Pollare, T., Lithell, H., & Livingston, J. N. (1987) · Diabetologia · doi:10.1007/bf00292549 · Cited by 178
Trovati, M., Carta, Q., Cavalot, F. L., Vitali, S., Banaudi, C., Lucchina, P. G., Fiocchi, F., Emanuelli, G., & Lenti, G. (1984) · Diabetes Care · doi:10.2337/diacare.7.5.416 · Cited by 173
Kahn, B. B., Shulman, G. I., DeFronzo, R. A., Cushman, S. W., & Rossetti, L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115031 · Cited by 171
Ren, J., Marshall, B. A., Mueckler, M. M., McCaleb, M. L., Amatruda, J. M., & Shulman, G. I. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117673 · Cited by 171
Hansen, P. A., Gulve, E. A., Marshall, B. A., Gao, J., Pessin, J. E., Holloszy, J. O., & Mueckler, M. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.1679 · Cited by 170
Gao, Y., Feng, H. C., Walder, K. R., Bolton, K. A., Sunderland, T., Bishara, N., Quick, M., Kantham, L., & Collier, G. R. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00296-0 · Cited by 165
Defective Signaling Through Akt-2 and -3 But Not Akt-1 in Insulin-Resistant Human Skeletal Muscle
Brozinick, J. T., Roberts, B. R., & Dohm, G. L. (2003) · Diabetes · doi:10.2337/diabetes.52.4.935 · Cited by 164
Beeson, M., Sajan, M. P., Dizon, M. N., Grebenev, D., Gomez-Daspet, J., Miura, A., Kanoh, Y., Powe, J. L., Bandyopadhyay, G. K., Standaert, M. L., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1926 · Cited by 163
Shadid, S., & Jensen, M. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3148 · Cited by 159
Kim, Y., Kotani, K., Ciaraldi, T. P., Henry, R. R., & Kahn, B. B. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1935 · Cited by 159
Tanis: A Link Between Type 2 Diabetes and Inflammation?
Walder, K. R., Kantham, L., McMillan, J. S., Trevaskis, J. L., Kerr, L. J., de Silva, A. M., Sunderland, T., Gödde, N., Gao, Y., Bishara, N., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1859 · Cited by 158
Handberg, A., Vaag, A. A., Damsbo, P., Beck‐Nielsen, H., & Vinten, J. (1990) · Diabetologia · doi:10.1007/bf00400207 · Cited by 150
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle
Dong, L., & Liu, F. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00011.2005 · Cited by 149
Activation of glucose transport in diabetic muscle: responses to contraction and insulin
Wallberg‐Henriksson, H., & Holloszy, J. O. (1985) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1985.249.3.c233 · Cited by 148
Krook, A., Kawano, Y., Song, X. M., Efendić, S., Roth, R. A., Wallberg‐Henriksson, H., & Zierath, J. R. (1997) · Diabetes · doi:10.2337/diab.46.12.2110 · Cited by 142
Self-citationArias, E. B., Kim, J., & Cartee, G. D. (2004) · Diabetes · doi:10.2337/diabetes.53.4.921 · Cited by 139
Mechanism of troglitazone action in type 2 diabetes.
Petersen, K. F., Krššák, M., Inzucchi, S. E., Cline, G. W., Dufour, S., & Shulman, G. I. (2000) · Diabetes · doi:10.2337/diabetes.49.5.827 · Cited by 136
Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients
Miyazaki, Y., He, H., Mandarino, L. J., & DeFronzo, R. A. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1943 · Cited by 135
Increased Muscle Glucose Uptake After Exercise: No Need for Insulin During Exercise
Richter, E. A., Ploug, T., & Galbo, H. (1985) · Diabetes · doi:10.2337/diab.34.10.1041 · Cited by 135
Didichenko, S. A., Tilton, B., Hemmings, B. A., Ballmer‐Hofer, K., & Thelen, M. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70713-6 · Cited by 133
Role of Skeletal Muscle in Thiazolidinedione Insulin Sensitizer (PPAR Agonist) Action
Zierath, J. R., Ryder, J. W., Doebber, T. W., Woods, J. W., Wu, M. S., Ventre, J. R., Li, Z., McCrary, C. T., Berger, J. P., Zhang, B., et al. (1998) · Endocrinology · doi:10.1210/endo.139.12.6364 · Cited by 133
Self-citationBoden, G., Homko, C., Mozzoli, M., Showe, L. C., Nichols, C., & Cheung, P. (2005) · Diabetes · doi:10.2337/diabetes.54.3.880 · Cited by 129
Kim, Y., Ciaraldi, T. P., Kong, A. P. S., Kim, D. S., Chu, N. V., Mohideen, P., Mudaliar, S. R. D., Henry, R. R., & Kahn, B. B. (2002) · Diabetes · doi:10.2337/diabetes.51.2.443 · Cited by 129
Wallberg‐Henriksson, H., ZETAN, N., & Henriksson, J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47618-1 · Cited by 124
Marshall, B. A., Ren, J., Johnson, D. W., Gibbs, E. M., Lillquist, J. S., Soeller, W. C., Holloszy, J. O., & Mueckler, M. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46645-2 · Cited by 122
Galuska, D., Nolte, L. A., Zierath, J. R., & Wallberg‐Henriksson, H. (1994) · Diabetologia · doi:10.1007/bf00404340 · Cited by 121
Self-citationKahn, B. B., & Pedersen, O. B. (1993) · Endocrinology · doi:10.1210/endo.132.1.8419118 · Cited by 121
Leturque, A., Loizeau, M., Vaulont, S., Salminen, M., & Girard, J. R. (1996) · Diabetes · doi:10.2337/diab.45.1.23 · Cited by 119
Ikemoto, S., Thompson, K., Takahashi, M. M., Itakura, H., Lane, M. D., & Ezaki, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3096 · Cited by 118
Vollenweider, P., Ménard, B., & NICOD, P. H. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1052 · Cited by 117
Nolan, J. J., Jones, N. P., Patwardhan, R., & Deacon, L. F. (2000) · Diabetic Medicine · doi:10.1046/j.1464-5491.2000.00269.x · Cited by 116
Wallberg‐Henriksson, H. (1987) · PubMed · Cited by 116
Acute exercise increases the number of plasma membrane glucose transporters in rat skeletal muscle
Hirshman, M. F., Wallberg‐Henriksson, H., Wardzala, L. J., Horton, E. D., & Horton, E. S. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80486-1 · Cited by 113
Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes
Boden, G. H., Cheung, P., Mozzoli, M. A., & Fried, S. K. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00055-6 · Cited by 113
Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.
Heydrick, S. J., Jullien, D., Gautier, N., Tanti, J., Giorgetti‐Peraldi, S., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116337 · Cited by 112
A comparison in a clinical setting of the efficacy and side effects of three thiazolidinediones.
King, A. B. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.557b · Cited by 111
Ahuja, H. S., Liu, S., Crombie, D. L., Boehm, M. F., Leibowitz, M. D., Heyman, R. A., Depré, C., Nagy, L., Tontonoz, P., & Davies, P. J. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.765 · Cited by 108
Nolan, J. J. (1994) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.2.471 · Cited by 108
Maegawa, H., Shigeta, Y., Egawa, K., & Kobayashi, M. (1991) · Diabetes · doi:10.2337/diab.40.7.815 · Cited by 107
Park, K. S., Ciaraldi, T. P., Lindgren, K., Abrams-Carter, L., Mudaliar, S. R. D., Nikoulina, S. E., Tufari, S. R., Veerkamp, J. H., Vidal‐Puig, A., & Henry, R. R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.5034 · Cited by 103
Rab11 is associated with GLUT4-containing vesicles and redistributes in response to insulin
Kessler, A., Tomás, E., Immler, D., Meyer, H. E., Antonio Zorzano, A., & Eckel, J. (2000) · Diabetologia · doi:10.1007/s001250051563 · Cited by 99
Björnholm, M., Kawano, Y., Lehtihet, M., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.3.524 · Cited by 98
Ebeling, P. R., Teppo, A.-M., Koistinen, H. A., Viikari, J. S. A., R�nnemaa, T., Niss�n, M., Bergkulla, S., Salmela, P. I., Saltevo, J. T., & Koivisto, V. A. (1999) · Diabetologia · doi:10.1007/s001250051315 · Cited by 95
Karlsson, H., Hällsten, K., Björnholm, M., Tsuchida, H., Chibalin, A., Virtanen, K. A., Heinonen, O. J., Lönnqvist, F., Nuutila, P., & Zierath, J. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1459 · Cited by 92
Self-citationLund, S. A., Holman, G. D., Schmitz, O., & Pedersen, O. B. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80895-2 · Cited by 91
Moving the insulin-regulated glucose transporter GLUT4 into and out of storage
Holman, G. D., & Sandoval, I. V. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)01953-5 · Cited by 88
Glucose-induced insulin resistance of skeletal-muscle glucose transport and uptake
Richter, E. A., Hansen, B. F., & Hansen, S. A. (1988) · Biochemical Journal · doi:10.1042/bj2520733 · Cited by 87
Wilson, C. M., & Cushman, S. W. (1994) · Biochemical Journal · doi:10.1042/bj2990755 · Cited by 86
Stenbit, A. E., Burcelin, R., Katz, E. B., Tsao, T., Gautier, N., Charron, M. J., & MARCHAND‐BRUSTEL, Y. L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118833 · Cited by 76
Picarel-Blanchot, F., Lubrano-Berthelier, C., Bailbé, D., & Portha, B. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.4.e755 · Cited by 76
Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15 (23):6541-6551
Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1997) · Cited by 76
Pedersen, O., Bak, J. F., Andersen, P. H., et al. (1990) · Diabetes · doi:10.2337/diabetes.39.7.865 · Cited by 76
Kristiansen, S., Hargreaves, M., & Richter, E. A. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.1.e197 · Cited by 75
Andreasson, K., Galuska, D., Thörne, A., SONNENFELD, T., & Wallberg‐Henriksson, H. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09154.x · Cited by 74
Cited by
Sorted by citations
Copps, K. D., & White, M. F. (2012) · Diabetologia · doi:10.1007/s00125-012-2644-8 · Cited by 1,017
“Direct observations of human muscle do not support diminished IRS protein concentration as a primary cause of insulin resistance, though most studies have not examined IRS2 ([80, 81], and reviewed in [4]).”
BackgroundPathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542
Sun, Y., Shi, H., Yin, S., Ji, C., Zhang, X., Zhang, B., Wu, P., Shi, Y., Mao, F., Yan, Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b07643 · Cited by 468
Commentary: IL-4 and IL-13 receptors and signaling
McCormick, S. M., & Heller, N. M. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.023 · Cited by 329
Metadata
- Authors
- Karlsson, H. K. R., & Zierath, J. R.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Zierath, Juleen R.
- Venue
- Cell Biochemistry and Biophysics
- Published
- 2007-04-17
- Volume
- 48
- Issue
- 2-3
- Pages
- 103-113
- ISSN
- 1085-9195 (ISSN-L)
- 1559-0283
- OpenAlex
- W2159080529
- Cited by
- 159
- References
- 231
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 16 · 2020: 12 · 2019: 5 · 2018: 13 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 10
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Locations
- Cell Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Open Archive (Karolinska Institutet) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- insulin signaling, glucose transport, skeletal muscle, insulin resistance, type 2 diabetes, glucose uptake, signal transduction, protein phosphorylation, glucose homeostasis, antidiabetic drugs, insulin sensitivity
- MeSH terms
- Diabetes Mellitus, Type 2, Glucose, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Models, Biological, Phosphoproteins, Signal Transduction, Muscle, Skeletal, Insulin Receptor Substrate Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review